TR200103696T2 - Makrofaj temizleyici reseptör antagonistleri. - Google Patents

Makrofaj temizleyici reseptör antagonistleri.

Info

Publication number
TR200103696T2
TR200103696T2 TR2001/03696T TR200103696T TR200103696T2 TR 200103696 T2 TR200103696 T2 TR 200103696T2 TR 2001/03696 T TR2001/03696 T TR 2001/03696T TR 200103696 T TR200103696 T TR 200103696T TR 200103696 T2 TR200103696 T2 TR 200103696T2
Authority
TR
Turkey
Prior art keywords
macrophage
receptor antagonists
clearing
clearing receptor
compounds
Prior art date
Application number
TR2001/03696T
Other languages
English (en)
Inventor
Weinstock Joseph
G. Franz Robert
E. Ga�Tanopoulos Dimitri
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of TR200103696T2 publication Critical patent/TR200103696T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Makrofaj temizleyici reseptör antagonistleri anlatilmaktadir. Ayrica bu bulusun bilesiklerinin uygulanmasi ile kardiyovasküler hastaliklarin tedavisi için metodlar da anlatilmistir. Bu bilesikler makrofajdan türetilen köpük hücrelerinde lipid birikimini önlemektedir.
TR2001/03696T 1999-06-24 2000-06-21 Makrofaj temizleyici reseptör antagonistleri. TR200103696T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14096599P 1999-06-24 1999-06-24

Publications (1)

Publication Number Publication Date
TR200103696T2 true TR200103696T2 (tr) 2002-06-21

Family

ID=22493567

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03696T TR200103696T2 (tr) 1999-06-24 2000-06-21 Makrofaj temizleyici reseptör antagonistleri.

Country Status (19)

Country Link
US (1) US6458845B1 (tr)
EP (1) EP1187531A4 (tr)
JP (1) JP2003502347A (tr)
KR (1) KR20020022716A (tr)
CN (1) CN1358062A (tr)
AU (1) AU5881000A (tr)
BR (1) BR0011571A (tr)
CA (1) CA2377288A1 (tr)
CO (1) CO5190711A1 (tr)
CZ (1) CZ20014642A3 (tr)
HK (1) HK1044449A1 (tr)
HU (1) HUP0202142A3 (tr)
IL (1) IL146513A0 (tr)
MX (1) MXPA02000123A (tr)
NO (1) NO20016077D0 (tr)
PL (1) PL352704A1 (tr)
TR (1) TR200103696T2 (tr)
WO (1) WO2000078145A1 (tr)
ZA (1) ZA200110350B (tr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02011160A (es) * 2000-05-12 2003-03-10 Smithkline Beecham Corp Inhibidores del transporte de fosfato.
EP1317260A2 (en) * 2000-08-30 2003-06-11 Signature Bioscience, Inc. Methods for treating tumors using sulfonyl compounds
DE10121003A1 (de) 2001-04-28 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE10121002A1 (de) * 2001-04-28 2002-11-14 Aventis Pharma Gmbh Verwendung von Anthranilsäureamiden als Medikament zur Behandlung von Arrhythmien sowie sie enthaltende pharmazeutische Zubereitungen
US20030216449A1 (en) * 2001-05-11 2003-11-20 Joseph Weinstock Phosphate transport inhibitors
DE10128331A1 (de) * 2001-06-12 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
GB2378179A (en) * 2001-08-03 2003-02-05 Pantherix Ltd Aromatic sulfonamides and their use in treating bacterial diseases
GB0228490D0 (en) * 2002-12-06 2003-01-08 Amersham Plc Novel imaging compounds
NZ542491A (en) 2003-03-28 2009-04-30 Janssen Pharmaceutica Nv Benzo[1,2,5]thiadiazole compounds as CCK2 modulators
CN101061116A (zh) 2004-09-24 2007-10-24 詹森药业有限公司 磺酰胺化合物
EP2147011A4 (en) 2007-04-16 2012-07-18 Health Research Inc METHOD FOR INHIBITING CLASS A PHAGOCYTE RECEPTOR AND INCREASING IMMUNE RESPONSE TO ANTIGENS
WO2011011514A1 (en) * 2009-07-21 2011-01-27 The Board Of Trustees Of The Leland Stanford Junior University Heteroaryl benzamides, compositions and methods of use
US8664425B2 (en) * 2010-02-02 2014-03-04 Honeywell International Inc. Bluegreen fluorescent compounds
JP6106685B2 (ja) 2011-11-17 2017-04-05 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド Ｃ−ｊｕｎ−ｎ−末端キナーゼ（ｊｎｋ）の阻害剤
CN103183623A (zh) * 2013-03-12 2013-07-03 中国医学科学院医药生物技术研究所 一组苯磺酰胺基苯甲酰胺类衍生物及制备和应用
EP2990403A1 (en) * 2014-08-29 2016-03-02 Novartis Tiergesundheit AG Anthranilamides, sulfonamides and nitro analogues derived therefrom as anthelmintics
CN105395532B (zh) * 2015-11-25 2017-11-14 中国医学科学院医药生物技术研究所 2‑苯磺酰胺基苯甲酰胺类化合物在肝损伤保护和肝纤维化防治中的应用
JP6713051B2 (ja) * 2016-08-30 2020-06-24 日本曹達株式会社 スルホニルアミノベンズアミド化合物および有害生物防除剤
WO2019232384A1 (en) 2018-06-01 2019-12-05 Promega Corporation Inhibitors of oplophorus luciferase-derived bioluminescent complexes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3357977A (en) 1964-01-06 1967-12-12 Minnesota Mining & Mfg Novel anthranyl intermediates
JPS6038695B2 (ja) * 1979-12-05 1985-09-02 富士写真フイルム株式会社 カラ−写真感光材料
JPS57198459A (en) 1981-06-01 1982-12-06 Fuji Photo Film Co Ltd Color photographic sensitive material
EP0420805A3 (en) * 1989-09-26 1991-10-16 Ciba-Geigy Ag Anthelmintic compounds
TW523506B (en) * 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
DE19830431A1 (de) * 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Sulfonylamino-carbonsäure-N-arylamide als Guanylatcyclase-Aktivatoren

Also Published As

Publication number Publication date
HUP0202142A2 (en) 2002-10-28
JP2003502347A (ja) 2003-01-21
CN1358062A (zh) 2002-07-10
KR20020022716A (ko) 2002-03-27
PL352704A1 (en) 2003-09-08
BR0011571A (pt) 2002-03-05
NO20016077L (no) 2001-12-13
AU5881000A (en) 2001-01-09
IL146513A0 (en) 2002-07-25
MXPA02000123A (es) 2002-07-02
NO20016077D0 (no) 2001-12-13
HK1044449A1 (zh) 2002-10-25
CA2377288A1 (en) 2000-12-28
CO5190711A1 (es) 2002-08-29
ZA200110350B (en) 2002-09-30
CZ20014642A3 (cs) 2002-06-12
US6458845B1 (en) 2002-10-01
HUP0202142A3 (en) 2005-05-30
EP1187531A1 (en) 2002-03-20
WO2000078145A1 (en) 2000-12-28
EP1187531A4 (en) 2003-05-28

Similar Documents

Publication Publication Date Title
TR200103696T2 (tr) Makrofaj temizleyici reseptör antagonistleri.
NL1014626A1 (nl) Opbouw voor CT-scanstelsel.
BRPI0010891B1 (pt) geração de microespuma terapêutica.
DK1632234T3 (da) (S,S)-reboxetin til behandling af kronisk træthedssyndrom
ATE263563T1 (de) Mittel gegen juckreiz
TR199901575T2 (tr) Vitronektin reseptör antagonistleri.
DE60025241D1 (de) HäMOPOIETINREZEPTOR-PROTEIN, NR12
DE60025639D1 (de) Substituierte diazepan
DZ3157A1 (fr) Solvates de pymetrozine.
BR0002966B1 (pt) dobradiÇa.
IT1305301B1 (it) Raccordo per anastomosi vascolari.
DE60000826D1 (de) 14.beta.,17-alpha-hydroxymethylandrostan derivate als androgene
ITMI20032037A1 (it) Supporto del cruscotto.
IT1311936B1 (it) Piede per mobili.
ES1041945Y (es) Util soporte de lacones.
ES1043726Y (es) Dispositivo de variacion del ancho util de aperos de labranza.
ES1043921Y (es) Soporte para la lista de compras.
IT1319418B1 (it) Tassello radiale ad eccentrico.
ES1044239Y (es) Pieza prefabricada para la reconstruccion de balcones.
ES1053787Y (es) Soporte de percha antiarrugas para pantalones.
IT1311656B1 (it) Struttura di inserto, particolarmente per applicazione di cerniere asupporti.
IT1311031B1 (it) Dispositivo per il fissaggio rapido di cerniera per mobili.
IT245540Y1 (it) Struttura di supporto, particolarmente per calzature.
ES1042188Y (es) Soporte para accesorios de baño.
ES1044739Y (es) Disposicion de soporte perfeccionada para toldos.