CO5080763A1 - Composiciones farmaceuticas con base en quinolonas sustitui- das en posicion 2 y metodos para su preparacion - Google Patents
Composiciones farmaceuticas con base en quinolonas sustitui- das en posicion 2 y metodos para su preparacionInfo
- Publication number
- CO5080763A1 CO5080763A1 CO99025654A CO99025654A CO5080763A1 CO 5080763 A1 CO5080763 A1 CO 5080763A1 CO 99025654 A CO99025654 A CO 99025654A CO 99025654 A CO99025654 A CO 99025654A CO 5080763 A1 CO5080763 A1 CO 5080763A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- aryl
- mono
- optionally substituted
- substituents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
Un compuesto de fórmula (I):<EMI FILE="99025654_1" ID="1" IMF=JPEG >en la cual:R1 es arilo opcionalmente sustituido con hasta cuatro sustituyentes tales como el alquil C(1-6), alkoxi C(1-6), halo, ciano, amino, sulfamoílo fenilcarbonilo, arilo y benciloxi o sustituyentes lipófilos del tipo de cloro, bromo, yodo, metilo, etoxi, aliloxi, fenitiloxi o trifluorometilo; o R1 puede ser también un heteroarilo que puede estar sustituido por sustituyentes lipófilos del tipo cloro, bromo, yodo, metilo, etoxi o trifluorometilo;R2 es hidrógeno, alquilo C(1-6), aril-alquilo C(1-4) , aril-alquenilo C(2-4) o alquil C(1-6) -carbonilo;R3 se selecciona de halo, ciano, hidroxi, alquilo C(1-6) (sustituido opcionalmente con halo, hidroxi, amino, mono a perfluoro-alquilo C(1-3), carboxi o alcoxi C(1-6)-carbonilo), cicloalquilo C(3-7), alcoxi C(1-6), amino, mono-o di-alquilamino C(1-6), acilamino, carboxi, alcoxi C(1-6)-carbonilo, carboxi-alquiloxi C(1-6), alquiltio C(1-6), alquilsulfinilo C(1-6), alquilsulfonilo (1-6), sulfamoílo, mono- y di-alquil C(1-6)- sulfamoílo, carbamoílo, mono-y di-alquil C(1-6)-carbamoílo, y heterociclilo;m es 0 o un número entero de 1 a 3;X es CHR4 (en cuya fórmula R4 es hidrógeno, alquilo C(1-6) o arilo), alquileno C(2-4) , alquenileno C(3-4) , o CO;Y es un grupo enlazador que tiene de 2 a 6 grupos metileno en cadena lineal y en el cual uno o más grupos metileno pueden tener uno o más sustituyentes alquilo C(1-6) , alcoxi C(1-6) o alquilidenilo C(1-6), y en cuya cadena los átomos de carbono 1,2 ó 1,3 pueden estar enlazados por un puente alquileno C(2-3) o alquenileno C3;R1 y X o R1 y R2 pueden estar unidos por una cadena de polimetileno para formar un anillo de 5 a 7 miembros, sustituido opcionalmente con alquilo C(1-6) ;X y R2 , X e Y o Y y R2 pueden estar unidos por una cadena de polimetileno para formar un anillo de 4 a 7 miembros, sustituido opcionalmente con alquilo C(1-6) ;Z es NH u O; ysus sales, preferiblemente sus sales farmacéuticamente aceptables.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9809050.9A GB9809050D0 (en) | 1998-04-29 | 1998-04-29 | Novel compounds |
| GBGB9824571.5A GB9824571D0 (en) | 1998-11-09 | 1998-11-09 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5080763A1 true CO5080763A1 (es) | 2001-09-25 |
Family
ID=26313554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99025654A CO5080763A1 (es) | 1998-04-29 | 1999-04-29 | Composiciones farmaceuticas con base en quinolonas sustitui- das en posicion 2 y metodos para su preparacion |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6320051B1 (es) |
| EP (1) | EP1084110A1 (es) |
| JP (1) | JP2002513005A (es) |
| KR (1) | KR20010043131A (es) |
| CN (1) | CN1307565A (es) |
| AR (1) | AR018199A1 (es) |
| AU (1) | AU3523599A (es) |
| BR (1) | BR9909994A (es) |
| CA (1) | CA2330564A1 (es) |
| CO (1) | CO5080763A1 (es) |
| HU (1) | HUP0103093A3 (es) |
| IL (1) | IL138906A0 (es) |
| NO (1) | NO20005400D0 (es) |
| PL (1) | PL343680A1 (es) |
| TR (1) | TR200003170T2 (es) |
| WO (1) | WO1999055677A1 (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040014121A1 (en) * | 1996-04-18 | 2004-01-22 | Smithkline Beecham Corporation | Novel compounds |
| GB9822241D0 (en) * | 1998-10-12 | 1998-12-09 | Smithkline Beecham Plc | Novel compounds |
| GB9827467D0 (en) * | 1998-12-15 | 1999-02-10 | Zeneca Ltd | Chemical compounds |
| EP1176958B1 (en) * | 1999-05-05 | 2004-07-28 | Merck & Co., Inc. | Novel catechols as antimicrobial agents |
| EP1466603A3 (en) * | 1999-05-05 | 2004-10-20 | Merck & Co., Inc. | Novel catechols as antimicrobial agents |
| GB9911594D0 (en) * | 1999-05-19 | 1999-07-21 | Smithkline Beecham Plc | Novel compounds |
| WO2000071524A1 (en) * | 1999-05-19 | 2000-11-30 | Smithkline Beecham Plc | 2-nh-pyridones and pyrimidones as mrs inhibitors |
| US20040053963A1 (en) * | 2000-12-11 | 2004-03-18 | Dashyant Dhanak | Urotensin-II receptor antagonists |
| AU2002226048A1 (en) * | 2000-12-11 | 2002-06-24 | Smith Kline Beecham Corporation | Urotensin-ii receptor antagonists |
| JP2004524295A (ja) | 2001-01-26 | 2004-08-12 | スミスクライン・ビーチャム・コーポレイション | ウロテンシン−ｉｉ受容体アンタゴニスト |
| SE0202134D0 (sv) * | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Therapeutic agents |
| EP1572215B1 (en) | 2002-12-20 | 2009-09-02 | Glaxo Group Limited | Benzo[d]azepine derivatives for the treatment of neurological disorders |
| GB0304809D0 (en) * | 2003-03-03 | 2003-04-09 | Glaxo Group Ltd | Novel compounds |
| WO2004078119A2 (en) | 2003-03-03 | 2004-09-16 | Replidyne Inc. | Substituted thiophenes with antibacterial activity |
| CA2523651A1 (en) * | 2003-05-01 | 2005-02-03 | Replidyne, Inc. | Antibacterial methods and compositions |
| EP1706384A1 (en) * | 2004-01-07 | 2006-10-04 | AstraZeneca AB | Therapeutic agents i |
| JO3077B1 (ar) * | 2005-07-28 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينولين مضادة للبكتيريا |
| FR2902100A1 (fr) * | 2006-06-13 | 2007-12-14 | Sanofi Aventis Sa | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique |
| WO2008039639A2 (en) * | 2006-09-26 | 2008-04-03 | Crestone, Inc. | Substituted thienopyridone compounds with antibacterial activity |
| US7994192B2 (en) | 2006-09-26 | 2011-08-09 | Crestone, Inc. | Substituted thienopyridone compounds with antibacterial activity |
| US7973050B2 (en) | 2006-09-26 | 2011-07-05 | Crestone, Inc. | Enantiomeric compounds with antibacterial activity |
| DK2091536T3 (da) * | 2006-09-26 | 2013-10-28 | Crestone Inc | Enantiomere forbindelser med antibakteriel aktivitet |
| US8658670B2 (en) | 2006-09-26 | 2014-02-25 | Crestone, Inc. | Methods and compounds for treatment of clostridium based infection |
| US8697720B2 (en) | 2006-09-26 | 2014-04-15 | Crestone, Inc. | Substituted phenylether-thienopyridone compounds with antibacterial activity |
| CN104546857B (zh) * | 2013-10-18 | 2017-01-04 | 北京北科德源生物医药科技有限公司 | 化合物naphthoylenequinazolone的抗菌用途 |
| JP7344125B2 (ja) * | 2017-03-30 | 2023-09-13 | エフ． ホフマン－ラ ロシュ アーゲー | 細菌感染の治療及び予防のための新規ピリド［２，３－ｂ］インドール化合物 |
| CN112939860B (zh) * | 2019-11-11 | 2022-11-11 | 山东畜牧兽医职业学院 | 一种治疗耐药性革兰阴阳性菌的化合物及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4005205A (en) * | 1974-04-24 | 1977-01-25 | Smith Kline & French Laboratories Limited | Compositions and methods for inhibiting H2 histamine receptors |
| GB8332091D0 (en) * | 1983-12-01 | 1984-01-11 | Smith Kline French Lab | Chemical compounds |
| KR950005301B1 (ko) | 1990-09-04 | 1995-05-23 | 주식회사대웅제약 | 신규한 퀴놀론 카르복실산 유도체 |
| KR960007566A (ko) * | 1994-08-19 | 1996-03-22 | 김정규 | 신규한 퀴놀릴아민 유도체, 그의 제조방법 및 항부정맥제로서의 용도 |
-
1999
- 1999-04-15 AU AU35235/99A patent/AU3523599A/en not_active Abandoned
- 1999-04-15 CN CN99807809A patent/CN1307565A/zh active Pending
- 1999-04-15 WO PCT/EP1999/002648 patent/WO1999055677A1/en not_active Application Discontinuation
- 1999-04-15 KR KR1020007012024A patent/KR20010043131A/ko not_active Application Discontinuation
- 1999-04-15 JP JP2000545837A patent/JP2002513005A/ja active Pending
- 1999-04-15 US US09/674,102 patent/US6320051B1/en not_active Expired - Fee Related
- 1999-04-15 HU HU0103093A patent/HUP0103093A3/hu unknown
- 1999-04-15 CA CA002330564A patent/CA2330564A1/en not_active Abandoned
- 1999-04-15 EP EP99916927A patent/EP1084110A1/en not_active Withdrawn
- 1999-04-15 PL PL99343680A patent/PL343680A1/xx unknown
- 1999-04-15 TR TR2000/03170T patent/TR200003170T2/xx unknown
- 1999-04-15 IL IL13890699A patent/IL138906A0/xx unknown
- 1999-04-15 BR BR9909994-2A patent/BR9909994A/pt not_active Application Discontinuation
- 1999-04-27 AR ARP990101937A patent/AR018199A1/es unknown
- 1999-04-29 CO CO99025654A patent/CO5080763A1/es unknown
-
2000
- 2000-10-26 NO NO20005400A patent/NO20005400D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL343680A1 (en) | 2001-08-27 |
| EP1084110A1 (en) | 2001-03-21 |
| TR200003170T2 (tr) | 2001-01-22 |
| CN1307565A (zh) | 2001-08-08 |
| CA2330564A1 (en) | 1999-11-04 |
| NO20005400L (no) | 2000-10-26 |
| BR9909994A (pt) | 2000-12-26 |
| US6320051B1 (en) | 2001-11-20 |
| HUP0103093A3 (en) | 2002-03-28 |
| AR018199A1 (es) | 2001-10-31 |
| KR20010043131A (ko) | 2001-05-25 |
| AU3523599A (en) | 1999-11-16 |
| NO20005400D0 (no) | 2000-10-26 |
| JP2002513005A (ja) | 2002-05-08 |
| HUP0103093A2 (hu) | 2002-02-28 |
| IL138906A0 (en) | 2001-11-25 |
| WO1999055677A1 (en) | 1999-11-04 |
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