CO4990947A1 - Antibioticos cefalosporinicos - Google Patents

Antibioticos cefalosporinicos

Info

Publication number
CO4990947A1
CO4990947A1 CO98073442A CO98073442A CO4990947A1 CO 4990947 A1 CO4990947 A1 CO 4990947A1 CO 98073442 A CO98073442 A CO 98073442A CO 98073442 A CO98073442 A CO 98073442A CO 4990947 A1 CO4990947 A1 CO 4990947A1
Authority
CO
Colombia
Prior art keywords
phenyl
alkyl
hydrogen
independently
cephalosporinic
Prior art date
Application number
CO98073442A
Other languages
English (en)
Inventor
Karl Robert Dahnke
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO4990947A1 publication Critical patent/CO4990947A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Abstract

Un Compuesto de fórmula IEn la que:Ra , Rb , Rc , Rd y Re son independientemente H, F o un grupo (alquiloC1 -C6 )-(Z)n - que tiene por lo menos un flúor como sustituyente, X es O o S, Y es S, O o -CH2 -, Z es O, S, -SO- o -SO2 -,m y n son independientemente 0 ó 1,R es Y R1 es H, alquilo C1 -C6 , fenilo o bencilo, cada uno de los cuales puede tener opcionalmente hasta tres sustituyentes seleccionados de halo, alcoxi C1 -C4 , fenilo, NO2 , alcanoílo C1 -C6 , benzoílo o alcanoiloxi C1 -C6 ;O una sal aceptable fisiológicamente del mismo;Con la condición de que :1) por lo menos uno de Ra , Rb , Rc , Rd o Re es distinto de hidrógeno y 2) cuando X e Y son S, y Rb o Rc es F, entonces uno de los restantes Ra , Rb , Rc , Rd o Re es distinto de hidrógeno.
CO98073442A 1997-12-12 1998-12-10 Antibioticos cefalosporinicos CO4990947A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6965597P 1997-12-12 1997-12-12
US8364698P 1998-04-30 1998-04-30

Publications (1)

Publication Number Publication Date
CO4990947A1 true CO4990947A1 (es) 2000-12-26

Family

ID=26750285

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98073442A CO4990947A1 (es) 1997-12-12 1998-12-10 Antibioticos cefalosporinicos

Country Status (9)

Country Link
US (1) US6329363B1 (es)
EP (1) EP0922705A1 (es)
JP (1) JP2002508381A (es)
AR (1) AR017837A1 (es)
AU (1) AU1719099A (es)
CA (1) CA2314139A1 (es)
CO (1) CO4990947A1 (es)
PE (1) PE133899A1 (es)
WO (1) WO1999031110A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3056497B1 (en) 2008-05-05 2018-08-29 The General Hospital Corporation Methods using bodipy-labelled enzyme substrates

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3335136A (en) 1965-12-27 1967-08-08 Lilly Co Eli Halophenylmercaptomethyl cephalosporins
BE793310A (fr) 1971-12-27 1973-06-27 Lilly Co Eli Procede de lutte contre staphylococcus aureus resistant a la methicilline
CA1017325A (en) 1971-12-27 1977-09-13 George W. Huffman Halogenated phenylthioacetamidocephalosporin derivatives
GB1325846A (en) * 1972-02-23 1973-08-08 Lilly Co Eli Process for the preparation of a 3-thiomethyl cephalosporin
US3907784A (en) * 1972-09-11 1975-09-23 Lilly Co Eli 7-Halophenylthioacetamido cephalosporins
US4261991A (en) * 1979-05-01 1981-04-14 Eli Lilly And Company Method of treating infections caused by Streptococcus faecalis
US4379739A (en) * 1980-03-31 1983-04-12 Eli Lilly And Company Electrolytic reduction of cephalosporin p-nitrobenzyl esters
EP0308558A1 (en) 1987-09-25 1989-03-29 Mobil Oil Corporation A process for preparing a macrostructural unit having a catalytically-active zeolite surface
GB8722477D0 (en) * 1987-09-24 1987-10-28 Beecham Group Plc Compounds
DE69016719T2 (de) 1989-09-04 1995-06-01 Beecham Group Plc Cephalosporinderivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate und Zwischenverbindungen.
MY106991A (en) 1989-09-04 1995-08-30 Pfizer Novel cephalosporin derivatives or compounds
US5559108A (en) 1994-09-02 1996-09-24 Bristol-Myers Squibb Company Cephalosporin derivatives
US5567698A (en) 1995-02-15 1996-10-22 Bristol-Myers Squibb Company Pyridinium thiomethyl substituted chepholosporin derivatives

Also Published As

Publication number Publication date
US6329363B1 (en) 2001-12-11
AR017837A1 (es) 2001-10-24
PE133899A1 (es) 2000-01-11
WO1999031110A1 (en) 1999-06-24
EP0922705A1 (en) 1999-06-16
AU1719099A (en) 1999-07-05
CA2314139A1 (en) 1999-06-24
JP2002508381A (ja) 2002-03-19

Similar Documents

Publication Publication Date Title
WO2003062259A3 (en) Non-aromatic 17.alpha.-esters of androstane-17.beta.-carboxylate esters as anti-inflammatory agents
PE20040688A1 (es) Inhibidores de quinasas
AR006390A1 (es) Derivados de lactama
TR199902400T2 (xx) Fungusit etkinlik g�steren terkiplerin birle�imleri.
AR034282A1 (es) Derivados de difenilazetidinona, medicamentos que contienen estos compuestos, procedimiento para su preparacion, y su utilizacion para la preparacion de medicamentos
AR025225A1 (es) Feniloxazolidinonas heterociclicas biciclicas sustituidas antibacterianas y composiciones farmacéuticas
NO20003930D0 (no) Sammensetninger som inneholder organiske forbindelser
NO20013379L (no) 4-okso-1,4-dihydro-3-kinolinkarboksamider som antivirusmidler
FI962800A0 (fi) Fenyyliheterosyklisiä yhdisteitä COX-2 inhibiittoreina
ES2096560T3 (es) Compuestos de benzocicloheptapiridina sustituida con fluor, composiciones y metodos para uso como compuestos antihistaminicos.
FR2619111B1 (fr) Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique
AR002012A1 (es) Un compuesto, una composicion farmaceutica que lo comprende, su uso, metodo de tratamiento terapeutico, metodo para la preparacion del compuesto.
AR036472A1 (es) Derivados de azetidina, procedimientos para su preparacion y su empleo como agentes pesticidas
DE60318826D1 (de) Alkoxypyridinderivate
ATE180781T1 (de) Kristallines tiagabinehydrochlorid-monohydrat, seine herstellung und verwendung
EA200000975A1 (ru) 6-(2-гало-4-алкоксифенил)триазолпиримидины с фунгицидным действием
ATE70056T1 (de) Oxopyrimidin-derivate und sie enthaltende pharmazeutische zubereitungen.
DE69839781D1 (en) Heterocyclische topoisomerase toxine
PT1089625E (pt) Agentes ectoparasiticidas
NO20004273L (no) Streptograminderivater, deres fremstilling samt preparater inneholdende forbindelsene
DE50101861D1 (de) Tocotrienolchinon- zyklisierungsprodukte mit antihypercholesterin wirkung
CO4650039A1 (es) Benzotiofenos amorfos, procedimientos de preparacion y procedimientos de uso
CO4990947A1 (es) Antibioticos cefalosporinicos
CO5080761A1 (es) Inhibidores de lad fkbp na inhibidores de las fkbp
BR1100967A (pt) Composto, e, composição farmacêutica