CO4790100A1 - Composicion cinergetica y metodos para tratar crecimientos neoplasicos o cancerosos y para restaurar o estimular hema- topoiesis - Google Patents
Composicion cinergetica y metodos para tratar crecimientos neoplasicos o cancerosos y para restaurar o estimular hema- topoiesisInfo
- Publication number
- CO4790100A1 CO4790100A1 CO98053593A CO98053593A CO4790100A1 CO 4790100 A1 CO4790100 A1 CO 4790100A1 CO 98053593 A CO98053593 A CO 98053593A CO 98053593 A CO98053593 A CO 98053593A CO 4790100 A1 CO4790100 A1 CO 4790100A1
- Authority
- CO
- Colombia
- Prior art keywords
- composition
- tween
- statement
- detergent
- cancer
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 11
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 230000011132 hemopoiesis Effects 0.000 title 1
- 230000001613 neoplastic effect Effects 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 239000003599 detergent Substances 0.000 abstract 4
- 238000009472 formulation Methods 0.000 abstract 4
- 230000000087 stabilizing effect Effects 0.000 abstract 2
- 229920001213 Polysorbate 20 Polymers 0.000 abstract 1
- 229920001214 Polysorbate 60 Polymers 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- IZWSFJTYBVKZNK-UHFFFAOYSA-N lauryl sulfobetaine Chemical compound CCCCCCCCCCCC[N+](C)(C)CCCS([O-])(=O)=O IZWSFJTYBVKZNK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000693 micelle Substances 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 239000007764 o/w emulsion Substances 0.000 abstract 1
- 230000003071 parasitic effect Effects 0.000 abstract 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 abstract 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 abstract 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
- 229920000136 polysorbate Polymers 0.000 abstract 1
- 229920000053 polysorbate 80 Polymers 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93335997A | 1997-09-18 | 1997-09-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4790100A1 true CO4790100A1 (es) | 1999-05-31 |
Family
ID=25463798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO98053593A CO4790100A1 (es) | 1997-09-18 | 1998-09-17 | Composicion cinergetica y metodos para tratar crecimientos neoplasicos o cancerosos y para restaurar o estimular hema- topoiesis |
Country Status (19)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197311B1 (en) * | 1991-07-25 | 2001-03-06 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
| EP1267946A4 (en) * | 2000-02-28 | 2008-07-02 | Genesegues Inc | SYSTEM AND METHOD FOR ENCAPSULATING NANOCAPSULES |
| US7244232B2 (en) * | 2001-03-07 | 2007-07-17 | Biomed Solutions, Llc | Process for identifying cancerous and/or metastatic cells of a living organism |
| US20040038303A1 (en) * | 2002-04-08 | 2004-02-26 | Unger Gretchen M. | Biologic modulations with nanoparticles |
| US7491395B2 (en) | 2002-11-20 | 2009-02-17 | Bestewil Holding B.V. | Compositions comprising antigen-complexes, method of making same as well as methods of using the antigen-complexes for vaccination |
| TW200510532A (en) | 2003-07-15 | 2005-03-16 | Chugai Pharmaceutical Co Ltd | IgM production by transformed cell and method of quantifying the same |
| US20090060925A1 (en) * | 2004-08-03 | 2009-03-05 | The Trustees Of Columbia University In The City Of | Rage Fusion Proteins and Methods of Use |
| NZ552128A (en) | 2004-08-03 | 2009-09-25 | Transtech Pharma Inc | Rage fusion proteins without Fc hinge region and methods of use |
| BRPI0620380B1 (pt) * | 2005-12-23 | 2018-04-24 | Gcoder Systems Ab | Padrão de posicionamento |
| US20090004190A1 (en) * | 2006-02-09 | 2009-01-01 | Mjalli Adnan M M | Rage Fusion Proteins And Methods Of Use |
| JP5558810B2 (ja) * | 2006-05-05 | 2014-07-23 | トランステック ファーマ，リミティド ライアビリティ カンパニー | Ｒａｇｅ融合タンパク質、製剤及びその使用方法 |
| WO2008100470A2 (en) * | 2007-02-15 | 2008-08-21 | Transtech Pharma, Inc. | Rage - immunoglobulin fusion proteins |
| JP2011502964A (ja) | 2007-10-23 | 2011-01-27 | ザ レジェンツ オブ ザ ユニバーシティ オブ コロラド | インバリアント鎖発現および／または異所性ｃｌｉｐ結合の競合的阻害剤 |
| AU2010240569A1 (en) | 2009-04-20 | 2011-10-20 | Pfizer Inc. | Control of protein glycosylation and compositions and methods relating thereto |
| PE20121689A1 (es) * | 2009-10-09 | 2012-12-14 | Sanofi Sa | Polipeptidos para union al receptor para productos finales de glicosilacion avanzada asi como composiciones y metodos que implican a los mismos |
| JP2014505666A (ja) * | 2010-11-18 | 2014-03-06 | ザ ジェネラル ホスピタル コーポレイション | 癌治療のための降圧剤の組成物および使用 |
| US9782452B2 (en) * | 2011-11-22 | 2017-10-10 | Cornell University | Methods for stimulating hematopoietic recovery by inhibiting TGFβ signaling |
| US20150056199A1 (en) | 2013-08-22 | 2015-02-26 | Acceleron Pharma, Inc. | Tgf-beta receptor type ii variants and uses thereof |
| KR20170054429A (ko) | 2014-09-03 | 2017-05-17 | 제네세규스 인코포레이티드 | 치료용 나노입자 및 관련 조성물, 방법, 및 시스템 |
| KR20180035884A (ko) | 2015-08-04 | 2018-04-06 | 악셀레론 파마 인코포레이티드 | 골수증식성 장애를 치료하기 위한 방법 |
| TWI787230B (zh) | 2017-01-20 | 2022-12-21 | 法商賽諾菲公司 | 抗ＴＧＦ-β抗體及其用途 |
| WO2018204594A1 (en) | 2017-05-04 | 2018-11-08 | Acceleron Pharma Inc. | Tgf-beta receptor type ii fusion proteins and uses thereof |
| CN112119157A (zh) | 2018-03-06 | 2020-12-22 | 宾夕法尼亚大学董事会 | 前列腺特异性膜抗原car及其使用方法 |
| CN114814223A (zh) * | 2022-04-20 | 2022-07-29 | 昆明市妇幼保健院 | 一种用于监测及控制疟原虫治疗的系统及设备 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4052A (en) * | 1845-05-13 | Tktjss | ||
| US20020004052A1 (en) * | 1990-05-08 | 2002-01-10 | David Berd | Composition comprising a tumor cell extract and method of using the composition |
| US6197311B1 (en) | 1991-07-25 | 2001-03-06 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
| DE69225710T3 (de) * | 1991-07-25 | 2004-10-14 | Idec Pharmaceuticals Corp., San Diego | Anregung von antworten zytotoxischer t-lymphozyten |
| US5709860A (en) * | 1991-07-25 | 1998-01-20 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
| JPH08504763A (ja) | 1992-10-29 | 1996-05-21 | セルトリックス ファーマシューティカルズ，インコーポレイテッド | 治療薬としてのＴＧＦ−βレセプターフラグメントの使用 |
| US5514670A (en) | 1993-08-13 | 1996-05-07 | Pharmos Corporation | Submicron emulsions for delivery of peptides |
| US5932212A (en) | 1996-05-24 | 1999-08-03 | Altus Biologics, Inc. | Crosslinked protein crystal formulations and their use as catalysts in organic solvents |
-
1998
- 1998-09-16 MY MYPI98004237A patent/MY131805A/en unknown
- 1998-09-16 ZA ZA988461A patent/ZA988461B/xx unknown
- 1998-09-17 RU RU2000109595/14A patent/RU2219947C2/ru not_active IP Right Cessation
- 1998-09-17 WO PCT/US1998/018495 patent/WO1999013912A1/en not_active Application Discontinuation
- 1998-09-17 IN IN2797DE1998 patent/IN190792B/en unknown
- 1998-09-17 EP EP98949313A patent/EP1015031A4/en not_active Withdrawn
- 1998-09-17 KR KR1020007002864A patent/KR100540267B1/ko not_active IP Right Cessation
- 1998-09-17 AR ARP980104649A patent/AR013012A1/es not_active Application Discontinuation
- 1998-09-17 CN CNB988112809A patent/CN1234413C/zh not_active Expired - Fee Related
- 1998-09-17 CO CO98053593A patent/CO4790100A1/es unknown
- 1998-09-17 JP JP2000511527A patent/JP2001516727A/ja active Pending
- 1998-09-17 CA CA002303178A patent/CA2303178A1/en not_active Abandoned
- 1998-09-17 IL IL13493798A patent/IL134937A0/xx not_active IP Right Cessation
- 1998-09-17 AU AU95658/98A patent/AU742216B2/en not_active Ceased
- 1998-11-04 SA SA98190719A patent/SA98190719B1/ar unknown
-
1999
- 1999-01-29 TW TW087115599A patent/TWI252108B/zh not_active IP Right Cessation
-
2000
- 2000-03-07 IL IL134937A patent/IL134937A/en unknown
- 2000-03-17 NO NO20001413A patent/NO20001413L/no not_active Application Discontinuation
-
2001
- 2001-05-14 US US09/853,580 patent/US20010018054A1/en not_active Abandoned
- 2001-05-14 US US09/853,581 patent/US6998125B2/en not_active Expired - Lifetime
- 2001-06-19 HK HK01104231A patent/HK1033653A1/xx not_active IP Right Cessation
-
2003
- 2003-12-24 US US10/743,739 patent/US20040137014A1/en not_active Abandoned
-
2005
- 2005-12-12 US US11/298,567 patent/US20060153848A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| SA98190719B1 (ar) | 2006-08-06 |
| AU742216B2 (en) | 2001-12-20 |
| HK1033653A1 (en) | 2001-09-14 |
| IL134937A (en) | 2008-04-13 |
| WO1999013912A1 (en) | 1999-03-25 |
| US20040137014A1 (en) | 2004-07-15 |
| NO20001413L (no) | 2000-05-18 |
| IN190792B (US06559137-20030506-C00112.png) | 2003-08-23 |
| TWI252108B (en) | 2006-04-01 |
| JP2001516727A (ja) | 2001-10-02 |
| CA2303178A1 (en) | 1999-03-25 |
| EP1015031A1 (en) | 2000-07-05 |
| NO20001413D0 (no) | 2000-03-17 |
| KR100540267B1 (ko) | 2006-01-10 |
| AR013012A1 (es) | 2000-11-22 |
| EP1015031A4 (en) | 2004-03-17 |
| US20060153848A1 (en) | 2006-07-13 |
| CN1234413C (zh) | 2006-01-04 |
| MY131805A (en) | 2007-09-28 |
| KR20010024109A (ko) | 2001-03-26 |
| US6998125B2 (en) | 2006-02-14 |
| ZA988461B (en) | 1999-03-30 |
| AU9565898A (en) | 1999-04-05 |
| IL134937A0 (en) | 2001-05-20 |
| US20010019715A1 (en) | 2001-09-06 |
| RU2219947C2 (ru) | 2003-12-27 |
| CN1279616A (zh) | 2001-01-10 |
| US20010018054A1 (en) | 2001-08-30 |
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