CO4650183A1 - Derivados del pirrol - Google Patents
Derivados del pirrolInfo
- Publication number
- CO4650183A1 CO4650183A1 CO95056926A CO95056926A CO4650183A1 CO 4650183 A1 CO4650183 A1 CO 4650183A1 CO 95056926 A CO95056926 A CO 95056926A CO 95056926 A CO95056926 A CO 95056926A CO 4650183 A1 CO4650183 A1 CO 4650183A1
- Authority
- CO
- Colombia
- Prior art keywords
- group
- halo
- rent
- independently
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
REIVINDICACION NUMERO UN COMPUESTO QUE TENGA LA ESTRUCTURA: FIGURA 1 DONDE: R1 ES -H, EL GRUPO ALQUILO INFERIOR, ALQUILO HALO- INFERIOR, ACETILO, ACETILO SUSTITUIDO, -(CHR24) (CH2)nR14, -(CHR24) (CH2)nC(O)15, -(CHR24) (CH2)n C(O)NR16R17 O BIEN -CHR24R18; DONDE n ES UN NUMERO ENTERO DEL 1 AL 5, R14 ES -CN, -OH, GRUPO ALCOXI INFERIOR, AXILOXI INFERIOR, ACILOXI SUSTITUIDO, DIALQUILAMINO INFERIOR, ALQUILTIO INGERIOR, AL- QUILSULFONILO INFERIOR, ALQUENO INFERIOR, ALQUINO INFERIOR O BIEN METANOSULFONAMIDO; R15 ES EL GRUPO ALCOXI INFERIOR; R16 Y R17 SE SELECCIONAN, INDE- PENDIENTEMENTE, DEL GRUPO FORMADO POR LOS RADICA- LES -H Y ALQUILO INFERIOR; R18 ES: FIGURA 2 DONDE R19 Y R20 SE SELECCIONAN INDEPENDIENTEMENTE, DEL GRUPO FORMADO POR LOS RADICALES -CN, HALO AL- COXI INFERIOR Y ALQUILO INFERIOR; Y R24 ES EL GRU- PO -H, ALQUILO INFERIOR O FENILO: R2 Y R3 SE SELECCIONAN, INDEPENDIENTEMENTE, DEL GRUPO FORMADO POR -H, HALO Y -CH3; R4 ES -H, ALQUILO INFERIOR O -CN R5 ES -H O EL ALQUILO INFERIOR; R6 Y R7 SE SELECCIONAN, INDEPENDIENTEMENTE, DEL GRUPO FORMADO POR -H, HALO, ALQUILO INFERIOR, AL- COXI INFERIOR Y ALQUILTIO INFERIOR; Y FIGURA 3 DONDE R9 ES -H, EL GRUPO HALO, ALQUILO INFERIOR, HALO-ALQUILO INFERIOR, AMINO, DIALQUILAMINO INFE- RIOR, ALQUILAMIDO INFERIOR, ALQUILTIO INFERIOR, ALCOXI INFERIOR, ALCOXI INFERIOR, ALQUENO INFERIOR O ALQUINO INFERIOR; R10 Y R11 SE SELECCIONAN, IN- DEPENDIENTEMENTE, DEL GRUPO FORMADO POR -H, HALO Y -CH3; Y R12 ES -H, -Cl o CH3; O LAS SALES DE LOS MISMOS ACEPTABLES DESDE UN PUNTO DE VISTA FARMA- CEUTICO. / / / /
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/347,915 US5622948A (en) | 1994-12-01 | 1994-12-01 | Pyrrole pyridazine and pyridazinone anti-inflammatory agents |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4650183A1 true CO4650183A1 (es) | 1998-09-03 |
Family
ID=23365840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO95056926A CO4650183A1 (es) | 1994-12-01 | 1995-11-30 | Derivados del pirrol |
Country Status (19)
Country | Link |
---|---|
US (1) | US5622948A (es) |
EP (1) | EP0714895A1 (es) |
JP (1) | JPH08208639A (es) |
KR (1) | KR960022506A (es) |
CN (1) | CN1066726C (es) |
AR (1) | AR001771A1 (es) |
AU (1) | AU3906295A (es) |
BR (1) | BR9505610A (es) |
CA (1) | CA2163490A1 (es) |
CO (1) | CO4650183A1 (es) |
CZ (1) | CZ316995A3 (es) |
FI (1) | FI955783A (es) |
HU (1) | HUT75117A (es) |
IL (1) | IL116139A0 (es) |
MA (1) | MA23735A1 (es) |
NO (1) | NO954878L (es) |
PL (1) | PL311536A1 (es) |
TR (1) | TR199501528A1 (es) |
ZA (1) | ZA9510027B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5622948A (en) * | 1994-12-01 | 1997-04-22 | Syntex (U.S.A.) Inc. | Pyrrole pyridazine and pyridazinone anti-inflammatory agents |
US6231888B1 (en) | 1996-01-18 | 2001-05-15 | Perio Products Ltd. | Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps |
CN1136197C (zh) * | 1996-05-30 | 2004-01-28 | 霍夫曼-拉罗奇有限公司 | 新的哒嗪酮衍生物 |
DE69716061T2 (de) * | 1996-05-30 | 2003-08-14 | F. Hoffmann-La Roche Ag, Basel | Pyrrolderivate |
CN1167687C (zh) * | 1997-08-22 | 2004-09-22 | 艾博特公司 | 作为前列腺素胞内过氧化物h合酶生物合成抑制剂的芳基哒嗪酮 |
WO1999010331A1 (en) * | 1997-08-22 | 1999-03-04 | Abbott Laboratories | Arylpyridazinones as prostaglandin endoperoxide h synthase biosynthesis inhibitors |
US6307047B1 (en) * | 1997-08-22 | 2001-10-23 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
US6525053B1 (en) | 1997-08-22 | 2003-02-25 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
MXPA00004036A (es) * | 1997-10-27 | 2006-05-24 | Reddys Lab Ltd Dr | Compuestos triciclicos novedosos y su uso en medicina; proceso para su preparacion y composiciones farmaceuticas que los contienen.. |
US6531152B1 (en) | 1998-09-30 | 2003-03-11 | Dexcel Pharma Technologies Ltd. | Immediate release gastrointestinal drug delivery system |
TR200101765T2 (tr) * | 1998-10-27 | 2002-02-21 | Abbott Laboratories | Prostaglandin endoperoksit H sentaz biyosentez inhibitörleri |
US6632451B2 (en) | 1999-06-04 | 2003-10-14 | Dexcel Pharma Technologies Ltd. | Delayed total release two pulse gastrointestinal drug delivery system |
ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
CA2492022A1 (en) * | 2002-07-11 | 2004-01-22 | Merck & Co., Inc. | Treatment of neuropathic pain with 6h-pyrrolo[3,4-d]pyridazine compounds |
EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
GB0610680D0 (en) * | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
CA2663377A1 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
JP5758630B2 (ja) * | 2007-11-15 | 2015-08-05 | エンメエッセディ・イタリア・エッセ・エッレ・エッレ | Parp阻害剤としてのピリダジノン誘導体 |
HUE059078T2 (hu) | 2009-02-20 | 2022-10-28 | Enhanx Biopharm Inc | Glutation-alapú hatóanyagszállító rendszer |
JP2012526144A (ja) | 2009-05-06 | 2012-10-25 | ラボラトリー スキン ケア インコーポレイテッド | 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法 |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
EP2527335B1 (en) | 2011-04-26 | 2013-09-18 | King Saud University | Triazole compounds as anti-inflammatory agents |
KR102233456B1 (ko) | 2017-05-31 | 2021-03-29 | 주식회사 대웅제약 | 4-메톡시피롤 유도체의 중간체 제조 방법 |
KR102233455B1 (ko) | 2017-06-21 | 2021-03-29 | 주식회사 대웅제약 | 4-메톡시피롤 유도체의 중간체 제조 방법 |
WO2022159980A1 (en) * | 2021-01-25 | 2022-07-28 | Athos Therapeutics, Inc. | Pharmaceutical compounds and methods of making and using the same |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2316942A (en) * | 1937-12-27 | 1943-04-20 | Schlumberger Well Surv Corp | Apparatus for measuring temperatures in boreholes |
US3726978A (en) * | 1967-11-02 | 1973-04-10 | Sandoz Ag | Tetrahydropyridazines and pyridazinones as anti-inflammatory agents |
US3586681A (en) * | 1967-11-02 | 1971-06-22 | Sandoz Ag | 1,4,5,6-tetrahydropyridazines |
US3752826A (en) * | 1970-01-26 | 1973-08-14 | Mcneilab Inc | Aroyl substituted pyrroles |
US4048191A (en) * | 1975-06-27 | 1977-09-13 | Mcneil Laboratories, Incorporated | Halo-substituted 1-loweralkyl-5-aroylpyrrole-2-acetic acid compounds |
JPS539788A (en) * | 1976-07-14 | 1978-01-28 | Syntex Inc | 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative |
US4089969A (en) * | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
US4247551A (en) * | 1979-09-17 | 1981-01-27 | Gruppo Lepetit S.P.A. | N-Pyrrolyl-pyridazineamines and their use as antihypertensive agents |
US4347187A (en) * | 1980-10-20 | 1982-08-31 | Syntex (U.S.A.) Inc. | Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein |
IT1150070B (it) * | 1980-12-22 | 1986-12-10 | Lepetit Spa | Procedimento per preparare derivati n-pirrolipiridazinamminici |
AU8509882A (en) * | 1981-06-30 | 1983-01-06 | Merck & Co., Inc. | Tricyclic derivatives of substituted pyrrole acids |
JPS58501432A (ja) * | 1981-09-11 | 1983-08-25 | エスディ−エス・バイオテック・コ−ポレ−ション | 抗炎症,鎮痛性4−ピリジルピリダジン(2h)−3−オン類 |
US4816454A (en) * | 1984-09-21 | 1989-03-28 | Cassella Aktiengesellschaft | 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use |
GB8501372D0 (en) * | 1985-01-18 | 1985-02-20 | Smith Kline French Lab | Chemical compounds |
US5086052A (en) * | 1987-07-17 | 1992-02-04 | Abbott Laboratories | Substituted 1,4,5,6-tetrahydro-2H-pyridazin-3-one and -3-thione compounds having lipoxygenase inhibitory activity |
US4992441A (en) * | 1987-10-14 | 1991-02-12 | Mcneilab, Inc. | 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia |
IE913866A1 (en) * | 1990-11-28 | 1992-06-03 | Ici Plc | Aryl derivatives |
ATE179756T1 (de) * | 1992-09-22 | 1999-05-15 | Univ Rochester | Stabil transformierte säugertierzellen, die eine geregelte, entzündliche cyclooxygenase exprimieren |
US5543297A (en) * | 1992-12-22 | 1996-08-06 | Merck Frosst Canada, Inc. | Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity |
US5332736A (en) * | 1993-11-01 | 1994-07-26 | Ortho Pharmaceutical Corporation | Anti-convulsant aroyl aminoacylpyrroles |
US5622948A (en) * | 1994-12-01 | 1997-04-22 | Syntex (U.S.A.) Inc. | Pyrrole pyridazine and pyridazinone anti-inflammatory agents |
KR102081455B1 (ko) * | 2017-06-09 | 2020-04-28 | 선상규 | 다중브러시를 이용한 직류발전장치 |
-
1994
- 1994-12-01 US US08/347,915 patent/US5622948A/en not_active Expired - Fee Related
-
1995
- 1995-11-20 EP EP95118227A patent/EP0714895A1/en not_active Withdrawn
- 1995-11-22 CA CA002163490A patent/CA2163490A1/en not_active Abandoned
- 1995-11-24 ZA ZA9510027A patent/ZA9510027B/xx unknown
- 1995-11-24 AU AU39062/95A patent/AU3906295A/en not_active Abandoned
- 1995-11-27 IL IL11613995A patent/IL116139A0/xx unknown
- 1995-11-27 HU HU9503384A patent/HUT75117A/hu unknown
- 1995-11-29 CZ CZ953169A patent/CZ316995A3/cs unknown
- 1995-11-30 PL PL95311536A patent/PL311536A1/xx unknown
- 1995-11-30 CO CO95056926A patent/CO4650183A1/es unknown
- 1995-11-30 KR KR1019950045751A patent/KR960022506A/ko not_active Application Discontinuation
- 1995-11-30 CN CN95120375A patent/CN1066726C/zh not_active Expired - Fee Related
- 1995-11-30 AR AR33445395A patent/AR001771A1/es unknown
- 1995-11-30 NO NO954878A patent/NO954878L/no unknown
- 1995-12-01 BR BR9505610A patent/BR9505610A/pt not_active Application Discontinuation
- 1995-12-01 TR TR95/01528A patent/TR199501528A1/xx unknown
- 1995-12-01 JP JP7313916A patent/JPH08208639A/ja active Pending
- 1995-12-01 MA MA24084A patent/MA23735A1/fr unknown
- 1995-12-01 FI FI955783A patent/FI955783A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
AU3906295A (en) | 1996-06-06 |
CN1132206A (zh) | 1996-10-02 |
PL311536A1 (en) | 1996-06-10 |
US5622948A (en) | 1997-04-22 |
EP0714895A1 (en) | 1996-06-05 |
NO954878D0 (no) | 1995-11-30 |
CA2163490A1 (en) | 1996-06-02 |
IL116139A0 (en) | 1996-01-31 |
FI955783A (fi) | 1996-06-02 |
KR960022506A (ko) | 1996-07-18 |
MA23735A1 (fr) | 1996-07-01 |
ZA9510027B (en) | 1996-06-03 |
AR001771A1 (es) | 1997-12-10 |
CN1066726C (zh) | 2001-06-06 |
TR199501528A1 (tr) | 1996-11-21 |
BR9505610A (pt) | 1997-09-16 |
FI955783A0 (fi) | 1995-12-01 |
JPH08208639A (ja) | 1996-08-13 |
CZ316995A3 (en) | 1996-06-12 |
HUT75117A (en) | 1997-04-28 |
HU9503384D0 (en) | 1996-01-29 |
NO954878L (no) | 1996-06-03 |
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