ATE179756T1 - Stabil transformierte säugertierzellen, die eine geregelte, entzündliche cyclooxygenase exprimieren - Google Patents

Stabil transformierte säugertierzellen, die eine geregelte, entzündliche cyclooxygenase exprimieren

Info

Publication number
ATE179756T1
ATE179756T1 AT93922753T AT93922753T ATE179756T1 AT E179756 T1 ATE179756 T1 AT E179756T1 AT 93922753 T AT93922753 T AT 93922753T AT 93922753 T AT93922753 T AT 93922753T AT E179756 T1 ATE179756 T1 AT E179756T1
Authority
AT
Austria
Prior art keywords
regulated
cells expressing
mammal cells
stable transformed
transformed mammal
Prior art date
Application number
AT93922753T
Other languages
English (en)
Inventor
Donald A Young
Michael K O'banion
Virginia D Winn
Original Assignee
Univ Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rochester filed Critical Univ Rochester
Application granted granted Critical
Publication of ATE179756T1 publication Critical patent/ATE179756T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99—Miscellaneous (1.14.99)
    • C12Y114/99001—Prostaglandin-endoperoxide synthase (1.14.99.1), i.e. cyclooxygenase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/88—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving prostaglandins or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT93922753T 1992-09-22 1993-09-22 Stabil transformierte säugertierzellen, die eine geregelte, entzündliche cyclooxygenase exprimieren ATE179756T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US94978092A 1992-09-22 1992-09-22
US98383592A 1992-12-01 1992-12-01
US3414393A 1993-03-22 1993-03-22
US5436493A 1993-04-28 1993-04-28

Publications (1)

Publication Number Publication Date
ATE179756T1 true ATE179756T1 (de) 1999-05-15

Family

ID=27488184

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93922753T ATE179756T1 (de) 1992-09-22 1993-09-22 Stabil transformierte säugertierzellen, die eine geregelte, entzündliche cyclooxygenase exprimieren

Country Status (9)

Country Link
EP (1) EP0667911B1 (de)
JP (3) JPH08501690A (de)
AT (1) ATE179756T1 (de)
AU (1) AU688282B2 (de)
CA (1) CA2144742A1 (de)
DE (1) DE69324820T2 (de)
HK (1) HK1013106A1 (de)
NZ (1) NZ256776A (de)
WO (1) WO1994006919A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543297A (en) * 1992-12-22 1996-08-06 Merck Frosst Canada, Inc. Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
WO1996040720A1 (en) * 1995-06-07 1996-12-19 University Of Rochester Mammalian prostaglandin h synthase-2
US6160108A (en) * 1995-10-06 2000-12-12 President And Fellows Of Harvard College Platelet activation protein
WO2001011026A1 (en) * 1999-08-06 2001-02-15 G.D. Searle & Co. Canine cyclooxygenase-1 (cox-1) and cyclooxygenase-2 (cox-2)
WO2001024627A1 (fr) * 1999-10-05 2001-04-12 Japan Science And Technology Corporation Animal exprimant un gene humain a grande echelle et procede de test utilisant ledit animal
US20040073958A1 (en) * 2001-02-23 2004-04-15 Motoya Katsuki Transgenic animal having drug metabolism enzyme gene and utilization thereof
CN1821423B (zh) * 2005-08-19 2012-07-25 凯惠科技发展(上海)有限公司 一种抗关节炎药物细胞靶标筛选系统及筛药的方法
JP5641232B2 (ja) * 2010-11-24 2014-12-17 石川県公立大学法人 オゴノリ由来のシクロオキシゲナーゼの遺伝子及び該遺伝子を利用するプロスタグランジン類生産方法

Also Published As

Publication number Publication date
JP2005068157A (ja) 2005-03-17
EP0667911A1 (de) 1995-08-23
EP0667911B1 (de) 1999-05-06
WO1994006919A3 (en) 1994-05-11
AU688282B2 (en) 1998-03-12
JPH08501690A (ja) 1996-02-27
DE69324820T2 (de) 2000-01-13
JP2004105186A (ja) 2004-04-08
AU5165293A (en) 1994-04-12
NZ256776A (en) 1997-10-24
CA2144742A1 (en) 1994-03-31
WO1994006919A2 (en) 1994-03-31
HK1013106A1 (en) 1999-08-13
DE69324820D1 (de) 1999-06-10

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee