DE69615200D1 - Asymetrische synthese von r und s warfarin und deren ähnlichen verbindungen - Google Patents

Asymetrische synthese von r und s warfarin und deren ähnlichen verbindungen

Info

Publication number
DE69615200D1
DE69615200D1 DE69615200T DE69615200T DE69615200D1 DE 69615200 D1 DE69615200 D1 DE 69615200D1 DE 69615200 T DE69615200 T DE 69615200T DE 69615200 T DE69615200 T DE 69615200T DE 69615200 D1 DE69615200 D1 DE 69615200D1
Authority
DE
Germany
Prior art keywords
formula
group
warfarin
compound
similar compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69615200T
Other languages
English (en)
Other versions
DE69615200T2 (de
Inventor
Hui-Yin Li
Jane Robinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
DuPont Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co, DuPont Pharmaceuticals Co filed Critical DuPont Merck Pharmaceutical Co
Application granted granted Critical
Publication of DE69615200D1 publication Critical patent/DE69615200D1/de
Publication of DE69615200T2 publication Critical patent/DE69615200T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69615200T 1995-07-13 1996-07-10 Asymetrische synthese von r und s warfarin und deren ähnlichen verbindungen Expired - Fee Related DE69615200T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US112795P 1995-07-13 1995-07-13
US64712696A 1996-05-09 1996-05-09
PCT/US1996/011489 WO1997003062A1 (en) 1995-07-13 1996-07-10 A novel asymmetric synthesis of r and s warfarin and its analogs

Publications (2)

Publication Number Publication Date
DE69615200D1 true DE69615200D1 (de) 2001-10-18
DE69615200T2 DE69615200T2 (de) 2002-06-06

Family

ID=26668597

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69615200T Expired - Fee Related DE69615200T2 (de) 1995-07-13 1996-07-10 Asymetrische synthese von r und s warfarin und deren ähnlichen verbindungen

Country Status (14)

Country Link
EP (1) EP0839142B1 (de)
JP (1) JP4063320B2 (de)
AT (1) ATE205488T1 (de)
AU (1) AU6675696A (de)
CA (1) CA2226752C (de)
DE (1) DE69615200T2 (de)
DK (1) DK0839142T3 (de)
ES (1) ES2163036T3 (de)
GR (1) GR3036896T3 (de)
HR (1) HRP960332A2 (de)
IL (1) IL122924A0 (de)
MX (1) MX9800371A (de)
PT (1) PT839142E (de)
WO (1) WO1997003062A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3064800A (en) * 1999-01-21 2000-08-07 Darwin Discovery Limited The therapeutic use of r-warfarin as anticoagulant
US6610862B2 (en) 2001-02-28 2003-08-26 Taro Pharmaceutical Industries Ltd. Preparation of warfarin sodium from warfarin sodium-2-propanol clathrate by solvent expulsion
US6673944B2 (en) 2001-02-28 2004-01-06 Taro Pharmaceutical Industries, Ltd. Preparation of warfarin sodium from warfarin acid

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171892A (en) * 1991-07-02 1992-12-15 E. I. Du Pont De Nemours And Company Chiral phospholanes via chiral 1,4-diol cyclic sulfates

Also Published As

Publication number Publication date
WO1997003062A1 (en) 1997-01-30
IL122924A0 (en) 1998-08-16
AU6675696A (en) 1997-02-10
JPH11509203A (ja) 1999-08-17
GR3036896T3 (en) 2002-01-31
ATE205488T1 (de) 2001-09-15
DK0839142T3 (da) 2001-10-29
DE69615200T2 (de) 2002-06-06
MX9800371A (es) 1998-11-29
EP0839142B1 (de) 2001-09-12
ES2163036T3 (es) 2002-01-16
PT839142E (pt) 2001-12-28
CA2226752C (en) 2002-02-19
HRP960332A2 (en) 1998-02-28
JP4063320B2 (ja) 2008-03-19
EP0839142A1 (de) 1998-05-06
CA2226752A1 (en) 1997-01-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BRISTOL-MYERS SQUIBB PHARMA CO., PRINCETON, N.J.,

8339 Ceased/non-payment of the annual fee