CO4230229A1 - Fenoxifenil ciclopentenil hidroxiureas - Google Patents

Fenoxifenil ciclopentenil hidroxiureas

Info

Publication number
CO4230229A1
CO4230229A1 CO94036772A CO94036772A CO4230229A1 CO 4230229 A1 CO4230229 A1 CO 4230229A1 CO 94036772 A CO94036772 A CO 94036772A CO 94036772 A CO94036772 A CO 94036772A CO 4230229 A1 CO4230229 A1 CO 4230229A1
Authority
CO
Colombia
Prior art keywords
pct
date
above compounds
phenoxifenil
hidroxiureas
Prior art date
Application number
CO94036772A
Other languages
English (en)
Inventor
Akiyoshi Kawai
Rodney W Stevens
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CO4230229A1 publication Critical patent/CO4230229A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE ENSENAN CIERTOS COMPUESTOS NOVEDOSOS CICLOPEN- TIL HIDROXIUREAS FENIL-SUBSTITUIDOS QUE TIENEN LA CAPACIDAD DE INHIBIR LA ENZIMA 5-LIPOXIGENASA Y SON LOS ISOMEROS DEXTROROTATORIOS DE LOS COMPUES- TOS QUE TIENEN LA SIGUIENTE FORMULA: FIGURA 1 Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LAS MISMAS, EN LA QUE R1 ES HIDROGENO, FLUOR O CLORO, Y R2 ES HIDROGENO O METILO. ESTOS COMPUESTOS SON UTILES EN LA PREVENCION, TRA- TAMIENTO O ALIVIO DE ENFERMEDADES INFLAMATORIAS, ALERGICAS O CARDIOVASCULARE EN MAMIFEROS, Y COMO INGREDIENTES ACTIVOS EN LAS COMPOSICIONES FARMA- CEUTICAS PARA EL TRATAMIENTO DE TALES CONDICIONES.
CO94036772A 1993-08-19 1994-08-19 Fenoxifenil ciclopentenil hidroxiureas CO4230229A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20545393 1993-08-19

Publications (1)

Publication Number Publication Date
CO4230229A1 true CO4230229A1 (es) 1995-10-19

Family

ID=16507136

Family Applications (1)

Application Number Title Priority Date Filing Date
CO94036772A CO4230229A1 (es) 1993-08-19 1994-08-19 Fenoxifenil ciclopentenil hidroxiureas

Country Status (27)

Country Link
US (1) US5792882A (es)
EP (1) EP0720598B1 (es)
JP (1) JP2794343B2 (es)
KR (1) KR0170623B1 (es)
CN (1) CN1077568C (es)
AT (1) ATE171939T1 (es)
AU (1) AU674776B2 (es)
BR (1) BR9407314A (es)
CA (1) CA2169066C (es)
CO (1) CO4230229A1 (es)
CZ (1) CZ288358B6 (es)
DE (1) DE69413831T2 (es)
DK (1) DK0720598T3 (es)
EC (1) ECSP941144A (es)
EG (1) EG20530A (es)
ES (1) ES2121218T3 (es)
FI (1) FI114466B (es)
IL (1) IL110628A (es)
MY (1) MY111140A (es)
NO (1) NO305595B1 (es)
NZ (1) NZ269849A (es)
PE (1) PE57194A1 (es)
PL (1) PL176223B1 (es)
RU (1) RU2125987C1 (es)
TW (2) TW418089B (es)
WO (1) WO1995005360A1 (es)
ZA (1) ZA946253B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL317873A1 (en) * 1994-06-27 1997-04-28 Cytomed Inc Compounds for and method of treating cardiovascular, inflammatory and immunological disorders
EP0790981B1 (en) * 1994-11-10 1999-09-08 Pfizer Inc. Aryloxycycloalkenyl and aryloxyiminocycloalkenylhydroxyureas as 5-lipoxygenase inhibitors
WO1996016054A1 (en) * 1994-11-18 1996-05-30 Pfizer Pharmaceuticals Inc. Cycloalkenyl-n-hydroxyureas
EP1745774A3 (en) 1997-08-11 2007-04-11 Pfizer Products Inc. Solid pharmaceutical dispersions with enhanced bioavailability
US6121323A (en) * 1997-12-03 2000-09-19 3M Innovative Properties Company Bishydroxyureas
KR100879423B1 (ko) 2004-12-02 2009-01-19 (주)아모레퍼시픽 Ｔｎｆ-알파의 생산을 저해하는 2-사이클로펜텐-1-온 옥심유도체
KR101567571B1 (ko) 2007-12-03 2015-11-11 (주)아모레퍼시픽 2-사이클로펜텐-1-온 옥심 유도체를 유효성분으로 포함하는 슬리밍 화장료 조성물
ES2552386T3 (es) 2009-04-03 2015-11-27 F. Hoffmann-La Roche Ag Composiciones de {3-[5-(4-cloro-fenil)-1H-pirrol[2,3-b]piridin-3-carbonil]-2,4-difluoro-fenil}-amida del ácido propano-1-sulfónico y usos de las mismas
US8512464B2 (en) * 2009-12-02 2013-08-20 3M Innovative Properties Company Functionalized zirconia nanoparticles and high index films made therefrom

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ222168A (en) * 1986-10-20 1991-05-28 Oncogene Science Inc Tumour growth inhibiting protein related to tgf-#b#1 and tgf-#b#2, preparation by genetic engineering methods, antibodies and pharmaceutical compositions
HU208523B (en) * 1989-02-03 1993-11-29 Wellcome Found Process for producing antiphlogistic aryl-compounds and pharmaceutical compositions containing them
US5120752A (en) * 1989-12-28 1992-06-09 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
GB9025514D0 (en) * 1990-11-23 1991-01-09 Wellcome Found Anti-inflammatory compounds
JP3007138B2 (ja) * 1990-11-27 2000-02-07 ファイザー製薬株式会社 新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物
JPH06256285A (ja) * 1990-12-11 1994-09-13 Pfizer Pharmaceut Co Ltd ヒドロキサム酸誘導体およびその用途
JPH05163229A (ja) * 1991-12-13 1993-06-29 Pfizer Pharmaceut Co Ltd 新規なシクロプロピル誘導体
JPH05294921A (ja) * 1992-04-17 1993-11-09 Pfizer Pharmaceut Co Ltd 新規なフェニル置換シクロアルキル尿素誘導体および組成物

Also Published As

Publication number Publication date
JP2794343B2 (ja) 1998-09-03
CN1129440A (zh) 1996-08-21
DE69413831T2 (de) 1999-02-25
NO960631D0 (no) 1996-02-16
EP0720598B1 (en) 1998-10-07
BR9407314A (pt) 1996-04-16
TW448144B (en) 2001-08-01
PE57194A1 (es) 1995-02-07
EP0720598A1 (en) 1996-07-10
CA2169066A1 (en) 1995-02-23
IL110628A0 (en) 1994-11-11
MY111140A (en) 1999-08-30
FI114466B (fi) 2004-10-29
FI943799A (fi) 1995-02-20
KR0170623B1 (ko) 1999-03-30
DE69413831D1 (de) 1998-11-12
IL110628A (en) 1998-12-27
RU2125987C1 (ru) 1999-02-10
PL176223B1 (pl) 1999-05-31
ES2121218T3 (es) 1998-11-16
NO960631L (no) 1996-02-16
ZA946253B (en) 1996-02-19
US5792882A (en) 1998-08-11
NO305595B1 (no) 1999-06-28
PL313037A1 (en) 1996-05-27
NZ269849A (en) 1997-10-24
FI943799A0 (fi) 1994-08-18
ATE171939T1 (de) 1998-10-15
DK0720598T3 (da) 1999-06-21
EG20530A (en) 1999-07-31
WO1995005360A1 (en) 1995-02-23
JPH08511031A (ja) 1996-11-19
KR960703845A (ko) 1996-08-31
AU7350994A (en) 1995-03-14
CN1077568C (zh) 2002-01-09
TW418089B (en) 2001-01-11
CA2169066C (en) 1999-06-22
ECSP941144A (es) 1995-02-27
CZ288358B6 (en) 2001-05-16
AU674776B2 (en) 1997-01-09
CZ48396A3 (en) 1996-07-17

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