CO2023015732A2 - Moduladores de trex1 - Google Patents

Moduladores de trex1

Info

Publication number
CO2023015732A2
CO2023015732A2 CONC2023/0015732A CO2023015732A CO2023015732A2 CO 2023015732 A2 CO2023015732 A2 CO 2023015732A2 CO 2023015732 A CO2023015732 A CO 2023015732A CO 2023015732 A2 CO2023015732 A2 CO 2023015732A2
Authority
CO
Colombia
Prior art keywords
trex1
modulators
compositions
compounds
variety
Prior art date
Application number
CONC2023/0015732A
Other languages
English (en)
Inventor
Avinash Khanna
Julian R Levell
Jonathan E Wilson
Aaron Coffin
Mary-Margaret Zablocki
David J Guerin
William T Mcelroy
Jennifer L Rocnik
Original Assignee
Constellation Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Constellation Pharmaceuticals Inc filed Critical Constellation Pharmaceuticals Inc
Publication of CO2023015732A2 publication Critical patent/CO2023015732A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Amplifiers (AREA)

Abstract

Compuestos de Fórmula (I) y sales farmacéuticamente aceptables y composiciones de los mismos, que son útiles para el tratamiento de una variedad de condiciones asociadas con la TREX1.
CONC2023/0015732A 2021-04-26 2023-11-21 Moduladores de trex1 CO2023015732A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163179723P 2021-04-26 2021-04-26
PCT/US2022/026103 WO2022232004A1 (en) 2021-04-26 2022-04-25 Modulators of trex1

Publications (1)

Publication Number Publication Date
CO2023015732A2 true CO2023015732A2 (es) 2024-02-05

Family

ID=81598085

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0015732A CO2023015732A2 (es) 2021-04-26 2023-11-21 Moduladores de trex1

Country Status (16)

Country Link
EP (1) EP4330254A1 (es)
JP (1) JP2024517715A (es)
KR (1) KR20240028979A (es)
CN (1) CN117545754A (es)
AR (1) AR125448A1 (es)
AU (1) AU2022264711A1 (es)
BR (1) BR112023022298A2 (es)
CA (1) CA3216752A1 (es)
CL (1) CL2023003168A1 (es)
CO (1) CO2023015732A2 (es)
CR (1) CR20230542A (es)
DO (1) DOP2023000236A (es)
EC (1) ECSP23088732A (es)
IL (1) IL308016A (es)
TW (1) TW202309019A (es)
WO (1) WO2022232004A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024061300A1 (en) * 2022-09-22 2024-03-28 Insilico Medicine Ip Limited Inhibitors of trex1 and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9328075B2 (en) * 2011-05-05 2016-05-03 St. Jude Children's Research Hospital Pyrimidinone compounds and methods for treating influenza
BR112021010919A2 (pt) * 2018-12-06 2021-08-24 Constellation Pharmaceuticals, Inc. Moduladores de trex1

Also Published As

Publication number Publication date
CA3216752A1 (en) 2022-11-03
CL2023003168A1 (es) 2024-04-12
EP4330254A1 (en) 2024-03-06
TW202309019A (zh) 2023-03-01
DOP2023000236A (es) 2024-02-29
WO2022232004A1 (en) 2022-11-03
AU2022264711A1 (en) 2023-11-09
ECSP23088732A (es) 2024-02-29
IL308016A (en) 2023-12-01
BR112023022298A2 (pt) 2023-12-26
KR20240028979A (ko) 2024-03-05
CR20230542A (es) 2024-03-19
AR125448A1 (es) 2023-07-19
JP2024517715A (ja) 2024-04-23
CN117545754A (zh) 2024-02-09

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