CO2023011907A2 - Anticuerpo triespecífico dirigido a bcma, gprc5d, y cd3 - Google Patents
Anticuerpo triespecífico dirigido a bcma, gprc5d, y cd3Info
- Publication number
- CO2023011907A2 CO2023011907A2 CONC2023/0011907A CO2023011907A CO2023011907A2 CO 2023011907 A2 CO2023011907 A2 CO 2023011907A2 CO 2023011907 A CO2023011907 A CO 2023011907A CO 2023011907 A2 CO2023011907 A2 CO 2023011907A2
- Authority
- CO
- Colombia
- Prior art keywords
- antigen
- binding fragments
- antibodies
- multispecific
- bcma
- Prior art date
Links
- 101100425747 Mus musculus Tnfrsf17 gene Proteins 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 10
- 102000036639 antigens Human genes 0.000 abstract 10
- 108091007433 antigens Proteins 0.000 abstract 10
- 239000012634 fragment Substances 0.000 abstract 10
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 abstract 6
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 abstract 6
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 abstract 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 abstract 1
- 102100021197 G-protein coupled receptor family C group 5 member D Human genes 0.000 abstract 1
- 101001040713 Homo sapiens G-protein coupled receptor family C group 5 member D Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En la presente descripción se proporcionan anticuerpos multiespecíficos que se unen a BCMA, GPRC5D y CD3 y fragmentos de unión al antígeno multiespecíficos de estos. Además, se describen polinucleótidos relacionados que tienen la capacidad de codificar anticuerpos multiespecíficos o fragmentos de unión al antígeno multiespecíficos proporcionados, células que expresan anticuerpos multiespecíficos o fragmentos de unión al antígeno multiespecíficos proporcionados, así como vectores asociados y anticuerpos multiespecíficos o fragmentos de unión al antígeno multiespecíficos marcados de forma detectable. Adicionalmente, se describen métodos para producir y usar los anticuerpos multiespecíficos y los fragmentos de unión al antígeno multiespecíficos proporcionados. En la presente invención se proporcionan además anticuerpos que se unen a BCMA y fragmentos de unión al antígeno de estos. Además, se describen polinucleótidos relacionados que tienen la capacidad de codificar anticuerpos específicos para BCMA o fragmentos de unión al antígeno proporcionados, células que expresan anticuerpos específicos para BCMA o fragmentos de unión al antígeno proporcionados, así como vectores asociados y anticuerpos específicos para BCMA o fragmentos de unión al antígeno marcados de forma detectable. Adicionalmente, se describen métodos para producir y usar los anticuerpos específicos para BCMA y los fragmentos de unión al antígeno proporcionados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163149921P | 2021-02-16 | 2021-02-16 | |
PCT/EP2022/053651 WO2022175255A2 (en) | 2021-02-16 | 2022-02-15 | Trispecific antibody targeting bcma, gprc5d, and cd3 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2023011907A2 true CO2023011907A2 (es) | 2023-09-18 |
Family
ID=80445956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2023/0011907A CO2023011907A2 (es) | 2021-02-16 | 2023-09-07 | Anticuerpo triespecífico dirigido a bcma, gprc5d, y cd3 |
Country Status (20)
Country | Link |
---|---|
US (1) | US20220267438A1 (es) |
EP (1) | EP4294528A2 (es) |
JP (1) | JP2024507180A (es) |
KR (1) | KR20230146578A (es) |
CN (1) | CN117279953A (es) |
AR (1) | AR124882A1 (es) |
AU (1) | AU2022221884A1 (es) |
BR (1) | BR112023016121A2 (es) |
CA (1) | CA3211163A1 (es) |
CL (1) | CL2023002382A1 (es) |
CO (1) | CO2023011907A2 (es) |
CR (1) | CR20230398A (es) |
DO (1) | DOP2023000158A (es) |
EC (1) | ECSP23069904A (es) |
IL (1) | IL305144A (es) |
MX (1) | MX2023009566A (es) |
PE (1) | PE20241170A1 (es) |
TW (1) | TW202302636A (es) |
UY (1) | UY39634A (es) |
WO (1) | WO2022175255A2 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3127025A1 (en) * | 2019-01-18 | 2020-07-23 | Janssen Biotech, Inc. | Gprc5d chimeric antigen receptors and cells expressing the same |
WO2023236889A1 (zh) * | 2022-06-06 | 2023-12-14 | 山东先声生物制药有限公司 | 靶向bcma、gprc5d和t细胞的多特异性抗体及其应用 |
CN118414351A (zh) * | 2022-09-09 | 2024-07-30 | 北京天广实生物技术股份有限公司 | 结合bcma、gprc5d和cd3的多特异性抗体及其用途 |
WO2024079015A1 (en) * | 2022-10-10 | 2024-04-18 | F. Hoffmann-La Roche Ag | Combination therapy of a gprc5d tcb and imids |
CN117924485A (zh) * | 2022-10-25 | 2024-04-26 | 上海祥耀生物科技有限责任公司 | 一种抗gprc5d的多特异性抗体 |
WO2024165030A1 (zh) * | 2023-02-07 | 2024-08-15 | 上海齐鲁制药研究中心有限公司 | 三特异性抗原结合分子及其应用 |
WO2024168192A1 (en) * | 2023-02-10 | 2024-08-15 | Celgene Corporation | Assessment of bcma in biological samples |
WO2024180469A1 (en) * | 2023-02-28 | 2024-09-06 | Janssen Biotech, Inc. | Compositions comprising a bispecific gprc5d/cd3 antibody |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020142000A1 (en) | 1999-01-15 | 2002-10-03 | Digan Mary Ellen | Anti-CD3 immunotoxins and therapeutic uses therefor |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
WO2001024812A1 (en) | 1999-10-06 | 2001-04-12 | N.V. Nutricia | USE OF TRANSFORMING GROWTH FACTOR β AND GROWTH FACTORS IN THE TREATMENT AND PREVENTION OF DISEASES OF THE INTESTINAL MUCOSA |
UA74798C2 (uk) | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
EP2301971A1 (en) | 2001-02-20 | 2011-03-30 | ZymoGenetics, L.L.C. | Antibodies that bind both BCMA and TACI |
US20060204493A1 (en) | 2004-09-02 | 2006-09-14 | Genentech, Inc. | Heteromultimeric molecules |
WO2006106905A1 (ja) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | 会合制御によるポリペプチド製造方法 |
DE102005028778A1 (de) | 2005-06-22 | 2006-12-28 | SUNJÜT Deutschland GmbH | Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage |
EP1940881B1 (en) | 2005-10-11 | 2016-11-30 | Amgen Research (Munich) GmbH | Compositions comprising cross-species-specific antibodies and uses thereof |
EP1973576B1 (en) | 2005-11-28 | 2019-05-15 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
US20090182127A1 (en) | 2006-06-22 | 2009-07-16 | Novo Nordisk A/S | Production of Bispecific Antibodies |
ES2432792T5 (es) | 2007-04-03 | 2023-01-16 | Amgen Res Munich Gmbh | Dominio de unión a CD3-épsilon específico de especies cruzadas |
HUE040467T2 (hu) | 2007-04-03 | 2019-03-28 | Amgen Res Munich Gmbh | Keresztfaj-specifikus kötõdomén |
WO2008119566A2 (en) | 2007-04-03 | 2008-10-09 | Micromet Ag | Cross-species-specific bispecific binders |
AU2009299794B2 (en) | 2008-10-01 | 2015-08-13 | Amgen Research (Munich) Gmbh | Cross-species-specific single domain bispecific single chain antibody |
ME02485B (me) | 2008-10-01 | 2017-02-20 | Amgen Res Munich Gmbh | Bispecifično jednolančano protutijelo psmaxcd3 s međuvrsnom specifičnošću |
EP2352763B2 (en) | 2008-10-01 | 2022-09-21 | Amgen Research (Munich) GmbH | Bispecific single chain antibodies with specificity for high molecular weight target antigens |
DK2356269T3 (en) | 2008-10-31 | 2016-08-15 | Janssen Biotech Inc | FIBRONECTIN TYPE III DOMAIN-BASED SCAFFOLD COMPOSITIONS, PROCEDURES AND APPLICATIONS |
WO2010093627A2 (en) | 2009-02-12 | 2010-08-19 | Centocor Ortho Biotech Inc. | Fibronectin type iii domain based scaffold compositions, methods and uses |
LT2406284T (lt) | 2009-03-10 | 2016-10-10 | Biogen Ma Inc. | Antikūnai prieš b ląstelių subrendimo antigenus |
ES2708124T3 (es) | 2009-04-27 | 2019-04-08 | Oncomed Pharm Inc | Procedimiento para preparar moléculas heteromultiméricas |
CN103097417B (zh) | 2010-04-20 | 2019-04-09 | 根马布股份公司 | 含异二聚体抗体fc的蛋白及其制备方法 |
AU2011325833C1 (en) | 2010-11-05 | 2017-07-13 | Zymeworks Bc Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
CA2854233C (en) | 2011-11-04 | 2020-05-12 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the fc domain |
SG11201704552TA (en) | 2014-12-05 | 2017-07-28 | Memorial Sloan Kettering Cancer Center | Antibodies targeting g-protein coupled receptor and methods of use |
MA53750A (fr) | 2015-08-17 | 2021-09-15 | Janssen Pharmaceutica Nv | Anticorps anti-bcma, molécules de liaison d'antigène bispécifiques qui se lient au bcma et cd3 et leurs utilisations |
TWI781108B (zh) | 2016-07-20 | 2022-10-21 | 比利時商健生藥品公司 | 抗gprc5d抗體、結合gprc5d與cd3之雙特異性抗原結合分子及其用途 |
RU2019128134A (ru) | 2017-02-07 | 2021-03-09 | Дайити Санкио Компани, Лимитед | Антитело против gprc5d и молекула, содержащая антитело |
CN111417652B (zh) | 2017-09-22 | 2023-10-20 | 凯德药业股份有限公司 | 嵌合多肽及其用途 |
TWI829667B (zh) | 2018-02-09 | 2024-01-21 | 瑞士商赫孚孟拉羅股份公司 | 結合gprc5d之抗體 |
MX2020012286A (es) * | 2018-05-16 | 2021-04-28 | Janssen Biotech Inc | Metodos para tratar canceres y potenciar la eficacia de agentes terapeuticos para el redireccionamiento de celulas t. |
US20200109195A1 (en) * | 2018-05-21 | 2020-04-09 | Compass Therapeutics Llc | Compositions and methods for enhancing the killing of target cells by nk cells |
JOP20190116A1 (ar) | 2018-05-24 | 2019-11-24 | Janssen Biotech Inc | الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها |
CA3127025A1 (en) * | 2019-01-18 | 2020-07-23 | Janssen Biotech, Inc. | Gprc5d chimeric antigen receptors and cells expressing the same |
US20210284731A1 (en) * | 2020-03-13 | 2021-09-16 | Janssen Biotech, Inc. | Methods and materials for modulating an immune response |
TW202227495A (zh) * | 2020-09-11 | 2022-07-16 | 美商健生生物科技公司 | 用於調節β鏈介導之免疫的方法及組成物 |
IL301242A (en) * | 2020-09-11 | 2023-05-01 | Janssen Biotech Inc | Multispecific vaccine targeting molecules and their uses |
CN112028996B (zh) * | 2020-10-30 | 2021-01-22 | 南京北恒生物科技有限公司 | 靶向bcma的单域抗体及其用途 |
-
2022
- 2022-02-15 EP EP22705543.1A patent/EP4294528A2/en active Pending
- 2022-02-15 US US17/672,123 patent/US20220267438A1/en active Pending
- 2022-02-15 KR KR1020237031153A patent/KR20230146578A/ko unknown
- 2022-02-15 AU AU2022221884A patent/AU2022221884A1/en active Pending
- 2022-02-15 CN CN202280028859.6A patent/CN117279953A/zh active Pending
- 2022-02-15 AR ARP220100304A patent/AR124882A1/es unknown
- 2022-02-15 WO PCT/EP2022/053651 patent/WO2022175255A2/en active Application Filing
- 2022-02-15 TW TW111105376A patent/TW202302636A/zh unknown
- 2022-02-15 MX MX2023009566A patent/MX2023009566A/es unknown
- 2022-02-15 CA CA3211163A patent/CA3211163A1/en active Pending
- 2022-02-15 BR BR112023016121A patent/BR112023016121A2/pt unknown
- 2022-02-15 IL IL305144A patent/IL305144A/en unknown
- 2022-02-15 PE PE2023002364A patent/PE20241170A1/es unknown
- 2022-02-15 JP JP2023549015A patent/JP2024507180A/ja active Pending
- 2022-02-15 CR CR20230398A patent/CR20230398A/es unknown
- 2022-02-16 UY UY0001039634A patent/UY39634A/es unknown
-
2023
- 2023-08-11 CL CL2023002382A patent/CL2023002382A1/es unknown
- 2023-08-11 DO DO2023000158A patent/DOP2023000158A/es unknown
- 2023-09-07 CO CONC2023/0011907A patent/CO2023011907A2/es unknown
- 2023-09-15 EC ECSENADI202369904A patent/ECSP23069904A/es unknown
Also Published As
Publication number | Publication date |
---|---|
BR112023016121A2 (pt) | 2023-11-28 |
TW202302636A (zh) | 2023-01-16 |
US20220267438A1 (en) | 2022-08-25 |
UY39634A (es) | 2022-08-31 |
AU2022221884A1 (en) | 2023-10-05 |
CR20230398A (es) | 2023-11-15 |
WO2022175255A3 (en) | 2022-09-29 |
WO2022175255A2 (en) | 2022-08-25 |
KR20230146578A (ko) | 2023-10-19 |
EP4294528A2 (en) | 2023-12-27 |
DOP2023000158A (es) | 2024-02-29 |
JP2024507180A (ja) | 2024-02-16 |
CL2023002382A1 (es) | 2024-03-15 |
IL305144A (en) | 2023-10-01 |
AR124882A1 (es) | 2023-05-17 |
MX2023009566A (es) | 2023-10-24 |
PE20241170A1 (es) | 2024-05-28 |
CN117279953A (zh) | 2023-12-22 |
ECSP23069904A (es) | 2023-10-31 |
CA3211163A1 (en) | 2022-08-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2023011907A2 (es) | Anticuerpo triespecífico dirigido a bcma, gprc5d, y cd3 | |
UY37340A (es) | Antianticuerpos gprc5d, moléculas de unión al antígeno biespecíficas que se unen a gprc5d y cd3, y usos de estas | |
CL2023000907A1 (es) | Anticuerpos de unión a gprc5d | |
UY36974A (es) | Anticuerpos anti-il1rap, moléculas de unión a antígenos biespecíficas que se unen a il1rap y cd3, y usos de estas | |
UY36859A (es) | Anticuerpos anti-bcma, moléculas de unión a antígenos biespecíficas que se unen a bcma y cd3, y usos de estas | |
CL2020003031A1 (es) | Agentes aglutinantes del psma y usos de estos. | |
CO2017008462A2 (es) | Anticuerpos anti-cd3, anticuerpos anti-cd123 y anticuerpos biespecíficos que se unen específicamente a cd3 y/o cd123 | |
PE20180484A1 (es) | Moleculas biespecificas de union a antigeno activadoras de celulas t | |
CO2019006500A2 (es) | Anticuerpos biespecíficos que se unen al factor de coagulación ix y al factor de coagulación x | |
CL2018000502A1 (es) | Anticuerpos biespecíficos para pd1 y tim3 útiles como inmunomoduladores o en el tratamiento del cáncer. | |
CO2023013511A2 (es) | Anticuerpo triespecífico dirigido a cd79b, cd20, y cd3 | |
PE20170263A1 (es) | Moleculas biespecificas de union a antigeno activadoras de celulas t | |
UY36289A (es) | ANTICUERPOS MONOCLONALES QUE ENLAZAN INMUNOESPECIFICAMENTE A CD123 y COMPOSICIONES QUE LOS CONTIENEN | |
CO2017010495A2 (es) | Anticuerpos que se unen a bcma y/o cd3 | |
UY37083A (es) | Anticuerpos anti-ror1, anticuerpos biespecíficos ror1 x cd3 y métodos para su uso | |
BR112019002168A2 (pt) | anticorpos trivalentes bispecíficos ligantes a claudina6 ou claudina18.2 e cd3 para o tratamento de doenças cancerígenas que expressam claudina | |
AR106365A1 (es) | Moléculas biespecíficas de unión a antígeno activadoras de células t | |
CO7250445A2 (es) | Proteínas de unión a antígeno st2 | |
AR119393A1 (es) | Anticuerpos que se unen a nkg2d | |
CL2020001629A1 (es) | Anticuerpos de unión a hla-a2/wt1. | |
AR125211A1 (es) | Anticuerpos triespecíficos dirigidos a cd79b, cd20 y cd3 | |
CO2021005178A2 (es) | Anticuerpo monoclonal que se une específicamente al antígeno cd20 | |
AR118080A2 (es) | Proteínas de unión a antígeno dirigidas contra el receptor | |
AR107834A1 (es) | Anticuerpos que se unen al factor de necrosis tumoral inducido por glucocorticoides (gitr), métodos y usos | |
AR121333A1 (es) | Moléculas de unión biespecíficas |