CO2023011623A2 - Compuestos inhibidores de fgfr3 - Google Patents
Compuestos inhibidores de fgfr3Info
- Publication number
- CO2023011623A2 CO2023011623A2 CONC2023/0011623A CO2023011623A CO2023011623A2 CO 2023011623 A2 CO2023011623 A2 CO 2023011623A2 CO 2023011623 A CO2023011623 A CO 2023011623A CO 2023011623 A2 CO2023011623 A2 CO 2023011623A2
- Authority
- CO
- Colombia
- Prior art keywords
- inhibitory compounds
- fgfr3 inhibitory
- achondroplasia
- fibrosis
- fgfr3
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 101150025764 FGFR3 gene Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 208000008919 achondroplasia Diseases 0.000 abstract 3
- 201000001079 SADDAN Diseases 0.000 abstract 2
- 208000017601 Severe achondroplasia-developmental delay-acanthosis nigricans syndrome Diseases 0.000 abstract 2
- 206010008723 Chondrodystrophy Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 208000007326 Muenke Syndrome Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000009594 Systemic Scleroderma Diseases 0.000 abstract 1
- 206010042953 Systemic sclerosis Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
- 201000003896 thanatophoric dysplasia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
La presente invención proporciona los compuestos de la fórmula: , para usar en el tratamiento de la esclerosis sistémica, la fibrosis (p. ej., fibrosis pulmonar), la acondroplasia, la displasia tanatofórica (p. ej., tipo I), la acondroplasia grave con retraso del desarrollo y acantosis nigricans (SADDAN), el síndrome de Muenke o el cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163156527P | 2021-03-04 | 2021-03-04 | |
PCT/US2022/018644 WO2022187443A1 (en) | 2021-03-04 | 2022-03-03 | Fgfr3 inhibitor compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2023011623A2 true CO2023011623A2 (es) | 2023-09-18 |
Family
ID=80937162
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2023/0011623A CO2023011623A2 (es) | 2021-03-04 | 2023-09-01 | Compuestos inhibidores de fgfr3 |
Country Status (17)
Country | Link |
---|---|
US (1) | US11878976B2 (es) |
EP (1) | EP4301468A1 (es) |
JP (1) | JP7480438B2 (es) |
KR (1) | KR20230130170A (es) |
CN (1) | CN117120439A (es) |
AR (1) | AR125588A1 (es) |
AU (1) | AU2022229380A1 (es) |
BR (1) | BR112023015519A2 (es) |
CA (1) | CA3210594A1 (es) |
CO (1) | CO2023011623A2 (es) |
CR (1) | CR20230427A (es) |
DO (1) | DOP2023000176A (es) |
EC (1) | ECSP23066654A (es) |
IL (1) | IL304886A (es) |
PE (1) | PE20231563A1 (es) |
TW (2) | TW202402754A (es) |
WO (1) | WO2022187443A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20240116932A1 (en) | 2022-09-07 | 2024-04-11 | Eli Lilly And Company | Cocrystalline forms of fgfr3 inhibitors |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010017047A1 (en) * | 2008-08-05 | 2010-02-11 | Merck & Co., Inc. | Therapeutic compounds |
ES2796377T3 (es) | 2010-03-10 | 2020-11-26 | Incyte Holdings Corp | Derivados de piperidin-4-IL azetidina como inhibidores de JAK1 |
CN101833512A (zh) | 2010-04-22 | 2010-09-15 | 中兴通讯股份有限公司 | 一种内存回收方法及其装置 |
AU2012323399A1 (en) | 2011-10-12 | 2014-05-29 | Array Biopharma Inc. | 5,7-substituted-imidazo[1,2-c]pyrimidines |
PL2872491T3 (pl) | 2012-07-11 | 2021-12-13 | Blueprint Medicines Corporation | Inhibitory receptora czynnika wzrostu fibroblastów |
US9376441B2 (en) | 2013-07-31 | 2016-06-28 | Gilead Sciences, Inc. | Substituted pyrrolidines as SYK inhibitors |
GB201416754D0 (en) * | 2014-09-23 | 2014-11-05 | Mission Therapeutics Ltd | Novel compounds |
ES2751669T3 (es) | 2015-02-20 | 2020-04-01 | Incyte Corp | Heterociclos bicíclicos como inhibidores FGFR |
ES2734048T3 (es) | 2015-04-29 | 2019-12-04 | Wuxi Fortune Pharmaceutical Co Ltd | Inhibidores de Janus cinasas (JAK) |
EP3298011B1 (en) * | 2015-05-22 | 2021-11-17 | Principia Biopharma Inc. | Quinolone derivatives as fibroblast growth factor receptor inhibitors |
JP6751977B2 (ja) | 2016-09-01 | 2020-09-09 | 南京薬捷安康生物科技有限公司 | 線維芽細胞増殖因子受容体の阻害剤及びそれらの使用 |
CN107315291B (zh) | 2017-07-19 | 2020-06-16 | 深圳市华星光电半导体显示技术有限公司 | 一种goa显示面板及goa显示装置 |
US11254668B2 (en) | 2017-08-14 | 2022-02-22 | Pfizer Inc. | Pyrazolo[1,5-A]pyrazin-4-yl and related derivatives |
WO2020131627A1 (en) * | 2018-12-19 | 2020-06-25 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases |
-
2022
- 2022-03-02 TW TW112137198A patent/TW202402754A/zh unknown
- 2022-03-02 TW TW111107515A patent/TWI820622B/zh active
- 2022-03-02 AR ARP220100462A patent/AR125588A1/es unknown
- 2022-03-03 BR BR112023015519A patent/BR112023015519A2/pt unknown
- 2022-03-03 EP EP22712686.9A patent/EP4301468A1/en active Pending
- 2022-03-03 CN CN202280019076.1A patent/CN117120439A/zh active Pending
- 2022-03-03 US US17/685,753 patent/US11878976B2/en active Active
- 2022-03-03 PE PE2023002463A patent/PE20231563A1/es unknown
- 2022-03-03 CA CA3210594A patent/CA3210594A1/en active Pending
- 2022-03-03 AU AU2022229380A patent/AU2022229380A1/en active Pending
- 2022-03-03 IL IL304886A patent/IL304886A/en unknown
- 2022-03-03 CR CR20230427A patent/CR20230427A/es unknown
- 2022-03-03 KR KR1020237029713A patent/KR20230130170A/ko not_active Application Discontinuation
- 2022-03-03 WO PCT/US2022/018644 patent/WO2022187443A1/en active Application Filing
- 2022-03-03 JP JP2023530844A patent/JP7480438B2/ja active Active
-
2023
- 2023-09-01 CO CONC2023/0011623A patent/CO2023011623A2/es unknown
- 2023-09-01 DO DO2023000176A patent/DOP2023000176A/es unknown
- 2023-09-04 EC ECSENADI202366654A patent/ECSP23066654A/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP7480438B2 (ja) | 2024-05-09 |
CR20230427A (es) | 2023-09-26 |
US11878976B2 (en) | 2024-01-23 |
AR125588A1 (es) | 2023-08-02 |
WO2022187443A1 (en) | 2022-09-09 |
TW202402754A (zh) | 2024-01-16 |
CA3210594A1 (en) | 2022-09-09 |
EP4301468A1 (en) | 2024-01-10 |
AU2022229380A1 (en) | 2023-08-24 |
PE20231563A1 (es) | 2023-10-03 |
BR112023015519A2 (pt) | 2023-10-03 |
IL304886A (en) | 2023-10-01 |
KR20230130170A (ko) | 2023-09-11 |
TWI820622B (zh) | 2023-11-01 |
TW202300491A (zh) | 2023-01-01 |
US20230095122A1 (en) | 2023-03-30 |
JP2023554598A (ja) | 2023-12-28 |
CN117120439A (zh) | 2023-11-24 |
ECSP23066654A (es) | 2024-02-29 |
DOP2023000176A (es) | 2023-09-29 |
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