CO2023006544A2 - Inmunoterapia oncolítica por remodelación del microambiente tumoral - Google Patents

Inmunoterapia oncolítica por remodelación del microambiente tumoral

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Publication number
CO2023006544A2
CO2023006544A2 CONC2023/0006544A CO2023006544A CO2023006544A2 CO 2023006544 A2 CO2023006544 A2 CO 2023006544A2 CO 2023006544 A CO2023006544 A CO 2023006544A CO 2023006544 A2 CO2023006544 A2 CO 2023006544A2
Authority
CO
Colombia
Prior art keywords
remodeling
tumor microenvironment
oncolytic viruses
oncolytic
immunotherapy
Prior art date
Application number
CONC2023/0006544A
Other languages
English (en)
Inventor
Stephen Howard Thorne
Mingrui Zhang
Daniel J Byrd
Original Assignee
Kalivir Immunotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalivir Immunotherapeutics Inc filed Critical Kalivir Immunotherapeutics Inc
Publication of CO2023006544A2 publication Critical patent/CO2023006544A2/es

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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86—Viral vectors
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    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/195—Chemokines, e.g. RANTES
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/575—Hormones
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La divulgación se relaciona con virus oncolíticos modificados. Los virus oncolíticos modificados de la divulgación comprenden la modificación en el genoma viral que codifica ácidos nucleicos exógenos para potenciar la inmunoterapia oncolítica por la remodelación del microambiente tumoral y con un suministro sistémico potenciado. La divulgación se relaciona además con composiciones que comprenden los virus oncolíticos modificados, kits que los contienen, y métodos para el uso de los virus oncolíticos.
CONC2023/0006544A 2020-11-19 2023-05-17 Inmunoterapia oncolítica por remodelación del microambiente tumoral CO2023006544A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063116004P 2020-11-19 2020-11-19
PCT/US2021/059887 WO2022109133A1 (en) 2020-11-19 2021-11-18 Oncolytic immunotherapy by tumor micro-environment remodeling

Publications (1)

Publication Number Publication Date
CO2023006544A2 true CO2023006544A2 (es) 2023-05-19

Family

ID=81709792

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0006544A CO2023006544A2 (es) 2020-11-19 2023-05-17 Inmunoterapia oncolítica por remodelación del microambiente tumoral

Country Status (17)

Country Link
US (1) US20230256041A1 (es)
EP (1) EP4247410A1 (es)
JP (1) JP2023552289A (es)
KR (1) KR20230110545A (es)
CN (1) CN116801899A (es)
AU (1) AU2021385059A1 (es)
CA (1) CA3197371A1 (es)
CL (1) CL2023001450A1 (es)
CO (1) CO2023006544A2 (es)
CR (1) CR20230268A (es)
DO (1) DOP2023000098A (es)
EC (1) ECSP23045508A (es)
IL (1) IL302897A (es)
MX (1) MX2023005853A (es)
PE (1) PE20231175A1 (es)
TW (1) TW202227621A (es)
WO (1) WO2022109133A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024086609A2 (en) * 2022-10-19 2024-04-25 Kalivir Immunotherapeutics, Inc. Nucleic acids encoding soluble pd-1 and il-12 and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL71275A0 (en) * 1983-03-21 1984-06-29 Sparamedica Ag Human interleukin-2-and its preparation
CN103255110B (zh) * 2006-08-25 2016-04-20 美国国有健康与人类服务部(马里兰州) 修饰的安卡拉痘苗病毒基因的基因组中保守基因之间的基因间位点
EP2184297A1 (en) * 2008-11-07 2010-05-12 Hla-G Technologies HLA-G polypeptides and pharmaceutical uses thereof
US11185586B2 (en) * 2016-11-22 2021-11-30 Alloplex Biotherapeutics, Inc. Allogeneic tumor cell vaccine
EP3973973A1 (en) * 2017-10-31 2022-03-30 KaliVir Immunotherapeutics, Inc. Platform oncolytic vector for systemic delivery
CA3087044A1 (en) 2018-01-26 2019-08-01 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Expression of metabolic modulators in tumor microenvironment to improve tumor therapy

Also Published As

Publication number Publication date
MX2023005853A (es) 2023-06-02
IL302897A (en) 2023-07-01
AU2021385059A1 (en) 2023-06-08
PE20231175A1 (es) 2023-08-01
JP2023552289A (ja) 2023-12-15
TW202227621A (zh) 2022-07-16
CR20230268A (es) 2023-07-26
CL2023001450A1 (es) 2023-10-20
KR20230110545A (ko) 2023-07-24
WO2022109133A1 (en) 2022-05-27
CN116801899A (zh) 2023-09-22
CA3197371A1 (en) 2022-05-27
EP4247410A1 (en) 2023-09-27
ECSP23045508A (es) 2023-07-31
US20230256041A1 (en) 2023-08-17
DOP2023000098A (es) 2023-08-15

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