CO2023006410A2 - Método de control del contenido total de ácido siálico (ctas) durante la fabricación de fosfatasa alcalina referencia cruzada a solicitudes relacionadas - Google Patents
Método de control del contenido total de ácido siálico (ctas) durante la fabricación de fosfatasa alcalina referencia cruzada a solicitudes relacionadasInfo
- Publication number
- CO2023006410A2 CO2023006410A2 CONC2023/0006410A CO2023006410A CO2023006410A2 CO 2023006410 A2 CO2023006410 A2 CO 2023006410A2 CO 2023006410 A CO2023006410 A CO 2023006410A CO 2023006410 A2 CO2023006410 A2 CO 2023006410A2
- Authority
- CO
- Colombia
- Prior art keywords
- ctas
- sialic acid
- control method
- related applications
- cross reference
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 102000002260 Alkaline Phosphatase Human genes 0.000 title abstract 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 title abstract 2
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 title abstract 2
- 229960003554 asfotase alfa Drugs 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 238000003908 quality control method Methods 0.000 abstract 1
- WBWWGRHZICKQGZ-HZAMXZRMSA-M taurocholate Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 WBWWGRHZICKQGZ-HZAMXZRMSA-M 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03001—Alkaline phosphatase (3.1.3.1)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Se presentan métodos de fabricación de fosfatasas alcalinas recombinantes, tales como asfotasa alfa, que proporcionan un control de calidad más preciso frente a la concentración del contenido total de ácido siálico (CTAS) en el producto final midiendo la concentración de CTAS durante la fermentación y ajustando los pasos de producción aguas abajo en respuesta.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063105052P | 2020-10-23 | 2020-10-23 | |
| PCT/US2021/055991 WO2022087229A1 (en) | 2020-10-23 | 2021-10-21 | Method of controlling total sialic acid content (tsac) during manufacturing of alkaline phosphatase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2023006410A2 true CO2023006410A2 (es) | 2023-08-09 |
Family
ID=81290076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2023/0006410A CO2023006410A2 (es) | 2020-10-23 | 2023-05-16 | Método de control del contenido total de ácido siálico (ctas) durante la fabricación de fosfatasa alcalina referencia cruzada a solicitudes relacionadas |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240052327A1 (es) |
| EP (1) | EP4232150A1 (es) |
| JP (1) | JP2023546682A (es) |
| KR (1) | KR20230088811A (es) |
| CN (1) | CN116670270A (es) |
| AU (1) | AU2021364779A1 (es) |
| CA (1) | CA3173820A1 (es) |
| CO (1) | CO2023006410A2 (es) |
| MX (1) | MX2023004621A (es) |
| WO (1) | WO2022087229A1 (es) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7112341B1 (en) * | 1999-04-13 | 2006-09-26 | Nektar Therapeutics | Pulmonary administration of dry powder formulations for treating infertility |
| KR101380740B1 (ko) * | 2012-06-29 | 2014-04-11 | 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 | 이듀로네이트-2-설파타제의 정제 |
| CN106459143A (zh) * | 2014-01-24 | 2017-02-22 | 安-法玛公司 | 碱性磷酸酶的下游处理 |
| EP3337894A1 (en) * | 2015-08-17 | 2018-06-27 | Alexion Pharmaceuticals, Inc. | Manufacturing of alkaline phosphatases |
| WO2017214130A1 (en) * | 2016-06-06 | 2017-12-14 | Alexion Pharmaceuticals, Inc. | Metal impact on manufacturing of alkaline phosphatases |
-
2021
- 2021-10-21 US US18/032,973 patent/US20240052327A1/en active Pending
- 2021-10-21 WO PCT/US2021/055991 patent/WO2022087229A1/en active Application Filing
- 2021-10-21 JP JP2023524624A patent/JP2023546682A/ja active Pending
- 2021-10-21 KR KR1020237016861A patent/KR20230088811A/ko active Search and Examination
- 2021-10-21 AU AU2021364779A patent/AU2021364779A1/en active Pending
- 2021-10-21 MX MX2023004621A patent/MX2023004621A/es unknown
- 2021-10-21 CN CN202180084227.7A patent/CN116670270A/zh active Pending
- 2021-10-21 CA CA3173820A patent/CA3173820A1/en active Pending
- 2021-10-21 EP EP21883877.9A patent/EP4232150A1/en active Pending
-
2023
- 2023-05-16 CO CONC2023/0006410A patent/CO2023006410A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2023004621A (es) | 2023-06-06 |
| KR20230088811A (ko) | 2023-06-20 |
| EP4232150A1 (en) | 2023-08-30 |
| WO2022087229A1 (en) | 2022-04-28 |
| CA3173820A1 (en) | 2022-04-28 |
| JP2023546682A (ja) | 2023-11-07 |
| AU2021364779A9 (en) | 2023-07-06 |
| CN116670270A (zh) | 2023-08-29 |
| AU2021364779A1 (en) | 2023-06-01 |
| US20240052327A1 (en) | 2024-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR122023000998A8 (pt) | Cristal de piroxassulfona, composição agroquímica, e, processos para a produção de um cristal de piroxassulfona e de uma composição agroquímica | |
| CO2022006019A2 (es) | Métodos mejorados para la producción, recuperación y secreción de compuestos hidrófobos en una fermentación | |
| CL2022001679A1 (es) | Células de levadura y métodos para la producción de e8,e10-dodecadienil coenzima a, codlemona y derivados | |
| CO6341608A2 (es) | Procesos para la preparación del metil-ester del acido 4-oxo-octahidro-indol-1-carbociclico y derivados del mismo | |
| CO2023006410A2 (es) | Método de control del contenido total de ácido siálico (ctas) durante la fabricación de fosfatasa alcalina referencia cruzada a solicitudes relacionadas | |
| BR112022012271A2 (pt) | Processo de produção de uma composição de gordura compreendendo uma etapa de esterificação | |
| AR119165A1 (es) | Control de perfusión basado en biomasa automatizado en la fabricación de productos biológicos | |
| CO2024004812A2 (es) | Método para producir células t | |
| BR112018000168A2 (pt) | método para produção de células ips de alta qualidade | |
| BR112022000683A2 (pt) | Novas betacaroteno oxidases | |
| CO2021008763A2 (es) | Enzima de desfosforilación del nuevo ácido psicosa-6-fosfórico, composición para producir psicosa que comprende la misma y método para preparar psicosa usando la misma | |
| BR112016009619A2 (pt) | métodos para sacarificar um material celulósico e para produzir um produto de fermentação a partir de material celulósico | |
| MX2021012754A (es) | Proceso para la produccion de acido metanosulfonico anhidro a partir de metano y so3. | |
| BR112022012184A2 (pt) | Método para produzir um material de polpa moldado para unidade de embalagem e unidade de embalagem | |
| BR112022016457A2 (pt) | Método para melhorar o crescimento de planta | |
| BR112015005797A2 (pt) | processo para a produção de gelatina | |
| BR112019006773A2 (pt) | processo e instalação para tratar água produzida a partir de um campo de óleo e gás | |
| AR115667A1 (es) | Cepas de microalgas del gen thraustochytrium y producción de ácidos grasos poliinsaturados utilizando las mismas | |
| CY1125566T1 (el) | Μεθοδος παραγωγης της ελαιοκανθαλης, της ελαιασινης και των αναλογων τους | |
| BR112012014416A2 (pt) | novos derivados de dioxolanos e de dioxanos, e método para sua produção. | |
| BR112022017197A2 (pt) | Sistema de produção haploide duplicado de sorgo | |
| WO2022046953A3 (en) | Mixed nuclear power conversion | |
| BR112022000235A2 (pt) | Processo para a produção de uma lignina estabilizada com alta superfície específica | |
| PH12015501255A1 (en) | Use of sodium dithionite in a cellulose pulping process | |
| PL435039A1 (pl) | Sposób wytwarzania serów topionych |