CO2022011388A2 - Inhibidores heterocíclicos de pad4 - Google Patents
Inhibidores heterocíclicos de pad4Info
- Publication number
- CO2022011388A2 CO2022011388A2 CONC2022/0011388A CO2022011388A CO2022011388A2 CO 2022011388 A2 CO2022011388 A2 CO 2022011388A2 CO 2022011388 A CO2022011388 A CO 2022011388A CO 2022011388 A2 CO2022011388 A2 CO 2022011388A2
- Authority
- CO
- Colombia
- Prior art keywords
- pad4
- compounds
- heterocyclic
- pad4 inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
La divulgación se refiere generalmente a compuestos heterocíclicos sustituidos de la Fórmula (Ia), que son inhibidores de PAD4, método para preparar estos compuestos, composiciones farmacéuticas que comprenden estos compuestos y uso de estos compuestos en el tratamiento de una enfermedad o trastorno asociado con la actividad de la enzima PAD4. (Ia) en donde es o ; es o ; y X1-X6 y R1–R8, junto con otras variables son como se definen en la presente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN202041006146 | 2020-02-12 | ||
PCT/US2021/017554 WO2021163254A1 (en) | 2020-02-12 | 2021-02-11 | Heterocyclic pad4 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2022011388A2 true CO2022011388A2 (es) | 2022-08-30 |
Family
ID=74856949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2022/0011388A CO2022011388A2 (es) | 2020-02-12 | 2022-08-12 | Inhibidores heterocíclicos de pad4 |
Country Status (16)
Country | Link |
---|---|
US (1) | US20230167131A1 (es) |
EP (1) | EP4103559A1 (es) |
JP (1) | JP2023515780A (es) |
KR (1) | KR20220140795A (es) |
CN (1) | CN115348961A (es) |
AR (1) | AR121299A1 (es) |
AU (1) | AU2021219710A1 (es) |
BR (1) | BR112022015792A2 (es) |
CA (1) | CA3167753A1 (es) |
CL (1) | CL2022002148A1 (es) |
CO (1) | CO2022011388A2 (es) |
IL (1) | IL295506A (es) |
MX (1) | MX2022009874A (es) |
PE (1) | PE20230679A1 (es) |
TW (1) | TW202140477A (es) |
WO (1) | WO2021163254A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3177532A1 (en) * | 2020-04-30 | 2021-11-04 | Gilead Sciences, Inc. | Macrocyclic inhibitors of peptidylarginine deiminases |
WO2022140390A1 (en) | 2020-12-22 | 2022-06-30 | Gilead Sciences, Inc. | Inhibitors of peptidylarginine deiminases |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7842713B2 (en) | 2006-04-20 | 2010-11-30 | Pfizer Inc | Fused phenyl amido heterocyclic compounds |
PL2877467T3 (pl) * | 2012-07-26 | 2017-08-31 | Glaxo Group Limited | 2-(azaindolo-2-ylo)benzoimidazole jako inhibitory pad4 |
JP6703553B2 (ja) * | 2015-05-21 | 2020-06-03 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Pad4阻害剤としてのベンゾイミダゾール誘導体 |
AR107030A1 (es) * | 2015-12-09 | 2018-03-14 | Padlock Therapeutics Inc | Inhibidores aza-bencimidazol de pad4 |
RU2747431C2 (ru) * | 2015-12-22 | 2021-05-05 | Кансера Аб | Бициклические гидроксамовые кислоты, полезные в качестве ингибиторов активности деацетилазы гистонов млекопитающих |
AU2018294054B2 (en) * | 2017-06-30 | 2022-05-26 | Beijing Tide Pharmaceutical Co., Ltd. | Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof |
HUE061607T2 (hu) * | 2017-10-18 | 2023-07-28 | Jubilant Epipad LLC | Imidazopiridin vegyületek mint PAD inhibitorok |
-
2021
- 2021-02-09 TW TW110105125A patent/TW202140477A/zh unknown
- 2021-02-10 AR ARP210100336A patent/AR121299A1/es unknown
- 2021-02-11 US US17/799,028 patent/US20230167131A1/en active Pending
- 2021-02-11 JP JP2022548707A patent/JP2023515780A/ja active Pending
- 2021-02-11 KR KR1020227031398A patent/KR20220140795A/ko unknown
- 2021-02-11 CN CN202180025726.9A patent/CN115348961A/zh active Pending
- 2021-02-11 BR BR112022015792A patent/BR112022015792A2/pt not_active Application Discontinuation
- 2021-02-11 AU AU2021219710A patent/AU2021219710A1/en active Pending
- 2021-02-11 IL IL295506A patent/IL295506A/en unknown
- 2021-02-11 PE PE2022001712A patent/PE20230679A1/es unknown
- 2021-02-11 WO PCT/US2021/017554 patent/WO2021163254A1/en active Application Filing
- 2021-02-11 CA CA3167753A patent/CA3167753A1/en active Pending
- 2021-02-11 EP EP21709851.6A patent/EP4103559A1/en active Pending
- 2021-02-11 MX MX2022009874A patent/MX2022009874A/es unknown
-
2022
- 2022-08-10 CL CL2022002148A patent/CL2022002148A1/es unknown
- 2022-08-12 CO CONC2022/0011388A patent/CO2022011388A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
TW202140477A (zh) | 2021-11-01 |
AR121299A1 (es) | 2022-05-04 |
PE20230679A1 (es) | 2023-04-21 |
CA3167753A1 (en) | 2021-08-19 |
JP2023515780A (ja) | 2023-04-14 |
MX2022009874A (es) | 2022-08-22 |
CL2022002148A1 (es) | 2023-02-24 |
CN115348961A (zh) | 2022-11-15 |
BR112022015792A2 (pt) | 2022-10-11 |
AU2021219710A1 (en) | 2022-10-06 |
WO2021163254A1 (en) | 2021-08-19 |
EP4103559A1 (en) | 2022-12-21 |
KR20220140795A (ko) | 2022-10-18 |
IL295506A (en) | 2022-10-01 |
US20230167131A1 (en) | 2023-06-01 |
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