CO2022010432A2 - Método basado en tecnología leaper para el tratamiento de mucopolisacaridosis ih y composición - Google Patents

Método basado en tecnología leaper para el tratamiento de mucopolisacaridosis ih y composición

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Publication number
CO2022010432A2
CO2022010432A2 CONC2022/0010432A CO2022010432A CO2022010432A2 CO 2022010432 A2 CO2022010432 A2 CO 2022010432A2 CO 2022010432 A CO2022010432 A CO 2022010432A CO 2022010432 A2 CO2022010432 A2 CO 2022010432A2
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Colombia
Prior art keywords
leaper
mucopolysaccharidoses
treatment
composition
technology
Prior art date
Application number
CONC2022/0010432A
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English (en)
Inventor
Pengfei Yuan
Yanxia Zhao
Nengyin Liu
Zexuan Yi
Gangbin Tang
Original Assignee
Edigene Therapeutics Beijing Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Edigene Therapeutics Beijing Inc filed Critical Edigene Therapeutics Beijing Inc
Publication of CO2022010432A2 publication Critical patent/CO2022010432A2/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01076—L-Iduronidase (3.2.1.76)
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    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04004—Adenosine deaminase (3.5.4.4)

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  • Health & Medical Sciences (AREA)
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Abstract

La presente solicitud se refiere a un método basado en LEAPER para la edición dirigida de ARN, que comprende: realizar in vivo de forma segura y eficaz la edición de adenosina a inosina de ARN (edición A a I de ARN) por medio de LEAPER, con ello los sitios con mutación patógena pueden ser reparados con precisión y todas las enfermedades causadas por las mutaciones G>A, tales como MPS IH, pueden ser tratadas.
CONC2022/0010432A 2019-12-30 2022-07-26 Método basado en tecnología leaper para el tratamiento de mucopolisacaridosis ih y composición CO2022010432A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2019129952 2019-12-30
PCT/CN2020/141506 WO2021136408A1 (zh) 2019-12-30 2020-12-30 一种基于leaper技术治疗mps ih的方法和组合物

Publications (1)

Publication Number Publication Date
CO2022010432A2 true CO2022010432A2 (es) 2022-08-09

Family

ID=76687311

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2022/0010432A CO2022010432A2 (es) 2019-12-30 2022-07-26 Método basado en tecnología leaper para el tratamiento de mucopolisacaridosis ih y composición

Country Status (16)

Country Link
US (1) US20230060518A1 (es)
EP (1) EP4086345A4 (es)
JP (1) JP2023509179A (es)
KR (1) KR20220119129A (es)
CN (1) CN114846139A (es)
AU (1) AU2020418228A1 (es)
CA (1) CA3163272A1 (es)
CL (1) CL2022001776A1 (es)
CO (1) CO2022010432A2 (es)
CR (1) CR20220365A (es)
EC (1) ECSP22059741A (es)
IL (1) IL294201A (es)
MX (1) MX2022008190A (es)
PE (1) PE20230037A1 (es)
TW (1) TW202128193A (es)
WO (1) WO2021136408A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220307020A1 (en) 2019-04-15 2022-09-29 Edigene Inc. Methods and compositions for editing rnas
CR20220063A (es) 2019-07-12 2022-07-22 Univ Beijing Edición de ácido ribonucleico (arn) dirigido aprovechando la adenosina desaminasa que actúa sobre ácido ribonucleico endógeno (adar) utilizando ácidos ribonucleicos (arn) modificados genéticamente
CN115038789A (zh) 2019-12-02 2022-09-09 塑造治疗公司 治疗性编辑
EP4137161A4 (en) * 2020-04-15 2023-10-11 EdiGene Therapeutics (Beijing) Inc. METHOD AND MEDICATION FOR THE TREATMENT OF HURLER SYNDROME
WO2023152371A1 (en) 2022-02-14 2023-08-17 Proqr Therapeutics Ii B.V. Guide oligonucleotides for nucleic acid editing in the treatment of hypercholesterolemia
WO2024013360A1 (en) 2022-07-15 2024-01-18 Proqr Therapeutics Ii B.V. Chemically modified oligonucleotides for adar-mediated rna editing
WO2024013361A1 (en) 2022-07-15 2024-01-18 Proqr Therapeutics Ii B.V. Oligonucleotides for adar-mediated rna editing and use thereof
GB202215614D0 (en) 2022-10-21 2022-12-07 Proqr Therapeutics Ii Bv Heteroduplex rna editing oligonucleotide complexes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016097212A1 (en) * 2014-12-17 2016-06-23 Proqr Therapeutics Ii B.V. Targeted rna editing
WO2017220751A1 (en) * 2016-06-22 2017-12-28 Proqr Therapeutics Ii B.V. Single-stranded rna-editing oligonucleotides
PL3507366T3 (pl) * 2016-09-01 2021-05-04 Proqr Therapeutics Ii B.V. Chemicznie modyfikowane jednoniciowe oligonukleotydy edytujące rna
BR112021006844A8 (pt) 2018-10-12 2023-03-21 Univ Beijing Métodos para editar um rna alvo e para tratar ou prevenir uma doença ou condição, rna editado ou uma célula hospedeira tendo um rna editado, rna que recruta desaminase, construção, biblioteca, composição, célula hospedeira, e, kit para editar um rna alvo .
CA3128876A1 (en) * 2019-02-13 2020-08-20 Beam Therapeutics Inc. Methods of editing a disease-associated gene using adenosine deaminase base editors, including for the treatment of genetic disease
US20220307020A1 (en) * 2019-04-15 2022-09-29 Edigene Inc. Methods and compositions for editing rnas

Also Published As

Publication number Publication date
JP2023509179A (ja) 2023-03-07
EP4086345A1 (en) 2022-11-09
ECSP22059741A (es) 2022-11-30
CN114846139A (zh) 2022-08-02
TW202128193A (zh) 2021-08-01
AU2020418228A1 (en) 2022-08-18
IL294201A (en) 2022-08-01
US20230060518A1 (en) 2023-03-02
KR20220119129A (ko) 2022-08-26
MX2022008190A (es) 2022-08-02
CL2022001776A1 (es) 2023-01-27
WO2021136408A1 (zh) 2021-07-08
CR20220365A (es) 2022-12-06
CA3163272A1 (en) 2021-07-08
EP4086345A4 (en) 2024-03-20
PE20230037A1 (es) 2023-01-10

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