CO2019013245A2 - Composiciones biofarmacéuticas y métodos relacionados - Google Patents
Composiciones biofarmacéuticas y métodos relacionadosInfo
- Publication number
- CO2019013245A2 CO2019013245A2 CONC2019/0013245A CO2019013245A CO2019013245A2 CO 2019013245 A2 CO2019013245 A2 CO 2019013245A2 CO 2019013245 A CO2019013245 A CO 2019013245A CO 2019013245 A2 CO2019013245 A2 CO 2019013245A2
- Authority
- CO
- Colombia
- Prior art keywords
- asthma
- eosinophilic
- moderate
- severe
- atopic dermatitis
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 229960000074 biopharmaceutical Drugs 0.000 title 1
- 208000006673 asthma Diseases 0.000 abstract 10
- 102000000743 Interleukin-5 Human genes 0.000 abstract 5
- 108010002616 Interleukin-5 Proteins 0.000 abstract 5
- 229940100602 interleukin-5 Drugs 0.000 abstract 5
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 2
- 201000008937 atopic dermatitis Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 abstract 1
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 abstract 1
- 206010048643 Hypereosinophilic syndrome Diseases 0.000 abstract 1
- 208000011623 Obstructive Lung disease Diseases 0.000 abstract 1
- 206010034277 Pemphigoid Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 208000000594 bullous pemphigoid Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 201000000708 eosinophilic esophagitis Diseases 0.000 abstract 1
- 208000015768 polyposis Diseases 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 208000037851 severe atopic dermatitis Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente descripción se refiere a composiciones de unión a antígeno, que incluyen anticuerpos, para tratar enfermedades mediadas por interleucina 5 (IL-5), y métodos relacionados. IL-5 es una proteína secretada. IL-5 desempeña un papel en una serie de enfermedades diferentes como asma, asma leve, asma moderada, asma severa, asma eosinofílica leve, asma eosinofílica moderada, asma eosinofílica severa, asma eosinofílica no controlada, asma eosinofílica, asma subeosinofílica, enfermedad pulmonar obstructiva crónica, granulomatosis eosinofílica con poliangeítis, síndrome hipereosinofílico, poliposis nasal, penfigoide ampolloso, esofagitis eosinofílica, dermatitis atópica, dermatitis atópica moderada y dermatitis atópica severa. Las composiciones descritas son adecuadas para tratar estas enfermedades mediadas por IL-5 graves..
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762511441P | 2017-05-26 | 2017-05-26 | |
| PCT/IB2018/053683 WO2018215964A1 (en) | 2017-05-26 | 2018-05-24 | Biopharmaceutical compositions and related methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2019013245A2 true CO2019013245A2 (es) | 2020-01-17 |
Family
ID=62683386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2019/0013245A CO2019013245A2 (es) | 2017-05-26 | 2019-11-26 | Composiciones biofarmacéuticas y métodos relacionados |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US10787509B2 (es) |
| EP (1) | EP3630824A1 (es) |
| JP (2) | JP7224304B2 (es) |
| KR (1) | KR102473898B1 (es) |
| CN (5) | CN117018189A (es) |
| AR (1) | AR111764A1 (es) |
| AU (2) | AU2018273174B2 (es) |
| BR (1) | BR112019024884A2 (es) |
| CA (1) | CA3064522A1 (es) |
| CL (1) | CL2019003418A1 (es) |
| CO (1) | CO2019013245A2 (es) |
| CR (1) | CR20190541A (es) |
| DO (1) | DOP2019000297A (es) |
| EA (1) | EA201992802A1 (es) |
| IL (1) | IL270719A (es) |
| MX (1) | MX2019014105A (es) |
| MY (1) | MY200912A (es) |
| NZ (1) | NZ760380A (es) |
| PE (1) | PE20191844A1 (es) |
| PH (1) | PH12019502619A1 (es) |
| SG (1) | SG10201913497XA (es) |
| TW (1) | TWI799417B (es) |
| UY (1) | UY37747A (es) |
| WO (1) | WO2018215964A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019024884A2 (pt) | 2017-05-26 | 2020-06-16 | Glaxosmithkline Intellectual Property Development Limited | Composições biofarmacêuticas e métodos relacionados |
| US11613571B2 (en) | 2018-05-23 | 2023-03-28 | Glaxosmithkline Intellectual Property Development Limited | Biopharmaceutical compositions comprising antibody variants |
| EP3896085A4 (en) * | 2018-12-12 | 2022-11-30 | Shanghai Pharmaexplorer Co., Ltd. | MONOCLONAL ANTIBODY TO HUMAN INTERLEUKIN 5 (IL-5) AND ITS USE |
| WO2022136209A1 (en) | 2020-12-22 | 2022-06-30 | Glaxosmithkline Intellectual Property Development Limited | Interleukin 5 binding protein dosage regimen |
| CA3239667A1 (en) | 2021-12-03 | 2023-06-08 | Glaxosmithkline Intellectual Property Development Limited | Interleukin 5 binding protein dosage regimen for use in treating polyangiitis, hypereosinophilic syndrome, hypereosinophilic syndrome chronic rhinosinusitis with nasal polyps (crswnp), or chronic rhinosinusitis without nasal polyps (crssnp |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5683892A (en) * | 1994-12-23 | 1997-11-04 | Smithkline Beecham Corporation | DNA encoding recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders |
| WO1996021000A2 (en) | 1994-12-23 | 1996-07-11 | Smithkline Beecham Corporation | Recombinant il-5 antagonists useful in treatment of il-5 mediated disorders |
| AU2008201419C1 (en) * | 2000-12-12 | 2018-01-18 | Board Of Regents, The University Of Texas System | Molecules with extended half-lives, compositions and uses thereof |
| WO2008134721A1 (en) | 2007-04-30 | 2008-11-06 | Smithkline Beecham Corporation | Methods for administering anti-il-5 antibodies |
| US9834600B2 (en) | 2008-03-28 | 2017-12-05 | Glaxosmithkline Llc | Methods of treatment of eosinophilic bronchitis with an anti-IL-5 antibody |
| JP6013915B2 (ja) * | 2010-11-17 | 2016-10-25 | 中外製薬株式会社 | 血液凝固第ｖｉｉｉ因子の機能を代替する機能を有する多重特異性抗原結合分子 |
| WO2012083370A1 (en) * | 2010-12-22 | 2012-06-28 | Cephalon Australia Pty Ltd | Modified antibody with improved half-life |
| US8790651B2 (en) * | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| JP6821659B2 (ja) * | 2015-08-24 | 2021-01-27 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ | バイオ医薬組成物 |
| EP3559030B1 (en) | 2016-12-23 | 2024-04-03 | Cephalon LLC | Anti-il-5 antibodies |
| BR112019024884A2 (pt) | 2017-05-26 | 2020-06-16 | Glaxosmithkline Intellectual Property Development Limited | Composições biofarmacêuticas e métodos relacionados |
| US11613571B2 (en) | 2018-05-23 | 2023-03-28 | Glaxosmithkline Intellectual Property Development Limited | Biopharmaceutical compositions comprising antibody variants |
-
2018
- 2018-05-24 BR BR112019024884-6A patent/BR112019024884A2/pt unknown
- 2018-05-24 AR ARP180101401A patent/AR111764A1/es unknown
- 2018-05-24 PE PE2019002461A patent/PE20191844A1/es unknown
- 2018-05-24 AU AU2018273174A patent/AU2018273174B2/en active Active
- 2018-05-24 TW TW107117675A patent/TWI799417B/zh active
- 2018-05-24 EA EA201992802A patent/EA201992802A1/ru unknown
- 2018-05-24 CN CN202311013609.8A patent/CN117018189A/zh active Pending
- 2018-05-24 JP JP2019565279A patent/JP7224304B2/ja active Active
- 2018-05-24 NZ NZ760380A patent/NZ760380A/en unknown
- 2018-05-24 CN CN202311014554.2A patent/CN117100853A/zh active Pending
- 2018-05-24 WO PCT/IB2018/053683 patent/WO2018215964A1/en active Application Filing
- 2018-05-24 CR CR20190541A patent/CR20190541A/es unknown
- 2018-05-24 CN CN202311013988.0A patent/CN117018190A/zh active Pending
- 2018-05-24 CA CA3064522A patent/CA3064522A1/en active Pending
- 2018-05-24 US US15/987,942 patent/US10787509B2/en active Active
- 2018-05-24 EP EP18732488.4A patent/EP3630824A1/en active Pending
- 2018-05-24 CN CN202311013236.4A patent/CN117018188A/zh active Pending
- 2018-05-24 MX MX2019014105A patent/MX2019014105A/es unknown
- 2018-05-24 MY MYPI2019006883A patent/MY200912A/en unknown
- 2018-05-24 CN CN201880046323.0A patent/CN110891968B/zh active Active
- 2018-05-24 KR KR1020197037587A patent/KR102473898B1/ko active IP Right Grant
- 2018-05-24 UY UY0001037747A patent/UY37747A/es unknown
- 2018-05-24 SG SG10201913497XA patent/SG10201913497XA/en unknown
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2019
- 2019-11-17 IL IL270719A patent/IL270719A/en unknown
- 2019-11-21 PH PH12019502619A patent/PH12019502619A1/en unknown
- 2019-11-22 DO DO2019000297A patent/DOP2019000297A/es unknown
- 2019-11-22 CL CL2019003418A patent/CL2019003418A1/es unknown
- 2019-11-26 CO CONC2019/0013245A patent/CO2019013245A2/es unknown
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2020
- 2020-08-07 US US16/988,257 patent/US11976113B2/en active Active
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2021
- 2021-09-17 AU AU2021232807A patent/AU2021232807A1/en active Pending
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2023
- 2023-01-31 JP JP2023013628A patent/JP2023058546A/ja active Pending
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