CO2019013021A2 - Amidas de piridona deuteradas y sus profármacos como moduladores de los canales de sodio - Google Patents
Amidas de piridona deuteradas y sus profármacos como moduladores de los canales de sodioInfo
- Publication number
- CO2019013021A2 CO2019013021A2 CONC2019/0013021A CO2019013021A CO2019013021A2 CO 2019013021 A2 CO2019013021 A2 CO 2019013021A2 CO 2019013021 A CO2019013021 A CO 2019013021A CO 2019013021 A2 CO2019013021 A2 CO 2019013021A2
- Authority
- CO
- Colombia
- Prior art keywords
- sodium channels
- deuterated
- prodrugs
- modulators
- compounds
- Prior art date
Links
- 108010052164 Sodium Channels Proteins 0.000 title abstract 2
- 102000018674 Sodium Channels Human genes 0.000 title abstract 2
- -1 Deuterated pyridone amides Chemical class 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762507172P | 2017-05-16 | 2017-05-16 | |
| US201762547718P | 2017-08-18 | 2017-08-18 | |
| PCT/US2018/032939 WO2018213426A1 (en) | 2017-05-16 | 2018-05-16 | Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2019013021A2 true CO2019013021A2 (es) | 2020-04-01 |
Family
ID=62567801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2019/0013021A CO2019013021A2 (es) | 2017-05-16 | 2019-11-21 | Amidas de piridona deuteradas y sus profármacos como moduladores de los canales de sodio |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11358977B2 (https=) |
| EP (1) | EP3625214B1 (https=) |
| JP (1) | JP7104070B2 (https=) |
| KR (1) | KR102714561B1 (https=) |
| CN (1) | CN110740993B (https=) |
| AU (1) | AU2018271110A1 (https=) |
| BR (1) | BR112019024016A2 (https=) |
| CA (1) | CA3063901A1 (https=) |
| CL (1) | CL2019003239A1 (https=) |
| CO (1) | CO2019013021A2 (https=) |
| ES (1) | ES2927712T3 (https=) |
| IL (1) | IL270680B (https=) |
| MA (1) | MA49137A (https=) |
| MX (1) | MX390793B (https=) |
| UA (1) | UA124857C2 (https=) |
| WO (1) | WO2018213426A1 (https=) |
| ZA (1) | ZA201907619B (https=) |
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| WO2020146612A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| CN112996774B (zh) * | 2019-01-25 | 2022-11-22 | 江苏恒瑞医药股份有限公司 | 2-氧代-1,2-二氢吡啶类衍生物、其制备方法及其在医药上的应用 |
| CN112996776B (zh) * | 2019-02-20 | 2024-03-15 | 福建盛迪医药有限公司 | 6-氧代-1,6-二氢哒嗪类前药衍生物、其制备方法及其在医药上的应用 |
| WO2020206119A1 (en) * | 2019-04-02 | 2020-10-08 | Vertex Pharmaceuticals Incorporated | Process for making pyridone amides and prodrugs thereof useful as modulators of sodium channels |
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| US12528782B2 (en) | 2019-07-16 | 2026-01-20 | Bristol-Myers Squibb Company | Prodrugs in the modulation of interleukin |
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| WO2022037647A1 (zh) * | 2020-08-19 | 2022-02-24 | 江苏恒瑞医药股份有限公司 | 一种选择性Nav抑制剂的结晶形式及其制备方法 |
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| JP2024502231A (ja) * | 2020-12-18 | 2024-01-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | Ｎａｖ１．８電位依存性ナトリウムチャネルを阻害するためおよびＮａｖ１．８介在疾患を治療するために有用な化学化合物 |
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| JP2024520646A (ja) | 2021-06-04 | 2024-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | ナトリウムチャネルのモジュレーターとしてのｎ－（ヒドロキシアルキル（ヘテロ）アリール）テトラヒドロフランカルボキサミド類似体 |
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-
2018
- 2018-05-16 US US16/614,015 patent/US11358977B2/en active Active
- 2018-05-16 EP EP18730543.8A patent/EP3625214B1/en active Active
- 2018-05-16 IL IL270680A patent/IL270680B/en unknown
- 2018-05-16 WO PCT/US2018/032939 patent/WO2018213426A1/en not_active Ceased
- 2018-05-16 KR KR1020197037074A patent/KR102714561B1/ko active Active
- 2018-05-16 BR BR112019024016A patent/BR112019024016A2/pt active Search and Examination
- 2018-05-16 AU AU2018271110A patent/AU2018271110A1/en not_active Abandoned
- 2018-05-16 CN CN201880037064.5A patent/CN110740993B/zh active Active
- 2018-05-16 UA UAA201911875A patent/UA124857C2/uk unknown
- 2018-05-16 JP JP2019563132A patent/JP7104070B2/ja not_active Expired - Fee Related
- 2018-05-16 ES ES18730543T patent/ES2927712T3/es active Active
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- 2018-05-16 MA MA049137A patent/MA49137A/fr unknown
- 2018-05-16 CA CA3063901A patent/CA3063901A1/en active Pending
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2019
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- 2019-11-18 ZA ZA2019/07619A patent/ZA201907619B/en unknown
- 2019-11-21 CO CONC2019/0013021A patent/CO2019013021A2/es unknown
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|---|---|
| CN110740993A (zh) | 2020-01-31 |
| ZA201907619B (en) | 2022-03-30 |
| WO2018213426A1 (en) | 2018-11-22 |
| KR102714561B1 (ko) | 2024-10-10 |
| UA124857C2 (uk) | 2021-12-01 |
| US11358977B2 (en) | 2022-06-14 |
| KR20200006128A (ko) | 2020-01-17 |
| MA49137A (fr) | 2021-04-21 |
| JP7104070B2 (ja) | 2022-07-20 |
| AU2018271110A1 (en) | 2019-12-05 |
| MX390793B (es) | 2025-03-21 |
| EP3625214B1 (en) | 2022-07-06 |
| US20210155643A1 (en) | 2021-05-27 |
| ES2927712T3 (es) | 2022-11-10 |
| EP3625214A1 (en) | 2020-03-25 |
| IL270680B (en) | 2022-06-01 |
| CA3063901A1 (en) | 2018-11-22 |
| CN110740993B (zh) | 2023-09-01 |
| BR112019024016A2 (pt) | 2020-06-09 |
| JP2020519661A (ja) | 2020-07-02 |
| CL2019003239A1 (es) | 2020-04-17 |
| MX2019013574A (es) | 2019-12-18 |
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