MX2019013574A - Amidas de piridona deuteradas y sus profarmacos como moduladores de los canales de sodio. - Google Patents

Amidas de piridona deuteradas y sus profarmacos como moduladores de los canales de sodio.

Info

Publication number
MX2019013574A
MX2019013574A MX2019013574A MX2019013574A MX2019013574A MX 2019013574 A MX2019013574 A MX 2019013574A MX 2019013574 A MX2019013574 A MX 2019013574A MX 2019013574 A MX2019013574 A MX 2019013574A MX 2019013574 A MX2019013574 A MX 2019013574A
Authority
MX
Mexico
Prior art keywords
sodium channels
deuterated
prodrugs
modulators
compounds
Prior art date
Application number
MX2019013574A
Other languages
English (en)
Inventor
Jiang Licong
Sabina Hadida Ruah Sara
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2019013574A publication Critical patent/MX2019013574A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Abstract

La presente invención se relaciona con compuestos y sus sales farmacéuticamente aceptables, útiles como inhibidores de los canales de sodio. Los compuestos tienen la fórmula (I), en donde R es H o CH2OPO(OH)2. También se proporcionan composiciones farmacéuticas que comprenden los compuestos o sales farmacéuticamente aceptables y métodos para usar los compuestos, sales farmacéuticamente aceptables y composiciones farmacéuticas en el tratamiento de varios trastornos, incluyendo dolor.
MX2019013574A 2017-05-16 2018-05-16 Amidas de piridona deuteradas y sus profarmacos como moduladores de los canales de sodio. MX2019013574A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762507172P 2017-05-16 2017-05-16
US201762547718P 2017-08-18 2017-08-18
PCT/US2018/032939 WO2018213426A1 (en) 2017-05-16 2018-05-16 Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels

Publications (1)

Publication Number Publication Date
MX2019013574A true MX2019013574A (es) 2019-12-18

Family

ID=62567801

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019013574A MX2019013574A (es) 2017-05-16 2018-05-16 Amidas de piridona deuteradas y sus profarmacos como moduladores de los canales de sodio.

Country Status (17)

Country Link
US (1) US11358977B2 (es)
EP (1) EP3625214B1 (es)
JP (1) JP7104070B2 (es)
KR (1) KR20200006128A (es)
CN (1) CN110740993B (es)
AU (1) AU2018271110A1 (es)
BR (1) BR112019024016A2 (es)
CA (1) CA3063901A1 (es)
CL (1) CL2019003239A1 (es)
CO (1) CO2019013021A2 (es)
ES (1) ES2927712T3 (es)
IL (1) IL270680B (es)
MA (1) MA49137A (es)
MX (1) MX2019013574A (es)
UA (1) UA124857C2 (es)
WO (1) WO2018213426A1 (es)
ZA (1) ZA201907619B (es)

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BR112019024016A2 (pt) 2020-06-09
CO2019013021A2 (es) 2020-04-01
US20210155643A1 (en) 2021-05-27
UA124857C2 (uk) 2021-12-01
JP2020519661A (ja) 2020-07-02
CN110740993B (zh) 2023-09-01
KR20200006128A (ko) 2020-01-17
CL2019003239A1 (es) 2020-04-17
AU2018271110A1 (en) 2019-12-05
EP3625214B1 (en) 2022-07-06
ZA201907619B (en) 2022-03-30
ES2927712T3 (es) 2022-11-10
JP7104070B2 (ja) 2022-07-20
EP3625214A1 (en) 2020-03-25
CA3063901A1 (en) 2018-11-22
CN110740993A (zh) 2020-01-31
MA49137A (fr) 2021-04-21
IL270680B (en) 2022-06-01
WO2018213426A1 (en) 2018-11-22
US11358977B2 (en) 2022-06-14

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