CO2019011719A2 - Método y sistema para producir partículas sustancialmente monodispersas de una sustancia - Google Patents

Método y sistema para producir partículas sustancialmente monodispersas de una sustancia

Info

Publication number
CO2019011719A2
CO2019011719A2 CONC2019/0011719A CO2019011719A CO2019011719A2 CO 2019011719 A2 CO2019011719 A2 CO 2019011719A2 CO 2019011719 A CO2019011719 A CO 2019011719A CO 2019011719 A2 CO2019011719 A2 CO 2019011719A2
Authority
CO
Colombia
Prior art keywords
particle size
size
average
microspheres
substance
Prior art date
Application number
CONC2019/0011719A
Other languages
English (en)
Inventor
Lucie Anne Aude Leduc
Robertus Franciscus Duwel
Nogue Miriam Girones
Gerrit Jan Veldhuis
Original Assignee
Nanomi B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanomi B V filed Critical Nanomi B V
Publication of CO2019011719A2 publication Critical patent/CO2019011719A2/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0492—Applications, solvents used
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/10—Filter screens essentially made of metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/4105—Methods of emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
    • B01F25/3142—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit the conduit having a plurality of openings in the axial direction or in the circumferential direction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Colloid Chemistry (AREA)
  • Biological Depolymerization Polymers (AREA)

Abstract

Un primer fluido se dispersa en un segundo fluido para formar una emulsión de microgotas que tienen un tamaño de gota promedio y que tienen una distribución de tamaño de gota alrededor de dicho tamaño de gota promedio y debajo de un tamaño de gota máximo. Dichas microgotas perderán su disolvente para transformarse en microesferas que muestran una distribución de tamaño de partícula alrededor de un tamaño de partícula promedio y sustancialmente por debajo de un tamaño de partícula máximo permitido. Dichas microesferas se someten a un microfiltro que tiene una distribución de tamaño de poro relativamente estrecha alrededor de un tamaño de poro promedio, cuyo tamaño de poro promedio está entre dicho tamaño de partícula promedio y dicho tamaño de partícula máximo. Un filtrado de dicho microfiltro comprende una mayoría de dichas microesferas que está desprovisto sustancialmente de microesferas que tienen un tamaño de partícula que supera el tamaño de partícula máximo permitido.
CONC2019/0011719A 2017-04-19 2019-10-23 Método y sistema para producir partículas sustancialmente monodispersas de una sustancia CO2019011719A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2018744 2017-04-19
PCT/IB2018/052690 WO2018193389A1 (en) 2017-04-19 2018-04-18 Method and system for producing substantially mono-disperse particles of a substance

Publications (1)

Publication Number Publication Date
CO2019011719A2 true CO2019011719A2 (es) 2020-02-28

Family

ID=59031372

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0011719A CO2019011719A2 (es) 2017-04-19 2019-10-23 Método y sistema para producir partículas sustancialmente monodispersas de una sustancia

Country Status (13)

Country Link
US (1) US11786881B2 (es)
EP (1) EP3612164A1 (es)
JP (1) JP2020525279A (es)
KR (1) KR20200002937A (es)
CN (1) CN110799178A (es)
AU (1) AU2018254225B2 (es)
BR (1) BR112019022045A2 (es)
CA (1) CA3060213A1 (es)
CL (1) CL2019002974A1 (es)
CO (1) CO2019011719A2 (es)
MX (1) MX2019012548A (es)
WO (1) WO2018193389A1 (es)
ZA (1) ZA201907306B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021013861A1 (en) 2019-07-22 2021-01-28 Nanomi, B.V. Sustained release trepostinil-compound microparticle compositions
KR102591957B1 (ko) * 2021-06-18 2023-10-19 가톨릭대학교 산학협력단 섬유형 미세유체채널을 포함하는 미세유체장치, 이의 제조방법 및 미세 액적의 제조방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100560060C (zh) * 2002-06-13 2009-11-18 王平康 纳米级药物微球及其制造方法
JP2004035446A (ja) * 2002-07-02 2004-02-05 Tendou Seiyaku Kk 微小球体の製造方法およびその製造装置
CN1241547C (zh) * 2003-07-24 2006-02-15 天津麦凯泰生物制品有限公司 制备乳状液及相关悬浮液和颗粒的乳化方法
JP3818384B2 (ja) * 2004-03-30 2006-09-06 独立行政法人食品総合研究所 エマルションの製造装置、反応装置、この反応装置を用いたマイクロカプセルの製造方法、マイクロチューブの製造方法およびマイクロチューブ
NL1026261C2 (nl) * 2004-05-25 2005-11-28 Nanomi B V Sproei inrichting met een nozzleplaat voorzien van structuren ter bevordering van self-breakup, een nozzleplaat, alsmede werkwijzen ter vervaardiging en toepassing van een dergelijke nozzleplaat.
WO2006123359A2 (en) 2005-03-01 2006-11-23 Sun Pharmaceutical Industries Limited A process of making microspheres
JP2007246660A (ja) * 2006-03-15 2007-09-27 Showa Denko Kk ポリマービーズ及びその製造方法並びにポリマービーズ製造用液滴生成装置
JP5350620B2 (ja) * 2006-11-24 2013-11-27 キヤノン株式会社 粒子の製造方法、及び粒子
WO2009011520A2 (en) * 2007-07-13 2009-01-22 Naraentec Co., Ltd. Nano-particles containing calcium and method for preparing the same
US20090297621A1 (en) * 2008-06-03 2009-12-03 Abbott Cardiovascular Systems Inc. Microparticles For The Treatment Of Disease
CN102068409A (zh) * 2011-01-13 2011-05-25 清华大学 一种基于微流控技术制备单分散性微乳、脂质体和微球的方法
CN102211008A (zh) * 2011-03-23 2011-10-12 浙江大学 可拆卸t型微通道装置及其制备单分散聚合物微球的方法
CN102772366B (zh) * 2012-07-02 2014-10-08 华南理工大学 生物可降解高分子包封水溶性分子微球的制备方法

Also Published As

Publication number Publication date
BR112019022045A2 (pt) 2020-05-12
WO2018193389A1 (en) 2018-10-25
ZA201907306B (en) 2021-09-29
KR20200002937A (ko) 2020-01-08
US11786881B2 (en) 2023-10-17
CL2019002974A1 (es) 2020-05-08
AU2018254225A1 (en) 2019-11-14
JP2020525279A (ja) 2020-08-27
CA3060213A1 (en) 2018-10-25
US20210138421A1 (en) 2021-05-13
CN110799178A (zh) 2020-02-14
EP3612164A1 (en) 2020-02-26
MX2019012548A (es) 2020-01-20
AU2018254225B2 (en) 2024-05-23

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