CL2019002974A1 - Metodo y sistema para producir particulas sustancialmente monodispersas de una sustancia - Google Patents
Metodo y sistema para producir particulas sustancialmente monodispersas de una sustanciaInfo
- Publication number
- CL2019002974A1 CL2019002974A1 CL2019002974A CL2019002974A CL2019002974A1 CL 2019002974 A1 CL2019002974 A1 CL 2019002974A1 CL 2019002974 A CL2019002974 A CL 2019002974A CL 2019002974 A CL2019002974 A CL 2019002974A CL 2019002974 A1 CL2019002974 A1 CL 2019002974A1
- Authority
- CL
- Chile
- Prior art keywords
- micro
- particle size
- average
- size
- spheres
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0492—Applications, solvents used
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D39/00—Filtering material for liquid or gaseous fluids
- B01D39/10—Filter screens essentially made of metal
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/4105—Methods of emulsifying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/30—Injector mixers
- B01F25/31—Injector mixers in conduits or tubes through which the main component flows
- B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
- B01F25/3142—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit the conduit having a plurality of openings in the axial direction or in the circumferential direction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Colloid Chemistry (AREA)
- Biological Depolymerization Polymers (AREA)
Abstract
A first fluid is dispersed in a second fluid to form an emulsion of micro-droplets having an average droplet size and having a droplet size distribution around said average droplet size and below a maximum droplet size. Said micro-droplets will lose their solvent to transform to micro-spheres exhibiting a particle size distribution around an average particle size and substantially below a maximum allowable particle size. Said micro-spheres are subjected to a micro-filter having a relatively narrow pore size distribution around an average pore size, which average pore size is between said average particle size and said maximum particle size. A filtrate of said micro-filter comprises a majority of said micro-spheres that is substantially void of micro-spheres having a particle size exceeding the maximum allowable particle size.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL2018744 | 2017-04-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2019002974A1 true CL2019002974A1 (es) | 2020-05-08 |
Family
ID=59031372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2019002974A CL2019002974A1 (es) | 2017-04-19 | 2019-10-17 | Metodo y sistema para producir particulas sustancialmente monodispersas de una sustancia |
Country Status (13)
Country | Link |
---|---|
US (1) | US11786881B2 (es) |
EP (1) | EP3612164A1 (es) |
JP (1) | JP2020525279A (es) |
KR (1) | KR20200002937A (es) |
CN (1) | CN110799178A (es) |
AU (1) | AU2018254225B2 (es) |
BR (1) | BR112019022045A2 (es) |
CA (1) | CA3060213A1 (es) |
CL (1) | CL2019002974A1 (es) |
CO (1) | CO2019011719A2 (es) |
MX (1) | MX2019012548A (es) |
WO (1) | WO2018193389A1 (es) |
ZA (1) | ZA201907306B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210022994A1 (en) | 2019-07-22 | 2021-01-28 | Lupin Holdings, B.V. | Sustained release trepostinil-compound microparticle compositions |
KR102591957B1 (ko) * | 2021-06-18 | 2023-10-19 | 가톨릭대학교 산학협력단 | 섬유형 미세유체채널을 포함하는 미세유체장치, 이의 제조방법 및 미세 액적의 제조방법 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100560060C (zh) * | 2002-06-13 | 2009-11-18 | 王平康 | 纳米级药物微球及其制造方法 |
JP2004035446A (ja) * | 2002-07-02 | 2004-02-05 | Tendou Seiyaku Kk | 微小球体の製造方法およびその製造装置 |
CN1241547C (zh) * | 2003-07-24 | 2006-02-15 | 天津麦凯泰生物制品有限公司 | 制备乳状液及相关悬浮液和颗粒的乳化方法 |
JP3818384B2 (ja) * | 2004-03-30 | 2006-09-06 | 独立行政法人食品総合研究所 | エマルションの製造装置、反応装置、この反応装置を用いたマイクロカプセルの製造方法、マイクロチューブの製造方法およびマイクロチューブ |
NL1026261C2 (nl) | 2004-05-25 | 2005-11-28 | Nanomi B V | Sproei inrichting met een nozzleplaat voorzien van structuren ter bevordering van self-breakup, een nozzleplaat, alsmede werkwijzen ter vervaardiging en toepassing van een dergelijke nozzleplaat. |
WO2006123359A2 (en) | 2005-03-01 | 2006-11-23 | Sun Pharmaceutical Industries Limited | A process of making microspheres |
JP2007246660A (ja) * | 2006-03-15 | 2007-09-27 | Showa Denko Kk | ポリマービーズ及びその製造方法並びにポリマービーズ製造用液滴生成装置 |
JP5350620B2 (ja) * | 2006-11-24 | 2013-11-27 | キヤノン株式会社 | 粒子の製造方法、及び粒子 |
KR20090007226A (ko) * | 2007-07-13 | 2009-01-16 | 주식회사 나라엔텍 | 칼슘을 함유하는 나노입자 및 그 제조방법 |
US20090297621A1 (en) * | 2008-06-03 | 2009-12-03 | Abbott Cardiovascular Systems Inc. | Microparticles For The Treatment Of Disease |
CN102068409A (zh) * | 2011-01-13 | 2011-05-25 | 清华大学 | 一种基于微流控技术制备单分散性微乳、脂质体和微球的方法 |
CN102211008A (zh) * | 2011-03-23 | 2011-10-12 | 浙江大学 | 可拆卸t型微通道装置及其制备单分散聚合物微球的方法 |
CN102772366B (zh) * | 2012-07-02 | 2014-10-08 | 华南理工大学 | 生物可降解高分子包封水溶性分子微球的制备方法 |
-
2018
- 2018-04-18 WO PCT/IB2018/052690 patent/WO2018193389A1/en unknown
- 2018-04-18 CA CA3060213A patent/CA3060213A1/en active Pending
- 2018-04-18 JP JP2020508091A patent/JP2020525279A/ja active Pending
- 2018-04-18 US US16/605,991 patent/US11786881B2/en active Active
- 2018-04-18 KR KR1020197034140A patent/KR20200002937A/ko not_active Application Discontinuation
- 2018-04-18 MX MX2019012548A patent/MX2019012548A/es unknown
- 2018-04-18 BR BR112019022045-3A patent/BR112019022045A2/pt unknown
- 2018-04-18 EP EP18721161.0A patent/EP3612164A1/en active Pending
- 2018-04-18 CN CN201880026379.XA patent/CN110799178A/zh active Pending
- 2018-04-18 AU AU2018254225A patent/AU2018254225B2/en active Active
-
2019
- 2019-10-17 CL CL2019002974A patent/CL2019002974A1/es unknown
- 2019-10-23 CO CONC2019/0011719A patent/CO2019011719A2/es unknown
- 2019-11-04 ZA ZA2019/07306A patent/ZA201907306B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3612164A1 (en) | 2020-02-26 |
AU2018254225A1 (en) | 2019-11-14 |
BR112019022045A2 (pt) | 2020-05-12 |
ZA201907306B (en) | 2021-09-29 |
US11786881B2 (en) | 2023-10-17 |
CO2019011719A2 (es) | 2020-02-28 |
AU2018254225B2 (en) | 2024-05-23 |
KR20200002937A (ko) | 2020-01-08 |
CA3060213A1 (en) | 2018-10-25 |
JP2020525279A (ja) | 2020-08-27 |
WO2018193389A1 (en) | 2018-10-25 |
CN110799178A (zh) | 2020-02-14 |
MX2019012548A (es) | 2020-01-20 |
US20210138421A1 (en) | 2021-05-13 |
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