CO2019006320A2 - Moléculas biespecíficas de unión al receptor 2 del ligando inductor de apoptosis relacionado con tnf y anti-cadherina 17 para el tratamiento del cáncer - Google Patents
Moléculas biespecíficas de unión al receptor 2 del ligando inductor de apoptosis relacionado con tnf y anti-cadherina 17 para el tratamiento del cáncerInfo
- Publication number
- CO2019006320A2 CO2019006320A2 CONC2019/0006320A CO2019006320A CO2019006320A2 CO 2019006320 A2 CO2019006320 A2 CO 2019006320A2 CO 2019006320 A CO2019006320 A CO 2019006320A CO 2019006320 A2 CO2019006320 A2 CO 2019006320A2
- Authority
- CO
- Colombia
- Prior art keywords
- tnf
- molecules
- inducing ligand
- related apoptosis
- receptor binding
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 title abstract 2
- 101710097160 Tumor necrosis factor ligand superfamily member 10 Proteins 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 108020003175 receptors Proteins 0.000 title abstract 2
- 102000005962 receptors Human genes 0.000 title abstract 2
- 102100024152 Cadherin-17 Human genes 0.000 abstract 2
- 101710196881 Cadherin-17 Proteins 0.000 abstract 2
- 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 abstract 1
- 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Abstract
La presente invención se refiere a moléculas de fijación que se fijan específicamente al receptor 2 del ligando inductor de la apoptosis relacionado con TNF (TRAILR2) y a cadherina 17 (CDH17) y su uso medicinal, composiciones farmacéuticas que las comprenden y métodos para usarlas como agentes para el tratamiento y/o la prevención del cáncer
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17155973.5A EP3360898A1 (en) | 2017-02-14 | 2017-02-14 | Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer |
PCT/EP2017/084002 WO2018115231A2 (en) | 2016-12-22 | 2017-12-21 | Binding molecules for the treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2019006320A2 true CO2019006320A2 (es) | 2019-06-28 |
Family
ID=58043942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2019/0006320A CO2019006320A2 (es) | 2017-02-14 | 2019-06-17 | Moléculas biespecíficas de unión al receptor 2 del ligando inductor de apoptosis relacionado con tnf y anti-cadherina 17 para el tratamiento del cáncer |
Country Status (15)
Country | Link |
---|---|
US (2) | US10858438B2 (es) |
EP (2) | EP3360898A1 (es) |
JP (1) | JP7196076B2 (es) |
KR (1) | KR102651761B1 (es) |
CN (1) | CN110582513B (es) |
AU (1) | AU2017384687A1 (es) |
BR (1) | BR112019011750A2 (es) |
CA (1) | CA3046591A1 (es) |
CO (1) | CO2019006320A2 (es) |
EA (1) | EA201991480A1 (es) |
MA (1) | MA47121A (es) |
MX (1) | MX2019007511A (es) |
PE (1) | PE20191251A1 (es) |
TW (1) | TWI790219B (es) |
WO (1) | WO2018115231A2 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3360898A1 (en) | 2017-02-14 | 2018-08-15 | Boehringer Ingelheim International GmbH | Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer |
EP3725370A1 (en) | 2019-04-19 | 2020-10-21 | ImmunoBrain Checkpoint, Inc. | Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease |
AU2021276332A1 (en) * | 2020-05-19 | 2022-11-17 | Boehringer Ingelheim International Gmbh | Binding molecules for the treatment of cancer |
JP2024503508A (ja) | 2021-01-15 | 2024-01-25 | シージェン インコーポレイテッド | 免疫調節性抗体-薬物コンジュゲート |
EP4288109A1 (en) | 2021-02-03 | 2023-12-13 | Seagen Inc. | Immunostimulatory compounds and conjugates |
EP4352218A1 (en) * | 2021-06-07 | 2024-04-17 | Flagship Pioneering Innovations VII, LLC | Compositions and methods for targeted delivery of therapeutic agents |
CN113512117B (zh) * | 2021-07-12 | 2023-08-22 | 武汉麦考津生物科技有限公司 | 一种可结合cd206的抗体及其应用 |
WO2023015169A1 (en) * | 2021-08-02 | 2023-02-09 | Tavotek Biotech (Suzhou) Ltd | Anti-cdh17 monoclonal and bispecific antibodies and uses thereof |
WO2023023677A1 (en) * | 2021-08-20 | 2023-02-23 | University Of Virginia Patent Foundation | Strategy for highly superior dr5 activation including in tumors and cancers |
WO2023215740A1 (en) | 2022-05-06 | 2023-11-09 | Seagen Inc. | Immunomodulatory antibody-drug conjugates |
US20240052065A1 (en) | 2022-07-15 | 2024-02-15 | Boehringer Ingelheim International Gmbh | Binding molecules for the treatment of cancer |
WO2024030577A1 (en) | 2022-08-03 | 2024-02-08 | Seagen Inc. | Immunostimulatory anti-pd-l1-drug conjugates |
EP4321522A1 (en) | 2022-08-12 | 2024-02-14 | Seagen Inc. | Cytotoxic compounds and conjugates thereof |
WO2024081930A1 (en) * | 2022-10-14 | 2024-04-18 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for targeted delivery of therapeutic agents |
CN115785269B (zh) * | 2022-11-01 | 2023-09-22 | 四川大学 | 抗pd-l1的抗体及其应用 |
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ATE87659T1 (de) | 1986-09-02 | 1993-04-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
AU634186B2 (en) | 1988-11-11 | 1993-02-18 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
DK1087013T3 (da) | 1992-08-21 | 2009-05-11 | Univ Bruxelles | Immunoglobuliner uden lette kæder |
CA2150262C (en) | 1992-12-04 | 2008-07-08 | Kaspar-Philipp Holliger | Multivalent and multispecific binding proteins, their manufacture and use |
ES2138662T3 (es) | 1993-06-03 | 2000-01-16 | Therapeutic Antibodies Inc | Produccion de fragmentos de anticuerpos. |
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NZ532881A (en) * | 2001-12-20 | 2008-04-30 | Human Genome Sciences Inc | Antibodies that immunospecifically bind to trail receptors |
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-
2017
- 2017-02-14 EP EP17155973.5A patent/EP3360898A1/en not_active Withdrawn
- 2017-12-21 BR BR112019011750-4A patent/BR112019011750A2/pt unknown
- 2017-12-21 CA CA3046591A patent/CA3046591A1/en active Pending
- 2017-12-21 EP EP17838041.6A patent/EP3559040A2/en active Pending
- 2017-12-21 PE PE2019001228A patent/PE20191251A1/es unknown
- 2017-12-21 US US15/850,895 patent/US10858438B2/en active Active
- 2017-12-21 CN CN201780085628.8A patent/CN110582513B/zh active Active
- 2017-12-21 AU AU2017384687A patent/AU2017384687A1/en active Pending
- 2017-12-21 JP JP2019534104A patent/JP7196076B2/ja active Active
- 2017-12-21 TW TW106144948A patent/TWI790219B/zh active
- 2017-12-21 MA MA047121A patent/MA47121A/fr unknown
- 2017-12-21 WO PCT/EP2017/084002 patent/WO2018115231A2/en unknown
- 2017-12-21 KR KR1020197018925A patent/KR102651761B1/ko active IP Right Grant
- 2017-12-21 MX MX2019007511A patent/MX2019007511A/es unknown
- 2017-12-21 EA EA201991480A patent/EA201991480A1/ru unknown
-
2019
- 2019-06-17 CO CONC2019/0006320A patent/CO2019006320A2/es unknown
-
2020
- 2020-10-30 US US17/084,881 patent/US11851495B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA3046591A1 (en) | 2018-06-28 |
US11851495B2 (en) | 2023-12-26 |
JP7196076B2 (ja) | 2022-12-26 |
US20180179287A1 (en) | 2018-06-28 |
WO2018115231A3 (en) | 2018-08-02 |
KR102651761B1 (ko) | 2024-03-26 |
CN110582513B (zh) | 2023-11-14 |
TWI790219B (zh) | 2023-01-21 |
TW201835102A (zh) | 2018-10-01 |
WO2018115231A2 (en) | 2018-06-28 |
EP3360898A1 (en) | 2018-08-15 |
MA47121A (fr) | 2019-10-30 |
CN110582513A (zh) | 2019-12-17 |
US10858438B2 (en) | 2020-12-08 |
JP2020501586A (ja) | 2020-01-23 |
BR112019011750A2 (pt) | 2019-10-29 |
MX2019007511A (es) | 2019-09-04 |
US20210095038A1 (en) | 2021-04-01 |
KR20190099223A (ko) | 2019-08-26 |
EP3559040A2 (en) | 2019-10-30 |
EA201991480A1 (ru) | 2020-01-15 |
PE20191251A1 (es) | 2019-09-18 |
AU2017384687A1 (en) | 2019-06-13 |
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