CO2019000513A2 - Formas cristalinas de un compuesto de tetraciclina sustituido con 9-aminometilo y un método de preparación de las mismas - Google Patents

Formas cristalinas de un compuesto de tetraciclina sustituido con 9-aminometilo y un método de preparación de las mismas

Info

Publication number
CO2019000513A2
CO2019000513A2 CONC2019/0000513A CO2019000513A CO2019000513A2 CO 2019000513 A2 CO2019000513 A2 CO 2019000513A2 CO 2019000513 A CO2019000513 A CO 2019000513A CO 2019000513 A2 CO2019000513 A2 CO 2019000513A2
Authority
CO
Colombia
Prior art keywords
crystalline forms
aminomethyl
preparation
compound substituted
tetracycline compound
Prior art date
Application number
CONC2019/0000513A
Other languages
English (en)
Inventor
Zhenhua Huang
Mei Hong
Chen Jiang
Original Assignee
Kbp Biosciences Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kbp Biosciences Co Ltd filed Critical Kbp Biosciences Co Ltd
Publication of CO2019000513A2 publication Critical patent/CO2019000513A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención pertenece al campo de la tecnología farmacéutica, y formas cristalinas de un compuesto de tetraciclina sustituido con 9-aminometilo y un proceso para preparar las mismas. Más específicamente, la presente invención se relaciona con formas cristalinas del compuesto representado por la fórmula (1), un proceso para preparar formas cristalinas del compuesto representado por la fórmula (1) y el uso de dichas formas cristalinas en la fabricación de medicamento para tratar y/o prevenir una enfermedad infecciosa causada por bacterias sensibles a la tetraciclina y/o bacterias resistentes a la tetraciclina.
CONC2019/0000513A 2016-06-22 2019-01-18 Formas cristalinas de un compuesto de tetraciclina sustituido con 9-aminometilo y un método de preparación de las mismas CO2019000513A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610457261 2016-06-22
PCT/CN2017/089470 WO2017219994A1 (zh) 2016-06-22 2017-06-22 9-氨基甲基取代的四环素类化合物的晶型及其制备方法

Publications (1)

Publication Number Publication Date
CO2019000513A2 true CO2019000513A2 (es) 2019-04-30

Family

ID=60783195

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0000513A CO2019000513A2 (es) 2016-06-22 2019-01-18 Formas cristalinas de un compuesto de tetraciclina sustituido con 9-aminometilo y un método de preparación de las mismas

Country Status (21)

Country Link
US (1) US10633337B2 (es)
EP (1) EP3476831B8 (es)
JP (1) JP6883593B2 (es)
KR (1) KR102205843B1 (es)
CN (1) CN109563035B (es)
AU (1) AU2017282891B2 (es)
CA (1) CA3028014C (es)
CL (1) CL2018003739A1 (es)
CO (1) CO2019000513A2 (es)
ES (1) ES2906885T3 (es)
IL (1) IL263868B (es)
MA (1) MA45461A (es)
MX (1) MX2019000086A (es)
MY (1) MY186900A (es)
PE (1) PE20190810A1 (es)
PH (1) PH12018502680A1 (es)
RU (2) RU2764723C2 (es)
SG (1) SG11201811499WA (es)
TW (1) TWI656116B (es)
WO (1) WO2017219994A1 (es)
ZA (1) ZA201900274B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD962414S1 (en) 2020-02-28 2022-08-30 Beijing Xiaomi Mobile Software Co., Ltd Fan
JP2023530415A (ja) * 2020-06-11 2023-07-18 パラテック ファーマシューティカルズ，インコーポレイテッド オマダサイクリンの結晶形態、その合成方法及びその使用方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064728A2 (en) * 2003-01-16 2004-08-05 Paratek Pharmaceuticals, Inc. Use of specific tetracycline compounds in therapy
AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
CN101861300B (zh) * 2007-11-14 2014-07-09 桑多斯股份公司 盐酸替吉环素的晶型
US20110124893A1 (en) * 2008-01-23 2011-05-26 Sandoz Ag Antibiotic compounds
TW202332671A (zh) * 2008-05-23 2023-08-16 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
PT2738156T (pt) * 2011-07-26 2018-03-28 Kbp Biosciences Usa Inc Compostos de tetraciclina substituídos por 9-aminometil
CN102417465B (zh) * 2011-10-27 2014-03-12 宫宁瑞 替加环素新晶型及其制备方法

Also Published As

Publication number Publication date
RU2019101248A3 (es) 2020-07-22
EP3476831B8 (en) 2021-12-29
RU2764723C2 (ru) 2022-01-19
US10633337B2 (en) 2020-04-28
CA3028014A1 (en) 2017-12-28
ZA201900274B (en) 2020-05-27
TWI656116B (zh) 2019-04-11
TW201800393A (zh) 2018-01-01
EP3476831A1 (en) 2019-05-01
ES2906885T3 (es) 2022-04-20
CN109563035B (zh) 2021-07-20
CA3028014C (en) 2021-09-07
CL2018003739A1 (es) 2019-04-05
EP3476831A4 (en) 2019-11-27
AU2017282891A1 (en) 2019-01-17
JP6883593B2 (ja) 2021-06-09
PH12018502680A1 (en) 2019-10-14
MA45461A (fr) 2019-05-01
IL263868A (en) 2019-01-31
JP2019520363A (ja) 2019-07-18
KR20190024900A (ko) 2019-03-08
RU2022100160A (ru) 2022-03-16
NZ749495A (en) 2020-12-18
US20190241515A1 (en) 2019-08-08
PE20190810A1 (es) 2019-06-13
MY186900A (en) 2021-08-26
MX2019000086A (es) 2019-05-02
EP3476831B1 (en) 2021-11-17
KR102205843B1 (ko) 2021-01-22
CN109563035A (zh) 2019-04-02
WO2017219994A1 (zh) 2017-12-28
AU2017282891B2 (en) 2020-01-02
SG11201811499WA (en) 2019-01-30
BR112018076726A2 (pt) 2019-04-02
IL263868B (en) 2022-08-01
RU2019101248A (ru) 2020-07-22

Similar Documents

Publication Publication Date Title
CL2020000501A1 (es) Inhibidores de la ectonucleótido pirofosfatasa-fosfodiesterasa 1 (enpp1) y usos de los mismos.
CL2016001120A1 (es) Compuestos derivados de pirrolo1,2-f1,2,4triazina ,composición farmacéutica que los comprende y su uso en el tratamiento de una infección por virus sincicial compuestos intermediarios. pct
BR112017023263A2 (pt) compostos antivirais rsv de pirazolo e triazolopirimidina
CR20150611A (es) Novedosas heteroarildihidropirimidinas unidas por puentes en 6 para el tratamiento y la profilaxis por el virus de la hepatitis b
CU20150096A7 (es) Compuestos de amida y composición farmacéutica para el tratamiento de vih
BR112017001565A2 (pt) ?composto, métodos para tratar uma infecção e para fabricar um medicamento, composição farmacêutica, e, uso de um composto?
EA201790389A1 (ru) Пирролопиримидиновые соединения, используемые в качестве агониста tlr7
BR112017023740A2 (pt) ?forma sólida de um composto, processo para a preparação de uma forma sólida, composição farmacêutica, método para o tratamento ou prevenção de doenças e utilização de uma forma sólida?
BR112014022214A2 (pt) fenólicos antibacterianos
UY36737A (es) 3-amino-1,5,6,7-tetrahidro-4h-indol-4-onas
MX2020004785A (es) Proceso para preparar tapinarof.
DOP2016000308A (es) Compuestos de 1, 3, 4-tiadiazol y uso de los mismos para el tratamiento del cáncer
BR112017003242A2 (pt) composto, métodos para tratar infecção por vírus e para fabricação de um medicamento, composição farmacêutica, e, uso de um composto.
BR112016016853A2 (pt) Compostos contendo nitrogênio, seu uso e seu processo de preparação, composição farmacêutica e seu uso
DOP2016000278A (es) Nuevos compuestos macrocíclicos
NI202000029A (es) Amidas de imidazopiridina sustituidas y su uso
NI201800071A (es) Compuestos de isoindol
CU20120137A7 (es) Hidrato del hidrocloruro de agomelatina y preparación de éste
CR20160016A (es) Pirazolpiridinas sustituidas
CL2021002263A1 (es) Compuestos antibacterianos (solicitud divisional 202001147)
CO2018007008A2 (es) "procesos mejorados para la preparación de osimertinib (azd9291) o una sal del mismo y "azd9291 anilina" o una sal del mismo"
MX2017009094A (es) Derivado de polimixina y usos del mismo.
CL2017001276A1 (es) Derivados de benzotiazol antibacterianos
CO2019000513A2 (es) Formas cristalinas de un compuesto de tetraciclina sustituido con 9-aminometilo y un método de preparación de las mismas
ECSP13012603A (es) Nueva formulacion del cetp(1)