PE20190810A1 - Formas cristalinas de un compuesto de tetraciclina sustituido con 9-aminometilo y un metodo de preparacion del mismo - Google Patents
Formas cristalinas de un compuesto de tetraciclina sustituido con 9-aminometilo y un metodo de preparacion del mismoInfo
- Publication number
- PE20190810A1 PE20190810A1 PE2018003293A PE2018003293A PE20190810A1 PE 20190810 A1 PE20190810 A1 PE 20190810A1 PE 2018003293 A PE2018003293 A PE 2018003293A PE 2018003293 A PE2018003293 A PE 2018003293A PE 20190810 A1 PE20190810 A1 PE 20190810A1
- Authority
- PE
- Peru
- Prior art keywords
- crystalline forms
- preparing
- aminomethyl
- same
- tetracycline
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
Referido a las formas cristalinas I, II y VII de un compuesto de tetraciclina (4S,4aS,5aR, 12aS)-9-(3-azabiciclo[3.1.0]hexano-3-ilmetilo)-4,7-bis(dimetilamino)-3,10,12,12a-tetrahidroxi-1, 11-dioxo-1,4,4a,5,5a,6,11,12a-octahidrotetraceno-2-carboxamida caracterizados por sus respectivos patrones de difraccion de rayos X en polvo. Tambien se refiere a un proceso para preparar las citadas formas cristalinas y a una composicion farmaceutica que las comprende; dicho compuesto es util para el tratar y/o prevenir una enfermedad causada por una bacteria sensible a la tetraciclina y/o una bacteria resistente a la tetraciclina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610457261 | 2016-06-22 | ||
| PCT/CN2017/089470 WO2017219994A1 (zh) | 2016-06-22 | 2017-06-22 | 9-氨基甲基取代的四环素类化合物的晶型及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20190810A1 true PE20190810A1 (es) | 2019-06-13 |
Family
ID=60783195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2018003293A PE20190810A1 (es) | 2016-06-22 | 2017-06-22 | Formas cristalinas de un compuesto de tetraciclina sustituido con 9-aminometilo y un metodo de preparacion del mismo |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10633337B2 (es) |
| EP (1) | EP3476831B8 (es) |
| JP (1) | JP6883593B2 (es) |
| KR (1) | KR102205843B1 (es) |
| CN (1) | CN109563035B (es) |
| AU (1) | AU2017282891B2 (es) |
| BR (1) | BR112018076726A2 (es) |
| CA (1) | CA3028014C (es) |
| CL (1) | CL2018003739A1 (es) |
| CO (1) | CO2019000513A2 (es) |
| ES (1) | ES2906885T3 (es) |
| IL (1) | IL263868B (es) |
| MA (1) | MA45461A (es) |
| MX (1) | MX2019000086A (es) |
| MY (1) | MY186900A (es) |
| PE (1) | PE20190810A1 (es) |
| PH (1) | PH12018502680A1 (es) |
| RU (2) | RU2022100160A (es) |
| SG (1) | SG11201811499WA (es) |
| TW (1) | TWI656116B (es) |
| WO (1) | WO2017219994A1 (es) |
| ZA (1) | ZA201900274B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USD962414S1 (en) | 2020-02-28 | 2022-08-30 | Beijing Xiaomi Mobile Software Co., Ltd | Fan |
| CN115667210A (zh) * | 2020-06-11 | 2023-01-31 | 帕拉特克药品公司 | 奥马环素的晶形、其合成方法及其使用方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004064728A2 (en) * | 2003-01-16 | 2004-08-05 | Paratek Pharmaceuticals, Inc. | Use of specific tetracycline compounds in therapy |
| AR057649A1 (es) * | 2005-05-27 | 2007-12-12 | Wyeth Corp | Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas |
| US8252946B2 (en) * | 2007-11-14 | 2012-08-28 | Sandoz Ag | Crystalline forms of tigecycline hydrochloride |
| US20110124893A1 (en) * | 2008-01-23 | 2011-05-26 | Sandoz Ag | Antibiotic compounds |
| TWI585071B (zh) * | 2008-05-23 | 2017-06-01 | 派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| PL2738156T3 (pl) | 2011-07-26 | 2018-06-29 | Kbp Biosciences Usa Inc. | Związki tetracyklinowe podstawione 9-aminometylem |
| CN102417465B (zh) * | 2011-10-27 | 2014-03-12 | 宫宁瑞 | 替加环素新晶型及其制备方法 |
-
2017
- 2017-06-22 US US16/312,404 patent/US10633337B2/en active Active
- 2017-06-22 TW TW106120947A patent/TWI656116B/zh active
- 2017-06-22 CA CA3028014A patent/CA3028014C/en active Active
- 2017-06-22 AU AU2017282891A patent/AU2017282891B2/en active Active
- 2017-06-22 RU RU2022100160A patent/RU2022100160A/ru unknown
- 2017-06-22 MY MYPI2018002825A patent/MY186900A/en unknown
- 2017-06-22 ES ES17814732T patent/ES2906885T3/es active Active
- 2017-06-22 IL IL263868A patent/IL263868B/en unknown
- 2017-06-22 JP JP2018567683A patent/JP6883593B2/ja active Active
- 2017-06-22 SG SG11201811499WA patent/SG11201811499WA/en unknown
- 2017-06-22 RU RU2019101248A patent/RU2764723C2/ru active
- 2017-06-22 BR BR112018076726-3A patent/BR112018076726A2/pt active Search and Examination
- 2017-06-22 KR KR1020187037477A patent/KR102205843B1/ko active IP Right Grant
- 2017-06-22 WO PCT/CN2017/089470 patent/WO2017219994A1/zh unknown
- 2017-06-22 EP EP17814732.8A patent/EP3476831B8/en active Active
- 2017-06-22 PE PE2018003293A patent/PE20190810A1/es unknown
- 2017-06-22 CN CN201780026902.4A patent/CN109563035B/zh active Active
- 2017-06-22 MA MA045461A patent/MA45461A/fr unknown
- 2017-06-22 MX MX2019000086A patent/MX2019000086A/es unknown
-
2018
- 2018-12-18 PH PH12018502680A patent/PH12018502680A1/en unknown
- 2018-12-21 CL CL2018003739A patent/CL2018003739A1/es unknown
-
2019
- 2019-01-15 ZA ZA2019/00274A patent/ZA201900274B/en unknown
- 2019-01-18 CO CONC2019/0000513A patent/CO2019000513A2/es unknown
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