CO2017010316A2 - Anticuerpo monoclonal aislado y / o recombinante y un método para identificar la infección por el virus de chikungunya glycoprotein e2 mediante el contacto con una muestra con un anticuerpo o fragmento de anticuerpos con secuencias cdr de cadena pesada y ligera - Google Patents
Anticuerpo monoclonal aislado y / o recombinante y un método para identificar la infección por el virus de chikungunya glycoprotein e2 mediante el contacto con una muestra con un anticuerpo o fragmento de anticuerpos con secuencias cdr de cadena pesada y ligeraInfo
- Publication number
- CO2017010316A2 CO2017010316A2 CONC2017/0010316A CO2017010316A CO2017010316A2 CO 2017010316 A2 CO2017010316 A2 CO 2017010316A2 CO 2017010316 A CO2017010316 A CO 2017010316A CO 2017010316 A2 CO2017010316 A2 CO 2017010316A2
- Authority
- CO
- Colombia
- Prior art keywords
- antibody
- sample
- heavy
- glycoprotein
- chikungunya virus
- Prior art date
Links
- 102000008394 Immunoglobulin Fragments Human genes 0.000 title abstract 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 208000004293 Chikungunya Fever Diseases 0.000 title abstract 2
- 206010067256 Chikungunya virus infection Diseases 0.000 title abstract 2
- 102000003886 Glycoproteins Human genes 0.000 title abstract 2
- 108090000288 Glycoproteins Proteins 0.000 title abstract 2
- 238000010367 cloning Methods 0.000 abstract 2
- 241001502567 Chikungunya virus Species 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/18—Togaviridae; Flaviviridae
- G01N2333/181—Alphaviruses or Group A arboviruses, e.g. sindbis, VEE, EEE, WEE or semliki forest virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/10—Detection of antigens from microorganism in sample from host
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
Abstract
Se proporciona un anticuerpo monoclonal aislado y /o recombinante, en el que el anticuerpo o fragmento de anticuerpo se caracteriza por secuencias CDR de cadena pesada y ligera emparejadas por clonación. Adicionalmente, la presente invención se refiere a un método para detectar una infección por virus Chikungunya en un sujeto que comprende las etapas de (a) poner en contacto una muestra de dicho sujeto con un anticuerpo o fragmento de anticuerpo que tiene CDR de cadena pesada y ligera emparejadas por clonación; y (b) detectar la glicoproteína E2 del virus Chikungunya en dicha muestra mediante la unión de dicho anticuerpo o fragmento de anticuerpo a E2 en dicha muestra. El método puede comprender además realizar las etapas (a) y (b) una segunda vez y determinar un cambio en los niveles de E2 en comparación con el primer ensayo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562147354P | 2015-04-14 | 2015-04-14 | |
| PCT/US2016/027466 WO2016168417A2 (en) | 2015-04-14 | 2016-04-14 | Antibody-mediated neutralization of chikungunya virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2017010316A2 true CO2017010316A2 (es) | 2017-12-15 |
Family
ID=57126199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2017/0010316A CO2017010316A2 (es) | 2015-04-14 | 2017-10-10 | Anticuerpo monoclonal aislado y / o recombinante y un método para identificar la infección por el virus de chikungunya glycoprotein e2 mediante el contacto con una muestra con un anticuerpo o fragmento de anticuerpos con secuencias cdr de cadena pesada y ligera |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US10787503B2 (es) |
| EP (1) | EP3283101A4 (es) |
| JP (3) | JP6979875B2 (es) |
| KR (2) | KR102541905B1 (es) |
| CN (2) | CN114478756A (es) |
| AR (1) | AR104264A1 (es) |
| AU (2) | AU2016250188C1 (es) |
| BR (1) | BR112017021952A2 (es) |
| CA (2) | CA2982491C (es) |
| CL (1) | CL2017002596A1 (es) |
| CO (1) | CO2017010316A2 (es) |
| CR (2) | CR20170518A (es) |
| DO (1) | DOP2017000236A (es) |
| EA (1) | EA037060B1 (es) |
| EC (1) | ECSP17075750A (es) |
| HK (1) | HK1246671A1 (es) |
| IL (2) | IL290449B2 (es) |
| MA (1) | MA41517A (es) |
| MX (2) | MX2017013286A (es) |
| MY (1) | MY191666A (es) |
| NZ (1) | NZ736445A (es) |
| PE (2) | PE20220297A1 (es) |
| PH (1) | PH12017501865A1 (es) |
| SG (2) | SG11201708152SA (es) |
| TN (1) | TN2017000438A1 (es) |
| TW (2) | TWI772257B (es) |
| UA (1) | UA125206C2 (es) |
| WO (1) | WO2016168417A2 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202300515A (zh) | 2016-10-20 | 2023-01-01 | 法商賽諾菲公司 | 抗ｃｈｉｋｖ抗體及其用途 |
| KR102029394B1 (ko) * | 2017-11-14 | 2019-10-07 | 재단법인 바이오나노헬스가드연구단 | 치쿤구니아 바이러스 감염 진단용 단일클론항체, 이를 생산하는 하이브리도마 및 이를 이용한 치쿤구니아 바이러스 감염 진단 방법 |
| EP3735270A1 (en) | 2018-01-05 | 2020-11-11 | Modernatx, Inc. | Polynucleotides encoding anti-chikungunya virus antibodies |
| US11851478B2 (en) | 2018-01-05 | 2023-12-26 | Vanderbilt University | Antibody-mediated neutralization of chikungunya virus |
| US11560421B2 (en) | 2018-02-09 | 2023-01-24 | Osaka University | Broad-spectrum monoclonal antibodies against chikungunya virus E1 structural protein |
| JP6906207B2 (ja) * | 2018-02-09 | 2021-07-21 | 国立大学法人大阪大学 | チクングニアウイルス検出用免疫クロマト分析装置 |
| US20220265806A1 (en) * | 2018-06-06 | 2022-08-25 | Albert Einstein College Of Medicine, Inc | Antibodies or antibody-fragments thereof targeting alphaviruses, and compositions and methods comprising same |
| WO2021042021A1 (en) * | 2019-08-31 | 2021-03-04 | Vanderbilt University | Human antibodies to alphaviruses |
| KR102202082B1 (ko) * | 2019-09-25 | 2021-01-11 | 충북대학교 산학협력단 | 치쿤군야 바이러스의 외피단백질 도메인 ⅱ에 대해 특이적으로 결합하는 단일클론항체, 이를 생산하는 하이브리도마 세포주 및 이의 용도 |
| CN110922478B (zh) * | 2019-12-07 | 2021-07-30 | 中国人民解放军军事科学院军事医学研究院 | 针对特异表位的抗基孔肯雅热的全人源单克隆抗体及应用 |
| WO2022101805A1 (en) * | 2020-11-13 | 2022-05-19 | Emergent Biosolutions Canada Inc. | Hyperimmune globulins for treatment of chikungunya virus infections |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2598966A1 (en) | 2007-09-07 | 2009-03-07 | Institut Pasteur | Anti-chikungunya monoclonal antibodies and uses thereof |
| US9000131B2 (en) * | 2008-07-31 | 2015-04-07 | The Regents Of The University Of California | Antibodies that neutralize botulinum neurotoxins |
| WO2011124635A1 (en) | 2010-04-07 | 2011-10-13 | Humalys | Binding molecules against chikungunya virus and uses thereof |
| US9902765B2 (en) * | 2013-07-19 | 2018-02-27 | Integral Molecular, Inc. | Antibodies against chikungunya virus and uses thereof |
| TW202300515A (zh) * | 2016-10-20 | 2023-01-01 | 法商賽諾菲公司 | 抗ｃｈｉｋｖ抗體及其用途 |
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2016
- 2016-04-13 MA MA041517A patent/MA41517A/fr unknown
- 2016-04-14 EP EP16780715.5A patent/EP3283101A4/en active Pending
- 2016-04-14 TW TW105111764A patent/TWI772257B/zh active
- 2016-04-14 CN CN202111464377.9A patent/CN114478756A/zh active Pending
- 2016-04-14 PE PE2022000095A patent/PE20220297A1/es unknown
- 2016-04-14 WO PCT/US2016/027466 patent/WO2016168417A2/en active Application Filing
- 2016-04-14 CA CA2982491A patent/CA2982491C/en active Active
- 2016-04-14 CA CA3176525A patent/CA3176525A1/en active Pending
- 2016-04-14 KR KR1020177032434A patent/KR102541905B1/ko active IP Right Grant
- 2016-04-14 US US15/566,283 patent/US10787503B2/en active Active
- 2016-04-14 TN TNP/2017/000438A patent/TN2017000438A1/en unknown
- 2016-04-14 UA UAA201711061A patent/UA125206C2/uk unknown
- 2016-04-14 MY MYPI2017703760A patent/MY191666A/en unknown
- 2016-04-14 AU AU2016250188A patent/AU2016250188C1/en active Active
- 2016-04-14 CN CN201680034592.6A patent/CN107708726B/zh active Active
- 2016-04-14 AR ARP160101021A patent/AR104264A1/es unknown
- 2016-04-14 SG SG11201708152SA patent/SG11201708152SA/en unknown
- 2016-04-14 CR CR20170518A patent/CR20170518A/es unknown
- 2016-04-14 EA EA201792220A patent/EA037060B1/ru unknown
- 2016-04-14 PE PE2017002105A patent/PE20180171A1/es unknown
- 2016-04-14 SG SG10202107295XA patent/SG10202107295XA/en unknown
- 2016-04-14 TW TW111131757A patent/TW202248210A/zh unknown
- 2016-04-14 IL IL290449A patent/IL290449B2/en unknown
- 2016-04-14 NZ NZ736445A patent/NZ736445A/en unknown
- 2016-04-14 CR CR20210438A patent/CR20210438A/es unknown
- 2016-04-14 JP JP2017553887A patent/JP6979875B2/ja active Active
- 2016-04-14 BR BR112017021952A patent/BR112017021952A2/pt active Search and Examination
- 2016-04-14 KR KR1020237018988A patent/KR20230087616A/ko not_active Application Discontinuation
- 2016-04-14 MX MX2017013286A patent/MX2017013286A/es unknown
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2017
- 2017-10-03 IL IL254891A patent/IL254891B/en unknown
- 2017-10-10 DO DO2017000236A patent/DOP2017000236A/es unknown
- 2017-10-10 CO CONC2017/0010316A patent/CO2017010316A2/es unknown
- 2017-10-11 PH PH12017501865A patent/PH12017501865A1/en unknown
- 2017-10-13 MX MX2021013207A patent/MX2021013207A/es unknown
- 2017-10-13 CL CL2017002596A patent/CL2017002596A1/es unknown
- 2017-11-14 EC ECIEPI201775750A patent/ECSP17075750A/es unknown
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2018
- 2018-05-15 HK HK18106245.0A patent/HK1246671A1/zh unknown
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2019
- 2019-10-10 US US16/598,380 patent/US11345743B2/en active Active
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2021
- 2021-06-01 JP JP2021092090A patent/JP2021144047A/ja active Pending
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2022
- 2022-04-28 AU AU2022202819A patent/AU2022202819A1/en active Pending
- 2022-08-31 JP JP2022137389A patent/JP2022174144A/ja active Pending
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