CO2017002166A2 - Proteínas de fusión de interleucina 2 / receptor de interleucina-2 alfa - Google Patents

Proteínas de fusión de interleucina 2 / receptor de interleucina-2 alfa

Info

Publication number
CO2017002166A2
CO2017002166A2 CONC2017/0002166A CO2017002166A CO2017002166A2 CO 2017002166 A2 CO2017002166 A2 CO 2017002166A2 CO 2017002166 A CO2017002166 A CO 2017002166A CO 2017002166 A2 CO2017002166 A2 CO 2017002166A2
Authority
CO
Colombia
Prior art keywords
interleukin
polypeptide
fusion protein
fusion proteins
alpha receptor
Prior art date
Application number
CONC2017/0002166A
Other languages
English (en)
Spanish (es)
Inventor
Thomas Malek
Original Assignee
Univ Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53836871&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO2017002166(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Miami filed Critical Univ Miami
Publication of CO2017002166A2 publication Critical patent/CO2017002166A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
CONC2017/0002166A 2014-08-06 2017-03-03 Proteínas de fusión de interleucina 2 / receptor de interleucina-2 alfa CO2017002166A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462033726P 2014-08-06 2014-08-06
PCT/US2015/043792 WO2016022671A1 (en) 2014-08-06 2015-08-05 Interleukin-2/interleukin-2 receptor alpha fusion proteins and methods of use

Publications (1)

Publication Number Publication Date
CO2017002166A2 true CO2017002166A2 (es) 2017-05-19

Family

ID=53836871

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0002166A CO2017002166A2 (es) 2014-08-06 2017-03-03 Proteínas de fusión de interleucina 2 / receptor de interleucina-2 alfa

Country Status (32)

Country Link
US (3) US12084483B2 (https=)
EP (2) EP4438621A3 (https=)
JP (3) JP6723982B2 (https=)
KR (1) KR102653758B1 (https=)
CN (2) CN107074967B (https=)
AU (3) AU2015301071C1 (https=)
BR (1) BR112017001940A2 (https=)
CA (1) CA2957273C (https=)
CL (1) CL2017000284A1 (https=)
CO (1) CO2017002166A2 (https=)
DK (1) DK3177307T3 (https=)
EA (2) EA035956B1 (https=)
ES (1) ES2986097T3 (https=)
FI (1) FI3177307T3 (https=)
HR (1) HRP20241258T1 (https=)
HU (1) HUE068478T2 (https=)
IL (2) IL250007B (https=)
LT (1) LT3177307T (https=)
MA (2) MA40094B1 (https=)
MX (1) MX388977B (https=)
MY (1) MY180831A (https=)
PE (1) PE20170503A1 (https=)
PH (1) PH12017500042A1 (https=)
PT (1) PT3177307T (https=)
RS (1) RS65930B1 (https=)
SA (1) SA517380842B1 (https=)
SG (2) SG10201913695PA (https=)
SI (1) SI3177307T1 (https=)
SM (1) SMT202400414T1 (https=)
TN (1) TN2017000020A1 (https=)
WO (1) WO2016022671A1 (https=)
ZA (1) ZA201700245B (https=)

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MA40094B1 (fr) 2014-08-06 2022-05-31 Univ Miami Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation
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CA3146156A1 (en) * 2019-07-12 2021-01-21 Proviva Therapeutics (Hong Kong) Limited Il-2 compositions and methods of use thereof
MX2022000991A (es) * 2019-07-25 2022-05-24 Univ Chicago Composiciones y metodos que comprenden agentes terapeuticos activados por proteasa.
US20220378933A1 (en) * 2019-09-19 2022-12-01 Proviva Therapeutics (Hong Kong) Limited Il-2 compositions and methods of use thereof
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KR20230050389A (ko) * 2020-08-13 2023-04-14 브리스톨-마이어스 스큅 컴퍼니 Il-2를 관심 표적 세포로 재지시하는 방법
TW202317623A (zh) * 2021-06-14 2023-05-01 美商再生元醫藥公司 基於il2之治療劑及其使用方法
CN118891055A (zh) * 2022-02-11 2024-11-01 穆拉肿瘤公司 用于癌症免疫疗法的组合物和方法
WO2023159135A2 (en) * 2022-02-16 2023-08-24 University Of Miami Il-2 and tl1a fusion proteins and methods of use thereof
CN114875069B (zh) * 2022-04-22 2023-09-15 四川大学 基因工程修饰的il2细胞因子的重组载体、宿主细胞及其用途
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Also Published As

Publication number Publication date
EP4438621A2 (en) 2024-10-02
SA517380842B1 (ar) 2021-12-26
SI3177307T1 (sl) 2024-09-30
EP3177307B1 (en) 2024-07-17
JP6723982B2 (ja) 2020-07-15
AU2022204034A1 (en) 2022-07-14
KR20170030646A (ko) 2017-03-17
LT3177307T (lt) 2024-08-12
EA035956B1 (ru) 2020-09-04
NZ766851A (en) 2024-07-26
MA40094B1 (fr) 2022-05-31
MX2017001062A (es) 2017-07-14
AU2015301071B2 (en) 2020-03-05
DK3177307T3 (da) 2024-10-07
US20170233448A1 (en) 2017-08-17
AU2015301071C1 (en) 2020-07-02
PT3177307T (pt) 2024-09-13
US20250163118A1 (en) 2025-05-22
EA202091342A2 (ru) 2020-11-30
BR112017001940A2 (pt) 2017-11-28
ZA201700245B (en) 2024-06-26
AU2015301071A1 (en) 2017-02-02
SG11201700706WA (en) 2017-02-27
AU2020203352B2 (en) 2022-03-10
AU2020203352A1 (en) 2020-07-02
EA202091342A3 (ru) 2020-12-30
TN2017000020A1 (en) 2018-07-04
IL250007B (en) 2020-07-30
MA40721A (fr) 2017-06-13
CA2957273C (en) 2023-03-14
EA201790063A1 (ru) 2017-06-30
JP7272663B2 (ja) 2023-05-12
WO2016022671A1 (en) 2016-02-11
MX388977B (es) 2025-03-20
IL275944B (en) 2022-02-01
NZ728042A (en) 2024-07-26
KR102653758B1 (ko) 2024-04-04
MY180831A (en) 2020-12-10
MA40094A1 (fr) 2021-09-30
JP2023099045A (ja) 2023-07-11
FI3177307T3 (fi) 2024-10-04
CL2017000284A1 (es) 2017-11-17
MA40721B1 (fr) 2024-08-30
HRP20241258T1 (hr) 2024-12-06
IL275944A (en) 2020-08-31
SG10201913695PA (en) 2020-03-30
PH12017500042A1 (en) 2017-05-22
CN113912737A (zh) 2022-01-11
CA2957273A1 (en) 2016-02-11
HUE068478T2 (hu) 2025-01-28
IL250007A0 (en) 2017-03-30
JP2021000084A (ja) 2021-01-07
CN107074967A (zh) 2017-08-18
US12084483B2 (en) 2024-09-10
CN107074967B (zh) 2021-06-08
JP2017523789A (ja) 2017-08-24
US20230079120A1 (en) 2023-03-16
ES2986097T3 (es) 2024-11-08
EP4438621A3 (en) 2024-12-18
EP3177307A1 (en) 2017-06-14
RS65930B1 (sr) 2024-10-31
SMT202400414T1 (it) 2024-11-15
PE20170503A1 (es) 2017-05-11

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