CN220105065U - Automatic plasma detection and sample adding device - Google Patents

Abstract

The utility model relates to the technical field of medical equipment, and particularly discloses a plasma automatic detection and sample adding device, which comprises a sample sucking and conveying system, wherein a sample containing system is arranged below the sample sucking and conveying system; the sample sucking and conveying system comprises a sample adding needle which is connected with a driving circuit; the sample holding system comprises a plurality of reagent tube boxes which are connected in sequence, a reagent tube assembly is arranged in each reagent tube box, each reagent tube assembly comprises a mounting seat, a reagent tube is arranged on each mounting seat, a detection assembly is movably arranged on the side wall of each reagent tube, and the detection assemblies are electrically connected with the driving circuit. According to the utility model, the plasma in the reagent tube is directly monitored, and after the plasma meets the detection requirement, the sampling needle is controlled by the driving circuit to stop sampling, so that the effect of accurate control is achieved, the requirement on the diameter of the sampling needle is reduced, the condition that the sampling needle is blocked is avoided, the sampling detection efficiency is improved, and the automatic sampling is realized.

Description

Automatic plasma detection and sample adding device

Technical Field

The utility model relates to the technical field of medical equipment, in particular to an automatic plasma detection and sample addition device.

Background

In recent years, as the amount of biological information is expanding with the deep research of various subjects such as medicine and biology, the clinical demands for sample detection are increasing, and therefore, the demands for high performance and high reliability of various clinical test instruments are triggered. In the process of detecting the sample plasma (or serum), an automatic sampling device is generally adopted at present, but due to the fact that the plasma is not well contracted or is not completely contracted, or a blood sample tube is adopted for directly sucking samples, or the blood is not sufficiently centrifuged, and the like, small clots exist in the plasma, and the sampling needle is easily blocked when the automatic sampling device is used for sampling, so that the sampling device is failed or even damaged.

Meanwhile, in order to ensure that the detection effect improves the detection efficiency, the detection precision can be improved by accurately controlling the sample adding amount, so that the high-precision extremely-thin sample adding needle is adopted as a sampling head at present, the effect of accurately controlling the sample adding amount is further achieved, the extremely-thin sample adding needle can be blocked by the sample adding needle more easily, and the requirement on the sample adding needle in the plasma sample adding device is extremely high.

Therefore, in order to solve the problem that the sample adding needle is easy to be blocked, the diameter requirement on the sample adding needle is reduced, and an automatic plasma detection sample adding device is needed.

Disclosure of Invention

The utility model aims to provide an automatic plasma detection sample adding device so as to solve the problem that a sample adding needle in the sample adding device is easy to block.

In order to achieve the above purpose, the utility model adopts the following technical scheme:

the utility model is mainly used for controlling the sample adding process by accurately monitoring the liquid level in the reagent tube, and ensuring the sample adding accuracy, thereby reducing the requirement of accurately controlling the amount by means of the high-accuracy superfine sample adding needle. The automatic plasma detection and sample adding device comprises a sample sucking and conveying system, wherein a sample containing system is arranged below the sample sucking and conveying system; the sample sucking and conveying system comprises a sample adding needle which is connected with a driving circuit; the sample containing system comprises a plurality of reagent tube boxes which are connected in sequence, and the width of each reagent tube box is one third of the width of the sample sucking and conveying system; the sample adding needle moves above the reagent tube box along the connecting direction of the reagent tube box; the reagent tube assembly comprises a mounting seat, a reagent tube is arranged on the mounting seat, the sample adding needle is right opposite to the upper part of the reagent tube, a detection assembly is movably arranged on the side wall of the reagent tube, and the detection assembly is electrically connected with the driving circuit.

The principle and the advantages of the scheme are as follows:

in practical application, the sample is automatically added into the reagent tube of the sample containing system through the sample adding needle, so that the automatic sample adding process is realized. Simultaneously, the plasma volume in the reagent tube is accurately monitored through the detection component, after the plasma in the reagent tube reaches the detection requirement, the plasma is timely fed back to the driving circuit, and the sampling needle is controlled by the driving circuit to stop sampling, so that the effect of accurate control quantity is achieved, the sampling dosage of the plasma is prevented from being controlled by adopting the high-precision superfine sampling needle, the requirement on the diameter of the sampling needle can be reduced, the condition that the sampling needle is easy to block is avoided, the sampling detection efficiency is improved, the damage probability of an instrument is reduced, and the service life of the instrument is prolonged. Simultaneously, this device simple structure, convenience simple to use greatly reduces manufacturing cost, more does benefit to medical detection and uses.

Further, a reagent tube position groove is formed in the reagent tube box, and the height of the reagent tube position groove is three fourths of the height of the reagent tube box; a power connector is arranged at the bottom of the reagent tube position groove; the reagent tube component is movably arranged in the reagent tube box and is electrically connected with the power connector. The reagent tube assembly is fixedly installed through the reagent tube position groove, so that the stability and the safety of the reagent tube assembly are ensured; meanwhile, the power connector at the bottom of the reagent tube position groove is used for directly providing power for the reagent tube assembly, so that the structure of the device is simplified, and the operation is more flexible and convenient.

Further, a detection groove is formed in the side wall of the reagent tube, and the detection groove is consistent with the wall of the reagent tube in height; the detection groove is internally provided with a sliding rail, the detection assembly is movably arranged on the sliding rail, and the detection assembly is electrically connected with the mounting seat through the sliding rail. The detection assembly is used for accurately positioning through the detection groove, so that accurate measurement of liquid in the reagent tube is guaranteed, and the effect of accurate control is achieved.

Further, the detection assembly comprises a connecting frame connected with the sliding rail, a signal emitter and a signal receiver are arranged on the connecting frame, a lens is arranged between the signal emitter and the signal receiver, the lens is arranged at the front end of the connecting frame, and the lens is opposite to the inside of the reagent tube; the signal receiver is connected with a detection circuit, and the detection circuit is connected with the driving circuit. After the liquid level shields the lens, the signal of the signal transmitter is directly refracted into the liquid and cannot be received by the signal receiver, so that the adding condition of the liquid in the reagent tube can be mastered timely and quickly, and the effect of automatic and accurate control of sample adding is achieved.

Further, a control panel is arranged on the reagent tube box and is electrically connected with the detection assembly; one side of the reagent tube box is also provided with a plurality of connecting buckles, and the other side of the reagent tube box is provided with a connecting ring matched with the connecting buckles. The amount of sample adding required in each reagent tube is set through the control panel, and the sample adding required amount can be flexibly set according to actual detection requirements. Meanwhile, a plurality of reagent tube boxes can be flexibly spliced according to requirements through the connecting buckle and the connecting ring, so that the detection requirements are met.

Further, the sample sucking and delivering system further comprises a needle tube box, and a needle tube sleeve is arranged below the needle tube box; a needle hole for penetrating the sample adding needle is formed in the bottom of the needle tube box, and the needle tube sleeve is sleeved at the lower part of the sample adding needle; the diameter of the needle tube sleeve is consistent with the diameter of the reagent tube position groove, and the height of the needle tube sleeve is two thirds of the height of the sample adding needle. The needle tube sleeve is sleeved outside the sample adding needle, so that the sample adding needle can be protected, and meanwhile, the environmental sanitation of the sample adding process is ensured, and the direct contact is avoided.

Further, a needle tube groove is further formed in the needle tube box, and the sample adding needle is placed in the needle tube groove; a push plate is arranged on the outer side of the needle tube groove, and is in movable contact with the needle tube groove; the push plate rear end is connected with the telescopic link, the telescopic link is connected with motor assembly, motor assembly with drive circuit connects. A plurality of disposable sample adding needles can be stored through the needle tube groove, so that the replacement is convenient.

Further, a clamping piece is further arranged above the needle hole, the clamping piece comprises clamping jaws, a connecting end is arranged above the clamping jaws, and the connecting end is connected with the top end of the sample adding needle; the connecting end is connected with the driving circuit. In the sample adding process, the clamping piece further fixes the sample adding needle, so that the stability of the sample adding needle in the whole moving process of the device is ensured; meanwhile, the automatic sample feeding and sucking process of the sample feeding needle is controlled through the connecting end.

Further, the intelligent control device also comprises a microprocessor, wherein the microprocessor is respectively connected with the detection circuit, the control panel and the driving circuit. Automatic control is realized, and the sample adding detection efficiency is improved.

Furthermore, the top of the sample adding needle is also provided with a stop bar for positioning. The sample adding needle is arranged on the needle hole through the stop bar, and cannot fall off, so that the accurate mounting position of the sample adding needle is ensured.

Drawings

FIG. 1 is a schematic view of an automatic plasma detection and sample addition device according to the present utility model;

FIG. 2 is a schematic diagram of a reagent kit of an automatic plasma detection and sample addition device according to the present utility model;

FIG. 3 is a schematic view of a reagent tube assembly of an automatic plasma detection and sample addition device according to the present utility model;

FIG. 4 is a schematic view of the detection assembly of the automatic plasma detection and sample addition device according to the present utility model;

FIG. 5 is a diagram showing the connection structure of a detection circuit of the automatic plasma detection and sample addition device according to the present utility model;

FIG. 6 is a schematic diagram of a sample suction and delivery system of an automatic plasma detection and loading device according to the present utility model;

FIG. 7 is an enlarged view of a portion of the sample suction and delivery system of an automatic plasma detection and loading device according to the present utility model.

Detailed Description

The following is a further detailed description of the embodiments:

reference numerals in the drawings of the specification include: sample sucking and transporting system 1, sample holding system 2, sample adding needle 3, reagent cartridge 4, reagent cartridge position groove 5, connecting buckle 6, reagent cartridge assembly 7, mounting seat 8, reagent cartridge 9, detecting groove 10, detecting assembly 11, connecting frame 12, signal emitter 13, signal receiver 14, lens 15, detecting circuit 16, microprocessor 17, control panel 18, driving circuit 19, needle cartridge 20, needle tube sleeve 21, needle hole 22, clamping piece 23, clamping jaw 201, connecting end 202, needle tube groove 24, push plate 25, telescopic rod 26, motor assembly 27, and power connector 28.

An example is substantially as shown in figure 1: an automatic plasma detection and sample addition device comprises a sample sucking and conveying system 1 and a sample containing system 2; the sample sucking and delivering system 1 is connected with the sample containing system 2 through a control circuit. The sample sucking and transporting system 1 sucks and transports the blood plasma or serum into a reagent tube 9 appointed in the sample containing system 2 by controlling a sample adding needle 3 to move along the length direction of the sample containing system 2, and meanwhile, the sample containing system 2 controls the starting and stopping of the sample sucking and transporting system 1 by monitoring the liquid level of the blood plasma or serum contained in the reagent tube 9.

Specifically, the whole cuboid structure that is of sample system 2 holds, sample system 2 includes that a plurality of concatenations form kit 4, application of sample needle 3 is followed the direction automatic cutout of kit 4 moves. As shown in fig. 2, the reagent tube box 4 is in a cuboid structure, the width of the reagent tube box 4 is one third of the width of the sample sucking and conveying system 1, so that the sample adding needle 3 can accurately convey plasma into a designated reagent tube under the condition of less movement, meanwhile, the reagent tube box 4 is ensured to meet the space requirement for placing the reagent tube, and the space volume of the reagent tube box 4 is reduced. The surface of each reagent tube box 4 is connected and embedded with a control panel 18, the reagent tube boxes 4 are provided with reagent tube position grooves 5 with a cylindrical structure as a whole, and the height of each reagent tube position groove 5 is three fourths of the height of each reagent tube box; the bottom of the reagent tube position groove 5 is provided with a power connector 28, so that the reagent tube can be stably placed in the reagent tube position groove 5, and meanwhile, a sufficient space is reserved for circuit arrangement, and the installation and the maintenance are more convenient. One side of the reagent tube box 4 is provided with a plurality of connecting buckles 6, the other side is provided with connecting rings matched with the connecting buckles 6, and the connecting buckles 6 and the connecting rings can be combined and spliced at will to form the sample containing system 2 with a plurality of reagent tube positions. In this embodiment, each of the reagent kits 4 is provided with 4 connectors 6 and 4 connecting rings matching with the connectors, and the 4 reagent kits 4 are spliced into the sample containing system 2 with 4 reagent tube positions.

Specifically, each reagent tube box 4 is internally embedded with a reagent tube assembly 7 adapted to the reagent tube position groove 5, as shown in fig. 3, the whole reagent tube assembly 7 is in a cylindrical structure, the reagent tube assembly 7 comprises a mounting seat 8 arranged at the bottom, and the bottom of the mounting seat 8 is electrically connected with a power connector 28 at the bottom of the reagent tube position groove 5. The mounting seat 8 is integrally provided with a reagent tube 9. A detection groove 10 is formed in one side of the wall of the reagent tube 9, and the detection groove 10 is consistent with the wall of the reagent tube in height; the inside of the detection groove 10 is vertically provided with a sliding rail, a detection assembly 11 is movably mounted on the sliding rail, and the detection assembly 11 is electrically connected with the mounting seat 8 through the sliding rail. When the reagent tube holds plasma, the detection component 11 detects the plasma liquid level, and controls the sample feeding and sucking system to stop sample feeding when the plasma liquid level reaches the detection requirement height, so that the effect of accurate control is achieved.

Specifically, as shown in fig. 4, the detection assembly 11 includes a connecting frame 12 that is clamped on the slide rail and is in a ring shape, a signal emitter 13 and a signal receiver 14 are disposed on the connecting frame 12, a lens 15 is disposed between the signal emitter 13 and the signal receiver 14, and the lens 15 is disposed at the front end of the connecting frame 12 and faces the inside of the reagent tube. The end of the signal receiver 14 is connected with a detection circuit 16.

Specifically, as shown in fig. 5, the detection circuit 16 is connected with a microprocessor 17, the microprocessor 17 is respectively connected with a control panel 18 and a driving circuit 19, the control panel 18 is arranged on the reagent kit 4, so that the sample loading amount parameter can be set through the control panel 18, and the driving circuit 19 is connected with the sample sucking and delivering system 1. In this embodiment, the signal transmitter 13 uses a light source Light Emitting Diode (LED), and the signal receiver 14 uses a pin photodiode; the detection circuit 16 can adopt a common differential amplification circuit and a comparison circuit to realize the comparison detection of the liquid level height value and the set value; the driving circuit 19 may be a PMOS driving circuit or a MOS transistor driving circuit; and are not limited herein. Light source signals are emitted through a light source Light Emitting Diode (LED), when liquid in the reagent tube 9 submerges the lens 15, light is refracted into the liquid, so that the needle-shaped photodiode cannot receive feedback information, at the moment, the information is sent to the microprocessor 17 through the detection circuit 16, the microprocessor 17 controls the driving circuit 19 to start and stop through circuit signals, and the driving circuit 19 controls the motor assembly 27 to start and stop, so that the sample suction and conveying system 1 is controlled to stop sample feeding, and the effect of accurate quantity control is achieved.

Specifically, as shown in fig. 6, the sample sucking and delivering system 1 includes a needle tube box 20 with a rectangular parallelepiped structure, and the width of the reagent tube box 4 is one third of the width of the needle tube box 20. A needle tube sleeve 21 is arranged below the needle tube box 20, and the sample adding needle 3 is sent out from the needle tube box 20 and sends the sucked blood plasma into the reagent tube 9 through the needle tube sleeve 21. The whole cylindrical structure that is of needle tube sleeve 21, needle tube sleeve 21 diameter with reagent tube position groove diameter is unanimous, the height of needle tube sleeve 21 is two-thirds of the height of application of sample needle 3, guarantees the accuracy of application of sample needle 3 sample feeding position, guarantees the stability of application of sample needle 3 simultaneously. The needle tube sleeve 21 is fixedly connected with the needle tube box 20 through a beam shaft, a through hole groove with a cuboid structure is further formed in the beam shaft, the length of the through hole groove is one third of that of the beam shaft, and the sample adding needle can be collected and recycled through the through hole groove. A needle tube groove 24 is further formed in the needle tube box 20, and a plurality of sample adding needles 3 can be placed in the needle tube groove 24.

Specifically, as shown in fig. 7, a needle hole 22 is formed under the needle tube box 20, and two special-shaped holes are formed on two sides of the needle hole 22; the top of the sample adding needle 3 is provided with a stop bar, so that the sample adding needle 3 can be clamped on the needle hole 22 through the stop bar, and meanwhile, when the sample adding needle 3 is rotated, the stop bar can pass through the special-shaped hole, so that the sample adding needle 3 is taken out. A clamping piece 23 is arranged above the pinhole 22, the clamping piece 23 is electrically connected with the motor assembly 27, and the clamping piece 23 is driven to be opened and closed by the motor assembly 27. The loading needle 3 is further secured in the needle aperture 22 by a clamp 23. The clamping piece 23 comprises a clamping jaw 201 and a connecting end 202 arranged above the clamping jaw 201, the connecting end 202 is buckled and connected with the top end of the sample adding needle 3, the sample adding needle 3 is communicated with the driving circuit 19 through the connecting end 202, and the internal air pressure of the sample adding needle 3 is controlled, so that the sample adding needle 3 is controlled to start or stop sucking plasma. In this embodiment, the connection end 202 may be an electrically controlled air extraction rod and a reset optocoupler assembly, so as to implement sampling control on the sample adding needle 3 and reset control on the air extraction rod.

The outside of needle tube groove 24 is equipped with push pedal 25, push pedal 25 with needle tube groove 24 movable contact, push pedal 25 passes through telescopic link 26 and is connected with motor assembly 27, motor assembly 27 with drive circuit 19 is connected, realizes the automatic change of application of sample needle 3 through control motor assembly 27. In this embodiment, the telescopic rod 26 is an electric telescopic rod, and the motor assembly 27 controls the electric telescopic rod to move back and forth, and the motor assembly 27 may be a stepping motor. The sample adding needle 3 can be a disposable sample adding needle, so that the detection effectiveness is ensured, the medical health is ensured, and the cross infection is prevented.

The specific implementation process is as follows:

as shown in fig. 1 to 7, when plasma or serum is to be sampled, the reagent tube assembly 7 is mounted into the reagent cartridge 4 and is powered on. The amount of plasma to be loaded is then set by the control panel 18, at which point the detection assembly 11 will move along the slide rail to the designated volume height position and lock in according to the set parameter values. Then the sample sucking and transporting system 1 is started, the sample adding needle 3 in the needle tube groove 24 is pushed to the needle hole 22 by the push plate 25, and slides downwards due to gravity, so that the stop bar of the sample adding needle 3 is clamped on the needle hole 22, meanwhile, the connector at the tail part of the sample adding needle 3 is fixedly connected with the connecting end 202 of the clamping piece 23, and the clamping jaw 201 is used for fixing the sample adding needle 3. Plasma is aspirated into the reagent tube 9 through the loading needle 3. When the sample adding amount in the reagent tube 9 reaches the set height, the liquid submerges the lens 15 in the detection assembly 11, and at the moment, light is refracted into the liquid, so that the needle type photodiode cannot receive feedback information, and the clamping piece 23 is controlled by the driving circuit 19 to stop the sample adding needle 3 to absorb the sample, so that the sample adding of plasma or serum is completed, and the accurate control of the sample adding amount is achieved. After the sample is added, the clamping jaw 201 releases the sample adding needle 3, and simultaneously rotates the sample adding needle 3 in the direction that the stop bars on the sample adding needle are opposite to the two sides of the needle hole 22, so that the sample adding needle 3 automatically falls out of the needle hole 22, and the sample adding needle 3 is replaced.

In this embodiment, the liquid level of the blood in the reagent tube 9 is detected, so that the accurate control of the sample loading amount is achieved, and the automatic sample loading is realized. Meanwhile, by detecting plasma in the reagent tube 9, the effect of accurately controlling the quantity through the sample adding needle 3 is avoided, so that the requirement of using the high-precision superfine sample adding needle 3 can be omitted, the requirement on the diameter of the sample adding needle 3 is reduced in the device, the sample adding needle 3 with the diameter of 0.6-0.8mm can be adopted, the diameter of 0.2mm is enlarged compared with the sample adding needle 3 (0.4-0.6 mm) with the current requirement, the blocking condition of the sample adding needle 3 is reduced, the fault frequency of the sample adding device is reduced, the service life of the sample adding device is effectively prolonged, and meanwhile, automatic accurate quantitative sample adding is realized.

The foregoing is merely exemplary of the present utility model, and specific technical solutions and/or features that are well known in the art have not been described in detail herein. It should be noted that, for those skilled in the art, several variations and modifications can be made without departing from the technical solution of the present utility model, and these should also be regarded as the protection scope of the present utility model, which does not affect the effect of the implementation of the present utility model and the practical applicability of the patent. The protection scope of the present utility model is subject to the content of the claims, and the description of the specific embodiments and the like in the specification can be used for explaining the content of the claims.

Claims (10)

1. An automatic plasma detection and sample addition device is characterized in that: the device comprises a sample sucking and conveying system, wherein a sample containing system is arranged below the sample sucking and conveying system; the sample sucking and conveying system comprises a sample adding needle which is connected with a driving circuit; the sample containing system comprises a plurality of reagent tube boxes which are connected in sequence, and the width of each reagent tube box is one third of the width of the sample sucking and conveying system; the sample adding needle moves above the reagent tube box along the connecting direction of the reagent tube box; the reagent tube assembly comprises a mounting seat, a reagent tube is arranged on the mounting seat, the sample adding needle is right opposite to the upper part of the reagent tube, a detection assembly is movably arranged on the side wall of the reagent tube, and the detection assembly is electrically connected with the driving circuit.

2. An automatic plasma detection and sample addition device according to claim 1, wherein: the reagent tube box is provided with a reagent tube position groove, and the height of the reagent tube position groove is three fourths of the height of the reagent tube box; a power connector is arranged at the bottom of the reagent tube position groove; the reagent tube component is movably arranged in the reagent tube box and is electrically connected with the power connector.

3. An automatic plasma detection and sample addition device according to claim 1, wherein: the side wall of the reagent tube is provided with a detection groove, and the detection groove is consistent with the wall of the reagent tube in height; the detection groove is internally provided with a sliding rail, the detection assembly is movably arranged on the sliding rail, and the detection assembly is electrically connected with the mounting seat through the sliding rail.

4. A plasma automatic detection and loading device according to claim 3, wherein: the detection assembly comprises a connecting frame connected with the sliding rail, a signal emitter and a signal receiver are arranged on the connecting frame, a lens is arranged between the signal emitter and the signal receiver, the lens is arranged at the front end of the connecting frame, and the lens is opposite to the inside of the reagent tube; the signal receiver is connected with a detection circuit, and the detection circuit is connected with the driving circuit.

5. The automated plasma test loading device of claim 4, wherein: a control panel is arranged on the reagent tube box and is electrically connected with the detection assembly; one side of the reagent tube box is also provided with a plurality of connecting buckles, and the other side of the reagent tube box is provided with a connecting ring matched with the connecting buckles.

6. An automatic plasma detection and sample addition device according to claim 2, wherein: the sample sucking and delivering system further comprises a needle tube box, and a needle tube sleeve is arranged below the needle tube box; a needle hole for penetrating the sample adding needle is formed in the bottom of the needle tube box, and the needle tube sleeve is sleeved at the lower part of the sample adding needle; the diameter of the needle tube sleeve is consistent with the diameter of the reagent tube position groove, and the height of the needle tube sleeve is two thirds of the height of the sample adding needle.

7. The automated plasma detection and loading device of claim 6, wherein: a needle tube groove is further formed in the needle tube box, and the sample adding needle is placed in the needle tube groove; a push plate is arranged on the outer side of the needle tube groove, and is in movable contact with the needle tube groove; the push plate rear end is connected with the telescopic link, the telescopic link is connected with motor assembly, motor assembly with drive circuit connects.

8. The automated plasma detection and loading device of claim 6, wherein: a clamping piece is further arranged above the needle hole, the clamping piece comprises a clamping jaw, a connecting end is arranged above the clamping jaw, and the connecting end is connected with the top end of the sample adding needle; the connecting end is connected with the driving circuit.

9. The automated plasma test loading device of claim 5, wherein: the device also comprises a microprocessor which is respectively connected with the detection circuit, the control panel and the driving circuit.

10. An automatic plasma detection and sample addition device according to claim 1, wherein: the top of the sample adding needle is also provided with a stop bar for positioning.