CN114200155A - Auxiliary sample introduction device, detection equipment and sample introduction method - Google Patents

Auxiliary sample introduction device, detection equipment and sample introduction method Download PDF

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Publication number
CN114200155A
CN114200155A CN202111298389.9A CN202111298389A CN114200155A CN 114200155 A CN114200155 A CN 114200155A CN 202111298389 A CN202111298389 A CN 202111298389A CN 114200155 A CN114200155 A CN 114200155A
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CN
China
Prior art keywords
sample
driving
sample introduction
rack
sensor
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CN202111298389.9A
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Chinese (zh)
Inventor
王盼
韩锦
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Shenzhen Furuikang Technology Co ltd
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Shenzhen Furuikang Technology Co ltd
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Priority to CN202111298389.9A priority Critical patent/CN114200155A/en
Publication of CN114200155A publication Critical patent/CN114200155A/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Abstract

The invention provides an auxiliary sample introduction device, detection equipment and a sample introduction method, wherein the auxiliary sample introduction device comprises: the sample platform can bear the sample racks, and comprises a loading buffer area, a sample introduction area and an unloading buffer area, wherein the loading buffer area can accommodate a plurality of sample racks; the driving component is connected to the sample platform and comprises a movable driving piece, and the driving piece is used for driving the sample rack to move relative to the sample platform; the position sensors are distributed at N positions and can be triggered by the driving piece which moves to the corresponding position, wherein N is a positive integer not less than 3; and the judgment sensor can be triggered by the sample rack moved to the sample feeding position. Through setting up position sensor and judging the sensor, can detect the positional information of driving piece and sample frame to and the motion information of sample frame at sample platform's the appearance position of advancing, the different suitable scenes of the check out test set discernment of being convenient for avoid appearing omitting the problem that detects, and can make the sample frame stop in correct position.

Description

Auxiliary sample introduction device, detection equipment and sample introduction method
Technical Field
The invention relates to the field of medical equipment, in particular to an auxiliary sample introduction device, detection equipment and a sample introduction method.
Background
The urea breath test is the first choice method for clinical detection of helicobacter pylori, and the working principle is that the helicobacter pylori secretes urease which does not exist in human body originally, and when the tested person takes orally, the urease contains14After the C nuclide labeled urea medicine is used, the urea can be decomposed by urease secreted by helicobacter pylori to produceGreen belt14C-labelled carbon dioxide and is exhaled from the lungs after blood circulation. The carbon dioxide reacts with the absorbing agent in the gas card to form the carbon dioxide14A compound of C nuclide, thereby14C nuclide is collected on the gas collecting card, and then the gas collecting card is transferred to the detection equipment to be captured14The beta rays generated by the decay of the C nuclide are converted into output current pulses, and the infection condition of the helicobacter pylori in the human body can be judged by recording the number of the pulses. In the related art, the sample rack is usually moved to a set position by a driving member moving along a linear direction, the driving member has a fixed stroke, however, an operator may cause a plurality of sample racks to be detected on the sample platform due to misuse or equipment failure when using the sample rack, and under the condition that the stroke of the driving member is fixed, a part of the sample racks may directly cross the set position, and the problem of detection omission occurs.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art. Therefore, the invention provides a sample platform which can simplify the structure and reduce the control difficulty.
The invention also provides auxiliary equipment and a sample introduction method based on the auxiliary equipment.
The scheme adopted by the invention is as follows:
providing an auxiliary sample introduction device comprising:
the sample platform can bear sample racks, and comprises a loading buffer area, a sample introduction area and an unloading buffer area, wherein the loading buffer area can accommodate a plurality of sample racks;
the driving component is connected to the sample platform and comprises a movable driving piece, and the driving piece is used for driving the sample rack to move relative to the sample platform;
the N position sensors are distributed at N positions and can be triggered by the driving piece moved to the corresponding position, wherein N is a positive integer not less than 3;
and the judgment sensor can be triggered by the sample rack which is moved to the sample feeding position of the sample feeding area.
Furthermore, the loading buffer area, the sample injection area and the unloading buffer area are arranged in a straight line along the sample injection direction of the sample rack.
The auxiliary sample introduction device according to claim 2, wherein the loading buffer area can be used for placing M sample racks in parallel, wherein M is a positive integer not less than 2;
n position sensor follows it is linear arrangement to advance the appearance direction, and satisfies: n ═ M + 1.
Further, the spacing between at least some adjacent position sensors is equal to the width of the sample rack in the sample introduction direction.
Further, one of the N position sensors corresponds to a stroke start point of the driving member, and the other corresponds to a stroke end point of the driving member.
Further, the auxiliary sample introduction device further comprises an unloading detection sensor, the unloading detection sensor is arranged in the unloading buffer area, and the unloading detection sensor can be triggered by the sample rack.
Further, the driving assembly further comprises a first triggering piece which moves synchronously with the driving piece, and the first triggering piece passes through and triggers each position sensor one by one along the moving direction of the driving piece.
Further, the driving assembly further comprises a first power part and a first connecting part, the first power part is connected with the first connecting part and used for driving the first connecting part to move relative to the sample platform, the driving part is rotatably connected to the first connecting part, and the driving part which rotates to a set posture along a first direction can be limited by the first connecting part, wherein when the driving part in the set posture moves along a sample introduction direction, the driving part can drive the sample rack to move; when the driving part moves along the reverse direction of the sample feeding direction, the driving part can be abutted with the sample rack and rotate along the reverse second direction to avoid the sample rack.
Further, the driving member includes:
a driving part for contacting the sample rack;
the counterweight part is used for driving the driving piece which rotates along the second direction to reset to the set posture under the action of gravity;
and the rotating connecting part is positioned between the driving part and the counterweight part and is used for rotationally connecting the driving part and the first connecting part.
Further, the auxiliary sample introduction device further comprises a second trigger piece, the second trigger piece is arranged in the sample introduction area, the second trigger piece is connected with the sample platform and comprises a contact end and a trigger end, and the contact end can be in contact with or separated from the sample rack to move, so that the trigger end moves to change the trigger state of the judgment sensor.
Further, the sample platform comprises:
a support for carrying the sample rack;
the limiting part extends along the sample feeding direction and is used for limiting the sample rack to move along the sample feeding direction;
at least one is followed the fool-proof portion that advances kind direction extension, fool-proof portion be used for with the sample frame cooperation makes the sample frame is placed according to setting for the gesture can be followed on the supporting part advance kind direction and remove.
Furthermore, the auxiliary sample introduction device further comprises a clamping assembly arranged in the sample introduction area, and the clamping assembly is used for clamping the sample rack located at the sample introduction position.
Further, the clamping assembly comprises:
the positioning piece is connected to one side of the sample platform along the sample introduction direction;
the compression joint piece is connected to the other side of the sample platform along the sample introduction direction relative to the positioning piece, and the initial distance between the compression joint piece and the positioning piece is smaller than the minimum length of the sample rack in the horizontal direction along the horizontal direction perpendicular to the sample introduction direction;
and the second power part can drive the crimping part to move along the horizontal direction, so that the distance between the crimping part and the positioning part along the horizontal direction is not less than the maximum length of the sample rack in the horizontal direction.
Further, the clamping assembly further comprises:
the bracket is connected with the sample platform and can be driven by the second power piece to move;
the second connecting piece is movably connected with the bracket through the second connecting piece so that the crimping piece can be abutted by the sample rack to deflect relative to the bracket;
an elastic member located between the crimping member and the holder, for applying a force to the crimping member to abut the crimping member against the sample rack.
The invention also proposes a detection device comprising:
the auxiliary sample introduction device;
the sample introduction device is used for obtaining a sample collection container from the sample rack at the sample introduction position;
a detecting device for detecting the characteristic amount of the sample in the sample collection container;
and the controller controls the driving component and/or the sample feeding device according to signals acquired by the auxiliary sample feeding device and/or the sensor in the sample feeding device.
The invention also provides a sample introduction method, which is applied to the detection equipment and comprises the following steps:
controlling the driving piece to move from the loading buffer area to the sampling area, and monitoring the change of the trigger state of each position sensor;
monitoring the change of the trigger state of the judgment sensor;
and controlling the sample introduction device to carry out sample introduction on the sample collection container according to the change of the trigger states of the position sensor and the judgment sensor.
Further, in the process of controlling the driving part to move, when the triggering state of one position sensor is monitored to change every time, whether the change of the triggering state of the judgment sensor meets a preset sample introduction condition is judged, and if the change of the triggering state of the judgment sensor meets the preset sample introduction condition, the driving part is controlled to stop moving and the sample introduction device is controlled to start sample introduction; otherwise, controlling the driving part to continuously move until the preset sample introduction condition is met or the driving part resets to the initial position after reaching the extreme position.
Further, the preset sample introduction conditions comprise: the change process of the trigger state of the judgment sensor accords with a preset sequence, and the final state of the judgment sensor accords with a set state.
Further, all the steps are preceded by:
and controlling the driving piece to move to the initial position.
Further, in the process of controlling the driving piece to move to the limit position, if the trigger state of the judgment sensor is unchanged and is consistent with the trigger state of the non-sample rack, the prompt message of the non-sample rack is output.
Further, when the change process of the trigger state of the judgment sensor and/or the duration time of the set state of the judgment sensor meets the corresponding preset fault condition, outputting corresponding fault prompt information.
Has the advantages that:
supplementary sampling device is through setting up position sensor and judging the sensor, can detect the positional information of driving piece and sample frame to and the motion information of sample frame at sample platform's the appearance position of advancing, thereby provide the control basis of controller in the check out test set, be convenient for check out test set discerns different suitable scenes, avoid appearing omitting the problem that detects, and can make the sample frame stop in correct position.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Drawings
The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
FIG. 1 is a schematic perspective view of a detection apparatus in an embodiment of the present invention;
FIG. 2 is a schematic perspective view of the auxiliary sample injection device in FIG. 1;
FIG. 3 is a schematic perspective view of the auxiliary sample injection device in FIG. 2 hiding the sample holder;
FIG. 4 is a top view of the auxiliary sample injection device of FIG. 1;
FIG. 5 is a schematic cross-sectional view of section A-A of FIG. 4;
FIG. 6 is a perspective view of the driving member of FIG. 2 coupled to a first coupling member;
FIG. 7 is a side view of FIG. 6;
FIG. 8 is a perspective view of the drive assembly of FIG. 2;
FIG. 9 is an enlarged partial view of the sample rack pressing the second trigger;
FIG. 10 is a schematic perspective view of a sample holder suitable for use in the assay device of the invention;
FIG. 11 is a schematic perspective view of the sample platform of FIG. 2 carrying a sample rack;
FIG. 12 is a schematic cross-sectional view of the sample platform of FIG. 2;
FIG. 13 is a side view of the sample rack of FIG. 10;
FIG. 14 is a schematic cross-sectional view of the sample platform and sample rack of FIG. 2 mated together;
FIG. 15 is a schematic cross-sectional view of the sample platform and sample rack of FIG. 2 mated together;
FIG. 16 is a perspective view of the clamping assembly of FIG. 2;
FIG. 17 is a schematic perspective view of the detection device of FIG. 1;
FIG. 18 is a schematic perspective view of the sample introduction device of FIG. 1;
FIG. 19 is a schematic cross-sectional view of an auxiliary sample injection device at various stages of a scenario I;
FIG. 20 is a schematic diagram of the level signal variation of the judgment sensor in scenario one;
FIG. 21 is a schematic cross-sectional view of an auxiliary sample injection device staged in the middle of a scene II;
FIG. 22 is a schematic cross-sectional view of an auxiliary sample injection device staged in the middle of a scene II;
fig. 23 is a schematic diagram illustrating a level signal change of the judgment sensor in the second scenario;
FIG. 24 is a schematic cross-sectional view of an auxiliary sample injection device at each stage of scenario three;
fig. 25 is a schematic diagram of a level signal change of the judgment sensor in scene three;
FIG. 26 is a schematic cross-sectional view of an auxiliary sample injection device staged in the middle-four portion of a scene;
FIG. 27 is a schematic cross-sectional view of an auxiliary sample injection device staged in the middle-four of a scene;
fig. 28 is a schematic diagram showing a level signal change of the judgment sensor in scene four;
fig. 29 is a schematic cross-sectional view of the auxiliary sample injection device at each stage in scene eight.
Detailed Description
The concept and technical effects of the present invention will be clearly and completely described below in conjunction with the embodiments to fully understand the objects, features and effects of the present invention. It is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and other embodiments obtained by those skilled in the art without inventive efforts based on the embodiments of the present invention belong to the protection scope of the present invention.
In the description of the embodiments of the present invention, if an orientation description is referred to, for example, the orientations or positional relationships indicated by "upper", "lower", "front", "rear", "left", "right", etc. are based on the orientations or positional relationships shown in the drawings, only for convenience of describing the present invention and simplifying the description, but not for indicating or implying that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention.
In the description of the embodiments of the present invention, if a feature is referred to as being "disposed", "fixed", "connected", or "mounted" to another feature, it may be directly disposed, fixed, or connected to the other feature or indirectly disposed, fixed, connected, or mounted to the other feature. In the description of the embodiments of the present invention, if "a number" is referred to, it means one or more, if "a plurality" is referred to, it means two or more, if "greater than", "less than" or "more than" is referred to, it is understood that the number is not included, and if "greater than", "lower" or "inner" is referred to, it is understood that the number is included. If reference is made to "first" or "second", this should be understood to distinguish between features and not to indicate or imply relative importance or to implicitly indicate the number of indicated features or to implicitly indicate the precedence of the indicated features.
Referring to fig. 1 and 2, an auxiliary sample introduction device 100 according to a first embodiment of the present invention includes a sample platform 110 and a driving assembly 120. The sample platform 110 of the auxiliary sample introduction device is used for placing the sample rack 400, the sample collection container 500 is placed in the sample rack 400, and the sample is stored in the sample collection container 500. The sample rack 400 can move in a sample injection direction (e.g., from left to right in the figure) relative to the sample platform 110 under the driving of the driving assembly 120, thereby achieving automatic sample injection of the sample rack 400. The sample rack 400 needs to stay at the sample injection position (e.g., the position shown in fig. 2) to wait for the sample injection device 200 of the testing apparatus to transfer the sample collection container 500 in the sample rack 400 to the testing device 300 of the testing apparatus for testing. In the present application, if the sample injection of the sample rack 400 is mentioned, it refers to a process of moving the sample rack 400 from the initial placement position to the sample injection position; if reference is made to the sample introduction of the sample collection container 500, this refers to the process of moving the sample collection container 500 from the sample holder 400 at the sample introduction position to the detection device 300.
As shown in fig. 3, the loading area of the sample platform 110 may be divided into a loading buffer area 111, a sample injection area 112 and an unloading buffer area 113 according to different functions, and for the convenience of identification, the areas are roughly divided by dashed boxes in the figure, but the areas are only for illustration and do not represent actual areas. The loading buffer area 111 is used for placing the sample rack 400 to be tested, the unloading buffer area 113 is used for placing the sample rack 400 after the testing is completed, the sample collection container 500 staying in the sample rack 400 of the sample entering area 112 can be moved to the testing device 300 by the sample feeding device 200 for testing, and the sample collection container 500 after the testing is completed can also be moved back to the sample rack 400 of the sample entering area 112. For the above purpose, the size of the loading buffer 111 in the left-right direction is substantially equal to an integral multiple of the width of the sample rack 400 in the direction, so that the loading buffer 111 can accommodate at least one sample rack 400. The unloading buffer area 113 and the sample injection area 112 are similar to each other, and can be used for placing at least one sample rack 400. Taking the example shown in the figure, the sample injection region 112 can be used for placing a sample rack 400, that is, when the sample rack 400 is located at the sample injection position, the sample injection region 112 and the sample rack 400 are overlapped along the sample injection direction. It can be understood that the width of the sample injection region 112 along the sample injection direction may also be slightly wider than the width of the sample holder 400, and when the sample holder 400 is located at the sample injection position, at least one side of the sample injection region 112 extends beyond the sample holder 400 along the sample injection direction.
As a specific implementation of the sample platform 110, the loading buffer 111 can be used to place more than two sample racks 400, specifically, as shown in the figure as an example, the loading buffer 111 includes a loading area 1111 and a first buffer 1112 that are disposed adjacent to each other, the sample rack 400 to be detected can be placed in the loading area 1111 first, the first buffer 1112 is used to buffer the sample rack 400 to be detected, and both of them can be used to place one sample rack 400. The width of the loading region 1111 in the sample injection direction may be larger than the first buffer region 1112, so that an operator can conveniently place the sample rack 400 into the loading region 11110. It is understood that more than two sample racks 400 may be placed in the first buffer area 1112 to increase the buffering capacity.
Similarly, the unloading buffer area 113 can also accommodate more than two sample racks 400, and for example, the unloading buffer area 113 includes an unloading area 1131 and a second buffer area 1132 which are disposed adjacently, the sample rack 400 subjected to the detection can leave the sample platform 110 from the unloading area 1131, and the second buffer area 1132 is used for buffering the sample rack 400 subjected to the detection, and both of them can accommodate one sample rack 400. The width of the second buffer region 1132 in the sample introduction direction may be greater than that of the unloading region 1131. It can be understood that the second buffer 1132 may also place more than two sample racks 400 to increase the buffering capacity.
In one embodiment, the loading buffer 111, the injection buffer 112 and the unloading buffer 113 are sequentially disposed along the injection direction, that is, the three are distributed along a straight line, and accordingly, the driving assembly 120 drives the sample rack 400 to move along the straight line. The sample racks 400 to be tested are continuously placed into the loading buffer area 111 and sequentially pass through the sample inlet area 112, and the tested sample racks 400 are continuously removed from the unloading buffer area 113, so that continuous testing is realized. When the loading buffer area 111 and the unloading buffer area 113 have separate partitions, the loading area 1111, the first buffer area 1112, the sample injection area 112, the second buffer area 1132 and the unloading area 1131 are sequentially arranged along the sample injection direction, the sample rack 400 to be detected is continuously placed into the loading area 1111 and sequentially passes through the first buffer area 1112, the sample injection area 112 and the second buffer area 1132, and the detected sample rack 400 is continuously moved out of the unloading area 1131, so that continuous detection is realized. It can be understood that even when an area is referred to as a "loading buffer" or an "unloading buffer", it does not necessarily mean that there is a partition, and for example, when the unloading buffer 113 can only hold one sample rack 400, it can be considered as having both the unloading function and the buffering function.
In general, the driving stroke of the driving component 120 is fixed, the loading buffer area 111 of the sample platform 110 is firstly placed into one sample rack 400, then the driving component 120 transports the sample rack 400 to the sample injection area 112 (sample injection position), the detecting device 300 performs a detecting operation on the sample rack 400, the second sample rack 400 is placed into the loading buffer area 111 at the same time of or after the detecting operation, after the detecting operation of the first sample rack 400 is completed, the driving component 120 transports the second sample rack 400 to the sample injection area 112, the first sample rack 400 is ejected to the unloading buffer area 113 by the second sample rack 400, the loop can realize the one-by-one detection of the sample racks 400, forming the sequence shown in fig. 1, specifically, two sample racks 400 of the loading buffer area 111 are sample racks to be injected, two sample racks 400 of the unloading buffer area 113 are sample racks after the detecting operation, the sample racks 400 of the sample injection area 112 are sample racks to be detected, it is necessary that the entire sequence moves to the right as a whole after the rightmost specimen rack 400 is removed.
Then, various accidents may occur during actual use, for example, when an operator puts two or more sample racks 400 at the same time, in the case that the driving stroke of the driving assembly 120 is fixed, a part of the sample racks 400 may directly cross the sample injection region 112, resulting in a problem of missing detection, or when the driving assembly 120 stops driving the sample racks 400 during sample injection, the sample racks 400 may remain at unspecified positions of the sample injection stroke due to power failure or equipment shutdown, and after the sample racks 400 are put into a new sample rack 400, the remaining sample racks 400 may also miss detection.
Based on the above, the auxiliary sample introduction device 100 further includes N position sensors 130 and a judgment sensor 140, where N is a positive integer not less than 3, for example, 3, 4, 5, etc., but usually 3 are preferable. The N position sensors 130 are all connected to the sample platform 110 and respectively distributed at N positions, taking the sample rack 400 moving along a linear direction as an example, the position sensors 130 are also sequentially arranged along the linear direction, and on the driving stroke of the driving member 121 of the driving assembly 120, there are corresponding positions corresponding to the installation positions of the position sensors 130, so that when the driving member 121 moves to a corresponding position, the corresponding position sensor 130 can be triggered. It is understood that the term "trigger" herein generally refers to the position sensor 130 being in a specific state, and in the case of a common photoelectric sensor, the term "trigger" refers to the state of the position sensor 130 from the first state to the second state, where the light receiving end can receive the light emitted from the light emitting end as the first state and can not receive the light as the second state.
The judgment sensor 140 is usually connected to the sample introduction region 112 so as to be capable of being triggered by the sample rack 400 moved to the sample introduction position, and it should be noted that the term "triggering" herein does not only mean that the judgment sensor 140 is in a specific state, but can be regarded as being triggered as long as the judgment sensor 140 has a state change, and similarly, taking the photoelectric sensor as an example, the term triggering does not refer to the sensor from the first state to the second state, and can be regarded as triggering of the judgment sensor 140 regardless of whether the sensor is switched from the first state to the second state or from the second state to the first state.
When only two position sensors 130 are provided, only the stroke start point and the stroke end point can be determined, and if the driver 121 is controlled by only two position sensors 130, the driving stroke of the driver 121 is necessarily fixed, which easily leads to the above-described case of missing detection. One solution is to add a camera or a grating scale to identify whether there are multiple sample racks or left sample racks, and identify the specific positions of the multiple sample racks or left sample racks, and then add a new control to the driving element 121, for example, precisely control the moving distance of the driving element 121 through a stepping motor and a lead screw, so that the driving element 121 can move flexibly, and in combination with the above, the problem of missing detection can be solved, but obviously, the above would greatly increase the control difficulty and control cost, in this embodiment, more than three position sensors 130 are provided, the driving element 121 moves step by step through sequential triggering of each position sensor 130, and meanwhile, in combination with the triggering state and state change of the judgment sensor 140, an external controller can control the driving element 121 to stop driving after the required number of steps of advancing along the sample introduction direction, so as to avoid the driving member 121 from directly reaching the end of the travel and causing part of the sample rack 400 to cross the sample inlet area 112, thereby improving the problem of missing detection of the sample rack 400. It should be noted that the term "step-by-step movement" in the present application only represents that there are multiple determination points in the movement process of the driving member 121 or the sample rack 400, and the driving member 121 receives the control of the controller when moving to the determination points, rather than representing that the movement stroke of the driving member 121 is intermittent, for example, when used as normal, the driving member 121 can certainly drive the sample rack 400 to move from the loading buffer area 111 to the sample injection area 112 without stopping.
It is understood that when referring to "a triggers B" or "B is triggered by a" in this application, B may be triggered by a directly or indirectly through another member connected to a and moving synchronously. The triggering mode can be contact type, such as a travel switch needing to be triggered by physical contact, or non-contact type, such as a photoelectric sensor, a magnetic induction sensor and the like.
In this embodiment, as a specific determination manner of the number of the position sensors 130, the number N of the position sensors 130 is related to the number M of the largest sample racks 400 that can be accommodated in the unloading buffer 113, and the following relationship is satisfied: n ═ M + 1. The number of position sensors 130 also determines the number of steps C of the actuator 121 and satisfies the following relationship: n +1, that is, the number of steps C of the driving member 121 is equal to the maximum accommodating amount M of the unloading buffer 113, because most of the cases the operator will put the sample rack 400 into the unloading buffer 113, and therefore the maximum accommodating amount M of the unloading buffer 113 determines the maximum amount that the operator can put in at a time, and considering the extreme case that the operator puts in M sample racks 400 at a time, the same number of steps is required to avoid the missing detection problem.
Based on the above, in a further improved embodiment, at least a part of the distance between the adjacent position sensors 130 is equal to the width of the sample rack 400 along the sample injection direction, that is, the distance of each step of the driving member 121 is equal to the above width, it can be understood that the distance of each step of the driving member 121 is only calculated to calculate the movement of the sample rack 400 driven by the driving member 121 along the sample injection direction, and does not include the movement except the synchronous movement with the sample rack 400, taking fig. 5 as an example, three position sensors 130 are provided, which are sequentially labeled as the first position sensor 131, the second position sensor 132 and the third position sensor 133 along the left-to-right direction, and at this time, the sample rack 400 is placed in the loading area 1111, and the driving member 121 is located at the starting point of the stroke and does not contact with the sample rack 400. The distance D2 between the second position sensor 132 and the third position sensor 133 is equal to the width of the sample rack 400, i.e. the distance of one step of the driver 121, and the distance D between the first position sensor 131 and the second position sensor 1321Is significantly greater than the distance D2That is, the driver 121 is shown from the figureThe position shown is initially moved a distance before contacting the sample holder 400, and only after contacting, the distance that the two synchronously move to the second position sensor 132 is considered as the distance that the driving member 121 moves in a single step, i.e., the distance D1Is equal to distance D2The sum of the distances traveled by the actuators 121 alone. The above arrangement may enable the driving member 121 to be offset from the loading position of the sample rack 400 when the driving member is located at the initial position, so as to avoid the sample rack 400 from contacting the sample rack 400 when the sample rack 400 is loaded.
As a modification of the first embodiment, referring to fig. 5, in N position sensors 130, one of the position sensors corresponds to the starting point of the stroke of the driving member 121, and the other corresponds to the ending point of the stroke of the driving member 121, specifically, the first position sensor 131 corresponds to the starting point of the stroke of the driving member 121, and the third position sensor 133 corresponds to the ending point of the stroke of the driving member 121, that is, in a normal use scenario, when the driving member 121 moves to the ending point of the stroke, the third position sensor 133 can be triggered, the driving member 121 stops moving, and the sample rack 400 driven by the driving member stops at the sample injection position. It will be appreciated that the start and end of travel of the actuator 121 may also be controlled by separate sensors, for example, by adding a new sensor to the left of the first position sensor 131 to locate the start of travel and a new sensor to the right of the third position sensor 133 to locate the end of travel, it is apparent that the start and end of travel of the actuator 121 may be reduced by the position sensors, reducing sensor usage.
As an improvement of the first embodiment, referring to fig. 1, fig. 2 and fig. 5, the auxiliary sample injection device 100 further includes an unloading detection sensor 150, the unloading detection sensor 150 is connected to the unloading buffer area 113 of the sample platform 110, and when a sample rack 400 enters the unloading buffer area 113, the unloading detection sensor 150 can be triggered by the sample rack 400, so as to remind an operator to take out the sample rack 400 that has been detected through the warning device. When there is a partition in the unloading buffer area 113, the unloading detection sensor 150 is located in the unloading area 1131, that is, only when there is a sample rack 400 in the unloading area 1131, the unloading detection sensor 150 prompts the operator to perform the fetching operation, so that the second buffer area 1132 can perform the buffering function.
As a specific implementation manner of the driving assembly in the first embodiment, it may be a manipulator or a finger, and both the manipulator and the finger need to perform a disengaging operation to leave the sample injection track of the sample rack 400 before performing a resetting operation, for example, the manipulator needs to move up to a position higher than the sample rack 400 after releasing the sample rack 400, and then horizontally reset, and the disengaging operation needs to consume additional time, and needs to be driven by a mating disengaging device, which increases the structural complexity of the whole driving device. Based on this, the embodiment further provides another implementation manner of the driving assembly 120, which includes the first power element 123 and the first connecting element 124, the first power element 123 drives the first connecting element 124 and the driving element 121 to move integrally, and the first connecting element 124 and the driving element 121 cooperate together, so that the sample rack 400 can be pushed to move along the sample injection direction, and cannot interfere with the subsequent sample rack 400 during the reverse reset, which is helpful for improving the efficiency.
Referring to fig. 6 and 7, the driving member 121 is connected to the first connecting member 124 through the rotating shaft 125, based on the above-mentioned connection structure, the driving member 121 can rotate relative to the first connecting member 124, the first connecting member 124 has a limiting portion 1241, and the limiting portion 1241 is used for limiting a rotation angle of the driving member 121 along a single direction. Specifically, it is noted that the counterclockwise direction in fig. 7 is a first direction, the clockwise direction is a second direction, the limiting portion 1241 is located at the front side of the driving member 121 along the sampling direction, the driving member 121 is located entirely below the sample rack 400, when the driving member 121 rotates along the first direction to the set posture shown in fig. 7, the limiting portion 1241 can block the driving member 121 for limiting, so that the driving member 121 is kept at the set posture, and the top end of the driving member 121 is higher than the bottom surface of the sample rack 400, so as to contact with the bottom of the left sidewall of the sample rack 400 to push the sample rack 400. On the other hand, when the driving member 121 is reset in the reverse direction of the sampling direction, the driving member 121 can abut against the sample rack 400 and rotate to the reset posture that the top end is lower than the bottom surface of the sample rack 400 in the second direction, at this time, the driving member 121 can pass under the sample rack 400 to avoid the sample rack 400, and the interference between the driving member 121 and the subsequent sample rack 400 during the reset is avoided, so that the driving member 121 does not need to perform an additional disengaging action first, thereby being beneficial to reducing the reset time and simplifying the structure of the driving assembly.
The first power member 123 can directly drive the first connecting member 124 and the driving member 121 to move, or can be driven by a transmission mechanism. Referring to fig. 8, the first power member 123 is a motor with a rotating shaft, the transmission mechanism includes a synchronous belt 126 and a synchronous wheel 127, the motor drives the synchronous wheel 127 to rotate, the synchronous belt 126 is wound on the synchronous wheel 127 and is parallel to the sample introduction direction, the first connecting member 124 is connected with the synchronous belt 126, the first connecting member 124 can move along the sample introduction direction and the opposite direction along with the driving of the motor, the response speed of the synchronous belt transmission mechanism is fast, and the requirements of fast moving the sample holder 400 and fast resetting can be met. It can be understood that the transmission mechanism may further include a screw rod and a screw nut, the screw rod is connected to the rotating shaft and parallel to the sample introduction direction, the first connecting member 124 is connected to the screw nut, and the screw rod and the screw nut are matched to have a high precision, so that the sample holder 400 can be accurately stopped at a desired position.
Referring to fig. 7, as a specific implementation manner of the driving member 121 in the above embodiment, the driving member 121 includes a driving portion 1211, a weight portion 1212 and a first rotating connection portion 1213, the driving portion 1211 is configured to directly contact with the sample rack 400, and when the driving member 121 rotates in the second direction and the driving member 121 is disengaged from the sample rack 400, the weight portion 1212 can drive the driving member 121 to return to the set posture under the action of gravity.
The first rotating connection portion 1213 has a rotating shaft hole, the rotating shaft 125 is disposed in the rotating shaft hole, and since the driving member 121 needs to be reset by gravity, the counterweight portion 1212 is connected below the driving portion 1211 through the first rotating connection portion 1213, and the center of gravity of the driving member 121 is lower than the center of the rotating shaft hole, so that the driving portion 1211 can maintain the posture of the driving portion 1211 when the driving member 121 is not abutted to the sample rack 400, and the driving portion 1211 is extended from the bottom of the sample rack 400 to push the sample rack 400. It can be understood that the driving portion 1211, the weight portion 1212 and the first rotation connecting portion 1213 may be separate structures or may be integrally connected as shown in the drawing, and in the latter case, the boundaries of the driving portion 1211, the weight portion 1212 and the first rotation connecting portion 1213 may be determined substantially according to the functions.
As an alternative to the above embodiment, the driving component may further include a torsion spring, and the driving component 121 is connected to the first connecting component 124 through the torsion spring, for example, sleeved on the rotating shaft 125. After the driving member 121 rotates in the second direction, the torsion spring can drive the driving member 121 to return to the set posture. The torsion spring can cooperate with the weight portion 1212 to reset the driving member 121, and can also replace the weight portion 1212 to reset the driving member 121, so as to adapt to the situation that the driving member 121 is located laterally on the sample rack 400.
Referring to fig. 1 and 2, in order to cooperate with the driving element 121 of the above embodiment, the supporting portion 114 has a through hole 1141, and the through hole 1141 extends along the sample injection direction. When the actuator 121 is in the set posture, the driving portion 1211 passes through the through hole 1141 and extends above the supporting portion 114. When the driving member 121 is reset in the reverse direction, the driving portion 1211 can be abutted by the sample rack 400 and rotated into the through hole 1141. In this embodiment, the driving assembly, except for the driving portion 1211, is located in the mounting cavity, so that the hidden mounting of the mechanism can be realized, and the integration level of the sample rack driving device can be improved.
One end of the through hole 1141 extends to the loading region 1111 and the other end extends to at least the sample injection region 112, so that the stroke of the driving member 121 sliding in the through hole 1141 can at least cover the stroke of the sample rack 400 moving from the loading region 1111 to the sample injection region 112. For example, the left end of the through hole 1141 extends to the left end of the loading region 1111, and the right end of the through hole 1141 extends into the sample injection region 112. Based on the above structure, the driving element 121 drives the first sample rack 400 to move to the sample injection region 112 and then reset, the first sample rack 400 performs the detection operation, after the detection of the first sample rack 400 is completed, the driving element 121 drives the second sample rack 400 to move to the sample injection region 112 and pushes the first sample rack 400 to enter the second buffer region 1132, so that the continuous sample injection can be realized by reciprocating, the length of a single pass of the driving element 121 can be reduced, and the sample injection efficiency is improved. It can be understood that the right end of the through hole 1141 can also pass through the sample injection region 1132 and extend into the second buffer region 1133 or the unloading region 1131, that is, the driving member 121 can move the sample rack 400 to the second buffer region 1133 or the unloading region 1131 furthest away.
The driving assembly 120 further includes a first triggering member 122 moving synchronously with the driving member 121, and the position sensor 130 is a photoelectric sensor. Specifically, the first triggering member 122 may be a triggering sheet integrally formed with the first connecting member 124 through a sheet metal process, and when the driving member 121 moves along the sample injection direction, the first triggering member 122 passes through between the light emitting end and the light receiving end of each position sensor 130 one by one, so as to trigger each position sensor 130.
As a specific implementation manner of triggering the determination sensor 140 by the sample rack 400 in the first embodiment, referring to fig. 9, the auxiliary sample introduction device 100 further includes a second trigger 160, the determination sensor 140 and the second trigger 160 are both directly or indirectly mounted to the sample platform 110, the determination sensor 140 is fixedly connected to the sample platform 110, the second trigger 160 is connected to the sample platform 110 through a rotating shaft, when the sample rack 400 does not act on the second trigger 160, the second trigger 160 is maintained at an initial posture (as shown in fig. 5, which is denoted as a first posture for convenience of description), and at this time, the determination sensor 140 is also in an initial state (i.e., the second state); when the specimen rack 400 moves to the set position, the posture of the second trigger 160 changes (as shown in fig. 9, for convenience of description, the posture is referred to as the second posture), and it is determined that the sensor 140 is switched to another trigger state (i.e., the first state).
As an implementation manner of the second trigger 160, referring to fig. 9, the second trigger 160 includes a first trigger 161 and a second trigger 162, the first trigger 161 is used for changing a trigger state of the determination sensor 140, and the second trigger 162 is used for cooperating with the sample rack 400, so as to drive the second trigger 160 to rotate integrally. It can be understood that the first trigger part 161 and the second trigger part 162 may be two separate members fixedly connected to each other, or may be two parts of one member. For example, the first trigger part 161 and the second trigger part 162 are formed by bending sheet metal parts, and the second trigger part 162 has a protrusion facing the sample holder 400 for achieving smooth contact between the second trigger part 160 and the sample holder 400.
In addition, the second trigger 160 may further include a second rotation connection part 163, a rotation shaft hole not shown is formed on the second rotation connection part 163, and the second trigger 160 is rotatably connected to the sample platform 110 through the second rotation connection part 163 and the rotation shaft. Taking the figure as an example, the first trigger part 161, the second trigger part 162 and the second rotation connecting part 163 are connected into a whole, the second trigger part 162 extends to the upper side of the second rotation connecting part 163, and the first trigger part 161 extends to the lower side of the second rotation connecting part 163, so that the second trigger part 160 can be maintained or reset to the first posture under the action of gravity when not contacting with the sample rack 400 or being separated from the sample rack 400.
It can be understood that the second trigger member 160 can also provide the power for resetting through an elastic member such as a torsion spring, etc., in which case the second trigger member 160 is not limited to the illustrated shape and installation position, for example, the second trigger member 160 can contact with the front side or the rear side of the sample rack 400, and the triggering function can also be realized, in which case the resetting of the second trigger member 160 is realized through a torsion spring.
Based on the structure, the invention also discloses an adaptive sample rack, and referring to fig. 9 and 10, the bottom of the sample rack 400 is sequentially provided with a first flange 410, a second flange 420 and a third flange 430 along the direction from right to left, a first gap 440 is formed between the first flange 410 and the second flange 420, and a second gap 450 is formed between the second flange 420 and the third flange 430. When the sample rack 400 moves from left to right, the first flange 410 first contacts the second trigger 162, and the second trigger 162 can sequentially perform the following actions with further movement of the sample rack 400:
first flange 410 presses second trigger 162, second trigger 162 is pressed to the lowest position (shown in fig. 9), it is determined that sensor 140 has switched from the second state to the first state,
the second triggering part 162 enters the first gap 440, the second triggering part 160 resets under the action of gravity, and the sensor 140 is judged to be switched from the first state to the second state;
third, the second flange 420 presses the second trigger 162 to determine that the sensor 140 is switched from the second state to the first state;
the second trigger 162 enters the second gap 450, the second trigger 160 resets under the action of gravity, and the determination sensor 140 is switched from the first state to the second state.
The third flange 430 presses the second trigger 162, and the determination sensor 140 is switched from the second state to the first state.
Sixthly, the sample holder 400 is separated from the second triggering part 162, the second triggering part 160 is reset under the action of gravity, and the judgment sensor 140 is switched from the first state to the second state.
Based on the above, when one sample rack 400 finishes passing through the second trigger 160, a series of state switching may occur. The controller of the detection device may select any state as a basis for controlling the driving member 121 to stop, for example, the first state of the determination sensor 140 may be selected as a basis for determining, in this case, it may be further subdivided, for example, when the second flange 420 presses the second trigger 162 as a time when the driving member 121 stops driving, it is necessary to satisfy that the determination sensor 140 undergoes the second state-the first state-the second state-the first state, and when the determination sensor 140 is finally in the first state, the controller controls the driving member 121 to stop moving, and the other subdivision conditions may be analogized accordingly. Similarly, it can be determined that the sensor 140 has just entered the second state as the basis for the determination, for example, when the second flange 420 has just separated from the second trigger 162 as the time when the driving member 121 stops driving, it is necessary to determine that the sensor 140 has gone through the second state-the first state-the second state, and when the sensor 140 is finally determined to be in the second state, the controller controls the driving member 121 to stop moving.
If the sensor 140 is just entering the second state as the basis for determination, the second trigger 160 needs a certain time to reset, so the sample holder 400 will continue to move rightward for a short distance before stopping, and if the reset time is too long, the moving distance will be correspondingly increased, thereby affecting the positioning accuracy. Based on this, in the present embodiment, the driving assembly 120 stops working when the sensor 140 is determined to be in the first state, so that the response speed can be increased, and the positioning accuracy can be improved.
It is understood that a plurality of flanges may be provided between the first flange 410 and the third flange 430, and the determination manner may be adjusted accordingly, as occasion demands. No additional flange may be provided between the first flange 410 and the third flange 430, and when one sample rack 400 is completely warped by the second triggering member 160, the above-mentioned actions (c) and (d) occur in sequence, and the judgment may be adjusted accordingly.
It can be understood that the corresponding relationship between the posture of the second trigger 160 and the state of the determination sensor 140 is not limited to the above, for example, the determination sensor 140 may be disposed on the left side of the second trigger 160 in fig. 9, the second trigger 160 shields the light receiving end of the determination sensor 140 after rotating from the first posture to the second posture, so that the determination sensor 140 is switched from the first state to the second state, and the determination sensor 140 is correspondingly switched from the second state to the first state after the second trigger 160 is reset from the second posture to the first posture.
As a modification of the sample platform 110 in the first embodiment, referring to fig. 11, the sample platform 110 includes a supporting portion 114, at least one fool-proof portion 116, and at least one position-limiting portion 115, and a sample rack 400 on which a sample collection container 500 (e.g., a gas collection card) is placed can be placed on the supporting portion 114 and can move relative to the sample platform 110 according to a set posture, for example, as shown in the figure, under the constraint of the fool-proof portion 116.
The supporting portion 114 is provided with at least one limiting portion 115 and at least one fool-proof portion 116, the limiting portion 115 and the fool-proof portion 116 both extend along the sample introduction direction of the sample rack 400, the limiting portion 115 can limit the movement of the sample rack 400 in the horizontal direction, so that the sample rack 400 can move along the sample introduction direction without being inclined, and it can be understood that the term "limiting movement" herein only means that the limiting portion 115 has the functions of limiting and guiding the sample rack 400, and does not mean that the sample rack 400 must contact with the limiting portion 115 when actually moving, for example, if the loading position of the sample rack 400 is proper and does not deviate from the correct track when moving, the limiting portion 115 may not contact with the sample rack 400 at this time, so as to reduce the friction force during the movement of the sample rack 400; when the sample rack 400 deviates from the correct loading position (the deviation distance is within the allowable range) during loading or deviates from the correct track (the deviation distance is within the allowable range) during moving, the limiting part 115 can contact with the sample rack 400, and further deviation of the sample rack 400 is prevented. Of course, the stopper 115 may be in full contact with the sample holder 400 to achieve full guidance.
The position-limiting portion 115 may be a whole continuous structure, such as a plate-shaped structure, a rib, a bump, etc., or may include a plurality of position-limiting elements, such as a plurality of position-limiting bosses, etc., disposed along the sample injection direction. Taking the example shown in the figure, the limiting portion 115 is a limiting plate and is disposed on a side of the supporting portion 114 parallel to the sample injection direction. In order to realize the two-side limitation, the two side edges of the supporting portion 114 are provided with the limiting portions 115, and the distance between the two side limiting portions 115 is slightly larger than the width of the sample rack 400 in the direction, so that when the sample rack 400 is not deviated, the two side limiting portions 115 do not contact with the sample rack 400, and when the sample rack 400 is deviated by a certain distance, the limiting portions 115 in the deviation direction can prevent the sample rack 400 from further deviating.
The fool-proof portion 116 is used to cooperate with the sample rack 400, so that the sample rack 400 can move along the sample feeding direction only when being placed on the supporting portion 100 according to the set posture (the posture shown in fig. 11), thereby achieving the fool-proof purpose, and likewise, the fool-proof portion 116 does not need to be in contact with the sample rack 400 at any time, and generally, when the sample rack 400 moves in other postures, the fool-proof portion 116 abuts against the sample rack 400 to achieve the fool-proof, and when the sample rack 400 moves in the set posture, the fool-proof portion 116 can be completely separated from the sample rack 400.
Similar to the position-limiting portion 115, the fool-proof portion 116 may be a whole continuous structure, such as a plate-mounted structure, a rib, a bump, etc., or may include a plurality of fool-proof elements arranged along the sample injection direction. Taking the example shown in fig. 12 as an example, the fool-proof portion 116 is fool-proof and is provided with the upper edges of the limiting portions 115, in this embodiment, the fool-proof portions 116 are provided on the upper edges of the two limiting portions 115, and the two fool-proof portions 116 are asymmetrically arranged. In general, the supporting portion 114 is disposed along a horizontal direction, and the limiting portion 115 extends along a vertical upward direction to define a cavity 117 together with the supporting portion 114. The fool-proof portion 116 of the rear stopper 115 protrudes forward, the fool-proof portion 116 of the front stopper 115 protrudes rearward, and the protruding distance of the rear fool-proof portion 116 is longer than the protruding distance of the front fool-proof portion 116.
As shown in fig. 13, the sample holder 400 suitable for the sample platform 110 of this embodiment includes a main body 460 substantially shaped like a rectangular parallelepiped, a plurality of parallel slots are disposed inside the main body 460, the slots of this embodiment are suitable for placing the air collecting card, the plurality of slots inside the main body 460 can be used for placing a plurality of air collecting cards, and one arrangement manner of the slots is: the length direction of the slots is parallel to the width direction (e.g., left and right direction in fig. 10) of the main body 460, the width direction is parallel to the length direction (e.g., front and back direction in fig. 4) of the main body 460, and the slots are sequentially arranged and aligned along the length direction of the main body, when the sample platform 110 is applied to an automatic detection device, the sample introduction device 200 on the detection device can perform sample introduction of the gas collection card one by one only by moving along the height direction and the length direction of the main body 460, thereby simplifying the structure and control of the sample introduction device.
At least one side of the sample rack 400 is provided with a fool-proof structure matched with the fool-proof part 116, when the sample rack 400 is placed on the sample platform 110, the sample rack can be placed to move relative to the sample platform 110 according to a set posture through the cooperation of the fool-proof part 116 and the fool-proof structure, so that the sample rack 400 can perform actions such as sample introduction and sample withdrawal of the gas collection card through the movement relative to the sample platform 110, and meanwhile, the gas collection card can participate in detection according to a required posture, and the gas collection card is prevented from being reversely put. To achieve the above object, the sample rack 400 of the present embodiment has two fool-proof structures, which are a first groove disposed on one side of the sample rack 400 and a second groove disposed on the other opposite side of the sample rack 400, and the first groove and the second groove are disposed along the side to the other sideThe maximum upward extension distances are unequal, thereby forming an asymmetric structure on opposite sides of the sample holder 400. Specifically, referring to fig. 13, a first boss 470 extends from one side (e.g., a rear side) of the main body 460, and a first recess 461 is defined between the first boss 470 and the main body 460. A second boss 480 extends from the other side (e.g., front side) of the main body 460, an outer slot 4621 defining a second slot 462 is disposed between the second boss 480 and the main body 460, an inner slot 4622 of the second slot 462 is further disposed inside the main body 460, the inner slot 4622 is communicated with the bottom of the outer slot 4621, and the maximum extension distance of the first slot 461 along the side-to-side direction is L1Let L denote the maximum extension distance of the second groove 462 in the left-right direction2Then the following relationship exists between the first recess 461 and the second recess 462: l is1<L2Thus, the first recess 461 and the second recess 462 are asymmetrically disposed on opposite sides of the sample platform.
Referring to fig. 14 and 15, the distance between the two position-limiting portions 115 is slightly greater than the maximum distance between the first protrusion 470 and the second protrusion 480, and the length of the front fool-proof portion 116 is greater than the maximum extending distance L of the first recess 4611Substantially equal to or slightly less than the maximum extension L of the second recess 4622Thus, when the sample platform is placed on the sample platform 110 according to the posture shown in fig. 11, the left fool-proof portion 116 can extend into the inner section 4622 of the second groove 462, the right fool-proof portion 116 can extend into the first groove 461, and the bottom of the sample holder 400 (including the first boss 470, the second boss 480 and the main body 460 connected to the first boss 470 and the second boss 480) is located in the cavity 117, so that the sample holder 400 can slide relative to the sample platform 110, and the fool-proof portions 116 on both sides can also limit the displacement of the sample holder 400 along the up-down direction. If the sample rack 400 is placed upside down, the fool-proof portion 116 on the left side cannot extend into the first recess 461, and the sample rack 400 cannot be placed on the sample platform 110 in a set posture and moves relative to the sample platform 110, so that the fool-proof purpose is achieved. In addition, as can be seen from fig. 14 and 15, when the sample rack 400 is placed in the set posture and is not deviated from the correct position, the stopper and the fool-proof portion are not required to be connected to the sample rack 400Contact, thereby enabling the sample holder 400 to smoothly slide.
As a specific implementation manner of the above-mentioned limiting portion 115 and the fool-proof portion 116, both ends of the fool-proof portion 116 are both exceeded by the limiting portion 115 along the sample injection direction, wherein when there is no partition between the loading buffer area 111 and the unloading buffer area 113, the limiting portion 115 extends from the loading buffer area 111 to the unloading buffer area 113 to provide a whole limiting and guiding function, and the fool-proof portion 116 is only disposed in the sample injection area 112, so that an operator is not hindered to place the sample rack 400 in the loading buffer area 111 and take it out of the unloading buffer area 113, and the sample rack 400 is prevented from entering the sample injection area 112 in an incorrect posture. Referring to fig. 11, when the loading buffer 111 and the unloading buffer 113 are partitioned, the limiting portion 115 extends from the loading region 1111 to the unloading region 1131 to provide a full limiting and guiding function, and the fool-proof portion 116 extends from the first buffer 1112 to the second buffer 1132 only, so that an operator can only put in the sample rack 400 from the loading region 1111, and the width of the loading region 1111 only allows to place one sample rack 400, thereby avoiding the situation that the operator puts in more than two sample racks 400 from the top at the same time, and of course, the operator may put in one sample rack 400 from the loading region 1111 and manually drive it to move towards the sample introduction region 112 before putting in a new sample rack 400, which results in the situation that more than two sample racks 400 to be detected exist at the same time, and therefore it is still necessary to control through the cooperation between the position sensor 130 and the judgment sensor 140.
In the above embodiment, the limiting portion 115, the fool-proof portion 116 and the supporting portion 114 are integrally formed, the limiting portion 115 is located on the side of the supporting portion 114, and the fool-proof portion 116 is located on the upper edge of the limiting portion 115, that is, the sample platform 110 of the embodiment can be integrally formed by bending a sheet metal part, and is easy to process. In other embodiments, the position-limiting portion 115, the fool-proof portion 116 and the supporting portion 114 may be separate structures.
It can be understood that there are other alternative embodiments for the arrangement of the position-limiting portion 115 and the fool-proof portion 116, for example, the heights of the two fool-proof portions 120 relative to the supporting portion 110 are different, that is, the height difference of the two fool-proof portions 120 is used to realize an asymmetric arrangement, rather than the difference of the extending distances, on this basis, the extending distances of the two fool-proof portions 120 may be the same or different.
As a modification of the first embodiment, referring to fig. 1, fig. 2 and fig. 16, the auxiliary sample introduction device 100 further includes a clamping assembly 170 disposed at the sample introduction region 112, wherein the clamping assembly 170 is used for clamping the sample rack 400 located at the sample introduction position, so as to facilitate the sample introduction device 200 to perform sample introduction on the sample collection container 500. In one embodiment, the clamping assembly 170 includes a positioning member 171, a pressing member 172 and a second power member 173, and the positioning member 171 and the pressing member 172 are respectively connected to two sides of the sample rack 400 and can cooperate with each other to clamp the sample rack 400. The pressing member 172 can be driven by the second power member 173 to move, so that the distance between the pressing member and the positioning member 171 can be adjusted, and the clamping state and the limiting state can be switched.
Taking the example shown in the figure, the positioning member 171 is connected to one side of the sample platform 110, such as the front side shown in the figure, and the pressing member 172 is connected to the other side, such as the rear side shown in the figure, opposite to the sample platform 110 along the sample injection direction. The pressing member 172 can move in a horizontal direction (e.g., a front-to-back direction in the figure) perpendicular to the sample injection direction under the driving of the second power member 173, and when the pressing member 172 is in the initial state, the initial distance between the pressing member 172 and the positioning member 171 is smaller than the minimum length of the sample rack 400 in the horizontal direction, so that the sample rack 400 will be blocked by the pressing member 172 and cannot enter the sample injection position; when the second power member 173 drives the crimp member 172 to move along the second horizontal direction, so that the distance between the crimp member 172 and the positioning member 171 along the second horizontal direction is not less than the maximum length of the sample rack 400 in the second horizontal direction, the sample rack 400 can move to the sample injection position without being obstructed; when the second power member 173 drives the pressing member 172 to move reversely until the pressing member 172 presses the sample rack 400, the pressing member 172 can cooperate with the positioning member 171 to clamp the sample rack 400, so as to fix the sample rack 400 at the sample injection position. In addition, if the sample holder 400 is skewed during movement, the clamp 172 can also correct the posture of the sample holder 400 during clamping.
It is understood that the positioning member 171 may be a separate structure or may be integrally formed on the sample platform 110. In this embodiment, the positioning member 171 is detachably connected to the sample platform 110 by a screw fastener, and the upper portion of the positioning member extends out of the bearing plane of the sample platform 110. On the other side, the pressing member 172 is also detachably connected to the sample platform 110 by a threaded fastener, the pressing member 172 is opposite to the positioning member 171 and extends out of the bearing plane, and the height of the pressing member 172 is substantially equal to the height of the positioning member 171.
The second power member 173 may be a power member having a telescopic shaft, such as an electric cylinder, or a power member having a rotary shaft, such as a motor, which converts the rotation of the rotary shaft into the linear movement of the crimping member 172 through a transmission mechanism.
The sample holder 400 may be tilted during the movement, so that the crimping piece 172 contacts with the surface part of the sample holder 400, and the crimping effect is affected. To solve the above problem, referring to fig. 16, as a modification of the clamping assembly 170, the clamping device further includes a bracket 174, a second connecting member 175, and an elastic member 176. Wherein the crimp member 172 is movably connected to the bracket 174 via the second connection member 175, and the crimp member 172 is configured to be abutted by the sample holder 400 and deflected when contacting the sample holder 400. It is to be understood that "deflection" as referred to herein includes at least one of the following: the crimping member 172 can rotate about the X axis (the X axis is parallel to the left-right direction in fig. 2); ② the crimping piece 172 can be rotated about the Z-axis (the Z-axis is parallel to the up-down direction in FIG. 2). In this embodiment, since the pressing member 172 is movably connected to the bracket 174, even if the contact surface of the sample holder 400 has a certain deflection relative to the pressing member 172, the deflection of the pressing member 172 can be compensated, so that the pressing member 172 can be kept in good contact with the sample holder 400, and the pressing member 172 can be conveniently pressed against the sample holder 400.
The elastic member 176 is located between the crimp member 172 and the bracket 174, and is used to apply a force to the crimp member 172 to abut the crimp member 172 against the sample holder 400, so that the crimp member 172 is held in close contact with the sample holder 400, and the crimp member 172 can be driven to return after the crimp member 172 is separated from the sample holder 400. The elastic member 176 may be a spring or a leaf spring, and both ends thereof may be respectively abutted against the pressing member 172 and the bracket 174, or may be respectively fixedly connected to the pressing member 172 and the bracket 174 by a member such as a fastener.
Based on the above structure, the clamping assembly 170 further includes a base 177 and a transmission mechanism, the second power member 173 is connected to the base, and the pressing member 172 is driven to move by the transmission mechanism, specifically, the second power member 173 may be a device having a rotation shaft, such as a motor, and the transmission mechanism may be a transmission device including a driving wheel, a driven wheel and a synchronous belt.
As a specific implementation manner of the second connecting member 175 in the above embodiment, the second connecting member 175 is a connecting shaft, one end (e.g., a rear end) of the connecting shaft is fixedly connected to the bracket 174, and the other end (e.g., a front end) of the connecting shaft extends away from the bracket 174. The crimp member 172 has a mounting hole, not shown, extending in the extension direction of the connecting shaft, and an opening is formed at least on the side of the crimp member 172 facing the bracket 174, through which the connecting shaft can extend into the mounting hole for carrying the crimp member 172. The mounting hole is larger than the connecting shaft so that the crimp member 172 can deflect relative to the connecting shaft.
Referring to fig. 1, the embodiment of the present invention further discloses a detection apparatus, which includes a sample injection device 200, a detection device 300, a controller (not shown) and the auxiliary sample injection devices of the above embodiments, wherein the sample injection device 200 is configured to obtain a sample collection container 500 in a sample rack 400 when the sample rack 400 moves to a sample injection position relative to a sample platform 110, and transfer the sample collection container 500 to the detection device 300, the detection device 300 is capable of detecting a sample in the sample collection container 500, the sample injection device 200 is further capable of transferring the sample collection container 500 to the sample rack 400 after the detection is completed, and the controller is capable of controlling the driving assembly 120 and/or the sample injection device 200 to perform corresponding actions according to signals obtained by sensors in the auxiliary sample injection device 100 and the sample injection device 200.
The detection device 300 may be a device for performing breath detection, and for example, includes a dark room 310 and a photomultiplier tube 320, the dark room 310 forming a dark environment required for detection, and the photomultiplier tube 320 being used for detecting the sample in the sample collection container 500. Because a plurality of sample collection containers 500 can be placed in one sample rack 400, and the detection of a single sample collection container generally requires a long time, in order to improve the detection capability of the detection device, a plurality of detection devices 300 are provided in this embodiment, a plurality of detection devices 300 can work independently to detect different samples individually, and the sample introduction device 200 is used for moving out the sample after the detection from the corresponding detection device 300, or sending the sample to be detected into the corresponding detection device 300.
As shown in fig. 17, the detecting device 300 includes a dark chamber 310, the dark chamber 310 is used for placing a sample to be detected, and as shown in the figure, the dark chamber 310 may be a substantially rectangular box structure, and a dark chamber cavity is provided in the dark chamber 310, and the sample can be placed in the dark chamber cavity for detection. The dark room 310 further has an opening 311 for allowing a sample to enter and exit the dark room cavity, the shape of the opening 311 is similar to the shape of the sample collection container 500 and is slightly larger than the sample collection container 500, so as to facilitate the entry and exit of the sample collection container 500, specifically, the opening 311 is a rectangular opening of a corresponding shape, the dimension in the length direction (front-back direction in fig. 17) is larger than the dimension in the width direction of the sample collection container 500, and the dimension in the width direction (left-right direction in fig. 17) of the opening 311 is larger than the dimension in the thickness direction of the sample collection container 500, so that the sample collection container 500 can pass through the opening 311 without being obstructed.
The sample introduction device 200 comprises a sampling mechanism 210 for taking and placing the sample collection container 500 from the darkroom cavity, the sampling mechanism 210 can be a sampling device with a clamping function, specifically, the sampling mechanism 210 comprises a clamping jaw, and two clamping jaws are driven by a power member (such as a finger air cylinder) to clamp or release the sample collection container 500. It is understood that the sampling mechanism 210 may be a sampling device having a suction function, such as the sampling mechanism 210 having a vacuum chuck, and specifically, the sampling mechanism 210 may include a base plate disposed in a vertical direction, and at least one vacuum chuck (the number of which may be adjusted according to the weight and the adsorbable surface of the sample collection container) is fixed to a side surface of the base plate, and the vacuum chuck is used for sucking the sample collection container 500 from a side direction of the sample collection container 500. The sampling mechanism 210 may also be a sampling device with an electromagnet, and accordingly, the sample collection container 500 is made of ferromagnetic material, or at least has a ferromagnetic adsorption member, and the electromagnet adsorbs the sample collection container 500 when it is powered on and releases the sample collection container 500 when it is powered off. Specifically, the sampling mechanism 210 may include a base plate disposed in a vertical direction, and an electromagnet is fixed to a side of the base plate, and the electromagnet is used to attract the sampling mechanism 210 from a side direction of the sample collection container 500.
According to the difference of the relative position relationship between the detecting device 300 and the sample collecting container 500 to be detected, the sampling mechanism 210 can drive the sample collecting container to move in one or more of the combination of vertical movement, horizontal movement and rotation, wherein the vertical movement is generally used for moving the sample collecting container 500 into and out of the detecting device 300, the horizontal movement is generally used for switching the sample collecting container 500 between different positions, and the rotation is generally used for posture adjustment of the sample collecting container 500. Taking the example shown in the figure, the detecting apparatus comprises two detecting devices 300, the arrangement direction (front-back direction in fig. 1) of the two detecting devices 300 is parallel to the arrangement direction of the sample collecting containers 500 in the sample rack 400, and the sample introduction position of the sample rack 400 and the two detecting devices 300 are on the same straight line of the sampling mechanism 210. The opening 311 is located the top of darkroom 310, and the gesture of each opening 311 keeps unanimous, the length direction that also says each opening 311 all is along the fore-and-aft direction, the width direction all is along the left and right sides direction, the long limit of homonymy aligns, thus, the butt joint with each darkroom 310 can be realized only to the removal of sampling mechanism 210 along above-mentioned array direction, combine along the motion of vertical direction can realize the appearance of advancing and drawing out of sample collection container 500, help shortening sampling mechanism 210's removal orbit, reduce the time of transferring the sample collection container, also help simplifying corresponding drive structure. In addition, the opening 311 may be disposed at the top of the darkroom 310, so that the sample collection container 500 may slide in the darkroom cavity along the vertical direction under the action of gravity, thereby ensuring that the sample collection container 500 can automatically reach the preset detection position.
Taking the sampling mechanism 210 moving along the front-back direction and the up-down direction as an example, referring to fig. 5, the sample injection device 200 further includes a first driving mechanism 220 and a second driving mechanism 230, the first driving mechanism 220 is used for driving the sampling mechanism 210 to move along the arrangement direction above the detection device 300; the second driving mechanism 230 is used for driving the sampling mechanism 210 to move in the vertical direction. Specifically, the first driving mechanism 220 includes a motor, the motor drives the second driving mechanism 230 to move through a synchronous belt, and similarly, the second driving mechanism 230 also includes a motor, the motor drives the sampling mechanism 210 to move through a screw rod and a screw nut, when the second driving mechanism 230 and the sampling mechanism 210 move forward to the position shown in fig. 18, the second driving mechanism 230 can drive the sampling mechanism 210 to move up and down to obtain the sample collection container 500 which is detected from the detection device 300, or place the sample collection container 500 to be detected into the detection device 300; when the second driving mechanism 230 and the sampling mechanism 210 move backward to the rear end shown in fig. 18, the second driving mechanism 230 can drive the sampling mechanism 210 to move in the up-down direction to transfer the detected sample collection container 500 into the sample rack 400 at the sample injection position, or to obtain the sample collection container 500 to be detected from the sample rack 400 at the sample injection position.
It can be understood that, since a plurality of sample collection containers 500 are disposed in the sample rack 400, when the sampling mechanism 210 moves to the sample injection position, the last stop position can be determined according to the specific positions of the sample collection containers 500 to be grabbed in the sample rack 400, and as shown in fig. 1 as an example, if the sample collection containers 500 are obtained one by one in the order from front to back, the sampling mechanism 210 needs to move more than the last time backwards each time, and the control of the moving distance is realized by the controller and the first driving mechanism 220.
In addition, as shown in fig. 1, when the sample collection container 500 is placed in the sample rack 400, the length direction of the opening 311 of the dark room 310 is perpendicular to the width direction of the sample collection container 500, so that the sampling mechanism 210 needs to drive the sample rack 400 to rotate 90 ° to be placed in the dark room 310, based on this, the sample injection device 200 further includes a third driving mechanism 240, the third driving mechanism 240 is connected to the driving end of the second driving mechanism 230, and can drive the sampling mechanism 210 to rotate around the vertical axis, and the third driving mechanism 240 may include a rotating motor.
In this embodiment, the initial position of the second driving mechanism 230 may be located at the middle of the stroke of the first driving mechanism 220 (or there may be a certain offset), and the second driving mechanism 230 may move forward or backward to reach different working positions, which can reduce the dead-time stroke of the second driving mechanism 230. The sample introduction device 200 is further provided with a plurality of sensors, and the sensors can control the position of the sampling mechanism 210 in each direction, so as to be conveniently connected with the darkroom 310 and the sample rack 400 in an abutting mode.
The controller controls the driving assembly 120 and/or the sample introduction device 200 according to signals obtained by the sensors in the auxiliary sample introduction device 100 and/or the sample introduction device 200, and it can be understood that the control at least comprises the following situations: the controller controls the driving component 120 to execute corresponding actions according to signals acquired by the sensor in the auxiliary sample introduction device 100, and is suitable for controlling the sample introduction process of the sample rack 400; the controller controls the sample feeding device 200 to perform corresponding actions according to signals acquired by the sensor in the sample feeding device 200, and is suitable for the process that the sample feeding device 200 independently drives the sample collecting container 500 to be sent into the detection device 300 or is moved out of the detection device 300; the controller controls the auxiliary sample feeding device 100 and the sample feeding device 200 to cooperate according to signals obtained by the sensors in the auxiliary sample feeding device 100 and the sample feeding device 200, for example, after the driving assembly 120 drives the undetected sample rack 400 to reach the sample feeding position, the controller controls the driving assembly 120 to stop and prepare for resetting, and correspondingly controls the sampling mechanism 210 in the sample feeding device 200 to move to the sample feeding position to obtain the sample collecting container 500.
Based on the above, the detection device can realize the automatic sample introduction of the sample rack 400, the automatic sample introduction of the sample collection container 500 and the automatic detection of the sample, thereby realizing the automation of the detection process.
The invention also discloses a sample introduction method which is implemented based on the detection equipment and comprises the following steps:
and S100, controlling the driving member 121 to move from the loading buffer area 111 to the sample injection area 112, and monitoring the change of the trigger state of each position sensor 130 by the controller. It can be understood that if there is a partition in the load buffer 111, it is specifically moved from the load 1111 to the sample 112. Furthermore, as can be seen from the above description, the change of the triggering state of the position sensor 130 herein generally means that the position sensor 130 is triggered to a specific state, for example, the second state where the light emitted from the light emitting end is not received by the light receiving end.
S200, during the movement of the driving member 121, the controller monitors and judges the change of the trigger state of the sensor 140. As described above, the change of the trigger state of the determination sensor 140 herein includes monitoring whether the determination sensor 140 is in a specific state, and detecting the number of changes and the change order of the determination sensor 140.
And S300, controlling the sample introduction device 200 to carry out sample introduction on the sample collection container 500 by the controller according to the change of the trigger states of the position sensor 130 and the judgment sensor 140. In addition, the controller can further enable the detection of the sample collection container 500.
As a specific implementation manner of the control method, in the process of moving the driving element 121, each time the change of the trigger state of one position sensor 130 is monitored, the change of the trigger state of the judgment sensor 140 is identified to judge whether the preset sample introduction condition is met. If the preset sample introduction condition is met, controlling the driving part 121 to stop moving and controlling the sample introduction device 200 to start sample introduction; if the preset sample introduction condition is not met, the driving part 121 is controlled to move continuously until the preset sample introduction condition is met or the driving part 121 resets to the initial position after reaching the extreme position. In a specific implementation manner, the preset sampling condition includes that it is determined that the change process of the trigger state of the sensor 140 conforms to a preset sequence, and it is determined whether the sensor 140 is in a set state. Specifically, the initial position may be a position at which the first trigger 122 triggers the first position sensor 131, and the extreme position may be a position at which the first trigger 122 triggers the third position sensor 133.
Further, in order to improve the accuracy of the control, before the step S100 is performed, the reset operation of the driver 121 needs to be performed so that the driver 121 can start moving from the initial position each time.
In the following description, the sample injection method is performed in combination with specific embodiments, and since the present invention discloses various embodiments, for convenience of description, the states and components of each sensor in the first embodiment of the sample injection method are defined as follows: the position sensor 130 is in the second state (the first trigger 122 of the driving assembly 120 is located between the light receiving end and the light emitting end of the corresponding position sensor 130), and the determination sensor 140 is in the first state (the sample holder 400 presses the second trigger 160, so that the second trigger 160 leaves between the light receiving end and the light emitting end of the determination sensor 140).
The detection device is provided with a total of three position sensors 130 corresponding to the initial, intermediate and extreme positions of the driving member 121. The loading buffer 111 has partitions, and the loading zone 1111 and the first buffer 1112 can each hold one sample rack 400. The sample holder 400 comprises a first flange 410, a second flange 420 and a third flange 430 which are sequentially arranged along the sample injection direction, a first gap 440 is formed between the first flange 410 and the second flange 420, a second gap 450 is formed between the second flange 420 and the third flange 430, and when the second flange 420 of the sample holder 400 presses the second trigger 160, the sample holder 400 is in the sample injection position. The driving member 121 needs to be reset to the initial state each time the controller determines that the sample rack 400 is in the sample injection position.
Scene one
The specimen rack 400 is not present on the specimen stage 110, the driving member 121 is in the initial position, and the judging sensor 140 is in the second state, in which one specimen rack 400 is placed in the loading zone 1111, as shown in fig. 19 (a).
When the controller receives the information that the sample rack 400 exists in the loading area 1111, the driving assembly 120 is activated (there are various ways of activation, for example, a detection sensor is disposed in the loading area 1111, and the sensor is triggered after the sample rack 400 is placed in the loading area, and whether the driving assembly 120 is activated is controlled according to the detection condition of the sample rack 400 at the sample feeding position, or an operator judges and manually activates the sample rack 400 after the sample rack 400 is placed in the loading area), the driving member 121 starts from the initial position, moves a certain distance to contact the sample rack 400, and then pushes the sample rack 400 at the loading area 1111 to move in the sample feeding direction until the second position sensor 132 is triggered, as shown in fig. 19 (b). At this time, since the sample rack 400 does not contact the second trigger 160, it is determined that the state of the sensor 140 is not changed and remains in the second state.
The driving member 121 drives the sample rack 400 to move to the right, and when the second trigger 160 moves to a position between the second position sensor 132 and the third position sensor 133, the third flange 430 first contacts and presses the second trigger 160, as shown in fig. 19 (c). At this time, the determination sensor 140 is switched from the second state to the first state.
The driving member 121 drives the sample rack 400 to move to the right, the third flange 430 is disengaged from the second trigger 160, the second trigger 160 is within the range corresponding to the second gap 450, and the second trigger 160 is reset, as shown in fig. 19 (d). At this time, the determination sensor 140 is switched from the first state to the second state.
The driving member 121 drives the sample rack 400 to move further to the right, and the second flange 420 contacts and presses the second trigger 160, as shown in fig. 19 (e). At this time, the determination sensor 140 is switched from the second state to the first state, and at the same time, the controller determines that the sample rack 400 has reached the sample injection position based on the current state of the determination sensor 140 and the specific state switching sequence before, and can further control the movement of the sampling mechanism 210 to perform the sample injection operation of the sample collection container 500. Referring to fig. 20, a schematic diagram of the above process is shown, in which the state change of the determination sensor 140 is represented by a level signal, the first state is a low level, and the second state is a high level. When the following conditions are satisfied: when the determination sensor 140 is initially high, changes in sequence from high-low-high-low, and finally remains low, and the third position sensor 133 is triggered, the following determination can be made: along advancing the appearance direction, there is not sample frame 400 in the place ahead of the sample frame 400 of newly putting into, and driving piece 121 need move to extreme position postposition and reset, just can make the sample frame 400 of newly putting into send to advancing the appearance position, and can not produce the problem of omitting the detection, also can guarantee simultaneously that sample frame 400 can the accurate stop in advance the appearance position.
Scene two
A second scenario is that a sample rack 400 to be detected is placed on the basis of the first scenario, that is, at this time, there is a sample rack 400 (for convenience of description, it is denoted as a first sample rack 491) that has been detected at the sample injection position, the second flange 420 of the sample rack 400 contacts and presses the second trigger 160, so that the determination sensor 140 is in the first state, and a sample rack 400 to be detected (for convenience of description, it is denoted as a second sample rack 492) is newly placed in the loading area 1111, which is the same as the first scenario, and the specific structure is shown in fig. 21 (a).
When the controller receives the information that the sample holder 400 is present in the loading zone 1111 and then activates the driving assembly 120, the driving member 121 starts from the initial position, moves a certain distance to contact the second sample holder 492, and then pushes the second sample holder 492 to move in the sample entering direction until the second position sensor 132 is triggered, as shown in fig. 21 (b). At this time, since the second sample holder 492 is just in contact with the first sample holder 491 and does not push the first sample holder 491, it is determined that the state of the sensor 140 has not changed, and the state is maintained in the first state.
The driving member 121 drives the second sample holder 492 to move further to the right, the second sample holder 492 simultaneously pushes the first sample holder 491 forward, when the second trigger 160 moves to a position between the second position sensor 132 and the third position sensor 133, the second flange 420 of the first sample holder 491 is already disengaged from the second trigger 160, the second trigger 160 corresponds to the first sample holder 491 within the range of the first gap 440, and the second trigger 160 is reset, as shown in fig. 21 (c). At this time, the determination sensor 140 is switched from the first state to the second state.
The driving member 121 drives the first sample holder 491 and the second sample holder 492 to move to the right, and the first flange 410 of the first sample holder 491 (since the two sample holders 400 are in close contact, there is no gap between the first flange 410 of the first sample holder 491 and the third flange 430 of the second sample holder 492, which can be regarded as one flange) contacts and presses the second trigger 160, as shown in fig. 22 (d). At this time, the determination sensor 140 is switched from the second state to the first state.
The driving member 121 drives the first sample holder 491 and the second sample holder 492 to move to the right, the first flange 410 of the first sample holder 491 (the third flange 430 of the second sample holder 492) is disengaged from the second trigger 160, the second trigger 160 enters the range of the second gap 450 of the second sample holder 492, and the second trigger 160 is reset, as shown in fig. 22 (e). At this time, the determination sensor 140 is switched from the first state to the second state.
The driving member 121 drives the first sample holder 491 and the second sample holder 492 to move to the right, and the second flange 420 of the second sample holder 492 contacts and presses the second trigger 160, as shown in fig. 22 (f). At this time, the determination sensor 140 is switched from the second state to the first state, and meanwhile, the controller determines that the first sample rack 491 has entered the second buffer 1132 and the second sample rack 492 has reached the sample injection position based on the state of the determination sensor 140 at this time and the previous specific state switching sequence, so as to further control the movement of the sampling mechanism 210 to perform the sample injection operation of the sample collection container 500. Referring to fig. 23, which is a brief illustration of the above process, when: when the determination sensor 140 is initially at a low level, changes the sequence to a low level-high level-low level, and finally remains at a low level, and the third position sensor 133 is triggered, it can be determined that: along the appearance direction of advance, there is the sample frame 400 that detects the completion in introduction area 112, and there is not the sample piece 400 that waits to detect in first buffer area 1112, and driving piece 121 needs to remove to reset after the extreme position, just can make the sample frame 400 of newly putting into send to the appearance position of advancing, and can not produce the problem of omitting the detection.
It can be understood that the second scenario is a normally applicable scenario.
Scene three
In the third scenario, on the basis of the first scenario, a sample rack 400 to be detected is placed, that is, the sample rack 400 to be detected exists in both the loading area 1111 and the first buffer area 1112 (for convenience of description, the sample rack 400 in the first buffer area 1112 is referred to as a first sample rack 491, and the sample rack 400 in the loading area 1111 is referred to as a second sample rack 492), while the sample rack 400 does not exist in the sample injection area 112, and the specific structure is the same as that in the first scenario, which is shown in fig. 24 (a).
When the controller receives the information that the sample holder 400 exists in the loading zone 1111 and then activates the driving assembly 120, the driving member 121 moves from the initial position to contact the second sample holder 492 and drives the second sample holder 492. After the second sample holder 492 is moved a distance again to the right after the driving member 121 is moved a distance again, the third flange 430 of the first sample holder 491 first contacts and presses the second trigger member 160, as shown in fig. 24 (b). At this time, the determination sensor 140 is switched from the second state to the first state.
The driving member 121 drives the first sample holder 491 and the second sample holder 492 to move to the right, the third flange 430 of the first sample holder 491 disengages from the second trigger 160, the second trigger 160 is within the range corresponding to the second gap 450 of the first sample holder 491, and the second trigger 160 is reset, as shown in fig. 24 (c). At this time, the determination sensor 140 is switched from the first state to the second state.
The driving member 121 drives the first sample holder 491 and the second sample holder 492 to move rightward, and the second flange 420 of the first sample holder 491 contacts and presses the second trigger 160, as shown in fig. 24 (d). At this time, the determination sensor 140 is switched from the second state to the first state, and meanwhile, the controller determines that the sample rack 400 has reached the sample injection position based on the state of the determination sensor 140 at this time and the previous specific state switching sequence, and may further control the movement of the sampling mechanism 210 to perform the sample injection operation of the sample collection container 500. Referring to fig. 25, which is a brief illustration of the above process, when: when the determination sensor 140 is initially high, changes the sequence high-low-high-low, and finally remains low, and the second position sensor 132 is triggered, the following determination can be made: the sample injection area 112 does not have the sample holder 400 with the detection completed, along the sample injection direction, the sample holder 400 to be detected exists in front of the newly-placed sample holder 400, the driving member 121 needs to be moved to the intermediate position and then reset, so that the second sample holder 492 can be conveyed to the sample injection position, and the problem of detection omission is avoided.
Scene four
Scene four is a further usage mode based on scene three, specifically, in the final state of scene three, that is, in the state shown in the diagram (d) in fig. 24, a new sample rack 400 is no longer placed, which is the case of scene four. It can be understood that scene four is mostly the same as scene two, the overlapped parts are the parts of the diagrams (b) and (c) in fig. 21 and the diagrams (d) to (f) in fig. 22, and the first step of the difference does not affect the subsequent determination, so that scene four can be equivalent to scene two.
Scene five
The fifth scenario is a further usage based on the third scenario, specifically, in a final state of the third scenario, that is, in a state shown in fig. 24 (d), a new sample rack 400 is placed in the loading area 1111, which is a case of the fifth scenario, at this time, there is a sample rack 400 (for convenience of description, denoted as a first sample rack 491) already detected at the sample introduction position, the second flange 420 of the sample rack 400 contacts and presses the second trigger 160, so that the judgment sensor 140 is in the first state, both the loading area 1111 and the first buffer area 1112 have sample racks 400 to be detected (for convenience of description, the sample rack 400 of the first buffer area 1112 is denoted as a second sample rack 492, and the sample rack 400 of the loading area 1111 is denoted as a third sample rack 493), and the rest are the same as the first scenario, and the specific structure is shown in fig. 26 (a).
When the controller receives the information that the sample rack 400 exists in the loading area 1111 and then activates the driving assembly 120, the driving member 121 starts from the initial position, moves a certain distance to contact the third sample rack 493 and drives the third sample rack 493 and the second sample rack 492 to move synchronously with the first sample rack 491, the second flange 420 of the first sample rack 491 disengages from the second trigger 160, the second trigger 160 corresponds to the first sample rack 491 within the range of the first gap 440, and the second trigger 160 resets, as shown in fig. 26 (b). At this time, the determination sensor 140 is switched from the first state to the second state.
The driving member 121 drives the three sample holders to move further to the right, and the first flange 410 of the first sample holder 491 (since the two sample holders 400 are in close contact, there is no gap between the first flange 410 of the first sample holder 491 and the third flange 430 of the second sample holder 492, which can be regarded as one flange) contacts and presses the second trigger 160, as shown in fig. 26 (c). At this time, the determination sensor 140 is switched from the second state to the first state.
The driving member 121 drives the three sample holders to move further to the right, the first flange 410 of the first sample holder 491 (the third flange 430 of the second sample holder 492) is disengaged from the second trigger 160, the second trigger 160 enters the range of the second gap 450 of the second sample holder 492, and the second trigger 160 is reset, as shown in fig. 27 (d). At this time, the determination sensor 140 is switched from the first state to the second state.
The driving member 121 drives the three sample holders to move further to the right, and the second flange 420 of the second sample holder 492 contacts and presses the second trigger 160, as shown in fig. 27 (e). At this time, the determination sensor 140 is switched from the second state to the first state, and at the same time, the controller determines that the first sample rack 491 has entered the second buffer 1132 and the second sample rack 492 has reached the sample injection position based on the state of the determination sensor 140 at this time and the specific state switching sequence before, and can further control the sample mechanism 210 to move to perform the sample injection operation of the sample collection container 500. Referring to fig. 28, which is a brief illustration of the above process, when: when the sensor 140 is initially at a low level, the sequence of changes is low-high-low, and finally remains at a low level, and the second position sensor 132 is triggered, it can be determined that: along the sample introduction direction, the sample introduction region 112 has the sample holder 400 with the detection completed, the first buffer region 1112 has the sample piece 400 to be detected, and the driving member 121 needs to be moved to the intermediate position and then reset, so that the second sample holder 492 can be sent to the sample introduction position, and the problem of detection omission is avoided.
Scene six
A sixth scenario is a further usage mode based on the fifth scenario, specifically, in the final state of the fifth scenario, that is, in the state shown in fig. 27 (e), a new sample rack 400 is placed in the loading area 1111, which is the case of the sixth scenario, and the sixth scenario is identical to the fifth scenario, and is not repeated here.
Scene seven
A sixth scenario is a further usage mode based on the fifth scenario, specifically, in the final state of the fifth scenario, that is, in the state shown in the diagram (e) in fig. 27, a new sample rack 400 is not placed in the loading area 1111, which is the case of the seventh scenario, and the seventh scenario is completely the same as the fourth scenario, and details thereof are not repeated.
Scene eight
The eighth scenario is the same as the fifth scenario, except that in the initial state, the first sample rack 491 to be detected in the first buffer area 1112 deviates from the normal position (possibly due to power failure or detection cancellation), the deviation direction is towards the sample injection area 112 (if the deviation direction is towards the loading area 1111, the first sample rack 491 will partially intrude into the loading area 1111, so that the second sample rack 492 cannot be loaded, and this situation can be manually eliminated), and it can be seen that when the second position sensor 132 is triggered, the final positions of the first sample rack 491 and the second sample rack 492 and the state change of the judgment sensor 140 are all the same, that is, the diagrams (b) to (d) in fig. 24 are the same as the diagrams (b) to (d) in fig. 29, so the eighth scenario can be the same as the fifth scenario.
Scene nine
In a ninth scenario, when the sample rack 400 is not present on the sample platform 110, the driving member 121 is in the initial position, the determination sensor 140 is in the second state, and the loading area 1111 is not placed in the sample rack 400, it can be imagined that, during the process of moving the driving member 121 from the initial position to the limit position, no change occurs in the state of the determination sensor 140, and therefore, when: determining that the sensor 140 is initially high, there is no level change, and the third position sensor 133 is triggered, the following determination can be made: there is no sample rack 400 present on the entire sample platform 110 and the drive member 121 is reset after moving to the extreme position.
According to the scenes, the control method can distinguish different scenes in the using process of the detection equipment, so that the driving part 121 and the sampling mechanism 210 are adaptively controlled, and the condition of missing detection is avoided.
It can be understood that the corresponding determination conditions can be adjusted according to the number of the flanges at the bottom of the sample holder 400, which is not listed here.
As a further improvement of the above control method, a time interval between trigger states of the sensor 140 can be introduced as a basis for determining whether a sampling failure occurs, where the time interval between trigger states refers to a duration of a certain state of the sensor 140, and fig. 20 is taken as an example, and a time period T1The duration of the first low level, i.e., the duration from graph (c) in FIG. 19, period T2The time period T is the duration of the second high level, i.e., the time required to proceed from graph (c) to graph (e) in FIG. 191The time period T is related to the width of the third flange 430 and the traveling speed of the specimen rack 4002In relation to the distance between the third flange 430 and the second flange 420, and the speed of travel of the sample rack 400, the width, distance, and speed of travel are typically fixed values, so that the time period T, if it is for normal sample injection operation1And period T2Should be within the set range, if below the set range, it is usually considered as a change caused by external disturbance and not considered as a state switching; if the set range is exceeded, the passing time of the sample rack 400 is considered to be longer, which is generally caused by the movement jamming of the sample rack 400, and an alarm signal needs to be sent to prompt an operator to check.
In summary, in this embodiment, the following conditions need to be satisfied: judging the final state of the sensor 140 to be a required set state; judging that the state switching sequence of the sensor 140 accords with a set sequence; and thirdly, judging that the duration of the set state of the sensor 140 meets the set range, judging that the sample injection process is normal, and if at least one of the conditions is not in accordance with expectation, sending out fault prompt information.
It is to be understood that the failure indication information may be issued only when at least one of the final state of the sensor 140 is judged to be the desired set state and the state switching order of the sensor 140 is judged to be in accordance with the set order is not expected regardless of the duration of the state.
It can be appreciated that the fault indication information can be at least one of an optical signal and an acoustic signal.
The embodiments of the present invention have been described in detail with reference to the drawings, but the present invention is not limited to the above embodiments, and various changes can be made within the knowledge of those skilled in the art without departing from the gist of the present invention. Furthermore, the embodiments of the present invention and the features of the embodiments may be combined with each other without conflict.

Claims (21)

1. Supplementary sampling device, its characterized in that includes:
the sample platform can bear sample racks, and comprises a loading buffer area, a sample introduction area and an unloading buffer area, wherein the loading buffer area can accommodate a plurality of sample racks;
the driving component is connected to the sample platform and comprises a movable driving piece, and the driving piece is used for driving the sample rack to move relative to the sample platform;
the N position sensors are distributed at N positions and can be triggered by the driving piece moved to the corresponding position, wherein N is a positive integer not less than 3;
and the judgment sensor can be triggered by the sample rack moved to the sample feeding position.
2. The auxiliary sample introduction device according to claim 1, wherein the loading buffer, the sample introduction buffer and the unloading buffer are arranged in a straight line along a sample introduction direction of the sample rack.
3. The auxiliary sample introduction device according to claim 2, wherein the loading buffer area can be used for placing M sample racks in parallel, wherein M is a positive integer not less than 2;
n position sensor follows it is linear arrangement to advance the appearance direction, and satisfies: n ═ M + 1.
4. The auxiliary sample introduction device according to claim 3, wherein a spacing between at least some adjacent position sensors is equal to a width of the sample rack in the sample introduction direction.
5. The auxiliary sample introduction device according to claim 1, wherein one of the N position sensors corresponds to a starting point of a stroke of the driving member, and the other corresponds to an end point of the stroke of the driving member.
6. The auxiliary sample introduction device according to claim 1, further comprising an unloading detection sensor disposed in the unloading buffer, wherein the unloading detection sensor can be triggered by the sample rack.
7. The auxiliary sample feeding device as claimed in claim 1, wherein the driving assembly further comprises a first triggering member moving synchronously with the driving member, and the first triggering member passes through and triggers each of the position sensors one by one along the moving direction of the driving member.
8. The auxiliary sample introduction device according to claim 1, wherein the driving assembly further comprises a first power member and a first connecting member, the first power member is connected with the first connecting member and used for driving the first connecting member to move relative to the sample platform, the driving member is rotatably connected with the first connecting member, and the driving member rotated to a set posture along a first direction can be limited by the first connecting member, wherein when the driving member in the set posture moves along the sample introduction direction, the driving member can drive the sample rack to move; when the driving piece moves along the reverse direction of the sample feeding direction, the driving piece can be abutted with the sample rack and rotates along the reverse second direction to avoid the sample rack.
9. The auxiliary sample introduction device according to claim 8, wherein the driving member comprises:
a driving part for contacting the sample rack;
the counterweight part is used for driving the driving piece which rotates along the second direction to reset to the set posture under the action of gravity;
and the rotating connecting part is positioned between the driving part and the counterweight part and is used for rotationally connecting the driving part and the first connecting part.
10. The auxiliary sample introduction device according to claim 1, further comprising a second trigger disposed in the sample introduction region, wherein the second trigger is connected to the sample platform and includes a contact end and a trigger end, and the contact end can contact with or separate from the sample rack to generate a motion, so that the trigger end moves to change a trigger state of the judgment sensor.
11. The auxiliary sample introduction device according to claim 1, wherein the sample platform comprises:
a support for carrying the sample rack;
the limiting part extends along the sample feeding direction and is used for limiting the sample rack to move along the sample feeding direction;
at least one is followed the fool-proof portion that advances kind direction extension, fool-proof portion be used for with the sample frame cooperation makes the sample frame is placed according to setting for the gesture can be followed on the supporting part advance kind direction and remove.
12. The auxiliary sample introduction device according to claim 1, further comprising a clamping assembly disposed in the sample introduction region, wherein the clamping assembly is configured to clamp the sample rack located at the sample introduction position.
13. The auxiliary sample introduction device according to claim 12, wherein the clamping assembly comprises:
the positioning piece is connected to one side of the sample platform along the sample introduction direction;
the compression joint piece is connected to the other side of the sample platform along the sample introduction direction relative to the positioning piece, and the initial distance between the compression joint piece and the positioning piece is smaller than the minimum length of the sample rack in the horizontal direction along the horizontal direction perpendicular to the sample introduction direction;
and the second power part can drive the crimping part to move along the horizontal direction, so that the distance between the crimping part and the positioning part along the horizontal direction is not less than the maximum length of the sample rack in the horizontal direction.
14. The sample introduction device according to claim 13, wherein the clamping assembly further comprises:
the bracket is connected with the sample platform and can be driven by the second power piece to move;
the second connecting piece is movably connected with the bracket through the second connecting piece so that the crimping piece can be abutted by the sample rack to deflect relative to the bracket;
an elastic member located between the crimping member and the holder, for applying a force to the crimping member to abut the crimping member against the sample rack.
15. Detection apparatus, characterized in that it comprises:
the auxiliary sample introduction device of any one of claims 1 to 14;
the sample introduction device is used for obtaining a sample collection container from the sample rack at the sample introduction position;
a detecting device for detecting the characteristic amount of the sample in the sample collection container;
and the controller controls the driving assembly and/or the sample feeding device according to signals acquired by the auxiliary sample feeding device and/or the sensor in the sample feeding device.
16. Sample introduction method, applied to the detection device according to claim 15, comprising the steps of:
controlling the driving piece to move from the loading buffer area to the sampling area, and monitoring the change of the trigger state of each position sensor;
monitoring the change of the trigger state of the judgment sensor;
and controlling the sample introduction device to carry out sample introduction on the sample collection container according to the change of the trigger states of the position sensor and the judgment sensor.
17. The sample introduction method according to claim 16, wherein in the process of controlling the driving member to move, when it is monitored that the trigger state of one position sensor changes each time, it is determined whether the change of the trigger state of the judgment sensor meets a preset sample introduction condition, and if so, the driving member is controlled to stop moving and the sample introduction device is controlled to start sample introduction; otherwise, controlling the driving part to continuously move until the preset sample introduction condition is met or the driving part resets to the initial position after reaching the extreme position.
18. The sample introduction method according to claim 17, wherein the preset sample introduction conditions comprise: the change process of the trigger state of the judgment sensor accords with a preset sequence, and the final state of the judgment sensor accords with a set state.
19. The sample injection method of claim 16, further comprising, prior to all steps:
and controlling the driving piece to move to the initial position.
20. The sample introduction method according to claim 16, wherein in the process of controlling the driving member to move to the limit position, if the trigger state of the judgment sensor is unchanged and is consistent with the trigger state of no sample rack, a prompt message of no sample rack is output.
21. The sample introduction method according to any one of claims 16 to 20, wherein when the change process of the trigger state of the judgment sensor and/or the duration of the set state of the judgment sensor meets the corresponding preset fault condition, the corresponding fault prompt information is output.
CN202111298389.9A 2021-11-04 2021-11-04 Auxiliary sample introduction device, detection equipment and sample introduction method Withdrawn CN114200155A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114660312A (en) * 2022-05-24 2022-06-24 深圳市帝迈生物技术有限公司 Sample analysis equipment

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114660312A (en) * 2022-05-24 2022-06-24 深圳市帝迈生物技术有限公司 Sample analysis equipment

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