CN114544603A - Full-automatic homogeneous phase chemiluminescence instant detection analyzer - Google Patents

Full-automatic homogeneous phase chemiluminescence instant detection analyzer Download PDF

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Publication number
CN114544603A
CN114544603A CN202210109459.XA CN202210109459A CN114544603A CN 114544603 A CN114544603 A CN 114544603A CN 202210109459 A CN202210109459 A CN 202210109459A CN 114544603 A CN114544603 A CN 114544603A
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CN
China
Prior art keywords
reagent strip
real
fully automated
time detection
assembly
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Pending
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CN202210109459.XA
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Chinese (zh)
Inventor
刘晓勇
包德泉
赵文扬
许勇
龙刚
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Chengdu Aixing Biotechnology Co ltd
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Chengdu Aixing Biotechnology Co ltd
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Priority to CN202210109459.XA priority Critical patent/CN114544603A/en
Publication of CN114544603A publication Critical patent/CN114544603A/en
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system

Abstract

The invention provides a full-automatic homogeneous phase chemiluminescence instant detection analyzer, which comprises a base, wherein the base is provided with: the device comprises a sample tube supply device with a plurality of sample tubes, a Tip head batch loading device, a reagent strip supply device and a reagent strip gripping device, wherein the reagent strip supply device comprises a reagent strip bin for storing a plurality of reagent strips and the reagent strip gripping device capable of gripping and transferring the reagent strips; a reaction disk mechanism having a plurality of reagent strip placement positions extending in a diameter direction thereof; the liquid taking device can be assembled with one Tip head conveyed by the Tip head batch loading device, sucks the sample in the sample tube conveyed by the sample tube supply device and the reagent in the reagent hole of the reagent strip positioned on the reagent strip placing position of the reaction disc assembly, and places the sample and/or the reagent in the detection hole of the same reagent strip. The invention greatly simplifies the real-time detection action process, realizes the batch online loading of consumables, reagents and samples, has high automation degree, meets the batch detection requirement, can realize unmanned operation and reduces the labor cost.

Description

Full-automatic homogeneous phase chemiluminescence instant detection analyzer
Technical Field
The invention belongs to the technical field of immunodiagnosis, and particularly relates to a full-automatic homogeneous chemiluminescence instant detection analyzer.
Background
In the current point-of-care testing (point-of-care testing) instruments used for single-person in vitro diagnosis, a single-sample or small-batch reagent loading mode is generally adopted (full-automatic continuous loading of original tube samples, reagents and consumables cannot be realized), and the operation mode is to perform the next test after one test round is completed, so that the operation mode greatly limits the test flux; if the functions of high throughput, online loading of original tube samples, reagents, consumables and the like are realized, the instrument is large in size (large in size and inconvenient for clinical use), complex in structure (poor in stability of operation of the instrument with the complex structure and high in failure rate), and high in cost (the material and labor cost of a large instrument are high).
Disclosure of Invention
Therefore, the technical problem to be solved by the invention is to provide a full-automatic homogeneous phase chemiluminescence real-time detection analyzer, which greatly simplifies the real-time detection action process, realizes batch online loading of consumables, reagents and samples, has high automation degree, meets the batch detection requirement, can realize unmanned operation, and reduces the labor cost.
In order to solve the above problems, the present invention provides a full-automatic homogeneous phase chemiluminescence real-time detection analyzer, which comprises a base, wherein the base is provided with:
a sample tube supply device having a plurality of sample tubes therein;
the Tip batch loading device is internally provided with a plurality of Tip heads;
the reagent strip supply device comprises a reagent strip bin for storing a plurality of reagent strips and a reagent strip grabbing device capable of grabbing and transferring the reagent strips;
the reaction disc mechanism comprises a reaction disc assembly capable of being driven to rotate, and a plurality of reagent strip placing positions extending along the diameter direction of the reaction disc assembly are arranged on the reaction disc assembly;
the liquid taking device can be assembled with one Tip head conveyed by the Tip head batch loading device, sucks the sample in the sample tube conveyed by the sample tube supply device and the reagent in the reagent hole of the reagent strip on the reagent strip placement position of the reaction disc assembly, and places the sample and/or the reagent in the detection hole of the same reagent strip;
the homogeneous phase chemiluminescence immunoassay module can collect luminescence information of reaction liquid in a detection hole of a reagent strip at a detection position.
In some embodiments, the sample tube supply device comprises:
the sample rack placing piece is used for placing the sample tube, a sample rack slide way is formed on the sample rack placing piece and used for placing a sample rack, and a through groove is formed in the bottom wall of the sample rack slide way;
and the sample rack supply driving assembly is used for driving the sample rack to slide back and forth along the extending direction of the sample rack slide way.
In some embodiments of the present invention, the substrate is,
the specimen rack supply drive assembly includes:
a connection assembly for selectively connecting with the sample rack;
the first sliding driving assembly is used for driving the connecting assembly to slide in a reciprocating mode along the extending direction of the sample rack slide way;
the sample rack slide ways on the sample rack placing piece are provided with a plurality of sample rack slide ways, and the connecting assembly can be controlled to move among the sample rack slide ways so as to realize selective connection of the sample racks placed in different sample rack slide ways.
In some embodiments of the present invention, the substrate is,
a jaw groove is formed in the outer wall of the bottom side of the sample frame, the connecting assembly comprises a first screw rod motor and a jaw connected to the tail end of a first screw rod of the first screw rod motor, and the first screw rod motor can drive the jaw to move towards or away from the sample frame so that the jaw can be clamped into or separated from the jaw groove; and/or the presence of a gas in the gas,
first slip drive assembly includes and follows first guide rail, the first rotary motor that the extending direction of sample frame slide set up, first rotary motor can drive coupling assembling follows first guide rail is reciprocal to be slided.
In some embodiments of the present invention, the substrate is,
the sample rack slide ways on the sample rack placing piece are provided with a plurality of sample rack slide ways, and the connecting assembly can be controlled to move among the sample rack slide ways so as to realize selective connection of the sample racks placed in different sample rack slide ways.
In some embodiments of the present invention, the substrate is,
the sample rack slide rail device further comprises a second sliding driving assembly capable of driving the connecting assembly to move among the sample rack slide rails, and the first sliding driving assembly can also drive the connecting assembly and the second sliding driving assembly to slide in a reciprocating mode in the extending direction of the sample rack slide rails as a whole.
In some embodiments of the present invention, the substrate is,
a photoelectric switch is arranged at a first position corresponding to each sample frame slide way, a correlation sensor is arranged at a second position, and the photoelectric switch and the correlation sensor are configured in pairs so as to ensure that two ends of the length of each sample frame can be respectively positioned at the first position and the second position; alternatively, the first and second electrodes may be,
the liquid taking device comprises a liquid taking head, the movement of the liquid taking head is limited in a first plane where an X axis and a Z axis are located, and a target sample tube of the sample rack can be fed to the position, where the Y axis intersects with the first plane, below the liquid taking head along the Y axis direction under the action of the sample rack supply driving assembly.
In some embodiments, the Tip head batch loading apparatus includes:
a consumable assembly comprising a tray and a plurality of the Tip heads on the tray;
the consumable bin frame comprises side plates which are oppositely arranged and a platform which is positioned at the upper parts of the ends of the two side plates, wherein the ends of the two side plates have the corresponding lengths;
and the feeding driving part can transfer the consumable assembly from a first position to a second position along the feeding track, and can transfer the consumable assembly exhausted by the Tip head from the second position to the platform, wherein the first position and the second position respectively correspond to two ends of the side plate in the length direction.
In some embodiments of the present invention, the substrate is,
every the curb plate with all be equipped with a switch board between the platform, the top of switch board with platform pivotal connection, the bottom of switch board under its dead weight effect contact connect in the top surface of curb plate, just switch board and horizontal plane slope set up, so as to do benefit to the consumptive material subassembly by the primary importance shifts to the second place and by the second place shifts to on the platform.
In some embodiments of the present invention, the substrate is,
the inclined included angle between the switching plate and the horizontal plane is a, and a is more than or equal to 10 degrees and less than or equal to 60 degrees.
In some embodiments, the feed drive component comprises:
the feeding guide rail comprises a linear reciprocating driving component and a push-pull component, wherein the push-pull component is used for applying force on the consumable component, and the linear reciprocating driving component is used for driving the push-pull component to generate linear reciprocating motion along the extension direction of the feeding guide rail.
In some embodiments of the present invention, the substrate is,
the push-pull assembly comprises a blocking piece deflection motor, a blocking piece is connected to a rotating shaft of the blocking piece deflection motor, and the blocking piece deflection motor can drive the blocking piece to switch between an initial position and a push-pull position.
In some embodiments of the present invention, the substrate is,
the baffle plate is provided with a caulking groove, and when the consumable component needs to be transferred from the first position to the second position, the vertical wall of the tray is partially inserted into the caulking groove; and/or when the consumable component needs to be transferred from the second position to the platform, one side end face of the baffle, far away from the baffle deflection motor, is partially abutted against the vertical wall of the tray.
In some embodiments of the present invention, the substrate is,
the linear reciprocating driving component comprises a rotary motor, the push-pull assembly further comprises a fixing frame, the blocking piece deflection motor is arranged on the fixing frame, and the rotary motor is in driving connection with the fixing frame through a belt transmission structure.
In some embodiments of the present invention, the substrate is,
the rotary motor is arranged on the inner side of one of the two side plates, the belt transmission structure is arranged on the outer side of the side plate and comprises a belt wheel sleeved on a rotating shaft of the rotary motor, a supporting roller arranged on a linear reciprocating path at intervals with the belt wheel and a transmission belt erected on the belt wheel and the supporting roller, and the transmission belt is fixedly connected with the fixed frame; or the fixing frame is provided with a first sensor for detecting the initial position of the blocking piece.
In some embodiments, the reagent strip grasping device comprises:
a mounting member;
the clamping jaw unit comprises two clamping jaw arms which are oppositely arranged;
the gripping device driving part is arranged on the mounting part, can drive the two clamping jaw arms to move towards or away from each other so as to clamp two opposite side walls of the reagent strip, and can drive the clamping jaw units to ascend along a straight line after the clamping jaw arms clamp the reagent strip;
and the transverse moving driving part can simultaneously translate the mounting part, the clamping jaw unit and the gripping device driving part along a horizontal straight line.
In some embodiments of the present invention, the substrate is,
the clamping jaw unit further comprises a clamping jaw rotating mounting plate which is fixedly connected with the mounting piece, the two clamping jaw arms are pivotally connected to the clamping jaw rotating mounting plate, corresponding ends of the two clamping jaw arms are also pivotally connected to a reciprocating slide block, the reciprocating slide block is connected with a power output shaft of the gripping device driving part, when the power output shaft moves close to the clamping jaw arms, the two clamping jaw arms move back to back, and when the power output shaft moves away from the clamping jaw arms, the two clamping jaw arms move towards each other; and/or clamping strips are arranged on the opposite sides of the two clamping claw arms.
In some embodiments of the present invention, the substrate is,
the reciprocating slide block is provided with a sliding groove extending along the horizontal direction, and the corresponding end of the clamping claw arm is connected in the sliding groove in a sliding manner through a bearing; alternatively, the first and second electrodes may be,
the grabbing device driving part comprises a screw rod motor, the power output shaft is a screw rod arranged on the screw rod motor, a guide rail is further arranged on the mounting part, and the reciprocating sliding block is connected to the guide rail in a sliding mode.
In some embodiments of the present invention, the substrate is,
and a first photoelectric sensor is arranged at one end, which is close to the screw rod and is far away from the clamping jaw unit, and is used for detecting the position of the screw rod.
In some embodiments of the present invention, the substrate is,
the clamping jaw unit further comprises a reagent strip pressing assembly capable of applying force to the reagent strip when the clamping jaw unit clamps or releases the clamping of the reagent strip.
In some embodiments of the present invention, the substrate is,
the reagent strip pressure applying assembly comprises a force applying column which is inserted on the clamping jaw rotating mounting plate in a vertically sliding manner, one end of the force applying column, facing the reagent strip, is a force applying disc, and an elastic piece is clamped between the force applying disc and the clamping jaw rotating mounting plate.
In some embodiments of the present invention, the substrate is,
the end of the force application column, which is far away from the reagent strip, is provided with a U-shaped piece, and the clamping jaw rotating and mounting plate is at least partially positioned in the opening area of the U-shaped piece; and/or one end of the force application column, which is far away from the reagent strip, is provided with a detection sheet, a second photoelectric sensor is arranged corresponding to the detection sheet, and the second photoelectric sensor is used for detecting the position of the force application column.
In some embodiments of the present invention, the substrate is,
reagent strip pressure applying assembly has two sets ofly, and is two sets of reagent strip pressure applying assembly is in one respectively the length direction's of clamping jaw rotating installation board both ends, the length direction's of clamping jaw rotating installation board both ends with the length direction's of reagent strip both ends correspond respectively, second photoelectric sensor has two, two second photoelectric sensor one-to-one respectively the length direction's of clamping jaw rotating installation board both ends set up.
In some embodiments, the reaction disk mechanism further comprises:
the mounting base comprises a top plate and two side vertical plates which are arranged in parallel at intervals, the opposite side walls of the two side vertical plates are provided with first clamping grooves, and the top plate is inserted into the first clamping grooves;
the reaction tray assembly is integrally mounted to the top plate.
In some embodiments of the present invention, the substrate is,
the mounting base further comprises a rear vertical plate connected to one end of each of the two side vertical plates and a front vertical plate detachably connected to the other end of each of the side vertical plates.
In some embodiments of the present invention, the substrate is,
a second clamping groove corresponding to the first clamping groove is formed in the inner side wall of the rear vertical plate, and/or a third clamping groove corresponding to the first clamping groove is formed in the inner side wall of the front vertical plate; or the rear vertical plate and/or the front vertical plate and the side vertical plate are/is bolted through a screw.
In some embodiments of the present invention, the substrate is,
the reaction disc assembly comprises a base body, a gear ring is arranged on one side, facing the top plate, of the base body, a first photoelectric switch is arranged on the outer side of the gear ring, and the first photoelectric switch can sense a tooth part of the gear ring to judge the rotation angular displacement of the base body; and/or, the inboard of ring gear is equipped with the second photoelectric switch, the second photoelectric switch can respond to be in the inboard photoelectric separation blade of ring gear is in order to judge the rotatory initial position of base member.
In some embodiments of the present invention, the substrate is,
the reaction disc assembly further comprises an incubation plate and a heating plate between the base body and the incubation plate, the base body is provided with a plurality of reagent strip placing positions extending along the radial direction of the base body, the incubation plate is provided with a plurality of incubation holes, the positions of the incubation holes correspond to the positions of detection holes of reagent strips placed on the reagent strip placing positions in a one-to-one mode, and the incubation holes are the same in quality as the incubation plate and are integrally formed.
In some embodiments, the liquid extraction device comprises a liquid extraction unit comprising:
a liquid-extracting mounting member having a sealed chamber formed therein;
the liquid taking head is connected in one through hole of the sealed cavity and can be assembled with the Tip head;
the piston rod is arranged in the sealed cavity and is driven by the reciprocating driving component to realize the liquid suction and discharge functions of the liquid taking head;
the telescopic rod of the reciprocating driving part is connected with the piston rod through magnetic attraction.
In some embodiments of the present invention, the substrate is,
a first magnet is arranged at one end, facing the piston rod, of the telescopic rod, and a second magnet is arranged at one end, facing the telescopic rod, of the piston rod; and/or the telescopic rod is a motor screw rod.
In some embodiments of the present invention, the substrate is,
one end of the telescopic rod, facing the piston rod, is connected with an adapter, and the first magnet is connected with one end of the telescopic rod through the adapter.
In some embodiments of the present invention, the substrate is,
the liquid taking device is characterized in that a guide assembly is arranged between the adapter and the liquid taking installation part, and the guide assembly comprises a pin shaft fixedly connected with the adapter and a bearing sleeved on the pin shaft.
In some embodiments of the present invention, the substrate is,
and a limiting structure is also arranged between the piston rod and the telescopic rod.
In some embodiments of the present invention, the substrate is,
the telescopic direction of the piston rod is perpendicular to the through-flow direction of the liquid taking head; and/or the device also comprises a lifting driving unit which is in driving connection with the liquid taking unit.
In some embodiments of the present invention, the substrate is,
the lift drive unit includes lead screw motor, slide rail, slider connecting piece, the slider connecting piece reaches get all sliding connection in of liquid installed part in just can be in on the slide rail follow under the drive of lead screw motor's the lead screw the slide rail goes up and down, the slider connecting piece with get and connect through the connecting axle between the liquid installed part.
In some embodiments of the present invention, the substrate is,
one end of the connecting shaft is located in the liquid taking installation part and can slide, and the connecting shaft is sleeved with a spring so that the force can be applied to the liquid taking installation part when the slider connecting part descends, and the liquid taking installation part is allowed to move towards the slider connecting part when the liquid taking head touches the bottom.
In some embodiments, the homogeneous chemiluminescent immunoassay module comprises:
the detection assembly comprises a detection head which can be driven to lift;
the light-tight piece subassembly, including the light-tight piece, the light-tight piece can switch between primary importance and second position, works as the light-tight piece is in when the primary importance, the light-tight piece can make the logical light structure of detection head realizes the light-tight, works as the light-tight piece is in when the second position, with the light-tight structure of the reagent strip that the detection head corresponds can make the logical light structure of detection head realizes the light-tight.
In some embodiments of the present invention, the substrate is,
one side of the detection head, which faces the reagent strip, is detachably connected with a dense-light rubber pad; and/or the presence of a gas in the gas,
one side of the detection head, which faces the reagent strip, is provided with a pressing strip, and when the light-tight structure of the reagent strip is light-tight and the light-transmitting structure of the detection head is light-tight, the pressing strip can be pressed on the top surface of the reagent strip and elastically deforms.
In some embodiments of the present invention, the substrate is,
the lifting driving assembly is used for driving the detection head to move towards or away from the reagent strip in a linear reciprocating manner; and/or the presence of a gas in the gas,
the device also comprises a swing driving component which is used for driving the light-tight piece to switch between the first position and the second position.
In some embodiments of the present invention, the substrate is,
the light-tight piece is provided with a support roller, and the light-tight piece can slide on a corresponding support carrier through the support roller.
In some embodiments of the present invention, the substrate is,
the supporting rollers are provided with two groups, and the two groups of supporting rollers are arranged on two opposite sides of the light-tight piece.
In some embodiments, the fully automated homogeneous chemiluminescent instant detection analyzer further comprises:
and the catcher unit is used for receiving the abnormal reagent strips grabbed by the reagent strip grabbing device.
The invention provides a full-automatic homogeneous phase chemiluminescence instant detection analyzer, which is simultaneously provided with a sample tube supply device with a plurality of sample tubes, a Tip head batch loading device with a plurality of Tip heads and a reagent strip supply device with a plurality of reagent strips, and the translation in parallel planes of a liquid taking device and a reagent strip grabbing device and the rotation in a rotating plane of a reaction disc mechanism realize the position change requirements of the sample tubes, the Tip heads and the reagent strips in each process of instant detection, thereby greatly simplifying the instant detection action process, realizing the batch online loading of consumables, reagents and samples, having high automation degree, meeting the continuous detection and batch loading requirements, realizing unmanned aerial vehicle and reducing the labor cost.
Drawings
FIG. 1 is a schematic perspective view of a fully automatic homogeneous chemiluminescence real-time detection analyzer according to an embodiment of the invention;
FIG. 2 is a schematic structural view (partially broken away) of the sample tube supply device of FIG. 1;
fig. 3 is a schematic structural view of the sample tube supply device in fig. 1 (in an assembled state, a sample rack shown by a dotted line in the figure is a sample rack in a supplied state, and only one sample rack is placed in the same sample rack slide way);
FIG. 4 is a schematic perspective view of the sample rack of FIG. 2;
FIG. 5 is a schematic diagram showing the relative positions of the sample tube supply device and the liquid sampling device in FIG. 1;
fig. 6 is a schematic perspective view of the Tip head batch loading apparatus in fig. 1;
fig. 7 is a schematic diagram illustrating a state that a baffle plate and a tray in the Tip head batch loading device in fig. 6 are connected through a caulking groove;
fig. 8 is a schematic view of the state that the outer end face of the baffle plate in the Tip head batch loading device in fig. 6 is in abutting connection with the tray;
FIG. 9 is a schematic perspective view of the reagent strip grasping device in FIG. 1;
FIG. 10 is a schematic front view of the reagent strip grasping device in FIG. 9.
FIG. 11 is a schematic structural view (in an assembled state) of the reaction disk mechanism in FIG. 1;
FIG. 12 is a schematic structural view (partially disassembled) of the reaction disk mechanism of FIG. 1;
FIG. 13 is a schematic view of the structure of the liquid extracting apparatus in FIG. 1;
fig. 14 is a partially enlarged schematic view at a in fig. 13;
FIG. 15 is a schematic view of the homogeneous chemiluminescent immunoassay module of FIG. 1 with the sealing member in a first position (the detection head not lowered);
FIG. 16 is a schematic view of the homogeneous chemiluminescent immunoassay module of FIG. 1 with the sealing member in a second position (the detection head not lowered);
fig. 17 is a schematic perspective view of the reagent strip cartridge in fig. 1.
The reference numerals are represented as:
1. a sample tube supply device; 11. a sample rack placement member; 111. a sample rack slide; 112. a through groove; 12. a sample rack; 121. a jaw slot; 122. a sample tube adapter; 1311. a first lead screw motor; 1312. a claw; 1321. a first guide rail; 1322. a first rotary electric machine; 1331. a second guide rail; 1332. a second rotary electric machine; 141. a photoelectric switch; 142. a correlation sensor; 2. a Tip head batch loading device; 211. a tray; 212. a Tip head; 221. a side plate; 222. a platform; 23. a switch board; 241. a catch deflection motor; 242. a baffle plate; 2421. caulking grooves; 243. a rotary motor; 244. a fixed mount; 245. a pulley; 246. a support roller; 247. a conveyor belt; 248. a linear guide rail; 249. a first sensor; 3. a reagent strip bin; 31. a reagent rack; 32. a reagent strip feed channel; 33. a feed drive device; 4. a reagent strip grasping device; 41. a mounting member; 411. a guide rail; 421. a gripper arm; 4211. a bearing; 4212. clamping the strip; 4213. a bearing pin; 422. the clamping jaw rotating mounting plate; 423. a reciprocating slide block; 4231. a chute; 4241. a force application column; 4242. a force application disc; 4243. an elastic member; 4244. a U-shaped piece; 4245. detecting a sheet; 43. a screw motor; 441. a first photosensor; 442. a second photosensor; 5. a reaction disk mechanism; 51. a reaction tray assembly; 511. a substrate; 512. a ring gear; 513. incubating the plate; 5131. incubating the wells; 514. heating plates; 515. a heat-insulating cover plate; 516. a rotating shaft assembly; 521. a top plate; 522. a side vertical plate; 5221. a first card slot; 523. a rear vertical plate; 524. a front vertical plate; 531. a first photoelectric switch; 532. a second photoelectric switch; 541. a rotary motor; 542. a belt transmission member; 55. the reagent strip in-situ detection component; 6. a liquid taking device; 611. taking a liquid and installing the component; 612. taking a liquid head; 613. a piston rod; 6131. a seal ring; 6132. a seal ring locking nut; 6141. a first magnet; 6142. a second magnet; 615. an adapter; 6151. a pin shaft; 6152. a bearing; 616. a limiting structure; 62. a reciprocating drive member; 631. a screw motor; 632. a slide rail; 633. a slider connection; 634. a screw rod; 635. a connecting shaft; 636. a spring; 641. a photoelectric barrier sheet; 642. a photoelectric sensor; 7. a homogeneous chemiluminescence immunoassay module; 711. a light-tight member; 712. supporting the rollers; 713. a swing drive motor; 721. a dense and smooth rubber mat; 722. layering; 723. a module fixing member; 724. detecting a module screw motor; 725. a baffle plate; 726. a linear shaft; 727. an elastic member; 728. a photoelectric switch; 731. a detection head fixing part; 732. a laser mount; 733. a laser; 734. a photomultiplier tube assembly; 8. a catcher unit; 9. a control box; 90. a reagent strip; 100. a base.
Detailed Description
Referring to fig. 1 to 17, the present invention provides a fully automatic homogeneous chemiluminescence real-time detection analyzer, which comprises a base 100, on which: a sample tube supply device 1 having a plurality of sample tubes therein; a Tip head batch loading apparatus 2 having a plurality of Tip heads 212 therein; the reagent strip supply device comprises a reagent strip bin 3 for storing a plurality of reagent strips and a reagent strip grabbing device 4 capable of grabbing and transferring the reagent strips; a reaction disk mechanism 5 comprising a reaction disk assembly 51 capable of being driven in rotation and having thereon a plurality of reagent strip placement sites extending diametrically thereof, and, as will be appreciated, an incubation mechanism; a liquid taking device 6 capable of being assembled with one Tip head 212 delivered by the Tip head batch loading device 2, sucking the sample in the sample tube delivered by the sample tube supplying device 1 and the reagent in the reagent well of the reagent strip on the reagent strip placement position of the reaction disk assembly 51, and placing the sample and/or the reagent in the detection well of the same reagent strip; the homogeneous phase chemiluminescence immunoassay module 7 can collect luminescence information of reaction liquid in a detection hole of the reagent strip at the detection position.
According to the technical scheme, the sample tube supply device 1 with a plurality of sample tubes, the Tip head batch loading device 2 with a plurality of Tip heads 212 and the reagent strip supply device with a plurality of reagent strips are simultaneously configured, the position change requirements of the sample tubes, the Tip heads 212 and the reagent strips in each process are detected at the moment by translation in parallel planes (XZ planes) of the liquid taking device 6 and the reagent strip grabbing device 4 and rotation in a rotating plane (XY plane) of the reaction disc mechanism 5, the instant detection action process is greatly simplified, the batch online loading of consumables (namely the Tip heads 211), the reagents and the samples is realized, the automation degree is high, the continuous detection and batch loading requirements are met, the unmanned machine can be realized, and the labor cost is reduced.
Referring specifically to fig. 2-5, in some embodiments, the sample tube supply device 1 includes: a sample rack placing member 11, on which a sample rack slide 111 is configured, for placing a sample rack 12 (on which a sample tube is loaded), a through groove 112 is configured on a bottom wall of the sample rack slide 111; a sample rack supply drive assembly for driving the sample rack 12 to slide reciprocally along the extending direction of the sample rack slide 111. In the technical scheme, the position of the sample rack 12 can generate feeding displacement under the driving of the sample rack supply driving assembly, so that the position of a liquid taking head in a corresponding liquid taking device can be adjusted in a translation mode in only one plane, the position of the liquid taking device does not need to be adjusted in a space above a fixed sample rack as in the prior art, the risk of a striker of the liquid taking device is remarkably reduced, and meanwhile, the positioning accuracy of the liquid taking head is improved and the control difficulty of the liquid taking head is reduced due to the fact that the liquid taking head is controlled and adjusted in only one plane.
In some embodiments, the sample rack supply drive assembly comprises: a connection assembly (not shown) for selectively connecting to the sample holder 12, i.e. either to the sample holder 12 or not; a first slide driving assembly (not shown) for driving the connecting assembly to slide reciprocally along the extending direction of the sample rack slide 111, so that the sample rack 12 can be driven by the connecting assembly to move linearly reciprocally toward or away from the liquid taking device under the action of the first slide driving assembly.
A jaw slot 121 is formed in an outer wall of the bottom side of the sample holder 12, the connection assembly includes a first screw motor 1311 and a jaw 1312 connected to a terminal end of a first screw of the first screw motor 1311, the first screw motor 1311 (specifically, a permanent magnet screw motor) can drive the jaw 1312 to move toward or away from the sample holder 12 so that the jaw 1312 is clamped into the jaw slot 121 or disengaged from the jaw slot 121, and the jaw 1312 specifically moves up and down along with the screw of the first screw motor 1311.
The first slide driving assembly comprises a first guide rail 1321 and a first rotary motor 1322 which are arranged along the extending direction of the sample rack slide rail 111, the first rotary motor 1322 can drive the connecting assembly to slide back and forth along the first guide rail 1321, and the stability and reliability of the reciprocating linear motion of the sample rack 12 can be ensured through the first guide rail 1321. The first rotating motor 1322 may specifically drive the connecting assembly to move through a belt transmission structure and a slider component fixedly connected to a belt.
Sample frame slide 111 on sample frame placing member 11 has a plurality ofly, coupling assembling can be controlled and is in a plurality ofly remove between the sample frame slide 111 to the realization is placed in the sample frame slide 111 of difference the selective connection of sample frame 12, as shown in fig. 1, be provided with three altogether on the sample frame placing member 11 sample frame slide 111, so, sample pipe feeding device can be under the liquid taking device is supplied with to sample frame 12 in the next sample frame slide 111 of controlled drive after sample pipe on the sample frame 12 in a sample frame slide 111 finishes taking a sample, thereby has realized the online loaded effect in batches, need not the machine halt state sample pipe, has greatly improved the work efficiency of correlation analysis appearance, has improved the measuring flux.
In this case, the sample tube supplying apparatus further includes a second slide driving unit capable of driving the connecting unit to move between the plurality of sample rack slide rails 111, and the first slide driving unit is further capable of driving the connecting unit and the second slide driving unit to slide back and forth as a whole in the extending direction of the sample rack slide rails 111, thereby improving the degree of automation of the apparatus. Specifically, the second sliding driving assembly includes a second guide rail 1331 and a second rotary motor 1332, which are perpendicular to the extending direction of the sample rack slide rail 111, and the second rotary motor 1332 can drive the connecting assembly to slide along the second guide rail 1331 in a reciprocating manner.
A photoelectric switch 141 is disposed at a first position corresponding to each sample rack slide 111, an opposite-incidence sensor 142 is disposed at a second position, and the photoelectric switch 141 and the opposite-incidence sensor 142 are configured in pairs to ensure that two ends of the sample rack 12 in the length direction can be respectively positioned at the first position and the second position, so that the sample rack 12 loaded into the sample rack slide 111 can be positioned at the same initial position each time the sample rack 12 is manually loaded into the sample tube supply device, and the accurate control of the subsequent supply position of the sample rack 12 can be ensured.
It should be noted that, in order to adapt to sample tubes with different tube diameters, a corresponding sample tube adapter 122 may be further disposed in the sample hole of the sample rack 12.
In some embodiments, the liquid taking device 6 comprises a liquid taking head 612, the movement of the liquid taking head 612 is limited in a first plane where the X axis and the Z axis are located, the target sample tube of the sample holder 12 can be fed to the position below the liquid taking head 612 where the Y axis intersects with the first plane along the Y axis direction under the action of the sample holder supply driving assembly, so that the position of the liquid taking head 612 is a position location in a two-dimensional plane (XZ plane), and the Y axis direction is driven by the sample holder supply driving assembly to realize adjustment, and the control is simple.
Referring specifically to fig. 6 to 8, the Tip head batch loading apparatus 2 includes: a consumable assembly comprising a tray 211 and a plurality of Tip heads 212 on the tray 211; the consumable bin rack comprises side plates 221 which are arranged oppositely, and a platform 222 which is positioned at the upper part of one end of each of the two side plates 221, wherein the length of each side plate is corresponding to that of each side plate, a feeding guide rail is formed at one opposite side of each side plate 221, and the tray 211 is connected to the feeding guide rail in a sliding mode; and a feeding driving part which can transfer the consumable components from the first position to the second position along the feeding track, and can transfer the consumable components which run out of the Tip heads 212 onto the platform 222 from the second position, wherein the first position and the second position respectively correspond to two ends of the side plate in the length direction. In the technical scheme, the feeding guide rail and the platform 222 form a double-rail which is overlapped up and down, the consumable component with the Tip head 212 is positioned on the feeding guide rail below, the consumable component (namely only the tray 211) which uses up the Tip head 212 is arranged on the platform 222 above, the occupation of the device on the space can be reduced, the feeding and the pushing of the consumable component are realized to move through the feeding driving part, only the consumable component needs to be arranged at the first position or taken away from the platform 222 by a user, the hand does not need to be stretched into the inside, the safety of the device is improved, and the operation of the user is convenient. It should be particularly noted that, in the technical scheme, the consumable assembly has a plurality of Tip heads 212 at the same time, and two consumable assemblies can be used in relay manner, so that a batch online loading function of consumables can be realized, a shutdown loading after the Tip heads 212 are used up is avoided, and a testing speed is increased.
The consumable components can be lifted up and down between the first position and the platform 222, but such lifting and lowering needs to be provided with a corresponding lifting and lowering mechanism, which complicates the structure of the equipment, has higher cost and is tedious to control, in some preferred embodiments, a switch plate 23 is provided between each side plate 221 and the platform 222, the top end of the switch plate 23 is pivotally connected to the platform 222, the bottom end of the switch plate 23 is in contact connection with the top surface of the side plate 221 under the action of its own weight, and the switch plate 23 is inclined with respect to the horizontal plane, so as to facilitate the consumable components to be transferred from the first position to the second position and from the second position to the platform 222, it should be noted that the platform 222 may be two guide rail sections configured on opposite side surfaces of the two side plates 221, the top end of the switch plate 23 is abutted with the guide rail section, and the bottom end of the switch plate 23 is abutted with the feeding guide rail, so that when the tray 211 moves from the first position to the second position, the switch plate 23 is jacked up (the bottom end of the switch plate 23 is rotatably lifted around a pivot point at the top end) to smoothly feed, and when the tray 211 moves from the second position to the first position, the inclined switch plate 23 is guided to enter the guide rail section, namely, is placed on the platform 222. In some embodiments, the inclined angle between the switching plate 23 and the horizontal plane is a, a is greater than or equal to 10 ° and less than or equal to 60 °, so that the length of the side plate 221 can be reduced while the tray 211 can be smoothly switched in the height direction, and the structure of the whole device is more compact.
In some embodiments, the feed drive component comprises: the feeding guide rail comprises a linear reciprocating driving component and a push-pull component, wherein the push-pull component is used for applying force on the consumable component, and the linear reciprocating driving component is used for driving the push-pull component to generate linear reciprocating motion along the extension direction of the feeding guide rail. In a specific embodiment, the push-pull assembly includes a flap deflecting motor 241, a flap 242 is connected to a rotating shaft of the flap deflecting motor 241, and the flap deflecting motor 241 can drive the flap 242 to switch between its initial position and a push-pull position, specifically, see the flap 242 shown in fig. 1, which is in a vertical state, which is the push-pull position, and when the flap 242 is in a horizontal state, which is the initial position. In the technical scheme, the baffle deflection motor 241 drives the state change of the baffle 242 to realize the connection with the tray 211, so that the push-pull assembly has a small and compact structure.
The catch 242 is configured with a slot 2421, when the consumable assembly needs to be transferred from the first position to the second position, the vertical wall of the tray 211 is partially inserted into the slot 2421, and at this time, the catch 242 will exert a pulling force on the tray 211, so as to ensure reliable and stable connection; when the consumable component needs to be transferred from the second position to the platform 222, an end surface of the blocking piece 242, which is far away from the blocking piece deflection motor 241, partially abuts against a vertical wall of the tray 211, and at this time, the blocking piece 242 applies a pushing force to the tray 211, and in this condition, the tray 211 does not need to be inserted into the insertion groove 2421, so that the blocking piece 242 and the tray 211 do not need to be accurately positioned, and the control logic is simplified.
In some embodiments, the consumable cartridge rack further has a positioning structure, which can precisely position the tray 211 at the first position, so that the relative position relationship between the retaining piece 242 and the tray 211 can be ensured by the specific displacement of the retaining piece. For example, after the push-pull assembly is displaced by a first preset distance along the feeding guide rail, the push-pull assembly is controlled to stop moving forward and control the blocking piece 242 to be at the initial position, then the push-pull assembly is controlled to move forward again by a second preset distance so that the caulking groove 2421 is aligned with the vertical wall of the tray 211, then the push-pull assembly stops moving forward and control the blocking piece 242 to be at the push-pull position, then the push-pull assembly is controlled to move forward in the reverse direction by a third preset distance to reach the second position, so that one feeding is completed, when all Tip heads 212 on the tray 211 are used up, the push-pull assembly is controlled to move forward toward the first position by a fourth preset distance, and then the tray 211 is automatically placed on the upper platform under the guidance of the switching plate 23, so that consumables can be stacked up and down in a forward-out manner.
The linear reciprocating driving component comprises a rotary motor 243, the push-pull component further comprises a fixed frame 244, the baffle deflection motor 241 is arranged on the fixed frame 244, the rotary motor 243 can adopt a gear transmission structure and a screw transmission structure to drive the fixed frame 244 to move, in a preferred embodiment, the rotary motor 243 is in driving connection with the fixed frame 244 through a belt transmission structure, and the belt transmission structure can have large length adjustment capacity and low manufacturing cost, and is more flexible in the aspect of arrangement of specific components. Specifically, the rotary motor 243 is disposed on the inner side of one of the two side plates 221, the belt transmission structure is disposed on the outer side of the side plate 221, the belt transmission structure includes a belt wheel 245 sleeved on the rotating shaft of the rotary motor 243, a supporting roller 246 spaced from the belt wheel 245 on the linear reciprocating path, and a transmission belt 247 mounted on the belt wheel 245 and the supporting roller 246, and the transmission belt 247 is fixedly connected to the fixing frame 244. The two supporting rollers 246 are arranged adjacently up and down, the sum of the diameters of the two supporting rollers 246 is equal to the diameter of the belt wheel 245, so that the conveying belt 247 is in a horizontal conveying state.
A first sensor 249 (specifically, a proximity switch) is disposed on the fixing frame 244 and is configured to detect an initial position of the blocking piece 242, and a second sensor (not shown in the drawings, and specifically, a diffuse reflection sensor) is further disposed on the fixing frame 244 and is configured to detect whether the tray 211 is successfully connected to the blocking piece 242, it can be understood that if the connection is successful, the tray 211 will be detected, and if the connection is unsuccessful, the tray 211 will not be detected.
In some embodiments, the outer side of the side plate 221 is further provided with a linear guide 248, and the fixing frame 244 is slidably connected to the linear guide 248 to ensure the stability of the linear reciprocating motion.
Referring specifically to fig. 9 to 10, the reagent strip grasping apparatus 4 includes: a mounting member 41; a jaw unit including two jaw arms 421 disposed oppositely; a grasping device driving part mounted on the mounting part 41, capable of driving the two jaw arms 421 to move towards or away from each other to form a grip on two opposite side walls of the reagent strip 90, and capable of driving the jaw units to ascend along a straight line after the jaw arms 421 grip the reagent strip 90; a traverse driving means (not shown in the drawings, not referenced) capable of simultaneously translating the mounting member 41, the gripper unit, and the gripper driving means in a horizontal straight line. In the technical scheme, the clamping jaw unit can clamp the reagent strip 90 and drive the reagent strip 90 to linearly move in the height direction, and the transverse moving driving component can drive the reagent strip 90 to linearly move in the horizontal direction, namely, the position of the reagent strip 90 can be adjusted in the height direction and the horizontal direction, so that the use scenes of the reagent strip gripping device can be enriched, the reasonable layout of corresponding components of a corresponding full-automatic chemiluminescence instant detection analyzer in the height and horizontal space is facilitated, and the structure can be designed to be more compact.
In some embodiments, the jaw unit further includes a jaw rotation mounting plate 422, which is fixedly connected to the mounting member 41, that is, the relative position between the jaw rotation mounting plate 422 and the mounting member 41 is not changed, two of the jaw arms 421 are pivotally connected to the jaw rotation mounting plate 422, and the corresponding ends of the two jaw arms 421 are further pivotally connected to a reciprocating slider 423, the reciprocating slider 423 is connected to a power output shaft of the grasping device driving member, when the power output shaft moves close to the jaw arms 421, the two jaw arms 421 move away from each other, and when the power output shaft moves away from the jaw arms 421, the two jaw arms 421 move toward each other. In this technical scheme, grabbing device drive unit drives reciprocating motion of reciprocating slide 423, utilizes reciprocating slide 423's reciprocal displacement variation application of force in two clamping jaw arm 421 correspond one end, thereby makes clamping jaw arm 421 can be around its with clamping jaw rotation mounting panel 422's pivot joint point is rotatory, thereby realizes two the motion in opposite directions or back to back of clamping jaw arm 421, and then realizes the centre gripping of reagent strip 90 or release the centre gripping, and this kind of drive mode utilizes reciprocating slide 423 with clamping jaw rotation mounting panel 422's relative position realizes the action of centre gripping and release centre gripping, and structural design is simple and compact, and control logic is simpler, need not to control separately for every clamping jaw arm 421's action.
In order to realize more reliable clamping, the opposite sides of the two clamping claw arms 421 are provided with clamping strips 4212, which can be matched with the grooves on the corresponding side walls of the reagent strip 90 when the two clamping claw arms 421 move towards each other, so as to effectively prevent the reagent strip 90 from slipping off during clamping. In a more preferred embodiment, a side of the clamping strip 4212 facing the reagent strip 90 is provided with a chamfer so as to perform functions of guiding and correcting the position of the clamping process, and ensure accurate grasping.
In some embodiments, the reciprocating slider 423 is configured with a sliding slot 4231 extending in a horizontal direction, the corresponding end of the gripper arm 421 is slidably connected to the sliding slot 4231 through a bearing 4211, specifically, a bearing pin 4213 is inserted through the corresponding end of the gripper arm 421, two ends of the bearing pin 4213 are respectively sleeved with the bearing 4211, and through the bearing 4211, the corresponding end of the gripper arm 421 can slide in the sliding slot 4231 along a length direction of a slot thereof, so that smooth driving of the reciprocating slider 423 to the movement of the gripper arm 421 is ensured, and a seizure phenomenon during clamping or contact clamping is prevented.
As a specific implementation manner, the grasping device driving part includes a screw motor 43 (which is fixedly connected to the mounting part 41 through a corresponding motor mounting seat), the power output shaft is a screw rod of the screw motor 43, the screw motor 43 can directly convert a rotation angular displacement into a linear displacement of the screw rod, the mounting part 41 is further provided with a guide rail 411, and the reciprocating slider 423 is slidably connected to the guide rail 411, so that the linear displacement driving of the reciprocating slider 423 is realized, the structure of the reagent strip grasping device is simplified, and the structure is more compact. Meanwhile, it should be noted that the screw motor 43 can also utilize the self-locking force of the screw to prevent the reagent strip 90 from falling off abnormally during the moving and grabbing processes.
In some embodiments, a first photoelectric sensor 441 is disposed adjacent to an end of the screw rod away from the jaw unit, and is used to detect a position of the screw rod, and it is understood that the first photoelectric sensor 441 is fixed on a component that is relatively immovable with respect to a mounting seat of the screw rod motor 43, for example, fixed on the mounting part 41, so as to be triggered to send a corresponding position signal when the side of the screw rod away from the jaw arm 421 moves and reaches a preset position, and then the screw rod motor 43 is controlled to stop operating. That is, the first photosensor 441 is provided to detect and limit the maximum retraction position of the lead screw.
The clamping jaw unit further comprises a reagent strip pressing assembly, the clamping jaw unit can clamp or release the reagent strip 90, force can be applied to the reagent strip 90, when the force is applied to the reagent strip 90 in the clamping process, the reagent strip 90 and the clamping strip 4212 on the clamping jaw arm 421 can form reliable clamping on the reagent strip 90 in the height direction, the reagent strip 90 is prevented from position changing, and when the reagent strip 90 is in the contact clamping process, the reagent strip 90 can be favorably and smoothly pulled out from the clamping jaw unit.
In some embodiments, the reagent strip pressing assembly includes a force application column 4241, the force application column 4241 is inserted in the clamping jaw rotation mounting plate 422 in a vertically slidable manner, one end of the force application column 4241 facing the reagent strip 90 is a force application disc 4242, and an elastic member 4243 is interposed between the force application disc 4242 and the clamping jaw rotation mounting plate 422, in this embodiment, the clamping jaw rotation mounting plate 422 is further used as a displacement guide member of the force application column 4241, so as to ensure that the force application column 4241 can slide vertically and stably, and simplify the structural design, the elastic member 4243 is, for example, a spring sleeved on the outer circumferential side of the force application column 4241, and by the elastic compensation effect of the elastic member 4243, the force can be flexibly applied to the reagent strip 90, and the impact damage caused by rigid contact can be prevented.
The end of the force application column 4241 far away from the reagent strip 90 is provided with a U-shaped piece 4244, and the clamping jaw rotating mounting plate 422 is at least partially positioned in the opening area of the U-shaped piece 4244, so that the circumferential displacement variation which can exist when the force application column 4241 is in a cylindrical rod shape can be effectively prevented; one end of the force application column 4241, which is away from the reagent strip 90, is provided with a detection sheet 4245, a second photoelectric sensor 442 is arranged corresponding to the detection sheet 4245, the second photoelectric sensor 442 is used for detecting the position of the force application column 4241, when the end of the force application column 4241 is provided with the U-shaped member 4244, the detection sheet 4245 is arranged on one side, facing the second photoelectric sensor 442, of the U-shaped member 4244, when the clamping claw arm 421 clamps the reagent strip 90, the force application column 4241 is pushed upwards by a certain displacement, and the corresponding detection sheet 4245 is also displaced on one side, which is close to the second photoelectric sensor 442, and enters the sensing range of the second photoelectric sensor 442, so as to detect whether the reagent strip 90 is clamped in place.
In some embodiments, there are two sets of reagent strip pressing assemblies, one at each end of the clamping jaw rotary mounting plate 422, the two ends of the clamping jaw rotating installation plate 422 in the length direction respectively correspond to the two ends of the reagent strip 90 in the length direction, the two second photosensors 442 are provided, the two second photosensors 442 are provided so as to correspond to both ends of the gripper rotation mounting plate 422 in the longitudinal direction, by providing the second photosensors 442 at both ends in the longitudinal direction, that is, by detecting both ends in the longitudinal direction of the reagent strip 90, it is possible to effectively monitor that the reagent strip 90 is abnormally jammed when unclamped and placed in a target position (e.g., a corresponding card slot) (when the jamming occurs, the two second photosensors 442 at both ends will not simultaneously detect the corresponding detection pad 4245).
Referring specifically to fig. 17, in some embodiments, the reagent strip magazine 3 includes a plurality of reagent strip feeding channels 32 independent from each other, a plurality of reagent racks 31 respectively disposed on each reagent strip feeding channel 32 in a one-to-one correspondence manner, and a feeding driving device 33, where the reagent strip feeding channels 32 can drive reagent strips at the bottommost of the reagent racks 31 to move linearly toward the reagent strip grasping device 4, and the reagent strip grasping device 4 can grasp and translate the reagent strips on an XZ plane to place the reagent strips on a placing position (an idle placing position) of the reaction disk mechanism 5, so that batch online supply of the reagent strips can be realized.
As shown in fig. 11 to 12, the reaction disk mechanism 5 further includes a mounting base, the mounting base includes a top plate 521 and two side vertical plates 522 arranged in parallel at intervals, opposite side walls of the two side vertical plates 522 are provided with first locking grooves 5221, and the top plate 521 is inserted into the first locking grooves 5221; the reaction tray assembly 51 is integrally mounted on the top plate 521. In this technical solution, since the top plate 521 is erected between the two side vertical plates 522 through the first slot 5221, the reaction disc assembly 51 can be integrally assembled with the top plate 521 before the top plate 521 is assembled in the first slot 5221, that is, the assembly and disassembly of the reaction disc assembly 51 do not need to be from top to bottom or from bottom to top on the mounting base as in the prior art, so that the assembly space requirement of the reaction disc mechanism is greatly reduced, no extra position correction is required, and the production and maintenance efficiency is improved.
The mounting base further comprises a rear vertical plate 523 connected to one end of each of the two side vertical plates 522 and a front vertical plate 524 detachably connected to the other end of each of the side vertical plates 522, and the rear vertical plate 523 and the front vertical plate 524 can further position the top plate 521 to prevent the top plate 521 from moving back and forth.
In some embodiments, the rear vertical plate 523 has a second locking groove (not referenced) on an inner sidewall thereof corresponding to the first locking groove 5221, and/or the front vertical plate 524 has a third locking groove (not referenced) on an inner sidewall thereof corresponding to the first locking groove 5221, so that the top plate 521 is precisely positioned by the second locking groove and the third locking groove.
The rear vertical plate 523 and/or the front vertical plate 524 are bolted to the side vertical plate 522 through screws, after the reaction disc assembly 51 is assembled on the top plate 521 and inserted into the first slot 5221, the front vertical plate 524 is connected to the end of the side vertical plate 522 through screws, so that the reaction disc assembly 51 is positioned synchronously without extra correction.
The reaction disc assembly 51 comprises a base body 511, a gear ring 512 is arranged on one side of the base body 511 facing the top plate 521, a first photoelectric switch 531 is arranged on the outer side of the gear ring 512, and the first photoelectric switch 531 can sense the tooth part of the gear ring 512 to judge the rotation angle displacement of the base body 511; and/or, the inboard of ring gear 512 is equipped with second photoelectric switch 532, second photoelectric switch 532 can respond to be in the inboard photoelectricity separation blade of ring gear 512 is in order to judge the rotatory initial position of base member 511, and compared with the technical scheme that relies on single pulse number to control the reaction dish and walk the position among the prior art, adopt first photoelectric switch 531 and second photoelectric switch 532's mode can promote the rotation control precision to reaction dish subassembly 51. Preferably, the first photoelectric switch 531 and the second photoelectric switch 532 are mounted on the top plate 521, so that the reaction disk mechanism is more compact.
Referring to fig. 12, the reaction tray assembly 51 further includes an incubation plate 513 and a heating plate 514 disposed between the substrate 511 and the incubation plate 513, the substrate 511 has a plurality of reagent strip placement positions (not labeled) extending along a radial direction thereof, the incubation plate 513 has a plurality of incubation holes 5131, the positions of the incubation holes 5131 correspond to the positions of the detection holes of the reagent strips 90 placed on the reagent strip placement positions one by one, it can be understood that the incubation holes 5131 have only one opening facing one side of the detection holes, other orientations can form all-around heating effects on the detection holes, and preferably, the incubation holes 5131 and the incubation plate 513 are made of the same material (e.g., aluminum) and are integrally formed, thereby ensuring uniform heat transfer of the heating plate 514 and uniform temperature of each incubation hole 5131, this is favorable to promoting the accuracy of testing result.
In some embodiments, the side of the incubation plate 513 facing away from the heating plate 514 is covered with a thermal cover plate 515, which can reduce the radiation of the temperature of the incubation plate 513 to the outside and improve the utilization rate of energy.
As can be appreciated, the reaction tray mechanism further comprises a reaction tray rotation driving assembly to drive the reaction tray assembly 51 to rotate and switch between different stations, in one embodiment, the reaction tray rotation driving assembly comprises a belt transmission member 542, the belt transmission member is disposed on the inner side of the top plate 521, the arrangement of the relevant components can be more flexible by using the belt transmission member 542, and the arrangement of the belt transmission member 542 on the inner side of the top plate 521 can improve the safety of the reaction tray mechanism, thereby effectively preventing the reaction tray mechanism from possible safety accidents facing operators.
The reaction disk assembly 51 includes a rotating shaft assembly 516, the rotating shaft assembly 516 pivotally supports the base 511 and various components thereon on the top plate 521, the reaction disk rotation driving assembly further includes a rotary motor 541, and the belt transmission member 542 can transmit the rotation displacement of the rotary motor 541 to the rotating shaft assembly 516.
In some embodiments, a reagent strip position detection component 55 (e.g., a diffuse reflection sensing switch) is further disposed on the top plate 521, and is disposed adjacent to the reaction disk assembly 51, so as to determine whether a reagent strip is disposed on each reagent strip placement position on the substrate 511, thereby improving the control intelligence of the reaction disk mechanism.
Referring specifically to fig. 13 to 14, the liquid taking device 6 includes a liquid taking unit, and the liquid taking unit includes: a fluid extraction mount 611 having a sealed cavity configured therein; a liquid extraction head 612 connected to one of the through holes of the sealed chamber; a piston rod 613 disposed in the sealed chamber and driven by the reciprocating driving member 62 to perform liquid suction and discharge functions of the liquid taking head 612; the telescopic rod (specifically, for example, a screw rod of a screw rod motor) of the reciprocating driving component 62 is connected with the piston rod 613 through magnetic attraction, so that the piston rod 613 can stretch along with the expansion of the telescopic rod to further achieve the liquid suction and discharge of the liquid taking head 612, and meanwhile, the liquid taking head 612 is directly communicated with the sealed cavity without adopting a corresponding hose for switching, thereby avoiding additional risks caused by hose connection.
In this technical scheme, the piston rod 613 with adopt the mode drive connection of magnetic force actuation between the telescopic link, can effectively prevent to take place because the piston rod 613 and the skew card pause phenomenon that brings of telescopic link axle center from taking place when guaranteeing that the piston rod 613 is not loose, and the liquid process of getting that can smoothly control does benefit to the accuracy of guaranteeing to get the liquid measure.
In some embodiments, one of the piston rod 613 and the telescopic rod may be made of a magnetic material such as iron, and the other one of the piston rod 613 and the telescopic rod may be made of a corresponding magnet, preferably, one end of each of the two rods is made of a magnet (preferably, a permanent magnet) to ensure the reliability of the magnetic attraction, and in particular, one end of the telescopic rod facing the piston rod 613 is provided with a first magnet 6141, and one end of the piston rod 613 facing the telescopic rod is provided with a second magnet 6142.
In another embodiment, an adaptor 615 is connected to one end of the telescopic rod facing the piston rod 613, the first magnet 6141 is connected to one end of the telescopic rod through the adaptor 615, a corresponding guide structure may be designed between the adaptor 615 and the fluid-taking mounting member 611 to ensure smooth extension and retraction, specifically, a guide assembly is disposed between the adaptor 615 and the fluid-taking mounting member 611, the guide assembly includes a pin 6151 fixedly connected to the adaptor 615 and a bearing 6152 sleeved on the pin 6151, the bearing 6152 may be a deep groove ball bearing, it can be understood that a corresponding clamping groove is formed on the fluid-taking mounting member 611, so that the positioning accuracy of the piston rod 613 and the telescopic rod can be ensured, and the telescopic rod has high sliding smoothness to further prevent the occurrence of a sliding and stopping phenomenon.
Preferably, a limiting structure 616 is further disposed between the piston rod 613 and the telescopic rod, for example, the limiting structure 616 may specifically adopt a limiting plate, one end of the limiting structure is fixedly connected to the adaptor 615, and the other end of the limiting structure may form a hook structure bent inward, so as to limit the piston rod 613, and prevent the piston rod 613 from being separated due to insufficient magnetic force of the magnet.
A sealing ring 6131 is sleeved on the piston rod 613 to ensure the sealing of the sealed cavity, and a sealing ring locking nut 6132 is screwed on one side of the sealing ring 6131, which is far away from the sealed cavity, to ensure the position reliability of the sealing ring 6131.
The telescopic direction of the piston rod 613 is perpendicular to the through-flow direction of the liquid taking head 612, so that the structure of the liquid taking device is more reasonable and compact, and correspondingly, at the moment, the liquid taking device further comprises a lifting driving unit which is in driving connection with the liquid taking unit so as to drive the liquid taking unit to move up and down along the vertical direction.
The lifting driving unit comprises a screw motor 631, a slide rail 632 and a slide block connecting piece 633, the slide block connecting piece 633 and the liquid taking installation piece 611 are connected to the slide rail 632 in a sliding mode and can be driven by the screw rod 634 of the screw motor 631 to lift along the slide rail 632, the slide block connecting piece 633 and the liquid taking installation piece 611 are connected through a connecting shaft 635, and in the technical scheme, the liquid taking unit can be guaranteed to move stably through the design of the slide rail 632, and the vertical degree of the liquid taking head 612 is guaranteed to move.
In some embodiments, one end of the connecting shaft 635 is located in the liquid extraction mounting member 611 and can slide, and the connecting shaft 635 is sleeved with a spring 636 to apply a force to the liquid extraction mounting member 611 when the slider connecting member 633 descends, and to allow the liquid extraction mounting member 611 to displace toward the slider connecting member 633 when the liquid extraction head 612 bottoms out, so as to physically protect the liquid extraction head 612. The Tip head matched with the liquid taking head 612 preferably adopts a disposable conductive Tip head, so that cross contamination can be avoided, and the function of detecting the liquid level of a sample can be realized.
The tail end of the telescopic rod is provided with a photoelectric blocking piece 641, and the resetting action can be realized by triggering the photoelectric sensor 642 during movement.
Referring specifically to fig. 15-16, the homogeneous chemiluminescent immunoassay module 7 comprises: the detection assembly comprises a detection head which can be driven to lift; the light-tight piece assembly comprises a light-tight piece 711, wherein a light-tight part is configured on the light-tight piece 711, the light-tight piece 711 can be switched between a first position and a second position, when the light-tight piece 711 is in the first position, the light-tight piece 711 can enable the light-passing structure of the detection head to realize light-tight, and when the light-tight piece 711 is in the second position, the light-tight structure of the reagent strip corresponding to the detection head can enable the light-passing structure of the detection head to realize light-tight. In the technical scheme, after the detection module finishes the detection operation on the reagent strip, the detection head can be connected with the light-tight structure of the light-tight piece 711 for light-tight connection after being separated from the light-tight structure of the reagent strip, so that the time of the detection head in the dark light-tight environment is greatly prolonged, the contact time of the detection head and the outer light-tight environment is only the switching time between the light-tight structure of the reagent strip and the light-tight piece 711, namely the switching time between the first position and the second position, and the photomultiplier tube of the detection head can be powered off at the switching time during specific operation, so that the possibility of damage of exposure to the photomultiplier tube due to light contact with the external environment is reduced, the power-on time of the photomultiplier tube can be prolonged, signals are more stable, the noise of the photomultiplier tube is effectively reduced, and the accuracy of detection results is improved.
In some embodiments, a light-tight rubber pad 721 is detachably connected to one side of the detection head facing the reagent strip, since the light-tight rubber pad 721 in this embodiment will have abrasion in contact with the light-tight member 711, and is easily damaged, and the light-tight rubber pad 721 is detachably connected to the detection head for replacement.
One side of the detection head facing the reagent strip is provided with a pressing strip 722, when the light-tight structure of the reagent strip is light-tight and the light-through structure of the detection head is light-tight, the pressing strip 722 can be pressed on the top surface of the reagent strip and elastically deformed, so that after the detection is finished, the reagent strip below the detection head rises together with the detection head in the driven rising process, namely, the pressing strip 722 can ensure the separation between the reagent strip and the detection head in the rising process of the detection head by means of the deformation of the pressing strip 722.
It can be understood that the detection module further comprises a lifting driving assembly, which is used for driving the detection head to move towards or away from the reagent strip to do linear reciprocating motion, specifically, the detection assembly further comprises a module fixing member 723, the lifting driving assembly comprises a detection module lead screw motor 724, a lead screw of the detection module lead screw motor 724 can drive the detection head to lift, so that the whole structure of the module is simple and compact.
It is understood that the detection head is connected to the module fixing member 723 through the detection head fixing member 731, and a laser fixing member 732 for fixing the laser 733 and a photomultiplier tube assembly 734 (including a PMT tube and a corresponding protection member) are further connected thereto, and are used as a conventional design structure of the homogeneous chemiluminescence immunoassay module, and are not described herein again.
One end of a screw rod of the detection module screw rod motor 724 is fixedly connected with one end of two linear shafts 726 which are arranged in parallel through a blocking piece 725, the other ends of the two linear shafts 726 are fixedly connected with the detection head, and the linear shafts 726 are inserted into guide holes of the module fixing piece 723, so that the stability and reliability of the lifting of the detection head can be ensured. Preferably, an elastic member 727 is sleeved on the linear shaft 726 between the blocking plate 725 and the guide hole, so as to perform buffering and shock absorption functions during the descending process of the detection head; a detection module photoelectric switch 728 is arranged on one side of the detection module lead screw motor 724 facing the blocking piece 725, and can detect and determine the retraction position (i.e. the highest elevation point) of the blocking piece 725.
In some embodiments, the homogeneous chemiluminescent immunoassay module further comprises a swing driving assembly for driving the light-tight member 711 to switch between the first position and the second position, wherein the swing driving assembly comprises a swing driving motor 713 configured to control the light-tight member 711 to be in the second position when a sample in a detection hole on a reagent strip needs to be detected, and control the light-tight member 711 to be in the first position when a reagent strip station needs to be switched after the detection.
The light-tight member 711 is provided with a support roller 712, and the light-tight member 711 can slide on a corresponding support carrier through the support roller 712, so that the contact friction force in the switching process can be reduced, the smooth switching of the positions can be ensured, and the deformation of the light-tight member 711 can be reduced through the support of the light-tight member 711. In some embodiments, the supporting rollers 712 have two sets, two sets of the supporting rollers 712 are disposed on opposite sides of the light-tight member 711, and the two sets of the supporting rollers 712 are disposed opposite to each other to further improve the smoothness of position switching.
It should be noted that the technical scheme of the invention mainly utilizes the upper and lower space structure, and adopts a plurality of two-dimensional motion superposition modes to realize the three-dimensional motion function; the functional modules are mutually matched to realize the automatic operation function of the instrument. Specifically, a dragging rod (i.e., a connecting assembly) in the sample tube supply device 1 can drag the sample rack 12 to move in the sample tube supply device 1 along the Y-axis direction, the liquid taking device 6 moves on the X-axis, and the liquid taking (sampling) displacement is completed by using the XY-axis intersection; the Tip head box in the Tip head batch loading device 2 is held by a Tip head box gripper (namely, the blocking piece 242, the same below) in the Tip head batch loading device 2 to move along the Y-axis direction, the liquid taking device 6 moves on the X-axis, and the taking of the Tip head 212 is completed by utilizing the XY-axis intersection point; a movement mechanism consisting of an electromagnet and a motor below the reagent strip bin 3 pushes the reagent to the lower part of the movement track of a gripper (namely, a clamping jaw arm 421 of the reagent strip grabbing device 4), and the gripper can grab the reagent strip 90 only by moving in the X-axis direction and the Z-axis direction; the reaction disc mechanism 5 solves the problem of the distance difference between two parallel X axes of the liquid taking device 6 and the reagent strip grabbing device 4 by using the radius difference of concentric circles; when the incubation channel (i.e., the position of the detection hole) on the reaction disk mechanism 5 is rotated to the position below the homogeneous chemiluminescence immunoassay module 7, the homogeneous chemiluminescence immunoassay module 7 can read the number of photons.
When the reagent strip gripping device 4 grips an abnormal reagent strip, the catcher unit 8 moves on the Y-axis to catch the abnormal reagent strip.
The analyzer has a control box 9 with a control module therein, which can process the motion time sequence between the functional modules and receive feedback signals.
Each functional module realizes online batch processing, and is specific:
the sample tube supplying apparatus 1 can simultaneously place three independent sample racks 12, each sample rack 12 has an independent moving channel (i.e. the sample rack slide 111), the channels do not interfere with each other, each sample rack can place 10 samples (specific examples, more or less can be possible), so 30 samples can be simultaneously online, and because each sample rack 12 is independent, the used sample rack or the unfilled sample rack can be loaded with new samples without stopping the machine; the sample frame 12 is placed into an instrument, the instrument automatically drives the sample frame to move, and sample information is automatically identified and transmitted; the sample tube supply device 1 is designed with a sample tube for detection, and can effectively correct the misplacement of the sample tube.
The Tip batch loading device 2 can be used for placing two tips, and one Tip uses a standby mode to increase the storage capacity of consumables; although the Tip head boxes are all in a forward and forward mode, the problem of continuous loading is solved by utilizing an upper channel and a lower channel; through the first quantity of system intelligent management Tip, whether the Tip in the suggestion instrument is enough in advance, stopped because of the shutdown that the consumptive material is not enough and caused.
The reagent strip bin 3 is designed with 8 independent channels, each channel can be provided with one reagent box (namely the reagent rack 31), each reagent box can be provided with 12 copies of reagent strips, and 96 copies of reagent strips can be loaded at one time; each channel of the reagent strip bin 3 is independent, so that the reagent strip bin can be independently used during operation, and the function of online loading is realized. The number and the project management of each reagent box 10 can be carried out through the system, and the defect that a fixed channel is used as a fixed project is avoided.
The tongs (claw clamping arms) of the reagent strip gripping device 4 are matched with the reagent strips for use, so that the stability of reagent strip gripping is ensured, the running speed of the instrument is increased, and the failure rate is reduced.
The reaction disk mechanism 5 has both a reagent strip transfer function and an incubation function. The reaction disc mechanism 5 can incubate 18 tests at the same time; the 18 incubation positions fully satisfied the requirements of the instrument cycling test.
The liquid taking device 6 samples the disposable Tip head, so that the cleaning design of the sample adding needle is avoided, and the liquid path is reduced. The liquid level detection and bottom collision test are designed for the liquid taking device 6, so that the sampling accuracy is greatly improved.
The homogeneous chemiluminescence immunoassay module 7 adopts a direct-up-direct-down mode to ensure that the module is simple to operate and has higher detection speed. The homogeneous phase chemiluminescence immunoassay module 7 adopts flexible rubber pad light for light sealing, and the light sealing effect of the method is good.
The catcher module 8 can collect abnormal reagent strips, and reagent waste is avoided.
It is readily understood by a person skilled in the art that the advantageous ways described above can be freely combined, superimposed without conflict.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention. The above is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several improvements and modifications can be made without departing from the technical principle of the present invention, and these improvements and modifications should also be regarded as the protection scope of the present invention.

Claims (42)

1. The utility model provides a full-automatic homogeneous phase chemiluminescence instant detection analysis appearance which characterized in that, includes base (100), is provided with on it:
a sample tube supply device (1) having a plurality of sample tubes therein;
a Tip head batch loading device (2) having a plurality of Tip heads (212) therein;
the reagent strip supply device comprises a reagent strip bin (3) for storing a plurality of reagent strips and a reagent strip grabbing device (4) capable of grabbing and transferring the reagent strips;
the reaction disc mechanism (5) comprises a reaction disc assembly (51) capable of being driven to rotate, and a plurality of reagent strip placing positions extending along the diameter direction of the reaction disc assembly are arranged on the reaction disc assembly;
the liquid taking device (6) can be assembled with one Tip head (212) conveyed by the Tip head batch loading device (2), sucks the sample in the sample tube conveyed by the sample tube supply device (1) and the reagent in the reagent hole of the reagent strip on the reagent strip placement position of the reaction disc assembly (51), and places the sample and/or the reagent in the detection hole of the same reagent strip;
the homogeneous phase chemiluminescence immunoassay module (7) can collect the luminescence information of the reaction liquid in the detection hole of the reagent strip at the detection position.
2. The fully automated homogeneous chemiluminescent in-line assay analyzer of claim 1 wherein the sample tube supply (1) comprises:
a sample rack placing piece (11) used for placing the sample tube, a sample rack slide way (111) is formed on the sample rack placing piece and used for placing a sample rack (12), and a through groove (112) is formed on the bottom wall of the sample rack slide way (111);
a sample rack supply driving assembly for driving the sample rack (12) to slide back and forth along the extending direction of the sample rack slide way (111).
3. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 2,
the specimen rack supply drive assembly includes:
a connection assembly for selectively connecting with the sample holder (12);
the first sliding driving assembly is used for driving the connecting assembly to slide back and forth along the extending direction of the sample rack slide way (111);
the sample rack slide ways (111) on the sample rack placing piece (11) are provided with a plurality of, and the connecting assembly can be controlled to move among the sample rack slide ways (111) so as to realize the selective connection of the sample racks (12) placed in different sample rack slide ways (111).
4. The fully automatic homogeneous chemiluminescent real-time detection analyzer of claim 3,
a jaw slot (121) is formed in the outer wall of the bottom side of the sample rack (12), the connecting assembly comprises a first lead screw motor (1311) and a jaw (1312) connected to the tail end of a first lead screw of the first lead screw motor (1311), and the first lead screw motor (1311) can drive the jaw (1312) to move towards or away from the sample rack (12) so that the jaw (1312) can be clamped into the jaw slot (121) or pulled out of the jaw slot (121); and/or the presence of a gas in the gas,
the first sliding driving assembly comprises a first guide rail (1321) and a first rotary motor (1322), wherein the first guide rail (1321) is arranged along the extension direction of the sample rack slide rail (111), and the first rotary motor (1322) can drive the connecting assembly to slide back and forth along the first guide rail (1321).
5. The fully automatic homogeneous chemiluminescent real-time detection analyzer of claim 4,
the sample rack slide ways (111) on the sample rack placing piece (11) are provided with a plurality of, and the connecting assembly can be controlled to move among the sample rack slide ways (111) so as to realize the selective connection of the sample racks (12) placed in different sample rack slide ways (111).
6. The fully automatic homogeneous chemiluminescent real-time detection analyzer of claim 5,
the sample rack slide rail device further comprises a second sliding driving component capable of driving the connecting component to move among the sample rack slide rails (111), and the first sliding driving component can also drive the connecting component and the second sliding driving component to slide back and forth as a whole along the extending direction of the sample rack slide rails (111).
7. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 2,
a photoelectric switch (141) is arranged at a first position corresponding to each sample rack slide way (111), an opposite-incidence sensor (142) is arranged at a second position, and the photoelectric switch (141) and the opposite-incidence sensor (142) are configured in pairs so as to ensure that two ends of the length of the sample rack (12) can be respectively positioned at the first position and the second position; alternatively, the first and second electrodes may be,
the liquid taking device (6) comprises a liquid taking head (612), the movement of the liquid taking head (612) is limited in a first plane where an X axis and a Z axis are located, and a target sample tube of the sample rack (12) can be fed to the position, where the Y axis intersects with the first plane, below the liquid taking head (612) along a Y axis direction under the action of the sample rack supply driving assembly.
8. The fully automated homogeneous chemiluminescent in-line assay analyzer of claim 1 wherein the Tip head batch loading device (2) comprises:
a consumable assembly comprising a tray (211) and a plurality of the Tip heads (212) on the tray (211);
the consumable bin rack comprises side plates (221) which are arranged oppositely, and a platform (222) which is positioned at the upper part of one end of each of the two side plates (221) with the corresponding length, wherein a feeding guide rail is formed at one opposite side of each of the two side plates (221), and the tray (211) is connected to the feeding guide rail in a sliding manner;
and the feeding driving part can transfer the consumable components from the first position to the second position along the feeding track, and can transfer the consumable components which run out of the Tip heads (212) from the second position to the platform (222), wherein the first position and the second position respectively correspond to two ends of the side plate in the length direction.
9. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 8,
every be equipped with one switch board (23) between curb plate (221) with platform (222), the top of switch board (23) with platform (222) pivotal connection, the bottom of switch board (23) under its dead weight effect contact connect in the top surface of curb plate (221), just switch board (23) and horizontal plane slope set up to do benefit to the consumptive material subassembly by the first position shift to the second position and by the second position shift to on platform (222).
10. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 9,
the inclined included angle between the switching plate (23) and the horizontal plane is a, and a is more than or equal to 10 degrees and less than or equal to 60 degrees.
11. The fully automated homogeneous chemiluminescent in-line assay analyzer of claim 8 wherein the feed drive assembly comprises:
the feeding guide rail comprises a linear reciprocating driving component and a push-pull component, wherein the push-pull component is used for applying force on the consumable component, and the linear reciprocating driving component is used for driving the push-pull component to generate linear reciprocating motion along the extension direction of the feeding guide rail.
12. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 11,
the push-pull assembly comprises a blocking piece deflection motor (241), a blocking piece (242) is connected to a rotating shaft of the blocking piece deflection motor (241), and the blocking piece deflection motor (241) can drive the blocking piece (242) to be switched between an initial position and a push-pull position.
13. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 12,
the catch (242) is provided with a caulking groove (2421), and when the consumable component needs to be transferred from the first position to the second position, the vertical wall of the tray (211) is partially inserted into the caulking groove (2421); and/or when the consumable component needs to be transferred from the second position to the platform (222), one side end face of the baffle (242) far away from the baffle deflection motor (241) is partially abutted with the vertical wall of the tray (211).
14. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 12,
the linear reciprocating driving component comprises a rotary motor (243), the push-pull assembly further comprises a fixed frame (244), the baffle deflection motor (241) is arranged on the fixed frame (244), and the rotary motor (243) is in driving connection with the fixed frame (244) through a belt transmission structure.
15. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 14,
the rotary motor (243) is arranged on the inner side of one of the two side plates (221), the belt transmission structure is arranged on the outer side of the side plate (221), the belt transmission structure comprises a belt wheel (245) sleeved on a rotating shaft of the rotary motor (243), supporting rollers (246) arranged on a linear reciprocating path at intervals with the belt wheel (245), and a transmission belt (247) erected on the belt wheel (245) and the supporting rollers (246), and the transmission belt (247) is fixedly connected with the fixed frame (244); or a first sensor (249) is arranged on the fixing frame (244) and used for detecting the initial position of the baffle plate (242).
16. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 1 wherein the reagent strip grasping device (4) comprises:
a mounting member (41);
the clamping jaw unit comprises two clamping jaw arms (421) which are oppositely arranged;
the gripping device driving part is arranged on the mounting part (41), can drive the two clamping claw arms (421) to move towards or away from each other so as to clamp two opposite side walls of the reagent strip (90), and can drive the clamping claw units to ascend along a straight line after the clamping claw arms (421) clamp the reagent strip (90);
and a traverse driving part capable of translating the mounting member (41), the jaw unit, and the gripper driving part simultaneously along a horizontal straight line.
17. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 16,
the clamping jaw unit further comprises a clamping jaw rotating mounting plate (422) fixedly connected with the mounting part (41), the two clamping jaw arms (421) are pivotally connected to the clamping jaw rotating mounting plate (422), corresponding ends of the two clamping jaw arms (421) are also pivotally connected to a reciprocating slide block (423), the reciprocating slide block (423) is connected with a power output shaft of the gripping device driving part, when the power output shaft moves close to the clamping jaw arms (421), the two clamping jaw arms (421) move back to back, and when the power output shaft moves away from the clamping jaw arms (421), the two clamping jaw arms (421) move towards each other; and/or clamping strips (4212) are arranged on the sides, opposite to each other, of the two clamping jaw arms (421).
18. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 17,
the reciprocating slider (423) is provided with a sliding groove (4231) extending along the horizontal direction, and the corresponding end of the clamping claw arm (421) is slidably connected into the sliding groove (4231) through a bearing (4211); alternatively, the first and second electrodes may be,
the gripping device driving part comprises a screw motor (43), the power output shaft is a screw rod arranged on the screw motor (43), a guide rail (411) is further arranged on the mounting part (41), and the reciprocating slide block (423) is connected to the guide rail (411) in a sliding mode.
19. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 18,
and a first photoelectric sensor (441) is arranged at one end, which is close to the screw rod and is far away from the clamping jaw unit, and is used for detecting the position of the screw rod.
20. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 17,
the clamping jaw unit further comprises a reagent strip pressing assembly capable of applying force to the reagent strip (90) when the clamping jaw unit clamps or releases the clamping of the reagent strip (90).
21. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 20,
the reagent strip pressure applying assembly comprises a force applying column (4241), the force applying column (4241) can be inserted on the clamping jaw rotating mounting plate (422) in a vertically sliding mode, one end, facing the reagent strip (90), of the force applying column (4241) is a force applying disc (4242), and an elastic piece (4243) is clamped between the force applying disc (4242) and the clamping jaw rotating mounting plate (422).
22. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 21,
the end of the force application column (4241) far away from the reagent strip (90) is provided with a U-shaped piece (4244), and the clamping jaw rotating mounting plate (422) is at least partially positioned in the opening area of the U-shaped piece (4244); and/or one end of the force application column (4241) far away from the reagent strip (90) is provided with a detection sheet (4245), a second photoelectric sensor (442) is arranged corresponding to the detection sheet (4245), and the second photoelectric sensor (442) is used for detecting the position of the force application column (4241).
23. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 22,
reagent strip pressure applying assembly has two sets ofly, and is two sets of reagent strip pressure applying assembly is in one respectively the length direction's of clamping jaw rotating installation board (422) both ends, the length direction's of clamping jaw rotating installation board (422) both ends with the length direction's of reagent strip (90) both ends correspond respectively, second photoelectric sensor (442) have two, two second photoelectric sensor (442) correspond one-to-one respectively the length direction's of clamping jaw rotating installation board (422) both ends set up.
24. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 1 wherein the reaction disk mechanism (5) further comprises:
the mounting base comprises a top plate (521) and two side vertical plates (522) which are arranged in parallel at intervals, first clamping grooves (5221) are formed in opposite side walls of the two side vertical plates (522), and the top plate (521) is inserted into the first clamping grooves (5221);
the reaction tray assembly (51) is integrally mounted on the top plate (521).
25. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 24,
the mounting base further comprises a rear vertical plate (523) connected to one end of each of the two side vertical plates (522) and a front vertical plate (524) detachably connected to the other end of each of the side vertical plates (522).
26. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 25,
a second clamping groove corresponding to the first clamping groove (5221) is formed in the inner side wall of the rear vertical plate (523), and/or a third clamping groove corresponding to the first clamping groove (5221) is formed in the inner side wall of the front vertical plate (524); or the rear vertical plate (523) and/or the front vertical plate (524) and the side vertical plate (522) are bolted through a screw.
27. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 24,
the reaction disc assembly (51) comprises a base body (511), a gear ring (512) is arranged on one side, facing the top plate (521), of the base body (511), a first photoelectric switch (531) is arranged on the outer side of the gear ring (512), and the first photoelectric switch (531) can sense the tooth part of the gear ring (512) to judge the rotation angular displacement of the base body (511); and/or a second photoelectric switch (532) is arranged on the inner side of the gear ring (512), and the second photoelectric switch (532) can sense a photoelectric barrier sheet on the inner side of the gear ring (512) to judge the rotation initial position of the base body (511).
28. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 27,
the reaction disc assembly (51) further comprises an incubation plate (513) and a heating plate (514) arranged between the base body (511) and the incubation plate (513), wherein the base body (511) is provided with a plurality of reagent strip placing positions extending along the radial direction of the base body, the incubation plate (513) is provided with a plurality of incubation holes (5131), the positions of the incubation holes (5131) correspond to the positions of detection holes of reagent strips (90) placed on the reagent strip placing positions in a one-to-one mode, and the incubation holes (5131) and the incubation plate (513) are made of the same materials and are integrally formed.
29. The fully automated homogeneous chemiluminescent in-line assay analyzer of claim 1 wherein the liquid extraction device (6) comprises a liquid extraction unit comprising:
a fluid-extracting mount (611) having a sealed cavity configured therein;
a liquid extraction head (612) connected in one through hole of the sealed cavity and capable of being assembled with the Tip head (212);
a piston rod (613) which is arranged in the sealed cavity and realizes the liquid suction and discharge functions of the liquid taking head (612) under the drive of a reciprocating drive component (62);
the telescopic rod of the reciprocating driving part (62) is connected with the piston rod (613) through magnetic attraction.
30. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 29,
a first magnet (6141) is arranged at one end, facing the piston rod (613), of the telescopic rod, and a second magnet (6142) is arranged at one end, facing the telescopic rod, of the piston rod (613); and/or the telescopic rod is a motor screw rod.
31. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 30,
one end, facing the piston rod (613), of the telescopic rod is connected with an adapter (615), and the first magnet (6141) is connected with one end of the telescopic rod through the adapter (615).
32. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 31,
a guide assembly is arranged between the adapter piece (615) and the liquid taking installation piece (611), and comprises a pin shaft (6151) fixedly connected with the adapter piece (615) and a bearing (6152) sleeved on the pin shaft (6151).
33. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 32,
a limiting structure (616) is further arranged between the piston rod (613) and the telescopic rod.
34. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 29,
the telescopic direction of the piston rod (613) is perpendicular to the through-flow direction of the liquid taking head (612); and/or the device also comprises a lifting driving unit which is in driving connection with the liquid taking unit.
35. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 34,
the lifting driving unit comprises a screw rod motor (631), a sliding rail (632) and a sliding block connecting piece (633), the sliding block connecting piece (633) and the liquid taking installation piece (611) are connected to the sliding rail (632) in a sliding mode and can be driven by a screw rod (634) of the screw rod motor (631) to lift along the sliding rail (632), and the sliding block connecting piece (633) is connected with the liquid taking installation piece (611) through a connecting shaft (635).
36. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 35,
one end of the connecting shaft (635) is located in the liquid taking installation piece (611) and can slide, a spring (636) is sleeved on the connecting shaft (635) to apply force to the liquid taking installation piece (611) when the slider connecting piece (633) descends, and the liquid taking installation piece (611) is allowed to displace towards the slider connecting piece (633) when the liquid taking head (612) bottoms.
37. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 1 wherein the homogeneous chemiluminescent immunoassay module (7) comprises:
the detection assembly comprises a detection head which can be driven to lift;
the light-tight piece assembly comprises a light-tight piece (711), wherein the light-tight piece (711) can be switched between a first position and a second position, when the light-tight piece (711) is located at the first position, the light-tight piece (711) can enable the light-passing structure of the detection head to realize light-tight, and when the light-tight piece (711) is located at the second position, the light-tight structure of the reagent strip corresponding to the detection head can enable the light-passing structure of the detection head to realize light-tight.
38. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 37,
one side of the detection head facing the reagent strip is detachably connected with a dense-smooth rubber pad (721); and/or the presence of a gas in the gas,
one side of the detection head, which faces the reagent strip, is provided with a pressing strip (722), and when the light-tight structure of the reagent strip is light-tight and the light-transmitting structure of the detection head is light-tight, the pressing strip (722) can be pressed on the top surface of the reagent strip and elastically deforms.
39. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 37,
the lifting driving assembly is used for driving the detection head to move towards or away from the reagent strip in a linear reciprocating manner; and/or the presence of a gas in the gas,
the device also comprises a swing driving component which is used for driving the light-tight piece (711) to switch between the first position and the second position.
40. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 39,
the light-tight piece (711) is provided with a support roller (712), and the light-tight piece (711) can slide on a corresponding support carrier through the support roller (712).
41. The fully automated homogeneous chemiluminescent real-time detection analyzer of claim 40,
the supporting rollers (712) are provided with two groups, and the two groups of supporting rollers (712) are arranged on two opposite sides of the light-tight piece (711).
42. The fully automated homogeneous chemiluminescent in-situ detection analyzer of claim 1 further comprising:
and the catcher unit (8) is used for receiving the abnormal reagent strips grabbed by the reagent strip grabbing device (4).
CN202210109459.XA 2022-01-28 2022-01-28 Full-automatic homogeneous phase chemiluminescence instant detection analyzer Pending CN114544603A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115078753A (en) * 2022-08-18 2022-09-20 广州誉康医药有限公司 Multi-channel sampling, sample adding and cleaning system and method and detector comprising system
CN115078752A (en) * 2022-08-16 2022-09-20 广州誉康医药有限公司 Multi-channel sampling and sample-adding system, method and detector comprising system

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115078752A (en) * 2022-08-16 2022-09-20 广州誉康医药有限公司 Multi-channel sampling and sample-adding system, method and detector comprising system
CN115078752B (en) * 2022-08-16 2022-10-28 广州誉康医药有限公司 Multi-channel sampling and sample adding system, method and detector comprising system
CN115078753A (en) * 2022-08-18 2022-09-20 广州誉康医药有限公司 Multi-channel sampling, sample adding and cleaning system and method and detector comprising system
CN115078753B (en) * 2022-08-18 2022-10-28 广州誉康医药有限公司 Multi-channel sampling, sample adding and cleaning system and method and detector comprising system

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