CN219972303U - Sample detection workstation - Google Patents
Sample detection workstation Download PDFInfo
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- CN219972303U CN219972303U CN202321683680.2U CN202321683680U CN219972303U CN 219972303 U CN219972303 U CN 219972303U CN 202321683680 U CN202321683680 U CN 202321683680U CN 219972303 U CN219972303 U CN 219972303U
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- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The utility model belongs to the technical field of detection instruments, and discloses a sample detection workstation, which comprises a machine table, wherein the machine table is provided with a sample storage table, a displacement mechanism, a sampling mechanism, a cover opening mechanism, an oscillation mechanism and a PCR detection mechanism, and the cover opening mechanism is provided with two groups; the sample storage platform is provided with a suction head storage area, a suction head discarding area, a sample storage area and a reagent bottle placing area; the displacement mechanism comprises an X electric slide rail, and a Y electric slide rail is arranged at the output end of the X electric slide rail; the cover opening mechanism comprises a mounting block; the vibration mechanism comprises a centrifugal machine and a wall breaking machine; the machine is provided with the reagent bottle discarding port between the cover opening mechanism and the vibration mechanism, and the structural design of the utility model replaces manual operation, saves labor, improves experimental efficiency, and improves the automatic test speed by several times compared with manual operation.
Description
Technical Field
The utility model belongs to the technical field of detection instruments, and particularly relates to a sample detection workstation.
Background
Fungal infection isPathogenic fungiInvasion of diseases caused by human body. Pathogenic fungi are clinically classified into superficial fungi and deep fungi according to the invasion of the human body. Superficial fungi (tinea) only invade the skin, hair and nails, while deep fungi can invade the skin, mucous membranes, deep tissues and viscera of the human body, even causing systemic disseminated infections.
In the case of pulmonary infections, pulmonary fungal infections are allergic, suppurative inflammatory reactions or chronic granulomas caused by different pathogens. Pathogenic fungi responsible for lower respiratory tract fungal infections and conditionally pathogenic fungi: (1) pathogenic fungi belong to primary pathogenic bacteria, often cause primary fungal infection, can attack a host with normal immune function, and is easy to spread on the whole body by patients with immunodeficiency. The pathogenic fungi mainly include histoplasma bacteria, coccidioidomycosis, paracoccidiomycosis, blastomycosis dermatitis, tinea pedis, sporotrichosis, etc. (2) The pathogenic fungi or opportunistic fungi include candida, aspergillus, cryptococcus, mucor and penicillium, rhizopus, colpitis, fusarium, pneumosporon and the like. Most of these fungi are saprophytes, which have weak pathogenicity to human body, but when host has susceptibility factors, they cause deep fungal infection, but cases without clear host factors are clinically seen. Clinically common fungal pathogens include candida, aspergillus, mucor, cryptococcus, histoplasma, and the like. In recent years, the incidence of pulmonary fungal infection has increased year by year with aging of the population, organ transplantation, tumor chemoradiotherapy, hematopoietic stem cell transplantation, ultra-broad-spectrum antibiotic application, corticosteroid hormone application, various catheter interventions, and the like.
Diagnostic factors for fungal infections include host factors, clinical features, microbiological examination, histopathology. The established disease must depend on invasive examination and operation such as histopathology, and the culture process requires a certain time, thus the diagnosis missing rate is increased intangibly, while the new serological diagnosis method comprises G test, GM test and Polymerase Chain Reaction (PCR) technology for fungus specific DNA, and provides more reference value data for starting preemptive treatment, monitoring disease course and evaluating treatment reaction together with clinical signs and microorganism culture, especially CT scan;
at present, when fungus detection is carried out on a biological sample by a PCR technology, manual operation is generally adopted, but the existing detection method needs to repeatedly open a reagent bottle cap for a plurality of times, remove waste liquid in a tube, add reagent, close the reagent bottle cap, and centrifugally process, so that the detection efficiency is low, and meanwhile, the problems of cross contamination, misoperation of operation sequence and the like cannot be avoided in the manual operation.
Disclosure of Invention
In view of the above-mentioned problems with the background art, the present utility model has as its object: it is intended to provide a sample testing workstation.
In order to achieve the technical purpose, the utility model adopts the following technical scheme:
the sample detection workstation comprises a machine table, wherein the machine table is provided with a sample storage table, a displacement mechanism, a sampling mechanism, a cover opening mechanism, an oscillation mechanism and a PCR detection mechanism, and the cover opening mechanism is provided with two groups;
the sample storage platform is provided with a suction head storage area, a suction head discarding area, a sample storage area and a reagent bottle placing area;
the displacement mechanism comprises an X electric slide rail, and a Y electric slide rail is arranged at the output end of the X electric slide rail;
the sampling mechanism comprises an installation box installed at the output end of the Y-shaped electric sliding rail, a lifting mechanism is installed on the side surface of the installation box in the direction of the sample storage table, a sampling gun is installed at the output end of the lifting mechanism, and a manipulator is installed on the other side surface of the installation box in the direction opposite to the direction of the sample storage table;
the cover opening mechanism is located under the sampling mechanism and comprises a mounting block, the mounting block is slidably provided with a bottle cap fixing plate, the mounting block is provided with a translation motor for controlling the bottle cap fixing plate to move, the cover opening mechanism comprises a lifting motor arranged on the machine table, the lifting motor is provided with a base plate, the base plate is provided with a guide pillar, the guide pillar is slidably provided with a placing bottom plate and a placing top plate, a placing cylinder is connected between the placing bottom plate and the placing top plate, the placing top plate is provided with a plurality of driven gears in an annular rotation mode, the placing top plate is provided with a rotating motor, and the output end of the rotating motor is connected with a driving gear which is meshed and matched with all the driven gears;
the vibration mechanism comprises a centrifugal machine and a wall breaking machine;
the machine is provided with a reagent bottle discarding port positioned between the cover opening mechanism and the oscillation mechanism.
Further limited, the machine is provided with a waste suction head drawer positioned at the lower side of the sample storage table, and is provided with a waste reagent bottle drawer positioned at the lower side of the reagent bottle discarding port, so that the waste suction head and the waste reagent bottle can be conveniently taken in and taken out.
Further limiting, the bottle cap fixing plate is provided with a latch, so that the clamping and fixing of the tube cap of the reagent tube are realized.
Further limited, elevating system includes four micro-motors in total that the symmetry set up, every micro-motor control one the sampling rifle, such design realizes single sample operation, mutually noninterfere, and the sample goes out the appearance more nimble.
Further limiting, the four corners of the bottom of the machine table are provided with height adjusting supporting legs, so that the leveling is convenient, and the placing level of the reagent bottles is ensured.
The beneficial effects of the utility model are that:
by adopting the structural design of the utility model, manual operation is replaced, labor is saved, meanwhile, the experimental efficiency is improved, and compared with manual operation, the automatic test speed is improved by several times;
the utility model replaces manual operation, so that the risks of process leakage and sample cross contamination during manual operation due to complicated experimental process are avoided;
compared with manual operation, the automatic detection method has the advantages that the experimental precision of the automatic equipment is higher, the consistency is better, and meanwhile, the related data in the experimental process can be stored in the upper computer software, so that the traceability is realized;
by adopting the structural design of the utility model, the equipment is small in size, and the crowded experimental space in a PCR laboratory can be saved.
Drawings
The utility model can be further illustrated by means of non-limiting examples given in the accompanying drawings;
FIG. 1 is a schematic diagram of a sample testing workstation according to an embodiment of the present utility model;
FIG. 2 is a schematic diagram showing the internal structure of a sample testing workstation according to an embodiment of the present utility model;
FIG. 3 is a schematic diagram showing an internal structure of a sample detection workstation according to an embodiment of the present utility model;
FIG. 4 is a schematic diagram of a sampling mechanism according to an embodiment of the present utility model;
FIG. 5 is a schematic view of a cover opening mechanism of an embodiment of a sample inspection workstation according to the present utility model;
FIG. 6 is a schematic cross-sectional view of a cover opening mechanism of an embodiment of a sample inspection workstation according to the present utility model;
the main reference numerals are as follows:
a machine 1; a sample storage stage 2; a displacement mechanism 3; a sampling mechanism 4; a cover opening mechanism 5; an oscillating mechanism 6; a PCR detection mechanism 7; a reagent bottle discarding port 8; a waste suction head drawer 9; a waste reagent bottle drawer 10; height-adjusting support legs 11;
a tip storage area 201; a tip disposal area 202; a sample storage area 203; a reagent bottle placement area 204;
x electric slide rail 301; y electric slide rail 302;
a mounting box 401; a lifting mechanism 402; a micro motor 4021; a sampling gun 403; a robot 404;
a mounting block 501; a bottle cap fixing plate 502; latch 5021; a translation motor 503; a lift motor 504; a substrate 505; guide post 506; placing a bottom plate 507; placing a top plate 508; a placement barrel 509; a driven gear 510; a rotating electric machine 511; a drive gear 512;
a centrifuge 601; wall breaking machine 602.
Detailed Description
In order that those skilled in the art will better understand the present utility model, the following technical scheme of the present utility model will be further described with reference to the accompanying drawings and examples.
As shown in fig. 1 to 6, a sample detection workstation of the utility model comprises a machine 1, wherein the machine 1 is provided with a sample storage table 2, a displacement mechanism 3, a sampling mechanism 4, a cover opening mechanism 5, an oscillation mechanism 6 and a PCR detection mechanism 7, and the cover opening mechanism 5 is provided with two groups;
the sample storage platform 2 is provided with a suction head storage area 201, a suction head discarding area 202, a sample storage area 203 and a reagent bottle placing area 204;
the displacement mechanism 3 comprises an X electric slide rail 301, and a Y electric slide rail 302 is arranged at the output end of the X electric slide rail 301;
the sampling mechanism 4 comprises an installation box 401 installed at the output end of the Y-shaped electric sliding rail 302, a lifting mechanism 402 is installed on the side surface of the installation box 401 in the direction of the sample storage table 2, a sampling gun 403 is installed at the output end of the lifting mechanism 402, and a manipulator 404 is installed on the other side surface of the installation box 401 in the direction opposite to the direction of the sample storage table 2;
the cover opening mechanism 5 is positioned right below the sampling mechanism 4 and comprises a mounting block 501, the mounting block 501 is slidably provided with a bottle cap fixing plate 502, the mounting block 501 is provided with a translation motor 503 for controlling the bottle cap fixing plate 502 to move, the cover opening mechanism 5 comprises a lifting motor 504 arranged on the machine table 1, the lifting motor 504 is provided with a base plate 505, the base plate 505 is provided with a guide pillar 506, the guide pillar 506 is slidably provided with a placing bottom plate 507 and a placing top plate 508, a placing cylinder 509 is connected between the placing bottom plate 507 and the placing top plate 508, the placing top plate 508 is provided with a plurality of driven gears 510 in an annular rotation manner, the placing top plate 508 is provided with a rotating motor 511, and the output end of the rotating motor 511 is connected with a driving gear 512 which is meshed and matched with all the driven gears 510;
the oscillating mechanism 6 comprises a centrifugal machine 601 and a wall breaking machine 602;
the machine 1 is provided with a reagent bottle discarding port 8 between the cover opening mechanism 5 and the oscillation mechanism 6.
In this embodiment, when a sample detection workstation is used, a sample tube with no tube cap for a sample to be detected is placed in the sample storage area 203, a reagent bottle with no tube cap for a detection reagent for a reagent in the sample tube is placed in the reagent bottle placement area 204 in the placement cylinder 509, a reagent tube with a tube cap is placed in the placement cylinder 509, a test tube with no tube cap for a reaction reagent for a reagent in the sample tube is placed in the working area of the wall breaking machine 602, and after the placement, the device is ready to be started;
firstly, it is to be noted that: after the reagent is injected into the sampling gun 403, the suction head is dropped into the suction head discarding area 202, and a new suction head is installed from the suction head storage area 201, so as to prevent cross infection, and the technology of dropping the sampling gun 403 and installing the suction head is mature at present as will be understood by those skilled in the relevant field;
the following is to be described: after the movement of each mechanism of the equipment is finished, the mechanism returns to a safe position to prevent the interference with the movement of other mechanisms of the equipment, and the operation of the automation equipment is common knowledge;
the displacement mechanism 3 operates to drive the sampling mechanism 4 to operate so that the sampling gun 403 moves to the upper side of the sample storage area 203, then the micro motor 4021 operates to drive the sampling gun 403 to move downwards, the sampling gun 403 sucks and returns a sample to be tested in a sample tube placed in the sample storage area 203, and the displacement mechanism 3 operates to move the sampling gun 403 to the position of the placing cylinder 509;
the cover opening mechanism 5 operates, the translation motor 503 operates to drive the bottle cap fixing plate 502 to move to the upper side of the placing cylinder 509, the lifting motor 504 ascends to enable the tube cap of the reagent tube with the tube cap in the placing cylinder 509 to be inserted into the latch 5021 in the bottle cap fixing plate 502, the lifting motor 504 descends and simultaneously the rotary motor 511 operates to drive the driving gear 512 to rotate, all the driven gears 510 start to rotate, under the action, the tube cap of the reagent tube is separated from the reagent tube, the translation motor 503 operates to enable the bottle cap fixing plate 502 to move to one side for standby along with the tube cap clamped in the latch 5021;
the sampling mechanism 4 is operated, the sampling gun 403 is moved into the uncapped reagent tube, the sample to be detected is injected into the reagent tube, the sampling mechanism 4 returns, the displacement mechanism 3 is operated, the sampling mechanism 4 is operated to suck the reaction reagent in the reagent bottle placing area 204 and then returns to be injected into the uncapped reagent tube, the uncapping mechanism 5 moves the bottle cap fixing plate 502 with the previously unscrewed tube cap to the upper side of the uncapped reagent tube, the lifting motor 504 is operated and the rotating motor 511 is operated at the same time, the tube cap is screwed on the reagent tube again, and the step is the addition of the reaction reagent;
the displacement mechanism 3 operates to grab a reagent tube filled with a sample and a corresponding reaction reagent by using the mechanical clamp 404, move the reagent tube upwards out of the placement cylinder 509, move the reagent tube into the centrifuge 601 for centrifugal vibration, grab the reagent tube again and put the reagent tube back into the placement cylinder 509 after the reagent tube is finished, the cover opening mechanism 5 operates to open the reagent tube again, the sampling mechanism 4 sucks another reaction reagent in the reagent bottle placement area 204 and then injects the reagent tube into the reagent tube, the cover opening mechanism 5 operates to seal the reagent tube again by using the tube cover, and the displacement mechanism 3 operates to enable the manipulator 404 to move the reagent tube to the centrifuge for vibration for the second time, so that the steps are adding and mixing of the reaction reagents of the sample for multiple times;
after the reaction reagent is added repeatedly for required times, the displacement mechanism 3 is matched with the mechanical collection 404 on the sampling mechanism 4 to move the reagent tube to the wall breaking machine 602 for wall breaking operation, after wall breaking is completed, the sampling gun 403 extracts supernatant to the PCR detection mechanism 7 for detection to obtain a result, and the reagent bottle is thrown into the waste reagent bottle drawer 10 for subsequent treatment;
the above is the automated inspection of a sample, because the sample storage area 203, the reagent bottle placement area 204, the placement cylinder 509 and the wall breaking machine 602 all have a plurality of placement openings, through the setting procedure, the non-interference inspection of a plurality of samples can be realized, and the inspection efficiency is ensured.
Preferably, the machine 1 is provided with a waste suction head drawer 9 positioned at the lower side of the sample storage table 2, and the machine 1 is provided with a waste reagent bottle drawer 10 positioned at the lower side of the reagent bottle discarding port 8, so that the waste suction head and the waste reagent bottle can be conveniently connected, and in practice, the structure of connecting the waste suction head and the waste reagent bottle can be considered according to specific conditions.
Preferably, the bottle cap fixing plate 502 is provided with a latch 5021, so that the tube cap of the reagent tube can be clamped and fixed, and in practice, a structure capable of clamping the tube cap and driving the tube cap to move can be considered according to specific conditions.
Preferably, the lifting mechanism 402 comprises four symmetrically arranged micro motors 4021, and each micro motor 4021 controls one sampling gun 403, so that single sampling operation is realized, mutual interference is avoided, sampling is more flexible, and in fact, the structure of the sampling mechanism can be considered according to specific situations.
Preferably, the four corners of the bottom of the machine table 1 are provided with height adjusting supporting legs 11, so that the leveling is convenient, the placing level of the reagent bottles is ensured, and in practice, leveling measures can be considered according to specific conditions.
The above embodiments are merely illustrative of the principles of the present utility model and its effectiveness, and are not intended to limit the utility model. Modifications and variations may be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the utility model. Accordingly, it is intended that all equivalent modifications and variations of the utility model be covered by the claims of this utility model, which are within the skill of those skilled in the art, can be made without departing from the spirit and scope of the utility model disclosed herein.
Claims (5)
1. Sample detection workstation, including board (1), its characterized in that: the machine table (1) is provided with a sample storage table (2), a displacement mechanism (3), a sampling mechanism (4), a cover opening mechanism (5), an oscillating mechanism (6) and a PCR detection mechanism (7), wherein the cover opening mechanism (5) is provided with two groups;
the sample storage table (2) is provided with a suction head storage area (201), a suction head discarding area (202), a sample storage area (203) and a reagent bottle placing area (204);
the displacement mechanism (3) comprises an X electric slide rail (301), and a Y electric slide rail (302) is arranged at the output end of the X electric slide rail (301);
the sampling mechanism (4) comprises an installation box (401) installed at the output end of the Y-shaped electric sliding rail (302), the installation box (401) is provided with a lifting mechanism (402) on the side surface of the direction of the sample storage table (2), the output end of the lifting mechanism (402) is provided with a sampling gun (403), and the installation box (401) is provided with a manipulator (404) on the other side surface of the direction opposite to the direction of the sample storage table (2);
the cover opening mechanism (5) is located right below the sampling mechanism (4), and comprises a mounting block (501), a bottle cap fixing plate (502) is slidably mounted on the mounting block (501), a translation motor (503) for controlling the bottle cap fixing plate (502) to move is mounted on the mounting block (501), the cover opening mechanism (5) comprises a lifting motor (504) mounted on the machine table (1), a base plate (505) is mounted on the lifting motor (504), a guide pillar (506) is mounted on the base plate (505), a placing bottom plate (507) and a placing top plate (508) are slidably mounted on the guide pillar (506), a placing cylinder (509) is connected between the placing bottom plate (507) and the placing top plate (508), a plurality of driven gears (510) are mounted on the placing top plate (508) in an annular rotation mode, and a driving gear (512) which is meshed with all the driven gears (510) is connected to the output end of the rotating motor (511);
the vibration mechanism (6) comprises a centrifugal machine (601) and a wall breaking machine (602);
the machine table (1) is provided with a reagent bottle discarding port (8) positioned between the cover opening mechanism (5) and the vibration mechanism (6).
2. A sample testing workstation according to claim 1, wherein: the machine (1) is provided with a waste suction head drawer (9) positioned at the lower side of the sample storage table (2), and the machine (1) is provided with a waste reagent bottle drawer (10) positioned at the lower side of the reagent bottle discarding port (8).
3. A sample testing workstation according to claim 2, wherein: the bottle cap fixing plate (502) is provided with a latch (5021).
4. A sample testing workstation according to claim 3, wherein: the lifting mechanism (402) comprises four micro motors (4021) which are symmetrically arranged, and each micro motor (4021) controls one sampling gun (403).
5. A sample testing workstation according to claim 4, wherein: the four corners of the bottom of the machine table (1) are provided with height adjusting supporting legs (11).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321683680.2U CN219972303U (en) | 2023-06-29 | 2023-06-29 | Sample detection workstation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321683680.2U CN219972303U (en) | 2023-06-29 | 2023-06-29 | Sample detection workstation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219972303U true CN219972303U (en) | 2023-11-07 |
Family
ID=88598461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321683680.2U Active CN219972303U (en) | 2023-06-29 | 2023-06-29 | Sample detection workstation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219972303U (en) |
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2023
- 2023-06-29 CN CN202321683680.2U patent/CN219972303U/en active Active
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