CN219905231U - Sample collection box and sample collection base for liquid chromatograph - Google Patents
Sample collection box and sample collection base for liquid chromatograph Download PDFInfo
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- CN219905231U CN219905231U CN202321136125.8U CN202321136125U CN219905231U CN 219905231 U CN219905231 U CN 219905231U CN 202321136125 U CN202321136125 U CN 202321136125U CN 219905231 U CN219905231 U CN 219905231U
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- sample collection
- liquid chromatograph
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- sample
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- 239000007788 liquid Substances 0.000 title claims abstract description 30
- 238000005192 partition Methods 0.000 claims abstract description 15
- 238000000926 separation method Methods 0.000 claims description 8
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 239000000523 sample Substances 0.000 description 109
- 150000007523 nucleic acids Chemical class 0.000 description 9
- 102000039446 nucleic acids Human genes 0.000 description 9
- 108020004707 nucleic acids Proteins 0.000 description 9
- 238000001514 detection method Methods 0.000 description 3
- 238000004811 liquid chromatography Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003245 working effect Effects 0.000 description 1
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- Sampling And Sample Adjustment (AREA)
Abstract
The utility model relates to the field of experimental instruments, in particular to a sample collection box and a sample collection base for a liquid chromatograph. In one aspect, the utility model relates to a sample collection box for a liquid chromatograph, which comprises a box body, wherein a plurality of collection holes are formed in the box body; the bottom of the box body is provided with a plug-in connection part, and the periphery of the plug-in connection part is provided with a limit flange. In a second aspect, the present utility model relates to a sample collection base for a liquid chromatograph, wherein a positioning groove is provided on the sample collection base, a partition plate is provided in the positioning groove, and the partition plate is connected with the sample collection base. Be provided with grafting portion on the sample collection box, set up the constant head tank on the sample collection base corresponds to realize the location to the sample collection box, can help promoting the collection efficiency of accounting sample.
Description
Technical Field
The utility model relates to the field of experimental instruments, in particular to a sample collection box and a sample collection base for a liquid chromatograph.
Background
Liquid chromatograph is an instrument for separating a mixture first and then analyzing and identifying the mixture by utilizing the difference of partition ratio of the mixture between two liquids which are liquid-solid or insoluble, and is widely applied to the field of biological sample detection, such as analysis and detection of nucleic acid samples.
Before the analysis and detection of the nucleic acid sample, the liquid chromatography sample collector is required to be used for injecting the nucleic acid sample into a plurality of centrifuge tubes in batches, and in the process, the plurality of centrifuge tubes are required to be installed on a collecting base of the liquid chromatography sample collector together, and the liquid chromatography sample collector is used for injecting the nucleic acid sample into the centrifuge tubes through an electromagnetic valve needle. For this purpose, a sample collection cartridge is placed on the sample collection base, and a plurality of centrifuge tubes can be placed in the sample collection cartridge in a batch manner, so that the nucleic acid samples can be collected in a batch manner.
However, since the conventional sample collection cartridge is directly placed on the sample collection base, it has the problems of inaccurate positioning and inconvenient fixing of the sample collection cartridge, which affects the collection efficiency of the nucleic acid sample.
Disclosure of Invention
In order to facilitate positioning of the nucleic acid collection cassette, the present utility model provides a sample collection cassette and a sample collection base for a liquid chromatograph.
In one aspect, the utility model provides a sample collection box for a liquid chromatograph, which adopts the following technical scheme:
the sample collection box for the liquid chromatograph comprises a box body, wherein a plurality of collection holes are formed in the box body;
the bottom of the box body is provided with a plug-in connection part, and the periphery of the plug-in connection part is provided with a limit flange.
Through adopting above-mentioned technical scheme, owing to be provided with grafting portion on the sample collection box, the accessible sets up the spliced eye on the sample collection base to the realization is to the location of sample collection box, and the setting of limit flange then can play the supporting role to the collection box, promotes the stability of sample collection box. Therefore, the sample collection box has the advantage of being convenient to fix and position, and can be helpful for improving the collection efficiency of accounting samples.
Preferably, the plugging part is annularly arranged and surrounds the bottom of the box body.
Through adopting above-mentioned technical scheme, grafting portion is annular setting, can play abundant support to the week side of sample collection box to when sample collection box places on surface such as desktop, the interference of protruding or other debris on the desktop can be avoided easily to the grafting portion of annular setting, helps improving the stability when sample collection box is placed.
In a second aspect, the utility model also discloses a sample collection base for a liquid chromatograph, which adopts the following technical scheme:
the utility model provides a sample collection base for liquid chromatograph, be provided with the constant head tank on the sample collection base, be provided with the division board in the constant head tank, and the division board is connected with the sample collection base.
Through adopting above-mentioned technical scheme, the sample collection box can prevent in the constant head tank, and the constant head tank can fix a position the sample collection box to the experimenter quick replacement sample collection box of being convenient for. The partition plate can separate the positioning groove, so that a plurality of sample collection boxes can be placed in the positioning groove conveniently, the number of the sample collection boxes on the sample collection base can be increased, the replacement frequency of the sample collection boxes can be reduced, and the collection efficiency of nucleic acid samples can be improved.
Preferably, the positioning device comprises a support frame and a positioning plate arranged on the support frame, wherein the positioning plate is detachably connected with the support frame, and the positioning groove is positioned on the positioning plate; the separation plate is connected with the positioning plate in a sliding way.
Through adopting above-mentioned technical scheme, sample collection box installs to the locating plate on, and the division board then can change the size of constant head tank to the sample collection box of the not unidimensional of installation of being convenient for.
Preferably, the division plate is provided with a sliding hole, and the division plate is provided with a sliding block in sliding fit with the sliding hole.
Through adopting above-mentioned technical scheme, the hole that slides can enough play the guide effect to the partition plate, still can realize the dismantlement of partition plate through the cooperation of slider and hole that slides to change the size of constant head tank.
Preferably, a fixing frame is arranged below the supporting frame; the fixing frame is provided with a lifting mechanism for driving the supporting frame to move up and down.
Through adopting above-mentioned technical scheme, elevating system can drive the support frame and place the sample collection box on the support frame and reciprocate to make the sample collection box be close to the electromagnetic valve needle of liquid chromatograph sample collector, reduce the probability that DNA/RNA nucleic acid sample spouted the sample collection box when spouting from electromagnetic valve needle in the emergence splashes.
Preferably, the lifting mechanism comprises a cylinder and a plurality of guide rods; the air cylinder is fixed on the fixing frame, and the output end of the air cylinder is fixedly connected with the supporting frame; the guide rod is vertically arranged and fixedly connected with the support frame; the fixing frame is provided with a guide hole which is in sliding fit with the guide rod.
Through adopting above-mentioned technical scheme, the guide bar can guarantee the stability when the support frame goes up and down, and the cylinder then has higher transmission rate and stability, helps promoting the working property of sample collection base.
Preferably, the positioning plate is further provided with a locking mechanism for fixing the sample collection cartridge.
Through adopting above-mentioned technical scheme, locking mechanical system can fix the sample collection box, promotes the stability of sample collection box when following the support frame and go up and down, is convenient for collect the nucleic acid sample.
In summary, the present utility model includes at least one of the following beneficial technical effects:
1. the sample collection box is provided with the plug-in part, and the sample collection base is correspondingly provided with the positioning groove, so that the sample collection box is positioned, a plurality of sample collection boxes can be arranged on the sample collection base, and the collection efficiency of accounting samples can be improved;
2. the lifting mechanism can drive the supporting frame and the sample collection box placed on the supporting frame to move up and down, so that the sample collection box is close to the electromagnetic valve needle of the liquid chromatograph sample collector, and the probability of splashing when the DNA/RNA nucleic acid sample is sprayed into the sample collection box from the electromagnetic valve needle is reduced.
Drawings
FIG. 1 is a schematic top view of a sample collection cartridge according to example 1 of the present utility model;
FIG. 2 is a schematic bottom view of the sample collection cartridge of example 1 of the present utility model;
FIG. 3 is a schematic view showing the overall structure of a sample collection base according to example 1 of the present utility model;
FIG. 4 is a schematic view showing an exploded structure of a sample collection base according to example 1 of the present utility model;
FIG. 5 is a schematic view showing the structure of the sample collection cartridge according to embodiment 1 of the present utility model when mounted to a sample collection base;
fig. 6 is a schematic view showing the structure of the sample collection cartridge according to embodiment 2 of the present utility model when mounted to a sample collection base.
The reference numerals in the drawings: 1. a case body; 11. a collection hole; 2. a plug-in part; 3. a limit flange; 4. a support frame; 41. a support step; 5. a positioning plate; 51. a positioning groove; 52. a slip hole; 6. a partition plate; 61. a slide block; 7. a fixing frame; 8. a lifting mechanism; 81. a cylinder; 82. a guide rod; 9. a locking mechanism; 91. and (5) pressing plates.
Detailed Description
The utility model is described in further detail below with reference to fig. 1-5.
Example 1
The embodiment of the utility model discloses a sample collection box for a liquid chromatograph. The sample collection cartridge of the embodiment of the present utility model is exemplified by collection of DNA/RNA nucleic acid samples, but its use is not limited to collection of DNA/RNA nucleic acid samples.
Referring to fig. 1 and 2, the sample collection cartridge includes a cartridge body 1, a top of the cartridge body 1 is provided with an opening, and a plurality of collection holes 11 are provided in the cartridge body 1. In the embodiment of the present utility model, the collection holes 11 are provided in 96 numbers and are distributed in an array of 8×12. A centrifuge tube may be placed within the collection well 11 to facilitate collection of the DNA/RNA nucleic acid sample.
The bottom of the box body 1 is provided with a plug-in part 2, the plug-in part 2 is annularly arranged and surrounds the bottom of the box body 1, and the periphery of the plug-in part 2 is provided with a limit flange 3.
The embodiment of the utility model also discloses a sample collection base for the liquid chromatograph, and referring to fig. 3 and 4, the sample collection base comprises a support frame 4 and a positioning plate 5 arranged on the support frame 4. The support frame 4 is the cell body setting to the support frame 4 is formed by five panels concatenation. The inner wall of the support frame 4 is fixed with a support step 41, and the positioning plate 5 is positioned at the inner side of the support frame 4 and is abutted against the support step 41.
The positioning plate 5 is in a square annular shape, and a positioning groove 51 is formed on the inner side of the positioning plate 5. The positioning plate 5 is also connected with a partition plate 6, and the partition plate 6 is arranged across the positioning groove 51 and is connected with the positioning plate 5, so that the partition plate 6 divides the positioning groove 51 into two parts.
Referring to fig. 5, the sample collection cartridge can be placed on both sides of the partition plate 6: the plug-in part 2 of the sample collection box is inserted into the positioning groove 51, and the limiting flange 3 is abutted with the positioning plate 5 and the separation plate 6, so that the positioning plate 5 and the separation plate 6 can play a supporting role on the sample collection box, and the positioning and the fixing of the sample collection box are realized.
Referring to fig. 4, in the embodiment of the present utility model, the positioning plate 5 is provided with a sliding hole 52, and the separation plate 6 is provided with a sliding block 61 slidably engaged with the sliding hole 52. Therefore, the separation plate 6 can move in the positioning groove 51, the size of the positioning grooves 51 on two sides of the separation plate 6 can be flexibly changed, the separation plate 6 can be detached from the positioning plate 5, and the space of the positioning groove 51 is effectively increased, so that sample collection boxes with different sizes can be conveniently placed.
As other embodiments of the present utility model, the partition plate 6 may be integrally formed with the positioning plate 5, or the partition plate 6 may be connected to the positioning plate 5 in a welded manner.
The sample collection box and the sample collection base in the embodiment of the utility model have the implementation principle that:
the sample collection box and the sample collection base are matched with model high performance liquid chromatography sample collectors such as 1525u and e2695 of Volter company.
The sample collection base is mounted in a high performance liquid chromatography collector.
Referring to fig. 5, four identical sample collection cartridges were placed on the positioning plate 5 to achieve simultaneous collection of 384-well liquid chromatograph samples at a time. The DNA/RNA nucleic acid sample collection device realizes that the collection of the DNA/RNA nucleic acid sample is in place once from the upper machine, and the operations of replacing a sample collection box, a centrifuge tube and the like are not needed frequently.
Example 2
The embodiment of the utility model discloses a sample collection base for a liquid chromatograph, which is different from the embodiment 1 in that:
referring to fig. 6, a fixing frame 7 is further arranged below the supporting frame 4, and a lifting mechanism 8 is arranged between the fixing frame 7 and the supporting frame 4.
The lifting mechanism 8 includes an air cylinder 81 and a plurality of guide rods 82. The cylinder 81 is fixed on the fixing frame 7, and the output end of the cylinder 81 is fixedly connected with the supporting frame 4. The guide rods 82 are positioned at four corners of the bottom of the support frame 4, the guide rods 82 are vertically arranged and fixedly connected with the support frame 4, and guide holes which are in sliding fit with the guide rods 82 are formed in the fixing frame 7.
The air cylinder 81 can drive the supporting frame 4 and the sample collection box placed on the supporting frame 4 to move up and down, so that the sample collection box is close to an electromagnetic valve needle of a sample collector of the liquid chromatograph, and the probability of splashing when DNA/RNA nucleic acid samples are sprayed into the sample collection box from the electromagnetic valve needle is reduced.
The positioning plate 5 is further provided with a locking mechanism 9 for fixing the sample collection cartridge.
In the embodiment of the utility model, the locking mechanism 9 adopts a set and structure of torsion springs, namely, the pressing plate 91 is rotationally connected with the positioning plate 5, and the torsion springs are arranged between the pressing plate 91 and the positioning plate 5, so that the torsion springs can ensure the pressure of the pressing plate 91 on the sample collection box, thereby ensuring the stability of the sample collection box.
In other embodiments of the present utility model, the locking mechanism 9 may be a set or structure of a bolt and a pressing plate 91, or a locking bolt, or a latch structure, so as to fix the sample collection cartridge and ensure the stability of the sample collection cartridge.
The implementation principle of the sample collection base in the embodiment of the utility model is as follows: when the high performance liquid chromatograph sample collector works, the lifting mechanism 8 drives the support frame 4 and the sample collection box to be close to the electromagnetic valve needle of the high performance liquid chromatograph sample collector, and then the DNA/RNA nucleic acid sample is injected into the sample collection box through the electromagnetic valve needle.
After the DNA/RNA nucleic acid sample is collected, the lifting mechanism 8 drives the support frame 4 to descend so as to facilitate the removal of the sample collection box from the support frame 4.
The above embodiments are not intended to limit the scope of the present utility model, so: all equivalent changes in structure, shape and principle of the utility model should be covered in the scope of protection of the utility model.
Claims (8)
1. A sample collection box for liquid chromatograph, characterized in that: the box comprises a box body (1), wherein a plurality of collecting holes (11) are formed in the box body (1);
the bottom of the box body (1) is provided with a plug-in connection part (2), and the periphery of the plug-in connection part (2) is provided with a limit flange (3).
2. The sample collection cartridge for a liquid chromatograph according to claim 1, wherein: the plug-in part (2) is annularly arranged and surrounds the bottom of the box body (1).
3. A sample collection base for liquid chromatograph, characterized in that: the sample collection base is provided with a positioning groove (51), a partition plate (6) is arranged in the positioning groove (51), and the partition plate (6) is connected with the sample collection base.
4. A sample collection base for a liquid chromatograph according to claim 3, wherein: the positioning device comprises a support frame (4) and a positioning plate (5) arranged on the support frame (4), wherein the positioning plate (5) is detachably connected with the support frame (4), and the positioning groove (51) is positioned on the positioning plate (5); the separation plate (6) is connected with the positioning plate (5) in a sliding way.
5. The sample collection base for a liquid chromatograph according to claim 4, wherein: the splitter plate (6) is provided with a sliding hole (52), and the splitter plate (6) is provided with a sliding block (61) which is in sliding fit with the sliding hole (52).
6. The sample collection base for a liquid chromatograph according to claim 5, wherein: a fixing frame (7) is arranged below the supporting frame (4); the fixing frame (7) is provided with a lifting mechanism (8) for driving the supporting frame (4) to move up and down.
7. The sample collection base for a liquid chromatograph according to claim 6, wherein: the lifting mechanism (8) comprises an air cylinder (81) and a plurality of guide rods (82); the air cylinder (81) is fixed on the fixing frame (7), and the output end of the air cylinder (81) is fixedly connected with the supporting frame (4); the guide rod (82) is vertically arranged and fixedly connected with the support frame (4); the fixing frame (7) is provided with a guide hole which is in sliding fit with the guide rod (82).
8. The sample collection base for a liquid chromatograph according to claim 5, wherein: the positioning plate (5) is also provided with a locking mechanism (9) for fixing the sample collection box.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321136125.8U CN219905231U (en) | 2023-05-11 | 2023-05-11 | Sample collection box and sample collection base for liquid chromatograph |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321136125.8U CN219905231U (en) | 2023-05-11 | 2023-05-11 | Sample collection box and sample collection base for liquid chromatograph |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219905231U true CN219905231U (en) | 2023-10-27 |
Family
ID=88438486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321136125.8U Active CN219905231U (en) | 2023-05-11 | 2023-05-11 | Sample collection box and sample collection base for liquid chromatograph |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219905231U (en) |
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2023
- 2023-05-11 CN CN202321136125.8U patent/CN219905231U/en active Active
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