CN218629523U - Sample reaction detection device, sample collection detection device and detection equipment - Google Patents

Abstract

The application discloses sample reaction detection device includes: the device comprises a shell (1) and detection test paper (2), wherein the detection test paper (2) is installed on the shell (1); the shell (1) is provided with a sample inlet (3) for a sample to flow in, and the reaction result of the detection test paper (2) can be observed from the outside of the shell (1); the detection test paper (2) is annularly mounted to the shell (1); the shell (1) is provided with an end face, and the detection test paper (2) faces the end face. The application also provides a sample collecting and detecting device, a manual detecting device, an automatic detecting device and a sample detecting device. The utility model provides a sample reaction detection device, sample collection detection device and check out test set, the sample gets into in the casing through the introduction port, later with test paper's reaction to and the show of reaction result all accomplishes in the casing, the difficult problem that takes place the sample and leak, can avoid polluting, guarantee safety and clean and tidy.

Description

Sample reaction detection device, sample collection detection device and detection equipment

Technical Field

The application relates to the technical field of detection equipment, in particular to a sample reaction detection device, a sample collection detection device and detection equipment.

Background

The clinical examination refers to a method for providing a series of detection results for clinical medicine by detecting samples of body fluid, secretion, excrement, falling objects and the like of a patient through visual observation, physical, chemical, instrument or molecular biological methods, and is used for diagnosing diseases.

In the existing detection method, a sample is generally collected and processed, and then is added to a carrier such as detection paper, a reaction cell and the like for detection. In the process, the sample liquid needs to be transferred from the container for storing the sample to other carriers, so that the problems of sample liquid leakage and flowing to an improper position are easy to occur, and pollution is generated; and the odor of the sample also affects the environment. Therefore, it is an urgent technical problem to be solved by those skilled in the art to provide a detection device to solve the problem that a sample needs to be transferred before detection.

SUMMERY OF THE UTILITY MODEL

In order to solve the above technical problems, a first object of the present invention is to provide a sample reaction detecting device; the second purpose of the utility model is to provide a sample collection and detection device; the third purpose of the utility model is to provide a manual detection device; the fourth purpose of the utility model is to provide an automatic detection device; the fifth objective of the present invention is to provide a sample testing device. The utility model provides a sample reaction detection device, sample collection detection device and check out test set, the sample gets into in the casing through the introduction port, later with test paper's reaction to and the show of reaction result all accomplishes in the casing, the difficult problem that takes place the sample and leak, can avoid polluting, guarantee safety and clean and tidy.

The utility model provides a technical scheme as follows:

a sample reaction detection device comprising: the test paper is mounted to the shell;

the shell is provided with a sample inlet for a sample to flow in, and the reaction result of the test paper can be detected from the appearance of the shell;

the detection test paper is annularly mounted to the shell; the shell is provided with an end face, and the detection test paper faces the end face.

Preferably, the test strip is arranged between the substrate and the shell, and the sample inlet is arranged on the substrate.

Preferably, the housing is formed with a cavity, a substrate is installed in the cavity, the substrate has a substrate top surface and a substrate back surface, and the substrate top surface faces the end surface of the housing; substrate top surface and/or casing are equipped with the installation cavity, test paper installs to the installation cavity, the introduction port set up in the substrate bottom surface, the introduction port with the installation cavity intercommunication.

Preferably, a plurality of installation cavities are arranged, and a plurality of sample inlets are arranged on the bottom surface of the substrate corresponding to the installation cavities.

Preferably, the aperture of the sample inlet is tapered along the direction from the bottom surface to the top surface of the substrate to form a flow guide cavity.

Preferably, a positioning structure for circumferential positioning is further arranged between the substrate and the shell.

Preferably, the substrate and the housing are connected by means of interference fit, gluing or snapping.

Preferably, the inner wall of the shell is provided with a connecting structure which can be connected with a sample container

Preferably, the end face of the shell is provided with an observation structure corresponding to the detection test paper, and the observation structure is an observation hole or a transparent window.

Preferably, the casing includes base and cover plate, be provided with the test paper chamber that is used for holding test paper between base and the cover plate, the introduction port is located base or cover plate, and still forms the introduction cavity between base and the cover plate, and the sample accessible the introduction port via the introduction cavity flows into the test paper chamber.

Preferably, the test paper cavity and the sample injection cavity are formed on the base and/or the cover plate, and the bottom, the top or the side edge of the test paper cavity is communicated with the sample injection cavity.

Preferably, the test paper cavity is provided in a plurality of, and at least two adjacent test paper cavities are communicated with each other.

Preferably, a plurality of the test paper chambers are communicated through an annular channel.

Preferably, a circumferential positioning piece is further arranged between the base and the cover plate.

Preferably, the base is connected with the cover plate in an interference fit, gluing or clamping manner.

Preferably, the base or the cover plate is provided with an observation structure which is set as an observation hole or a transparent window.

A sample collection and detection device comprises a collection tube and any one of the sample reaction and detection devices, wherein the sample reaction and detection device is detachably arranged at the opening of the collection tube, and a sample inlet of the sample reaction and detection device is communicated with the opening of the collection tube.

Preferably, a sealing component is further arranged at the opening of the collection tube, and the sample reaction detection device is provided with a puncturing piece for puncturing the sealing component.

A manual detection device comprises a collection tube, a colorimetric card and the sample reaction detection device.

An automatic detection device comprises a detection mechanism and the sample reaction detection device, wherein the detection mechanism is used for detecting the reaction result of detection test paper.

Preferably, the detection mechanism is any one of a photoelectric reflection detection device and a CCD detection device.

Preferably, the device further comprises a driving component for driving the sample reaction detection device to rotate relative to the detection mechanism.

Preferably, the sample reaction detection device further comprises a collection tube and a turnover mechanism, wherein the sample reaction detection device is mounted to the collection tube, and the turnover mechanism is used for turning over the collection tube to enable a sample in the collection tube to enter the sample reaction detection device for reaction.

A sample detection device comprises the sample reaction detection device, a sample adding mechanism and a detector, wherein the sample adding mechanism is arranged to inject a sample into the sample reaction detection device, and the detector is arranged to detect a reaction result of detection test paper.

The application firstly provides a sample reaction detection device, which comprises a shell and detection test paper, wherein the detection test paper is arranged on the shell, and the shell is provided with an injection port for a sample to flow in and contact with the detection test paper, so that the sample enters the shell from the injection port, contacts and reacts with the detection test paper, and then presents a reaction result on the detection test paper; moreover, the reaction result can be observed from the outside of the shell, so that an external instrument or a worker can observe the reaction result on the detection test paper. The application provides a sample reaction detection device, the sample gets into in the casing through the introduction port, later with test paper's reaction to and the show of reaction result all accomplishes in the casing, the difficult problem that takes place the sample and leak, can avoid polluting, guarantee safety and clean and tidy. Meanwhile, as the result is displayed in the shell and can be observed from the outside, both professionals and common patients can use the result for detection, and the application range is wide and the difficulty is low.

The application also provides a sample collection and detection device, which combines the sample reaction and detection device with a collection tube. When the sample reaction detection device is used, a sample is stored in the collection tube, then the sample reaction detection device is arranged at the opening of the collection tube, the sample reaction detection device is kept above the collection tube during storage and transportation, and the sample reaction detection device plays a role in sealing the opening of the collection tube, preventing the sample from being polluted by the outside and preventing the sample from leaking; when detection is needed, the collection tube is inclined or inverted, the sample reaction detection device is positioned below the collection tube, and at the moment, a sample in the collection tube flows into the sample reaction detection device, contacts and reacts with the detection test paper, and finally, a reaction result is presented on the detection test paper.

The application still provides a manual check out test set, utilizes the colorimetric card of above-mentioned sample reaction detection device, collection pipe and outfit, can realize manual collection sample, reaction to thereby compare test paper's result and colorimetric card and draw the conclusion. The application provides a manual check out test set can swiftly, conveniently detect, and need not large-scale equipment or professional instrument supplementary, is particularly useful for POCT detection or patient at home and detects by oneself.

The application also provides an automatic detection device, which utilizes a detection mechanism to detect the result of the detection paper in the sample reaction detection device and give the result, thereby reducing the labor intensity of personnel and avoiding the error possibly brought by manual color comparison (especially by non-professional personnel).

The application also provides a detection device, which corresponds to a sample reaction detection device using the base and the cover plate, injects a sample into the sample reaction detection device through the sample injection mechanism, and then detects the result of detection paper in the sample reaction detection device by the detector.

Drawings

In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments described in the present application, and other drawings can be obtained by those skilled in the art without creative efforts.

FIG. 1 is a schematic view of a first structure of a sample reaction detecting device according to an embodiment of the present invention (in the form of a first side surface and a first top surface);

FIG. 2 is an exploded view of FIG. 1;

FIG. 3 is a schematic cross-sectional view of FIG. 1;

fig. 4 is a schematic view of a first structure of the sample reaction detecting device according to the present invention (in the form of a first side surface and a first top surface, a first limiting member is provided);

FIG. 5 is a schematic view of the combination of the sample reaction detecting device and the collecting tube (upright test paper) according to the embodiment of the present invention;

FIG. 6 is a schematic cross-sectional view of FIG. 5;

FIG. 7 is a schematic cross-sectional view of a combination of a sample reaction detecting device and a collecting tube (upright test strip) in an embodiment of the present invention;

FIG. 8 is a schematic diagram of a second structure of a sample reaction detecting device according to an embodiment of the present invention (side, bottom and top modes);

FIG. 9 is a schematic cross-sectional view of FIG. 8;

FIG. 10 is an exploded view of FIG. 8;

FIG. 11 is a schematic diagram of a second structure of a sample reaction detecting device according to an embodiment of the present invention (in terms of side, bottom and top surfaces, it is composed of a first housing part and a second housing part, wherein a detecting strip can be placed on the first housing part or the second housing part);

FIG. 12 is a schematic view of the second shell member of FIG. 11 (without test paper installed);

FIG. 13 is a top view of the second housing piece of FIG. 11 (with test strip installed);

FIG. 14 is a schematic cross-sectional view of FIG. 11 (taken along c-c, without test paper installed);

FIG. 15 is a schematic view of the first housing piece of FIG. 11 (without test paper);

FIG. 16 is an exploded view of the first housing piece and test strip of FIG. 11;

FIG. 17 is a schematic view of the first housing member and the test strip of FIG. 11 assembled together;

FIG. 18 is a schematic view of a third structure of a sample reaction detecting device according to an embodiment of the present invention (a manner of a substrate and a mounting chamber);

FIG. 19 is an exploded view of FIG. 18;

FIG. 20 is an exploded view (inverted 180 degrees) of FIG. 18;

FIG. 21 is a bottom view of the housing of FIG. 18 without a substrate;

FIG. 22 is a schematic diagram of a fourth structure of the device for detecting a sample reaction according to the embodiment of the present invention (a manner of mounting a cavity and an upper cover plate on a test strip);

FIG. 23 is a schematic diagram of a fifth structure of the device for detecting a sample reaction according to the embodiment of the present invention (an annular channel is formed at the bottom of the test paper chamber);

FIG. 24 is an exploded view of FIG. 23;

FIG. 25 is an exploded schematic view (inverted 180 degrees) of FIG. 23;

FIG. 26 is a schematic bottom view of the flap of FIG. 23;

FIG. 27 is a schematic cross-sectional view of FIG. 26 (taken along line c-c);

FIG. 28 is a schematic view of another structure of the base of the fifth structure of the device for detecting a sample reaction in an embodiment of the present invention (the test paper chamber is provided with an annular channel at a side edge);

FIG. 29 is another schematic view of a fifth configuration of a sample reaction detecting device according to an embodiment of the present invention (a sample introduction structure includes a transfer chamber and a branch channel);

FIG. 30 is an exploded view of FIG. 29 (the sample application channel of the second base is composed of a main well and a branch channel);

FIG. 31 is a schematic view from another angle of FIG. 30 (test strip not shown);

FIG. 32 is a schematic view of the sample reaction detecting device combined with the collecting tube and provided with a sealing member according to an embodiment of the present invention;

FIG. 33 is a schematic view of FIG. 33 partially broken away;

reference numerals: 1-a shell; 1 a-a first housing piece; 1 b-a second housing part; 101-a first side; 102-a first top surface; 103-a first stop; 111-side; 112-a top surface; 113-a bottom surface; 114-a circumferential limit; 115-end face stop; 1151-a bearing surface; 116-a radial stop; 117-a flow guide; 118-a mounting groove; 121-a substrate; 122-a mounting cavity; 123-a positioning structure; 124-a flow guide cavity; 131-test paper mounting cavity; 132-an upper cover plate; 141-a base; 142-a cover slip; 143-test paper chamber; 144-sample introduction cavity; 145-a transit chamber; 146-a branched channel; 147-a circumferential positioning element; 2-detecting test paper; 2 a-reagent block; 2 b-a base strip; 3-a sample inlet; 4-a collection tube; 5-a sealing member; 51-a fixation sleeve; 52-sealing film; 6-piercing element.

Detailed Description

In order to make those skilled in the art better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

It will be understood that when an element is referred to as being "fixed" or "disposed" on another element, it can be directly on the other element or be indirectly disposed on the other element; when an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.

It will be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like, refer to an orientation or positional relationship illustrated in the drawings for convenience in describing the present application and to simplify description, and do not indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present application.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or to implicitly indicate the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, the meaning of a plurality or a plurality is two or more unless explicitly defined otherwise.

It should be understood that the structures, ratios, sizes, and the like shown in the drawings are only used for matching the disclosure of the specification, so as to be understood and read by those skilled in the art, and are not used to limit the practical limit conditions of the present application, so that the modifications of the structures, the changes of the ratio relationships, or the adjustment of the sizes, do not have the technical essence, and the modifications, the changes of the ratio relationships, or the adjustment of the sizes, are all within the scope of the technical contents disclosed in the present application without affecting the efficacy and the achievable purpose of the present application.

As shown in the drawings, an embodiment of the present invention provides a sample reaction detecting device, including: the device comprises a shell 1 and detection test paper 2, wherein the detection test paper 2 is mounted on the shell 1;

the shell 1 is provided with a sample inlet 3 for a sample to flow in, and the reaction result of the test paper 2 can be detected from the appearance of the shell 1;

the test strip 2 is mounted to the housing 1 in a ring shape.

The application firstly provides a sample reaction detection device, which comprises a shell 1 and detection test paper 2, wherein the detection test paper 2 is installed on the shell 1, and the shell 1 is provided with an injection port 3 for a sample to flow in and contact with the detection test paper 2, so that the sample enters the shell 1 from the injection port 3, contacts and reacts with the detection test paper 2, and then a reaction result is presented on the detection test paper 2; moreover, the reaction result can be observed from the outside of the housing 1, so that an external instrument or a worker can observe the reaction result on the test paper 2. The application provides a sample reaction detection device, sample through introduction port 3 get into casing 1 in, later with test paper 2's reaction to and the show of reaction result all accomplishes in casing 1, the difficult problem that takes place the sample and leak, can avoid polluting, guarantee safety and clean and tidy. Meanwhile, as the result is displayed in the shell 1 and can be observed from the outside, both professionals and common patients can use the result for detection, and the application range is wide and the difficulty is low.

Can react with a sample and present the reaction result, and can be used as the test strip 2 of the present application. The detection test paper 2 can be a multi-joint test paper or a single reagent unit. The single reagent unit can be in any structure such as a sheet shape, a block shape, a bulk shape and the like.

The multi-joint test paper generally comprises a base strip and one or more reagent blocks arranged on the base strip, wherein reagents contained in different reagent blocks can be the same or different, and a sample can show a color or a state corresponding to a reaction result after contacting and reacting with the reagents in the reagent blocks. In addition, the test strip 2 may be a separate reagent block without including a base strip.

The application limits that the detection test paper 2 is annularly mounted to the housing 1, which means that the detection test paper 2 is arranged in the housing 1 in a surrounding manner, or the detection test paper 2 is arranged in a certain plane of the housing 1, but the detection test paper 2 is arranged in an annular manner when viewed perpendicular to the plane. By mounting the detection test paper 2 to the shell 1 in a ring shape, the presented result can be detected by rotating the sample reaction detection device after the reaction is finished; the instrument can also rotate around the sample reaction detection device to detect reaction results at different positions. The rotary detection mode has high efficiency, easy control of alignment accuracy and high adaptability with the existing instruments, and the test paper 2 is surrounded in the shell 1 and can be better matched with sample containers such as a test tube which is generally cylindrical. The test paper 2 may be in a complete ring shape, or in a ring shape with a gap, or in an elliptical shape, a polygon similar to a ring shape, or the like.

In addition to this, the test strip 2 may be mounted upright to the housing 1. The vertically mounted test strip 2 may be angled at various angles with respect to the housing 1. When a plurality of vertical test strips 2 are placed at the same time, the orientation of the test strips 2 may be the same or opposite. For convenience of preparation and taking, the test paper 2 is oriented in the same direction. When the test strip 2 is upright, detection is performed by translating the sample reaction detection device or translating the instrument relative thereto.

As the first embodiment, it is preferable that the housing 1 includes a first side surface 101 and a first top surface 102, and the first side surface 101 and the first top surface 102 jointly enclose a first chamber; the test paper 2 is located in the first chamber, and the test paper 2 is disposed toward the first side surface 101. A first chamber is defined by the first side surface 101 and the first top surface 102, and a bottom surface of the first chamber is an opening and can be regarded as the sample inlet 3. More preferably, the first side surface 101 is provided with an observation structure, and the observation structure enables an area of the test paper 2 presenting a reaction result to be communicated with the outside; alternatively, the first side 101 is at least partially made of a colorless transparent material. And "the reaction result of the test paper 2 can be detected from the external appearance of the casing 1" is realized by the observation structure communicated to the outside or by setting the first side surface 101 portion to be transparent. More preferably, a first stopper 103 is disposed in the housing 1, and the first stopper 103 is used for restricting the movement of the test strip 2 along the circumferential direction of the housing 1, so as to keep the relative position of the test strip 2 and the observation structure or the colorless transparent portion stable.

Preferably, the housing 1 includes a side surface 111, a top surface 112 and a bottom surface 113, and the side surface 111, the top surface 112 and the bottom surface 113 together enclose a receiving cavity;

the detection test paper 2 is positioned in the accommodating cavity, and the detection test paper 2 is arranged towards the side surface 111;

the sample inlet 3 is arranged on the top surface 112 or the bottom surface 113;

the side 111 is provided with an observation structure, and the observation structure is arranged as an observation hole or a transparent window.

As a second embodiment, it is preferable that the housing 1 includes a side surface 111, a top surface 112 and a bottom surface 113, which together form a containing cavity, and the test strip 2 is disposed toward the side surface 111; the sample inlet 3 is arranged on the top surface 112 or the bottom surface 113, so that the sample enters the accommodating cavity from the top surface 112 or the bottom surface 113; the side 111 is provided with an observation structure with an observation hole or a transparent window to realize observation of the reaction result from the outside.

The observation hole is a through hole formed in the side surface 111, and the detection test paper 2 in the shell 1 can be observed from the outside through the through hole; the transparent window is a window with a colorless and transparent material on the side 111, and the outside is observed through the transparent window. By controlling the amount of the sample, the sample just meets the reaction requirement of the detection test paper 2, and the sample liquid can be kept from leaking when the observation hole is used; when the transparent window is used, the side surface 111 is not communicated with the outside, and the sample cannot leak from the side surface. In addition, the housing 1 may be made of a colorless transparent material.

The colorless and transparent material can be glass, acrylic and the like.

Preferably, a circumferential limiting member 114 is disposed in the housing 1, and the circumferential limiting member 114 is configured to limit the movement of the test paper 2 along the circumferential direction of the housing 1.

Preferably, a circumferential stopper 114 is provided in the housing 1 to restrict the movement of the test strip 2 in the circumferential direction of the housing 1, and to maintain the relative position of the test strip 2 to the side surface 111 stable.

Preferably, a black separating strip is disposed outside the side surface 111, and the separating strip is disposed corresponding to the circumferential limiting member 114.

The circumferential position-limiting members 114 are clamped between the reagent blocks to realize position limitation, preferably, black partition bars are arranged outside the side surface 111, the black partition bars are arranged corresponding to the circumferential position-limiting members 114, and thus the black partition bars do not block the reagent blocks, but separate the adjacent reagent blocks. The black auxiliary detecting instrument of the separating strip is used for identifying different reagent blocks, thereby identifying different reaction results. Meanwhile, black as a background can also reduce background interference.

Preferably, an end surface stopper 115 is disposed in the housing 1, the end surface stopper 115 has a supporting surface 1151 for supporting the test paper 2, and a gap is formed between the supporting surface 1151 and the top surface 112 or the bottom surface 113.

Preferably, an end stop 115 is provided in the housing 1, and the test strip 2 is held by the holding surface 1151, and since there is a gap between the holding surface 1151 and the top surface 112 or the bottom surface 113, the edge of the test strip 2 will also have a gap between the top surface 112 or the bottom surface 113, so that the sample can pass through (especially through the base strip of the test strip 2) and fully contact and react with the reagent block.

Preferably, end surface stoppers 115 are disposed above and below the test strip 2, and a distance between the supporting surface 1151 above the test strip 2 and the supporting surface 1151 below the test strip 2 is greater than or equal to a width of the test strip 2, so that the test strip 2 can be conveniently installed between the two section stoppers 115, and the relative distance between the test strip 2 and the top surface 112 and/or the bottom surface 113 can be kept stable.

Preferably, a radial limiting member 116 is disposed in the housing 1, and the test strip 2 is mounted between the side surface 111 and the radial limiting member 116.

Preferably, a radial stopper 116 is further disposed in the housing 1, and the test strip 2 is mounted between the side surface 111 and the radial stopper 116, so that the distance between the test strip 2 and the side surface 111 can be kept stable.

The circumferential stopper 114, the end surface stopper 115, and the radial stopper 116 may be provided simultaneously as needed, or one or more of them may be optionally provided. Meanwhile, the circumferential position limiter 114, the end position limiter 115 and the radial position limiter 116 may be optionally connected to the side surface 111, the top surface 112 or the bottom surface 113 of the housing 1.

For convenience of processing, the end surface limiting piece 115 and the radial limiting piece 116 may also be processed together to form an L-shaped integral structure, and simultaneously achieve the limiting function of the end surface and the radial direction. Alternatively, the circumferential stopper 114, the end surface stopper 115, and the radial stopper 116 may be machined together to form a U-shaped integral structure.

Preferably, the sample inlet 3 is located on the bottom surface 113, and the bottom surface 113 is provided with a water guiding inclined surface.

Preferably, the sample inlet 3 is located on the bottom surface 113, and the bottom surface 113 is provided with a water guide slope, so that after the sample enters the sample reaction detection device and fully contacts with the detection test paper 2, by inverting the sample reaction detection device, the redundant sample flows into the sample inlet 3 along the water guide slope and flows out from the sample inlet 3, thereby preventing the sample from being retained to influence the detection result of the detection test paper 2. More preferably, the inner wall of the bottom surface 113 is further provided with a radially radiating flow guide 117 to further assist in guiding the liquid sample.

Preferably, the side 111 and the top 112 form a first housing part, and the bottom 113 forms a second housing part, to which the first housing part is detachably connected.

For convenience of processing and assembling, the housing 1 may be formed by assembling a first housing member and a second housing member, the side surface 111 and the top surface 112 form the first housing member, and the bottom surface 113 forms the second housing member, so that the two housing members are assembled after the test paper 2 is placed in the first housing member; meanwhile, the structure setting and processing of the circumferential direction limiting piece 114, the end surface limiting piece 115, the radial direction limiting piece 116 and the like are also simpler.

Preferably, the bottom surface 113 is provided with a mounting groove 118, and the side surface 111 extends into the mounting groove 118 to connect the first housing member to the second housing member.

In order to facilitate the assembly of the first housing part and the second housing part, the first housing part can be provided with a mounting groove 118 for the second housing part to insert, and the assembly efficiency is high

Preferably, a circumferential positioning structure is arranged between the first shell part and the second shell part.

Preferably, a circumferential positioning structure is arranged between the first shell part and the second shell part, so that the first shell part and the second shell part can be accurately aligned when being installed.

Preferably, the housing 1 has an end face, and the test strip 2 is disposed toward the end face.

In a third embodiment of the present application, the housing 1 has an end face, and when the test strip 2 is disposed toward the end face, the result of the test strip 2 is also displayed toward the end face, and the worker or the instrument observes from the end face.

Preferably, the device further comprises a substrate 121 connected to the housing 1, the test strip 2 is disposed between the substrate 121 and the housing 1, and the sample inlet 3 is disposed on the substrate 121.

Preferably, the housing 1 further comprises a substrate 121, the substrate 121 is connected to the housing 1, the test strip 2 is located between the substrate 121 and the housing 1, and the sample inlet 3 is located on the substrate 121, so that the sample passes through the substrate 121 and reacts with the detection reagent 2.

Preferably, the housing 1 is formed with a cavity, a substrate 121 is mounted in the cavity, the substrate 121 has a substrate top surface and a substrate back surface, and the substrate top surface faces the end surface of the housing 1; substrate top surface and/or casing are equipped with installation cavity 122, test paper 2 is installed to installation cavity 122, the sample inlet set up in the substrate bottom surface, the sample inlet with installation cavity 122 intercommunication.

It is further preferable that the housing 1 is formed with a cavity in which the substrate 121 is mounted. The substrate 121 has a substrate top surface and a substrate back surface, the substrate top surface faces the end surface of the housing 1, the substrate top surface and/or the housing 1 is provided with a mounting cavity 122 for accommodating the test paper 2, the sample inlet 3 is arranged on the substrate bottom surface, and the sample inlet 3 is communicated with the mounting cavity 122.

The test strip 2 is mounted to the mounting chamber 122, and both the base strip and the reagent block may be mounted to the mounting chamber 122, and more preferably, only the reagent block is mounted. The mounting cavity 122 is arranged on the top surface of the substrate and/or the housing 1, which means that the top surface of the substrate or the wall of the housing 1 is provided with a groove, and the groove is the mounting cavity 122; or both the top surface of the substrate and the walls of the housing 1 are recessed and assembled to form the mounting cavity 122.

Specifically, the reagent blocks may be cut or sheared from the base strip and then placed in each of the mounting cavities 122; the single reagent block which is not connected with the base strip can be directly placed into the installation cavity 122, and then the shell 1 and the substrate 121 are assembled, wherein the assembly can be carried out manually or automatically by using a machine.

Preferably, a plurality of mounting cavities 122 are formed in the top surface of the substrate, and a plurality of sample inlets 3 are formed in the bottom surface of the substrate corresponding to the mounting cavities 122.

A mounting chamber 122 may be provided, with one or more reagent blocks located within the mounting chamber 122; more preferably, a plurality of mounting cavities 122 are formed on the top surface of the substrate, and each mounting cavity 122 is used for placing a reagent block, and a plurality of sample inlets 3 are formed on the bottom surface of the substrate corresponding to the mounting cavities 122, so as to ensure that a sample can flow into each mounting cavity 122.

Preferably, the aperture of the sample inlet 3 is tapered along the direction from the bottom surface to the top surface of the substrate to form the diversion cavity 124.

Preferably, the aperture of the sample inlet 3 is tapered along the direction from the bottom surface to the top surface of the substrate to form a diversion cavity 124, so that the sample is accumulated in the diversion cavity 124 and gradually enters the installation cavity 122.

Preferably, a positioning structure 123 for circumferential positioning is further provided between the substrate 121 and the housing 1.

Preferably, a positioning structure 123 is disposed between the substrate 121 and the housing 1 for circumferentially positioning the substrate 121 and the housing 1 to maintain the position accurately. The positioning structure 123 may be a positioning column and a positioning hole, or other structures.

Preferably, the substrate 121 is connected to the housing 1 by interference fit, gluing or snapping.

The connection of the substrate 121 and the housing 1 may be achieved by interference fit, gluing, snapping, etc.

Preferably, the inner wall of the shell 1 is provided with a connecting structure which can be connected with a sample container

Preferably, the inner wall of the housing 1 is further provided with a linking structure for connecting with a sample container (e.g., a test tube). The attachment mechanism may be a thread, protrusion, groove, etc.

Preferably, the end face of the shell 1 is provided with an observation structure corresponding to the detection test paper, and the observation structure is an observation hole or a transparent window.

Preferably, the end face of the shell 1 is provided with an observation structure corresponding to the detection test paper, and the observation structure is an observation hole or a transparent window, so that a reaction result can be observed conveniently.

Preferably, the upper end surface of the housing 1 is provided with a test paper installation cavity 131 for installing the test paper 2, and the sample inlet 3 is arranged on the back surface of the upper end surface and communicated with the test paper installation cavity 131.

Preferably, the housing 1 further includes an upper cover plate 132, the upper cover plate 132 is connected to the upper end face of the housing 1, an observation structure is provided on the upper cover plate 132, and the observation structure is set as an observation hole or a transparent window.

As a fourth embodiment of the present application, it is preferable that the upper end surface of the housing 1 is provided with a test strip installation cavity 131 for installing the test strip 2, and the sample inlet 3 is disposed on the back surface of the upper end surface and is communicated with the test strip installation cavity 131. Preferably, the casing 1 further includes an upper cover plate 132, the upper cover plate 132 is connected to the upper end surface of the casing 1, and the upper cover plate 132 is provided with an observation structure, and the observation structure is an observation hole or a transparent window. In this embodiment, the upper cover 132 is located outside the upper end surface of the housing 1, and the test strip is also mounted on the upper end surface of the housing 1.

Similarly, the reagent block may be cut or sheared from the base strip and then respectively placed in each test strip installation cavity 131; the reagent block which is independent and not connected with the base strip can be directly placed into the test paper mounting cavity 131, and then the shell 1 and the upper cover plate 132 are assembled, so that the assembly can be carried out manually or automatically by using a machine.

Preferably, the housing 1 includes a base 141 and a cover 142, a test strip cavity 143 for accommodating the test strip 2 is disposed between the base 141 and the cover 142, the sample inlet 3 is located on the base 141 or the cover 142, and a sample inlet structure 144 is further formed between the base 141 and the cover 142, through which the sample can flow into the test strip cavity 143 through the sample inlet 3 via the sample inlet structure 144.

As a fifth embodiment of the present application, the housing 1 includes a base 141 and a cover 142, a test strip cavity 143 for accommodating the test strip 2 is disposed between the base 141 and the cover 142, and a sample injection structure 144 is further disposed; the sample flows into the test strip cavity 143 through the sample inlet 3 via the sample injection structure 144 to react with the test strip 2. The sample injection structure 144 is arranged to communicate the sample injection port 3 and the test paper cavity 143, so that the position of the sample injection port 3 can be more flexibly arranged. Preferably, the test paper cavity 143 and the sample injection structure 144 are formed on the base 141 and/or the cover 142, and the bottom, the top or the side of the test paper cavity 143 is communicated with the sample injection structure 144.

The test paper cavity 143 and the sample injection structure 144 are formed on the base 141 and/or the cover 142, which means that the base 141 or the cover 142 is provided with a groove as the test paper cavity 143 and the sample injection structure 144; or, the base 141 or the cover 142 is respectively provided with a groove, and the grooves are correspondingly assembled to serve as the test paper cavity 143 and the sample injection structure 144, and the depth of the grooves can be different in different setting modes.

Similarly, the reagent blocks may be cut or sheared from the base strip and placed in each of the test paper cavities 143; the reagent block which is independent and not connected with the base strip can be directly put into the test paper cavity 143, and then the base 141 and the cover 142 are assembled, and the assembly can be carried out manually or automatically by a machine.

Meanwhile, the bottom, top or side of the test paper cavity 143 is connected to the sample injection structure 144 for the sample to flow in. In addition, the test paper cavity 143 may or may not have an observation hole, and the reaction result is displayed through an observation window or other structures.

Preferably, the test paper cavities 143 are provided in plurality, and at least two adjacent test paper cavities 143 are communicated with each other.

Preferably, a plurality of the test paper chambers 143 communicate through an annular passage.

Preferably, the plurality of test paper chambers 143 are provided, and at least two adjacent test paper chambers 143 communicate with each other, so that the sample can flow between adjacent test paper chambers 143 after flowing into one test paper chamber 143, thereby preventing the sample from being accumulated and sufficiently reacting with the test paper 2 in each test paper chamber 143. More preferably, a plurality of the test paper cavities 143 are communicated with each other through an annular passage, so that the sample can freely flow through the annular passage regardless of the entrance of the sample, thereby improving the efficiency of contacting the sample with the test paper 2.

The sample introduction structure 144 may be a chamber only, or a combination of a chamber and a channel, or a channel only. That is, the bottom, top or side of the test paper cavity 143 is communicated with the sample injection structure 144, the two cavities may be directly communicated with each other, or the two cavities may be communicated with each other through a channel, or the test paper cavity 143 is communicated with the sample injection port 3 through the sample injection structure 144 in the form of a channel only.

In the application, a plurality of test paper cavities 143 are communicated through an annular channel, and the annular channel can be arranged at the bottom of the test paper cavity 143 or at the side edge of the test paper cavity 143; the annular channel is provided at the side of the test paper chamber 143 and preferably further communicates with each test paper chamber through a branched channel.

Preferably, the sample injection structure 144 includes a transfer cavity 145 and at least one branch channel 146, and two ends of the branch channel 146 are respectively communicated with the transfer cavity 145 and one test paper cavity 143.

As another implementation manner of the sample injection structure, the sample injection structure 144 includes a transfer cavity 145 and at least one branch channel 146, and two ends of the branch channel 146 are respectively communicated with the transfer cavity 145 and one test paper cavity 143.

Preferably, a circumferential positioning member 147 is further disposed between the base 141 and the cover 142.

Preferably, a circumferential positioning member 147 is disposed between the base 141 and the cover 142 for circumferential positioning of the base 141 and the cover 142 to maintain the position.

Preferably, the base 141 and the cover 142 are connected by interference fit, gluing or clipping.

The connection between the base 141 and the cover 142 can be achieved by interference fit, gluing, or snapping.

Preferably, the base 141 or the cover 142 is provided with an observation structure, and the observation structure is configured as an observation hole or a transparent window.

Preferably, one of the base 141 or the cover 142 is provided with an observation structure configured as a viewing port or a transparent window to facilitate observation of the reaction result. The base 141 or the cover 142 is optionally provided with an observation structure, and the position provided with the observation structure can be observed by turning the sample reaction detecting apparatus or moving the probe of the instrument when in use.

A sample collection and detection device comprises a collection tube 4 and any one of the sample reaction and detection devices, wherein the sample reaction and detection device is detachably arranged at the opening of the collection tube 4, and a sample inlet 3 of the sample reaction and detection device is communicated with the opening of the collection tube 4.

The application also provides a sample collection and detection device, which combines the sample reaction and detection device with the collection tube 4. When the device is used, a sample is stored in the collecting tube 4, then the sample reaction detection device is arranged at the opening of the collecting tube 4, the sample reaction detection device is kept above the collecting tube 4 during storage and transportation, and the sample reaction detection device plays a role in sealing the opening of the collecting tube 4, preventing the sample from being polluted by the outside and simultaneously preventing the sample from leaking; when detection is needed, the collection tube 4 is inclined or inverted, so that the sample reaction detection device is positioned below the collection tube 4, and at the moment, the sample in the collection tube 4 flows into the sample reaction detection device, contacts and reacts with the detection test paper 2, and finally, a reaction result is presented on the detection test paper 2.

When the amount of the sample in the collecting tube 4 is large, the remaining sample can be retained in the collecting tube 4 after the reaction, and the sample can be rechecked by replacing the sample reaction detection device or by taking the sample and sending the sample into the detection instrument.

Preferably, the opening of the collection tube 4 is further provided with a sealing component 5, and the sample reaction detection device is provided with a puncturing part 6 for puncturing the sealing component 5.

Preferably, a sealing member 5 is further disposed between the opening of the collection tube 4 and the sample reaction detecting device, so as to seal the collection tube 4. Between the breaking seal members 5, the sample does not flow out or leak out even if the collection tube 4 is tilted; when a test is required, the sealing member 5 is broken by the puncture member 6 of the sample reaction detection apparatus, and the sample is allowed to flow into the case 1 to react.

It is further preferred that the sealing member 5 comprises a retaining sleeve 51 and a sealing membrane 52, the retaining sleeve 51 being able to be fitted over the outside of the collection tube 5, while the sealing membrane 52 is tensioned against the retaining sleeve 51. The fit between the hub 51 and collection tube 5 may be by threads, splines, or other means. The connection of the sample reaction detection means with the sealing member 5 or with the collection tube 5 may also be achieved in the above manner. For example, collection tube 5 is externally provided with a first thread, and hub 51 is provided with an internal thread that mates with the first thread; meanwhile, the outer wall of the fixing sleeve 51 is provided with a second thread, and the sample reaction detection device is provided with an internal thread matched with the second thread, so that the three parts are assembled.

Preferably, the puncturing element 6 is arranged in the housing 1 by means of at least two cantilever arms 51, while the housing 1 is deformed by a force, which causes the tip of the puncturing element 6 to puncture the sealing membrane 52.

The shell 1 can be deformed by selecting deformable materials such as plastics, metals and the like.

A manual detection device comprises a collection tube, a colorimetric card and the sample reaction detection device.

The application still provides a manual check out test set, utilizes the colorimetric card of above-mentioned sample reaction detection device, collection pipe and outfit, can realize manual collection sample, reaction to thereby compare test paper 2's result and colorimetric card and draw the conclusion. The application provides a manual check out test set can be swiftly, conveniently detect, and need not large-scale equipment or professional instrument supplementary, is particularly useful for POCT detection or patient at home self-detection.

The colorimetric card can be attached to the collecting tube, and can also be packaged in the same package with the device. When a plurality of sample reaction detection devices and collection tubes are packaged and sold together, one or more colorimetric cards can be given.

And according to the difference of the samples, the sample can be directly collected and then detected by using the sample reaction detection device, or after the sample is collected, diluent (water or other reagents) can be added and then the sample reaction detection device is used for detecting. The diluent can be given away, or an operator can prepare clear water by himself, large-scale equipment is still not needed for assistance, and convenient detection at home can be achieved.

An automatic detection device comprises a detection mechanism and the sample reaction detection device, wherein the detection mechanism is used for detecting the reaction result of the detection test paper 2.

The application also provides an automatic detection device, which utilizes a detection mechanism to detect the result of the detection paper 2 in the sample reaction detection device and give the result, thereby reducing the labor intensity of personnel and avoiding the error possibly brought by manual color comparison (especially by non-professional personnel).

When the automatic detection equipment is used, the process of inclining or inverting the sample reaction detection device needs external force to be completed, and the automatic detection equipment is suitable for scenes with small detection quantity and low frequency, and is flexible and convenient.

Preferably, the detection mechanism is any one of a photoelectric reflection detection device and a CCD detection device.

Preferably, the detection mechanism is one of a photoelectric reflection detection device and a CCD detection device. Preferably, the device further comprises a driving component for driving the sample reaction detection device to rotate relative to the detection mechanism.

Preferably, the detection mechanism further comprises a drive member for rotating or moving the sample reaction detection device relative to the detection mechanism to detect and provide results for each part of the test strip 2.

The drive means may drive the sample reaction detection means in motion while the detection mechanism remains stationary, or may drive the detection mechanism in motion while the sample reaction detection means remains stationary, provided that relative motion occurs between the two.

Preferably, the sample reaction detection device further comprises a collection tube and a turnover mechanism, wherein the sample reaction detection device is mounted to the collection tube, and the turnover mechanism is used for turning over the collection tube 4 so that a sample in the collection tube 4 enters the sample reaction detection device for reaction.

According to the automatic detection equipment, the detection mechanism is used for detecting the detection test paper 2 in the sample reaction detection device, and the sample can be added into the sample reaction detection device in a dropwise adding or other mode; more preferably, a collection tube is used, a sample is firstly added into the collection tube, then the sample reaction detection device is assembled with the collection tube, and then the detection mechanism is used for detection; meanwhile, the automatic detection equipment is also provided with a turnover mechanism for turning over the collection tube 4, so that a sample enters the sample reaction detection device, the labor intensity is further reduced, the efficiency is improved, and the automatic detection equipment is particularly suitable for being used in hospitals and other places with a large number of samples.

The turnover mechanism can incline or turn over the collecting tube 4, and then directly detect the sample in a state of contacting with the detection test paper 2; the position of the collection tube 4 can also be adjusted after the sample is in full contact with the sample reaction detection device, so that the redundant sample flows back to the collection tube 4 for detection.

More preferably, the device comprises an upper cover mechanism for mounting the sample reaction detection device at the opening of the collection tube 4. More preferably, the sampling device also comprises a sample feeding mechanism which is used for conveying the collecting tube 4 to the working position of the upper cover mechanism.

A sample detection device comprises the sample reaction detection device, a sample adding mechanism and a detector, wherein the sample adding mechanism is arranged to inject a sample into the sample reaction detection device, and the detector is arranged to detect a reaction result of detection test paper.

The application also provides a detection device, which corresponds to a sample reaction detection device using a base and a cover plate, and a sample is injected into the sample reaction detection device through a sample injection mechanism, and then the result of detection paper 2 in the sample reaction detection device is detected by a detector.

The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (24)

1. A sample reaction detecting device, comprising: the device comprises a shell (1) and detection test paper (2), wherein the detection test paper (2) is installed on the shell (1);

the shell (1) is provided with a sample inlet (3) for a sample to flow in, and the reaction result of the detection test paper (2) can be observed from the outside of the shell (1);

the detection test paper (2) is annularly mounted to the shell (1); the shell (1) is provided with an end face, and the detection test paper (2) faces the end face.

2. The sample reaction detecting device according to claim 1, further comprising a substrate (121) connected to the housing (1), the detection test paper (2) being disposed between the substrate (121) and the housing (1), the sample inlet (3) being disposed on the substrate (121).

3. The sample reaction detecting device according to claim 2, wherein the housing (1) is formed with a cavity in which a substrate (121) is mounted, the substrate (121) having a substrate top surface and a substrate back surface, the substrate top surface facing the end surface of the housing (1); substrate top surface and/or casing (1) are equipped with installation cavity (122), test paper (2) are installed to installation cavity (122), introduction port (3) set up in the substrate bottom surface, introduction port (3) with installation cavity (122) intercommunication.

4. The sample reaction detecting device according to claim 3, wherein a plurality of mounting cavities (122) are provided, and a plurality of sample inlets (3) are provided on the bottom surface of the substrate corresponding to the mounting cavities (122).

5. The sample reaction detecting device according to claim 4, wherein the aperture of the sample inlet (3) is tapered along the direction from the bottom surface to the top surface of the substrate to form a flow guide cavity (124).

6. The sample reaction detection device according to claim 2, characterized in that a positioning structure (123) for circumferential positioning is further provided between the substrate (121) and the housing (1).

7. The sample reaction detecting device according to claim 2, characterized in that the substrate (121) is connected with the housing (1) by means of interference fit, gluing or snapping.

8. The sample reaction detecting device according to any one of claims 1 to 7, wherein the inner wall of the housing (1) is provided with a connecting structure connectable to a sample container.

9. The sample reaction detection device according to any one of claims 1 to 7, wherein the end face of the housing (1) is provided with an observation structure corresponding to the detection test paper, and the observation structure is configured as an observation hole or a transparent window.

10. The sample reaction detecting device according to claim 1, wherein the housing (1) comprises a base (141) and a cover (142), a test strip cavity (143) for accommodating the test strip (2) is disposed between the base (141) and the cover (142), the sample inlet (3) is located on the base (141) or the cover (142), and a sample inlet cavity (144) is further formed between the base (141) and the cover (142), and the sample can flow into the test strip cavity (143) through the sample inlet (3) via the sample inlet cavity (144).

11. The sample reaction detecting device according to claim 10, wherein the test paper cavity (143) and the sample injection cavity (144) are formed on the base (141) and/or the cover sheet (142), and the bottom, the top or the side of the test paper cavity (143) is communicated with the sample injection cavity (144).

12. The sample reaction detecting device according to claim 10, wherein the test paper chamber (143) is provided in plurality, and at least two adjacent test paper chambers (143) communicate with each other.

13. The sample reaction detecting device according to claim 12, wherein a plurality of the test paper chambers (143) communicate with each other through an annular passage.

14. The device for detecting the reaction of a sample according to claim 10, wherein a circumferential positioning member (147) is further disposed between the base (141) and the cover (142).

15. The sample reaction detection device according to claim 10, wherein the base (141) and the cover (142) are connected by interference fit, gluing or clipping.

16. The sample reaction detecting device according to any one of claims 10 to 15, wherein the base (141) or the cover sheet (142) is provided with an observing structure configured as a viewing hole or a transparent window.

17. A sample collection and testing device, comprising a collection tube (4) and a sample reaction and testing device as claimed in any one of claims 1 to 9, wherein the sample reaction and testing device is detachably disposed at the opening of the collection tube (4), and the sample inlet (3) of the sample reaction and testing device is communicated with the opening of the collection tube (4).

18. The sample collection and testing device according to claim 17, wherein a sealing member (5) is further provided at the opening of the collection tube (4), and the sample reaction testing device is provided with a piercing member (6) for piercing the sealing member (5).

19. A manual testing device comprising a collection tube, a colorimetric card, and a sample reaction testing apparatus according to any one of claims 1 to 9.

20. An automatic test apparatus, comprising a test mechanism for testing a reaction result of a test strip (2) and a sample reaction testing device according to any one of claims 1 to 9.

21. The automatic detection apparatus according to claim 20, wherein the detection mechanism is any one of a photoelectric reflection detection device and a CCD detection device.

22. The automated detection apparatus of claim 20, further comprising a drive member for driving rotation of the sample reaction detection device relative to the detection mechanism.

23. The automated testing device of claim 20, further comprising a collection tube, and a flipping mechanism, wherein the sample reaction testing device is mounted to the collection tube, and wherein the flipping mechanism is configured to flip the collection tube (4) to allow the sample in the collection tube (4) to enter the sample reaction testing device for reaction.

24. A sample testing device comprising a sample reaction and detection apparatus according to any of claims 10 to 16, and a sample application mechanism configured to inject a sample into the sample reaction and detection apparatus, and a detector configured to detect a reaction result of the test strip.

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