CN115508342A

CN115508342A - Sample reaction detection device, sample collection detection device and detection equipment

Info

Publication number: CN115508342A
Application number: CN202210922948.7A
Authority: CN
Inventors: 丁建文
Original assignee: AVE Science and Technology Co Ltd
Current assignee: AVE Science and Technology Co Ltd
Priority date: 2022-08-02
Filing date: 2022-08-02
Publication date: 2022-12-23

Abstract

The application discloses sample reaction detection device includes: the test paper detection device comprises a shell (1) and detection test paper (2), wherein the detection test paper (2) is mounted to the shell (1); the shell (1) is provided with a sample inlet (3) for a sample to flow in, and the reaction result of the detection test paper (2) can be observed from the outside of the shell (1); the test paper (2) is mounted to the housing (1) in a ring shape. The application also provides a sample collecting and detecting device, a manual detecting device, an automatic detecting device and a sample detecting device. According to the sample reaction detection device, the sample collection detection device and the detection equipment, a sample enters the shell through the sample inlet, then the reaction with the detection test paper and the display of the reaction result are finished in the shell, the problem of sample leakage is not easy to occur, pollution can be avoided, and safety and tidiness are ensured.

Description

Sample reaction detection device, sample collection detection device and detection equipment

Technical Field

The application relates to the technical field of detection equipment, in particular to a sample reaction detection device, a sample collection detection device and detection equipment.

Background

The clinical examination refers to a method for diagnosing diseases by detecting samples of body fluids, secretions, excretions, and casts of patients through visual observation, physical, chemical, instrumental, or molecular biological methods to provide a series of detection results for clinical medicine.

In the existing detection method, a sample is generally collected and processed, and then is added to a carrier such as detection paper, a reaction cell and the like for detection. In the process, the sample liquid needs to be transferred from the container for storing the sample to other carriers, so that the problems of sample liquid leakage and flowing to an improper position are easy to occur, and pollution is generated; and the odor of the sample also affects the environment.

Therefore, it is an urgent technical problem to be solved by those skilled in the art to provide a detection device to solve the problem that a sample needs to be transferred before detection.

Disclosure of Invention

In order to solve the above technical problems, a first object of the present invention is to provide a sample reaction detecting device; the second purpose of the invention is to provide a sample collection and detection device; a third object of the present invention is to provide a manual detection device; a fourth object of the present invention is to provide an automatic inspection apparatus; it is a fifth object of the present invention to provide a sample testing device. According to the sample reaction detection device, the sample collection detection device and the detection equipment, a sample enters the shell through the sample inlet, then the reaction with the detection test paper and the display of the reaction result are finished in the shell, the problem of sample leakage is not easy to occur, pollution can be avoided, and safety and tidiness are ensured.

The technical scheme provided by the invention is as follows:

a sample reaction detection device comprising: the device comprises a shell and detection test paper, wherein the detection test paper is installed on the shell;

the shell is provided with a sample inlet for a sample to flow in, and the reaction result of the test paper can be detected from the appearance of the shell;

the test paper is mounted to the housing in a ring shape.

Preferably, the housing comprises a side surface, a top surface and a bottom surface, and the side surface, the top surface and the bottom surface jointly enclose an accommodating cavity;

the detection test paper is positioned in the accommodating cavity and faces the side face;

the sample inlet is arranged on the top surface or the bottom surface;

the side is provided with observes the structure, observe the structure and set up to observation hole or transparent window.

Preferably, a circumferential limiting part is arranged in the housing, and the circumferential limiting part is used for limiting the movement of the detection test paper along the circumferential direction of the housing.

Preferably, a black separating strip is arranged outside the side face, and the separating strip is arranged corresponding to the circumferential limiting piece.

Preferably, an end surface limiting part is arranged in the housing, the end surface limiting part is provided with a bearing surface for bearing the test paper, and a gap is formed between the bearing surface and the top surface or the bottom surface.

Preferably, a radial limiting piece is arranged in the shell, and the detection test paper is installed between the side face and the radial limiting piece.

Preferably, the sample inlet is located on the bottom surface, and the bottom surface is provided with a water guide inclined plane.

Preferably, the side faces and the top face form a first housing part, the bottom face forms a second housing part, and the first housing part is detachably connected to the second housing part.

Preferably, the bottom surface is provided with a mounting groove, and the side surface extends into the mounting groove to connect the first housing part and the second housing part.

Preferably, a circumferential positioning structure is arranged between the first shell piece and the second shell piece.

Preferably, the housing has an end face, and the test strip is disposed toward the end face.

Preferably, the device further comprises a substrate connected to the housing, the detection test paper is arranged between the substrate and the housing, and the sample inlet is arranged on the substrate.

Preferably, the housing is formed with a cavity, a substrate is mounted in the cavity, the substrate has a substrate top surface and a substrate back surface, and the substrate top surface faces the end surface of the housing; substrate top surface and/or casing are equipped with the installation cavity, test paper installs to the installation cavity, the introduction port set up in the substrate bottom surface, the introduction port with the installation cavity intercommunication.

Preferably, the top surface of the substrate is provided with a plurality of mounting cavities, and the bottom surface of the substrate is provided with a plurality of sample inlets corresponding to the mounting cavities.

Preferably, the aperture of the sample inlet is tapered along the direction from the bottom surface to the top surface of the substrate to form a flow guide cavity.

Preferably, a positioning structure for circumferential positioning is further arranged between the substrate and the shell.

Preferably, the substrate and the housing are connected by means of interference fit, gluing or snapping.

Preferably, the inner wall of the shell is provided with a connecting structure which can be connected with a sample container

Preferably, the end face of the shell is provided with an observation structure corresponding to the detection test paper, and the observation structure is an observation hole or a transparent window.

Preferably, the up end of casing is provided with the test paper installation cavity that is used for installing the test paper, the introduction port set up in the back of up end and with the test paper installation cavity intercommunication.

Preferably, the casing still includes the upper cover plate, the upper cover plate is connected with the up end of casing, be provided with on the upper cover plate and observe the structure, it sets up to observation hole or transparent window to observe the structure.

Preferably, the casing includes base and cover plate, be provided with the test paper chamber that is used for holding test paper between base and the cover plate, the introduction port is located base or cover plate, and still forms a kind structure between base and the cover plate, and the sample accessible the introduction port via it flows into to advance a kind structure the test paper chamber.

Preferably, the test paper cavity and the sample introduction structure are formed on the base and/or the cover plate, and the bottom, the top or the side edge of the test paper cavity is communicated with the sample introduction structure.

Preferably, the test paper cavity is provided in a plurality of, and at least two adjacent test paper cavities are communicated with each other.

Preferably, a plurality of the test paper chambers are communicated through an annular channel.

Preferably, the sample introduction structure comprises a transfer cavity and at least one branch channel, and two ends of the branch channel are respectively communicated with the transfer cavity and a test paper cavity.

Preferably, a circumferential positioning piece is further arranged between the base and the cover plate.

Preferably, the base and the cover sheet are connected in an interference fit, gluing or clamping manner.

Preferably, the base or the cover plate is provided with an observation structure which is set as an observation hole or a transparent window.

Preferably, the housing comprises a second base and a second cover plate, and at least one second test paper cavity for accommodating the test paper is formed between the second base and the second cover plate;

the sample inlet is arranged on the second base or the second cover plate;

the second base and/or the second cover plate are/is also provided with sample adding channels which are respectively communicated with the sample inlet and the second test paper cavity.

Preferably, the second base or the second cover plate is provided with an observation structure, and the observation structure is set to be an observation hole or a transparent window.

A sample collection and detection device comprises a collection tube and any one of the sample reaction and detection devices, wherein the sample reaction and detection device is detachably arranged at the opening of the collection tube, and a sample inlet of the sample reaction and detection device is communicated with the opening of the collection tube.

Preferably, the opening of the collection tube is further provided with a sealing component, and the sample reaction detection device is provided with a puncture element for puncturing the sealing component.

A manual detection device comprises a collection tube, a colorimetric card and the sample reaction detection device.

An automatic detection device comprises a detection mechanism and the sample reaction detection device, wherein the detection mechanism is used for detecting the reaction result of detection test paper.

Preferably, the detection mechanism is any one of a photoelectric reflection detection device and a CCD detection device.

Preferably, the device further comprises a driving component for driving the sample reaction detection device to rotate relative to the detection mechanism.

Preferably, the sample reaction detection device further comprises a collection tube and a turnover mechanism, wherein the sample reaction detection device is mounted to the collection tube, and the turnover mechanism is used for turning over the collection tube to enable a sample in the collection tube to enter the sample reaction detection device for reaction.

A sample detection device comprises the sample reaction detection device, a sample adding mechanism and a detector, wherein the sample adding mechanism is arranged to inject a sample into the sample reaction detection device, and the detector is arranged to detect a reaction result of a detection test paper.

The application firstly provides a sample reaction detection device, which comprises a shell and detection test paper, wherein the detection test paper is arranged on the shell, and the shell is provided with a sample inlet through which a sample flows in and contacts the detection test paper, so that the sample enters the shell from the sample inlet, contacts and reacts with the detection test paper, and then a reaction result is presented on the detection test paper; moreover, the reaction result can be observed from the outside of the shell, so that an external instrument or a worker can observe the reaction result on the detection test paper. The application provides a sample reaction detection device, the sample gets into in the casing through the introduction port, later with test paper's reaction to and the show of reaction result all accomplishes in the casing, the difficult problem that takes place the sample and leak, can avoid polluting, guarantee safety and clean and tidy. Meanwhile, as the result is displayed in the shell and can be observed from the outside, both professionals and common patients can use the result for detection, and the application range is wide and the difficulty is low.

The application also provides a sample collection and detection device, which combines the sample reaction and detection device with a collection tube. When the sample reaction detection device is used, a sample is stored in the collection tube, then the sample reaction detection device is arranged at the opening of the collection tube, the sample reaction detection device is kept above the collection tube during storage and transportation, and the sample reaction detection device plays a role in sealing the opening of the collection tube, preventing the sample from being polluted by the outside and preventing the sample from leaking; when detection is needed, the collection tube is inclined or inverted, the sample reaction detection device is positioned below the collection tube, and at the moment, the sample in the collection tube flows into the sample reaction detection device, contacts and reacts with the detection test paper, and finally, a reaction result is presented on the detection test paper.

The application still provides a manual check out test set, utilizes the colorimetric card of above-mentioned sample reaction detection device, collection pipe and outfit, can realize manual collection sample, reaction to thereby compare test paper's result and colorimetric card and draw the conclusion. The application provides a manual check out test set can be swiftly, conveniently detect, and need not large-scale equipment or professional instrument supplementary, is particularly useful for POCT detection or patient at home self-detection.

The application also provides an automatic detection device, which utilizes a detection mechanism to detect the result of the detection paper in the sample reaction detection device and give a result, thereby reducing the labor intensity of personnel and avoiding the error possibly brought by manual color comparison (especially the manual color comparison of non-professionals).

The application also provides a detection device, which corresponds to a sample reaction detection device using the base and the cover plate, injects a sample into the sample reaction detection device through the sample injection mechanism, and then detects the result of detection paper in the sample reaction detection device by the detector.

Drawings

In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments described in the present application, and other drawings can be obtained by those skilled in the art without creative efforts.

FIG. 1 is a schematic view of a first structure of a sample reaction detecting device according to an embodiment of the present invention (a first side surface and a first top surface);

FIG. 2 is an exploded view of FIG. 1;

FIG. 3 is a schematic cross-sectional view of FIG. 1;

FIG. 4 is a schematic view of a first structure of the sample reaction detecting device according to the present invention (a first side surface and a first top surface, a first position-limiting member is disposed thereon);

FIG. 5 is a schematic view of the structure of the combination of the sample reaction detecting device and the collecting tube (upright test paper);

FIG. 6 is a cross-sectional schematic view of FIG. 5;

FIG. 7 is a schematic cross-sectional view of a combination of a sample reaction detection device and a collection tube (upright test strip) according to an embodiment of the present invention;

FIG. 8 is a schematic diagram of a second structure of a sample reaction detecting device according to an embodiment of the present invention (side, bottom and top modes);

FIG. 9 is a schematic cross-sectional view of FIG. 8;

FIG. 10 is an exploded view of FIG. 8;

FIG. 11 is a second schematic diagram of the sample reaction detecting device according to the embodiment of the present invention (in terms of side, bottom and top surfaces, the sample reaction detecting device is composed of a first housing member and a second housing member, wherein the detecting test paper can be placed on the first housing member or the second housing member);

FIG. 12 is a schematic view of the second shell member of FIG. 11 (without test paper installed);

FIG. 13 is a top view of the second housing piece of FIG. 11 (with test paper attached);

FIG. 14 is a schematic cross-sectional view of FIG. 11 (taken along c-c, without test paper installed);

FIG. 15 is a schematic view of the first shell member of FIG. 11 (without test paper installed);

FIG. 16 is an exploded view of the first housing piece and test strip of FIG. 11;

FIG. 17 is a schematic view of the first housing member and the test strip of FIG. 11 assembled together;

FIG. 18 is a schematic view showing a third structure of a sample reaction detecting apparatus according to an embodiment of the present invention (manner of a substrate and a mounting chamber);

FIG. 19 is an exploded view of FIG. 18;

FIG. 20 is an exploded schematic view (inverted 180 degrees) of FIG. 18;

FIG. 21 is a bottom view of the housing of FIG. 18 without a substrate;

FIG. 22 is a schematic diagram of a fourth structure of a sample reaction detecting device according to an embodiment of the present invention (in the manner of a test strip mounting cavity and an upper cover plate);

FIG. 23 is a schematic diagram of a fifth structure of the device for detecting a sample reaction according to the embodiment of the present invention (an annular channel is disposed at the bottom of the test paper chamber);

FIG. 24 is an exploded view of FIG. 23;

FIG. 25 is an exploded schematic view (inverted 180 degrees) of FIG. 23;

FIG. 26 is a schematic bottom view of the flap of FIG. 23;

FIG. 27 is a schematic cross-sectional view of FIG. 26 (taken along line c-c);

FIG. 28 is a schematic diagram of another structure of a base seat of a fifth structure of a sample reaction detection apparatus according to an embodiment of the present invention (a ring-shaped channel is disposed on a lateral side of a test paper cavity);

FIG. 29 is another schematic view showing a fifth configuration of a sample reaction detecting unit according to an embodiment of the present invention (a sample introduction structure includes a transfer chamber and a branch channel);

FIG. 30 is an exploded view of FIG. 29;

FIG. 31 is a schematic view from another angle of FIG. 30 (test strip not shown);

FIG. 32 is a schematic view of a sample reaction detecting device combined with a collecting tube and provided with a sealing member according to an embodiment of the present invention;

FIG. 33 is a schematic view of FIG. 33 partially broken away;

reference numerals are as follows: 1-a shell; 1 a-a first housing piece; 1 b-a second housing part; 101-a first side; 102-a first top surface; 103-a first stop; 111-side; 112-a top surface; 113-a bottom surface; 114-a circumferential stop; 115-end face limit piece; 1151-a bearing surface; 116-a radial stop; 117-a flow guide; 118-a mounting groove; 121-a substrate; 122-a mounting cavity; 123-a positioning structure; 124-a flow guide cavity; 131-a test paper mounting cavity; 132-an upper cover plate; 141-a base; 142-a cover slip; 143-test paper chamber; 144-sample introduction structure; 145-a transit chamber; 146-a branched channel; 147-a circumferential positioning element; 2-detecting test paper; 2 a-reagent block; 2 b-a base strip; 3-a sample inlet; 4-a collection tube; 5-a sealing member; 51-a fixation sleeve; 52-a sealing film; 6-piercing element.

Detailed Description

In order to make those skilled in the art better understand the technical solutions in the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

It will be understood that when an element is referred to as being "fixed" or "disposed" to another element, it can be directly on the other element or be indirectly disposed on the other element; when an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.

It will be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like, refer to an orientation or positional relationship illustrated in the drawings for convenience in describing the present application and to simplify description, and do not indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present application.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, the meaning of a plurality of or a plurality of is two or more unless specifically limited otherwise.

It should be understood that the structures, ratios, sizes, and the like shown in the drawings are only used for matching the disclosure of the specification, so as to be understood and read by those skilled in the art, and are not used to limit the practical limit conditions of the present application, so that the modifications of the structures, the changes of the ratio relationships, or the adjustment of the sizes, do not have the technical essence, and the modifications, the changes of the ratio relationships, or the adjustment of the sizes, are all within the scope of the technical contents disclosed in the present application without affecting the efficacy and the achievable purpose of the present application.

As shown in the drawings, an embodiment of the present invention provides a sample reaction detecting apparatus, including: the device comprises a shell 1 and detection test paper 2, wherein the detection test paper 2 is mounted on the shell 1;

the shell 1 is provided with a sample inlet 3 for sample to flow in, and the reaction result of the test paper 2 can be detected from the appearance of the shell 1;

the test strip 2 is mounted to the housing 1 in a ring shape.

The application firstly provides a sample reaction detection device, which comprises a shell 1 and detection test paper 2, wherein the detection test paper 2 is installed on the shell 1, and the shell 1 is provided with an injection port 3 for a sample to flow in and contact with the detection test paper 2, so that the sample enters the shell 1 from the injection port 3, contacts and reacts with the detection test paper 2, and then a reaction result is presented on the detection test paper 2; moreover, the reaction result can be observed from the outside of the housing 1, so that an external instrument or a worker can observe the reaction result on the test paper 2. The application provides a sample reaction detection device, sample through introduction port 3 get into casing 1 in, later with test paper 2's reaction to and the show of reaction result all accomplishes in casing 1, the difficult problem that takes place the sample and leak, can avoid polluting, guarantee safety and clean and tidy. Meanwhile, the result is displayed in the shell 1 and can be observed from the outside, so that both professionals and common patients can use the result for detection, and the application range is wide and the difficulty is low.

Can react with a sample and present a reaction result, and can be used as the test strip 2 of the present application. The detection test paper 2 can be a multi-joint test paper or a single reagent unit. The single reagent unit can be in any structure such as a sheet shape, a block shape, a bulk shape and the like.

The multiple test paper generally comprises a base strip and one or more reagent blocks arranged on the base strip, wherein reagents contained in different reagent blocks can be the same or different, and a sample can be in a color or a state corresponding to a reaction result after contacting and reacting with the reagents in the reagent blocks. In addition, the test strip 2 may be a separate reagent block without including a base strip.

The application limits that the detection test paper 2 is annularly mounted to the housing 1, which means that the detection test paper 2 is arranged in the housing 1 in a surrounding manner, or the detection test paper 2 is arranged in a certain plane of the housing 1, but the detection test paper 2 is observed perpendicular to the plane, and the detection test paper 2 is annularly arranged. By mounting the test paper 2 to the housing 1 in a ring shape, the presented result can be detected by rotating the sample reaction detection device after the reaction is finished; the instrument can also rotate around the sample reaction detection device to detect reaction results at different positions. The rotary detection mode has high efficiency, easy control of alignment accuracy and high adaptability with the existing instruments, and the test paper 2 is surrounded in the shell 1 and can be better matched with sample containers such as a test tube which is generally cylindrical. The test paper 2 may be in a complete ring shape, or in a ring shape with a gap, or in an elliptical shape, a polygon similar to a ring shape, or the like.

In addition to this, the test strip 2 may be mounted upright to the housing 1. The vertically mounted test strip 2 may be angled at various angles with respect to the housing 1. When a plurality of vertical test strips 2 are placed at the same time, the orientation of the test strips 2 may be the same or opposite. The test strips 2 are oriented in the same direction for ease of preparation and handling. When the test strip 2 is upright, detection is performed by translating the sample reaction detection device or translating the instrument relative thereto.

As the first embodiment, it is preferable that the housing 1 includes a first side surface 101 and a first top surface 102, and the first side surface 101 and the first top surface 102 jointly enclose a first chamber; the test strip 2 is located in the first chamber, and the test strip 2 is disposed toward the first side 101. A first chamber is defined by the first side surface 101 and the first top surface 102, and a bottom surface of the first chamber is an opening and can be regarded as the sample inlet 3. More preferably, the first side surface 101 is provided with an observation structure, and the observation structure enables an area of the test paper 2 presenting a reaction result to be communicated with the outside; alternatively, the first side 101 is at least partially made of a colorless transparent material. And "the reaction result of the test paper 2 can be detected from the external appearance of the casing 1" is realized by the observation structure communicated to the outside or by setting the first side surface 101 portion to be transparent. More preferably, a first limiting member 103 is disposed in the housing 1, and the first limiting member 103 is used for limiting the movement of the test strip 2 along the circumferential direction of the housing 1, so as to keep the relative position of the test strip 2 and the observation structure or the colorless transparent portion stable.

Preferably, the housing 1 includes a side surface 111, a top surface 112 and a bottom surface 113, and the side surface 111, the top surface 112 and the bottom surface 113 together enclose an accommodating cavity;

the detection test paper 2 is located in the accommodating cavity, and the detection test paper 2 faces the side surface 111;

the sample inlet 3 is arranged on the top surface 112 or the bottom surface 113;

the side 111 is provided with an observation structure, and the observation structure is arranged as an observation hole or a transparent window.

As a second embodiment, it is preferable that the housing 1 includes a side surface 111, a top surface 112 and a bottom surface 113, which together form a containing cavity, and the test strip 2 is disposed toward the side surface 111; the sample inlet 3 is arranged on the top surface 112 or the bottom surface 113, so that the sample enters the accommodating cavity from the top surface 112 or the bottom surface 113; the side surface 111 is provided with an observation structure which is provided with an observation hole or a transparent window so as to observe the reaction result from the outside.

The observation hole is a through hole formed in the side surface 111, and the detection test paper 2 in the shell 1 can be observed from the outside through the through hole; the transparent window is a window with a colorless and transparent material on the side 111, and the outside is observed through the transparent window. By controlling the amount of the sample, the sample just meets the reaction requirement of the detection test paper 2, and the sample liquid can be kept from leaking when the observation hole is used; when the transparent window is used, the side surface 111 is not communicated with the outside, and the sample cannot leak from the side surface. In addition, the housing 1 may be made of a colorless transparent material.

The colorless and transparent material can be glass, acrylic and the like.

Preferably, a circumferential limiting member 114 is disposed in the housing 1, and the circumferential limiting member 114 is configured to limit the movement of the test paper 2 along the circumferential direction of the housing 1.

Preferably, a circumferential stopper 114 is provided in the housing 1 to restrict the movement of the test strip 2 in the circumferential direction of the housing 1 and to keep the relative position of the test strip 2 to the side surface 111 stable.

Preferably, a black separating strip is disposed outside the side surface 111, and the separating strip is disposed corresponding to the circumferential limiting member 114.

The circumferential position-limiting members 114 are clamped between the reagent blocks to realize position limitation, preferably, black partition bars are arranged outside the side surface 111, the black partition bars are arranged corresponding to the circumferential position-limiting members 114, and thus the black partition bars do not block the reagent blocks, but separate the adjacent reagent blocks. The black auxiliary detection instrument of the separation strip is used for identifying different reagent blocks, so that different reaction results are identified. Meanwhile, black as a background can also reduce background interference.

Preferably, an end surface stopper 115 is disposed in the housing 1, the end surface stopper 115 has a supporting surface 1151 for supporting the test paper 2, and a gap is formed between the supporting surface 1151 and the top surface 112 or the bottom surface 113.

Preferably, an end stop 115 is provided in the housing 1, and the test strip 2 is held by the holding surface 1151, and since there is a gap between the holding surface 1151 and the top surface 112 or the bottom surface 113, the edge of the test strip 2 will also have a gap between the top surface 112 or the bottom surface 113, so that the sample can pass through (especially through the base strip of the test strip 2) and fully contact and react with the reagent block.

Preferably, end surface stoppers 115 are disposed above and below the test strip 2, and a distance between a supporting surface 1151 above the test strip 2 and a supporting surface 1151 below the test strip 2 is greater than or equal to a width of the test strip 2, so that the test strip 2 can be conveniently installed between the two section stoppers 115, and the relative distance between the test strip 2 and the top surface 112 and/or the bottom surface 113 can be kept stable.

Preferably, a radial limiting member 116 is disposed in the housing 1, and the test strip 2 is mounted between the side surface 111 and the radial limiting member 116.

Preferably, a radial stopper 116 is further disposed in the housing 1, and the test paper 2 is mounted between the side surface 111 and the radial stopper 116, so that the distance between the test paper 2 and the side surface 111 can be kept stable.

The circumferential stopper 114, the end surface stopper 115, and the radial stopper 116 may be provided simultaneously as needed, or one or more of them may be optionally provided. Meanwhile, the circumferential position limiter 114, the end position limiter 115 and the radial position limiter 116 may be optionally connected to the side surface 111, the top surface 112 or the bottom surface 113 of the housing 1.

For convenience of processing, the end surface limiting piece 115 and the radial limiting piece 116 may also be processed together to form an L-shaped integral structure, and simultaneously achieve the limiting function of the end surface and the radial direction. Alternatively, the circumferential stopper 114, the end surface stopper 115, and the radial stopper 116 may be machined together to form a U-shaped integral structure.

Preferably, the sample inlet 3 is located on the bottom surface 113, and the bottom surface 113 is provided with a water guide slope.

Preferably, the sample inlet 3 is located on the bottom surface 113, and the bottom surface 113 is provided with a water guiding inclined surface, so that after the sample enters the sample reaction detection device and fully contacts with the detection test paper 2, by turning the sample reaction detection device upside down, the redundant sample flows into the sample inlet 3 along the water guiding inclined surface and flows out from the sample inlet 3, thereby preventing the sample from being retained and influencing the detection result of the detection test paper 2. More preferably, the inner wall of the bottom surface 113 is further provided with a radially radiating flow guide 117 to further assist in guiding the liquid sample.

Preferably, the side surface 111 and the top surface 112 form a first housing part, and the bottom surface 113 forms a second housing part, to which the first housing part is detachably connected.

For convenience of processing and assembling, the housing 1 may be formed by assembling a first housing member and a second housing member, the side surface 111 and the top surface 112 form the first housing member, and the bottom surface 113 forms the second housing member, so that the two housing members are assembled after the test paper 2 is placed in the first housing member; meanwhile, the structure setting and processing of the circumferential limiting piece 114, the end surface limiting piece 115, the radial limiting piece 116 and the like are also simpler.

Preferably, the bottom surface 113 is provided with a mounting slot 118, and the side surfaces 111 extend into the mounting slot 118 to connect the first housing piece to the second housing piece.

In order to facilitate the assembly of the first housing part and the second housing part, the first housing part can be provided with a mounting groove 118 for the second housing part to insert, and the assembly efficiency is high

Preferably, a circumferential positioning structure is arranged between the first shell part and the second shell part.

Preferably, a circumferential positioning structure is arranged between the first shell part and the second shell part, so that the first shell part and the second shell part can be accurately aligned when being installed.

Preferably, the housing 1 has an end face, and the test strip 2 is disposed toward the end face.

In a third embodiment of the present application, the housing 1 has an end face, and when the test strip 2 is disposed toward the end face, the result of the test strip 2 is also displayed toward the end face, and the worker or the instrument observes from the end face.

Preferably, the device further comprises a substrate 121 connected to the housing 1, the test strip 2 is disposed between the substrate 121 and the housing 1, and the sample inlet 3 is disposed on the substrate 121.

Preferably, the housing 1 further comprises a substrate 121, the substrate 121 is connected to the housing 1, the test strip 2 is located between the substrate 121 and the housing 1, and the sample inlet 3 is located on the substrate 121, so that the sample passes through the substrate 121 and reacts with the detection reagent 2.

Preferably, the housing 1 is formed with a cavity, a substrate 121 is mounted in the cavity, the substrate 121 has a substrate top surface and a substrate back surface, and the substrate top surface faces the end surface of the housing 1; substrate top surface and/or casing are equipped with installation cavity 122, test paper 2 is installed to installation cavity 122, the sample inlet set up in the substrate bottom surface, the sample inlet with installation cavity 122 intercommunication.

It is further preferable that the housing 1 is formed with a cavity in which the substrate 121 is mounted. The substrate 121 has a substrate top surface and a substrate back surface, the substrate top surface faces the end surface of the housing 1, the substrate top surface and/or the housing 1 is provided with a mounting cavity 122 for accommodating the test paper 2, the sample inlet 3 is arranged on the substrate bottom surface, and the sample inlet 3 is communicated with the mounting cavity 122.

The test strip 2 is mounted to the mounting chamber 122, and both the base strip and the reagent block may be mounted to the mounting chamber 122, and more preferably, only the reagent block is mounted. The mounting cavity 122 is formed on the top surface of the substrate and/or the housing 1, which means that the top surface of the substrate or the wall of the housing 1 is provided with a groove, i.e. the mounting cavity 122; or both the top surface of the substrate and the walls of the housing 1 are recessed and assembled to form the mounting cavity 122.

Specifically, the reagent blocks may be cut or sheared from the base strip and then placed in each of the mounting cavities 122; the single reagent block which is not connected with the base strip can be directly placed into the installation cavity 122, and then the shell 1 and the substrate 121 are assembled, wherein the assembly can be carried out manually or automatically by using a machine.

Preferably, a plurality of mounting cavities 122 are formed on the top surface of the substrate, and a plurality of sample inlets 3 are formed on the bottom surface of the substrate corresponding to the mounting cavities 122.

A mounting chamber 122 may be provided, with one or more reagent blocks located within the mounting chamber 122; more preferably, a plurality of mounting cavities 122 are formed on the top surface of the substrate, and each mounting cavity 122 is used for placing a reagent block, and a plurality of sample inlets 3 are formed on the bottom surface of the substrate corresponding to the mounting cavities 122, so as to ensure that a sample can flow into each mounting cavity 122.

Preferably, the aperture of the sample inlet 3 is tapered along the direction from the bottom surface to the top surface of the substrate to form the diversion cavity 124.

Preferably, the aperture of the sample inlet 3 is tapered along the direction from the bottom surface to the top surface of the substrate to form a diversion cavity 124, so that the sample is accumulated in the diversion cavity 124 and gradually enters the installation cavity 122.

Preferably, a positioning structure 123 for circumferential positioning is further provided between the substrate 121 and the housing 1.

Preferably, a positioning structure 123 is disposed between the substrate 121 and the housing 1 for circumferential positioning of the substrate 121 and the housing 1, so as to maintain the position accurately. The positioning structure 123 may be a positioning column and a positioning hole, or other structures.

Preferably, the substrate 121 is connected to the housing 1 by interference fit, gluing or snapping.

The connection of the substrate 121 and the housing 1 may be achieved by interference fit, gluing, snapping, etc.

Preferably, the inner wall of the shell 1 is provided with a connecting structure which can be connected with a sample container

Preferably, the inner wall of the housing 1 is further provided with a linking structure for connecting with a sample container (e.g., a test tube). The attachment mechanism may be a thread, protrusion, groove, etc.

Preferably, the end face of the shell 1 is provided with an observation structure corresponding to the detection test paper, and the observation structure is an observation hole or a transparent window.

Preferably, the end face of the shell 1 is provided with an observation structure corresponding to the detection test paper, and the observation structure is an observation hole or a transparent window, so that a reaction result can be observed conveniently.

Preferably, a test paper installation cavity 131 for installing the test paper 2 is formed in the upper end face of the housing 1, and the sample inlet 3 is formed in the back face of the upper end face and is communicated with the test paper installation cavity 131.

Preferably, the casing 1 further includes an upper cover plate 132, the upper cover plate 132 is connected with the upper end face of the casing 1, an observation structure is arranged on the upper cover plate 132, and the observation structure is set as an observation hole or a transparent window.

As a fourth embodiment of the present application, it is preferable that the upper end surface of the housing 1 is provided with a test strip installation cavity 131 for installing the test strip 2, and the sample inlet 3 is disposed on the back surface of the upper end surface and is communicated with the test strip installation cavity 131. Preferably, the casing 1 further comprises an upper cover plate 132, the upper cover plate 132 is connected with the upper end face of the casing 1, an observation structure is arranged on the upper cover plate 132, and the observation structure is an observation hole or a transparent window. In this embodiment, the upper cover 132 is located outside the upper end surface of the housing 1, and the test strip is also mounted on the upper end surface of the housing 1.

Similarly, the reagent block may be cut or sheared from the base strip and then respectively placed in each test strip installation cavity 131; the reagent block which is independent and not connected with the base strip can be directly placed into the test paper mounting cavity 131, and then the shell 1 and the upper cover plate 132 are assembled, so that the assembly can be carried out manually or automatically by using a machine.

Preferably, the housing 1 includes a base 141 and a cover 142, a test strip cavity 143 for accommodating the test strip 2 is disposed between the base 141 and the cover 142, the sample inlet 3 is located on the base 141 or the cover 142, and a sample inlet structure 144 is further formed between the base 141 and the cover 142, through which the sample can flow into the test strip cavity 143 through the sample inlet 3 via the sample inlet structure 144.

As a fifth embodiment of the present application, the housing 1 includes a base 141 and a cover 142, a test strip cavity 143 for accommodating the test strip 2 is disposed between the base 141 and the cover 142, and a sample injection structure 144 is further disposed; the sample flows into the test strip cavity 143 through the sample inlet 3 via the sample injection structure 144 to react with the test strip 2. The sample injection structure 144 is arranged to communicate the sample injection port 3 and the test paper cavity 143, so that the position of the sample injection port 3 can be more flexibly arranged. Preferably, the test paper cavity 143 and the sample injection structure 144 are formed on the base 141 and/or the cover sheet 142, and the bottom, the top or the side of the test paper cavity 143 is communicated with the sample injection structure 144.

The test paper cavity 143 and the sample injection structure 144 are formed on the base 141 and/or the cover plate 142, which means that the base 141 or the cover plate 142 is provided with a groove as the test paper cavity 143 and the sample injection structure 144; or, the base 141 or the cover 142 is respectively provided with a groove, and the grooves are correspondingly assembled to serve as the test paper cavity 143 and the sample injection structure 144, and the depth of the grooves can be different in different setting modes.

Similarly, the reagent blocks may be cut or sheared from the base strip and then placed in each of the test paper cavities 143; the reagent block which is independent and not connected with the base strip can be directly put into the test paper cavity 143, and then the base 141 and the cover 142 are assembled, and the assembly can be carried out manually or automatically by a machine.

Meanwhile, the bottom, top or side of the test paper cavity 143 is connected to the sample injection structure 144 for the sample to flow in. In addition, the test paper cavity 143 may or may not have an observation hole, and the reaction result is displayed through an observation window or other structures.

Preferably, the test paper cavities 143 are provided in plurality, and at least two adjacent test paper cavities 143 are communicated with each other.

Preferably, a plurality of the test paper chambers 143 communicate through an annular passage.

Preferably, the plurality of test paper chambers 143 are provided, and at least two adjacent test paper chambers 143 communicate with each other, so that the sample can flow between adjacent test paper chambers 143 after flowing into one test paper chamber 143, thereby preventing the sample from being accumulated and sufficiently reacting with the test paper 2 in each test paper chamber 143. More preferably, a plurality of the test paper cavities 143 are communicated with each other through an annular passage, so that the sample can freely flow through the annular passage wherever it enters, thereby improving the efficiency of contacting the sample with the test paper 2.

The sample introduction structure 144 may be a chamber only, or a combination of a chamber and a channel, or a channel only. That is, the bottom, top or side of the test paper cavity 143 is communicated with the sample injection structure 144, and the two cavities may be directly communicated with each other, or the two cavities may be communicated with each other through a channel, or the test paper cavity 143 may be communicated with the sample injection port 3 through the sample injection structure 144 in the form of a channel only.

In the application, a plurality of test paper cavities 143 are communicated through an annular channel, and the annular channel may be disposed at the bottom of the test paper cavity 143 or at the side of the test paper cavity 143; the annular channel is provided at the side of the test paper chamber 143 and preferably further communicates with each test paper chamber through a branched channel.

Preferably, the sample injection structure 144 includes a transfer chamber 145, and at least one branch channel 146, and two ends of the branch channel 146 are respectively communicated with the transfer chamber 145 and a test paper chamber 143.

As another implementation manner of the sample injection structure, the sample injection structure 144 includes a transit cavity 145, and at least one branch channel 146, and two ends of the branch channel 146 are respectively communicated with the transit cavity 145 and one test paper cavity 143.

Preferably, a circumferential positioning member 147 is further disposed between the base 141 and the cover plate 142.

Preferably, a circumferential positioning member 147 is disposed between the base 141 and the cover 142 for circumferential positioning of the base 141 and the cover 142 to maintain the position.

Preferably, the base 141 and the cover 142 are connected by interference fit, gluing or clipping.

The connection between the base 141 and the cover 142 can be achieved by interference fit, gluing, or snapping.

Preferably, the base 141 or the cover 142 is provided with a viewing structure configured as a viewing hole or a transparent window.

It is preferable that one of the base 141 or the cover 142 is provided with an observation structure which is provided as an observation hole or a transparent window to facilitate observation of the reaction result. The base 141 or the cover 142 is optionally provided with an observation structure, and the position provided with the observation structure can be observed by turning the sample reaction detecting apparatus or moving the probe of the instrument when in use.

A sample collection and detection device comprises a collection tube 4 and any one of the sample reaction and detection devices, wherein the sample reaction and detection device is detachably arranged at the opening of the collection tube 4, and a sample inlet 3 of the sample reaction and detection device is communicated with the opening of the collection tube 4.

The application also provides a sample collection and detection device, which combines the sample reaction and detection device with the collection tube 4. When the sample reaction detection device is used, a sample is stored in the collection tube 4, then the sample reaction detection device is arranged at the opening of the collection tube 4, the sample reaction detection device is kept above the collection tube 4 during storage and transportation, and the sample reaction detection device plays a role in sealing the opening of the collection tube 4, preventing the sample from being polluted by the outside and preventing the sample from leaking; when detection is needed, the collection tube 4 is tilted or inverted, so that the sample reaction detection device is positioned below the collection tube 4, and at the moment, the sample in the collection tube 4 flows into the sample reaction detection device, contacts and reacts with the detection test paper 2, and finally, a reaction result is presented on the detection test paper 2.

When the sample amount in the collection tube 4 is large, the remaining sample can be retained in the collection tube 4 after the reaction, and the sample can be rechecked by replacing the sample reaction detection device or by extracting the sample and sending the sample into the detection instrument.

Preferably, a sealing component 5 is further disposed at the opening of the collection tube 4, and the sample reaction detection device is provided with a puncturing element 6 for puncturing the sealing component 5.

Preferably, a sealing member 5 is further disposed between the opening of the collection tube 4 and the sample reaction detection device, so as to seal the collection tube 4. Between the breaking seal members 5, the sample does not flow out or leak out even if the collection tube 4 is tilted; when a test is required, the sealing member 5 is broken by the puncture device 6 of the sample reaction detection apparatus, and the sample flows into the case 1 to be reacted.

It is further preferred that the sealing member 5 comprises a retaining sleeve 51 and a sealing membrane 52, the retaining sleeve 51 being able to be fitted over the outside of the collecting tube 5, while the sealing membrane 52 is tensioned against the retaining sleeve 51. The fit between the hub 51 and collection tube 5 may be by threads, splines, or other means. The connection of the sample reaction detection means with the sealing member 5 or with the collection tube 5 may also be achieved in the above manner. For example, collection tube 5 is externally provided with a first thread, and hub 51 is provided with an internal thread that mates with the first thread; meanwhile, the outer wall of the fixing sleeve 51 is provided with a second thread, and the sample reaction detection device is provided with an internal thread matched with the second thread, so that the three parts are assembled.

Preferably, the puncturing element 6 is arranged in the housing 1 by at least two cantilever arms 51, and the housing 1 can be deformed by a force to drive the tip of the puncturing element 6 to puncture the sealing membrane 52.

The shell 1 can be deformed by selecting deformable materials such as plastics, metals and the like.

The application still provides a manual check out test set, utilizes the colorimetric card of above-mentioned sample reaction detection device, collection pipe and outfit, can realize manual collection sample, reaction to thereby compare test paper 2's result and colorimetric card and draw the conclusion. The application provides a manual check out test set can be swiftly, conveniently detect, and need not large-scale equipment or professional instrument supplementary, is particularly useful for POCT detection or patient at home self-detection.

The colorimetric card can be attached to the collecting tube, and can also be packaged in the same package with the device. When a plurality of sample reaction detection devices and collection tubes are packaged and sold together, one or more colorimetric cards can be given.

And according to different samples, the sample can be directly collected and then detected by using the sample reaction detection device, or after the sample is collected, a diluent (water or other reagents) is added, and then the sample reaction detection device is used for detection. The diluent can be given away, or an operator can prepare clear water by himself, large-scale equipment is still not needed for assistance, and convenient detection at home can be achieved.

An automatic detection device comprises a detection mechanism and the sample reaction detection device, wherein the detection mechanism is used for detecting a reaction result of a detection test paper 2.

The application also provides an automatic detection device, which utilizes a detection mechanism to detect the result of the detection paper 2 in the sample reaction detection device and give the result, thereby reducing the labor intensity of personnel and avoiding the error possibly brought by manual color comparison (especially by non-professional personnel).

When the automatic detection equipment is used, the process of inclining or inverting the sample reaction detection device needs external force to be completed, and the automatic detection equipment is suitable for scenes with small detection quantity and low frequency, and is flexible and convenient.

Preferably, the detection mechanism is one of a photoelectric reflection detection device and a CCD detection device. Preferably, the device further comprises a driving component for driving the sample reaction detection device to rotate relative to the detection mechanism.

Preferably, the detection mechanism further comprises a drive member for rotating or moving the sample reaction detection device relative to the detection mechanism to detect and provide results for each part of the test strip 2.

The drive means may drive the sample reaction detection means in motion while the detection mechanism remains stationary, or may drive the detection mechanism in motion while the sample reaction detection means remains stationary, provided that relative motion occurs between the two.

Preferably, the sample reaction detection device further comprises a collection tube and a turnover mechanism, wherein the sample reaction detection device is mounted to the collection tube, and the turnover mechanism is used for turning over the collection tube 4 to enable a sample in the collection tube 4 to enter the sample reaction detection device for reaction.

According to the automatic detection equipment, the detection mechanism is used for detecting the detection test paper 2 in the sample reaction detection device, and the sample can be added into the sample reaction detection device in a dropwise adding or other mode; more preferably, a collection tube is used, a sample is firstly added into the collection tube, then the sample reaction detection device is assembled with the collection tube, and then the detection mechanism is used for detection; meanwhile, the automatic detection equipment is also provided with a turnover mechanism for turning over the collecting tube 4, so that a sample enters the sample reaction detection device, the labor intensity is further reduced, the efficiency is improved, and the automatic detection equipment is particularly suitable for being used in hospitals and other places with large number of samples.

The turnover mechanism can incline or turn over the collection tube 4, and then directly detect the sample in a state of contacting with the detection test paper 2; the position of the collection tube 4 can also be adjusted after the sample is in full contact with the sample reaction detection device, so that the redundant sample flows back to the collection tube 4 for detection.

More preferably, the device comprises an upper cover mechanism for mounting the sample reaction detection device at the opening of the collection tube 4. More preferably, the sample feeding mechanism is further included and is used for conveying the collecting tube 4 to the working position of the upper cover mechanism.

A sample detection device comprises the sample reaction detection device, a sample adding mechanism and a detector, wherein the sample adding mechanism is arranged to inject a sample into the sample reaction detection device, and the detector is arranged to detect a reaction result of detection test paper.

The application also provides a detection device, which corresponds to a sample reaction detection device using the base and the cover plate, injects a sample into the sample reaction detection device through the sample injection mechanism, and then detects the result of the detection paper 2 in the sample reaction detection device by the detector.

The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A sample reaction detecting device, comprising: the test paper detection device comprises a shell (1) and detection test paper (2), wherein the detection test paper (2) is mounted to the shell (1);

the shell (1) is provided with a sample inlet (3) for a sample to flow in, and the reaction result of the detection test paper (2) can be observed from the outside of the shell (1);

the test paper (2) is mounted to the housing (1) in a ring shape.

2. The sample reaction detection device according to claim 1, wherein the housing (1) comprises a side surface (111), a top surface (112) and a bottom surface (113), and the side surface (111) and the top surface (112) and the bottom surface (113) jointly enclose a containing cavity;

the detection test paper (2) is positioned in the accommodating cavity, and the detection test paper (2) is arranged towards the side surface (111);

the sample inlet (3) is arranged on the top surface (112) or the bottom surface (113);

side (111) are provided with observes the structure, observe the structure and set up to observation hole or transparent window.

3. The sample reaction detecting device according to claim 2, wherein a circumferential stopper (114) is provided in the housing (1), and the circumferential stopper (114) is used for limiting the movement of the test strip (2) along the circumferential direction of the housing (1).

4. The sample reaction detecting device according to claim 2, wherein a black separating strip is provided outside the side surface (111), and the separating strip is provided corresponding to the circumferential stopper (114).

5. The device for detecting a reaction of a sample according to claim 2, wherein an end-stop member (115) is disposed in the housing (1), the end-stop member (115) has a supporting surface (1151) for supporting the test strip (2), and the supporting surface (1151) has a gap with the top surface (112) or the bottom surface (113).

6. The device for detecting the reaction of a sample according to claim 2, wherein a radial stop (116) is provided in the housing (1), and the test strip (2) is installed between the side surface (111) and the radial stop (116).

7. The sample reaction detecting device according to claim 2, wherein the sample inlet (3) is located on the bottom surface (113), and the bottom surface (113) is provided with a water guiding slope.

8. The sample reaction detecting device according to any of claims 2 to 7, wherein the side surface (111) and the top surface (112) form a first housing member, the bottom surface (113) forms a second housing member, and the first housing member is detachably connected to the second housing member.

9. The sample reaction detecting device according to claim 8, wherein the bottom surface (113) is provided with a mounting groove (118), and the side surface (111) extends into the mounting groove (118) to connect the first housing member with the second housing member.

10. The sample reaction detection device according to claim 8, wherein a circumferential positioning structure is provided between the first housing member and the second housing member.

11. The sample reaction detecting device according to claim 1, wherein the housing (1) has an end face, and the test strip (2) is disposed toward the end face.

12. The sample reaction detecting device according to claim 11, further comprising a substrate (121) connected to the housing (1), wherein the test strip (2) is disposed between the substrate (121) and the housing (1), and the sample inlet (3) is disposed on the substrate (121).

13. The sample reaction detecting device according to claim 12, wherein the housing (1) is formed with a cavity in which a substrate (121) is mounted, the substrate (121) having a substrate top surface and a substrate back surface, the substrate top surface facing the end surface of the housing (1); substrate top surface and/or casing (1) are equipped with installation cavity (122), test paper (2) are installed to installation cavity (122), inlet (3) set up in the substrate bottom surface, inlet (3) with installation cavity (122) intercommunication.

14. The sample reaction detecting device according to claim 13, wherein the top surface of the substrate is provided with a plurality of mounting cavities (122), and the bottom surface of the substrate is provided with a plurality of sample inlets (3) corresponding to the mounting cavities (122).

15. The sample reaction detecting device according to claim 14, wherein the aperture of the sample inlet (3) is tapered along the direction from the bottom surface to the top surface of the substrate to form a flow guide cavity (124).

16. The sample reaction detection device according to claim 12, characterized in that a positioning structure (123) for circumferential positioning is further provided between the substrate (121) and the housing (1).

17. The sample reaction detection device according to claim 12, wherein the substrate (121) is connected to the housing (1) by interference fit, gluing or snapping.

18. The sample reaction detecting device according to any one of claims 11 to 17, wherein the inner wall of the housing (1) is provided with a connecting structure connectable to a sample vessel.

19. The sample reaction detection device according to any one of claims 11 to 17, wherein the end face of the housing (1) is provided with an observation structure corresponding to the detection test paper, and the observation structure is configured as an observation hole or a transparent window.

20. The sample reaction detection device according to claim 11, wherein a test strip installation cavity (131) for installing a detection test strip (2) is arranged on an upper end face of the housing (1), and the sample inlet (3) is arranged on a back face of the upper end face and is communicated with the test strip installation cavity (131).

21. The sample reaction detecting device according to claim 20, wherein the housing (1) further comprises an upper cover plate (132), the upper cover plate (132) is connected with the upper end surface of the housing (1), the upper cover plate (132) is provided with an observing structure, and the observing structure is configured as an observing hole or a transparent window.

22. The sample reaction detecting device according to claim 11, wherein the housing (1) comprises a base (141) and a cover (142), a test strip cavity (143) for accommodating the test strip (2) is disposed between the base (141) and the cover (142), the sample inlet (3) is located on the base (141) or the cover (142), and a sample inlet structure (144) is further formed between the base (141) and the cover (142), and the sample can flow into the test strip cavity (143) through the sample inlet (3) via the sample inlet structure (144).

23. The sample reaction detecting device according to claim 22, wherein the test paper cavity (143) and the sample injection structure (144) are formed on the base (141) and/or the cover sheet (142), and the bottom, the top or the side of the test paper cavity (143) is communicated with the sample injection structure (144).

24. The sample reaction detecting device according to claim 22, wherein the test paper chamber (143) is provided in plurality, and at least two adjacent test paper chambers (143) communicate with each other.

25. The sample reaction detecting device according to claim 24, wherein a plurality of the test paper chambers (143) communicate through an annular passage.

26. The device for detecting the reaction of the sample according to claim 22, wherein the sample injection structure (144) comprises a transfer chamber (145), and at least one branch channel (146), and both ends of the branch channel (146) are respectively communicated with the transfer chamber (145) and one test paper chamber (143).

27. The apparatus according to claim 22, wherein a circumferential positioning member (147) is further disposed between the base (141) and the cover (142).

28. The sample reaction detecting device according to claim 22, wherein the base (141) and the cover (142) are connected by interference fit, gluing or clipping.

29. The sample reaction detecting device according to any one of claims 22 to 28, wherein the base (141) or the cover sheet (142) is provided with a viewing structure configured as a viewing hole or a transparent window.

30. A sample collection and testing device comprising a collection tube (4) and a sample reaction and testing device as claimed in any one of claims 1 to 21, wherein the sample reaction and testing device is detachably disposed at the opening of the collection tube (4), and the sample inlet (3) of the sample reaction and testing device is in communication with the opening of the collection tube (4).

31. The sample collection and testing device according to claim 30, wherein a sealing member (5) is further disposed at the opening of the collection tube (4), and the sample reaction and testing device (1) is provided with a puncturing member (6) for puncturing the sealing member (5).

32. A manual assay device comprising a collection tube, a colorimetric card, and a sample reaction assay device according to any one of claims 1-21.

33. An automatic test apparatus, comprising a test mechanism for testing a reaction result of a test strip (2) and a sample reaction testing device according to any one of claims 1 to 21.

34. The automatic detection apparatus according to claim 33, wherein the detection mechanism is any one of a photoelectric reflection detection device and a CCD detection device.

35. The automated detection apparatus of claim 33, further comprising a drive member for driving rotation of the sample reaction detection device relative to the detection mechanism.

36. The automated testing device of claim 33, further comprising a collection tube, and a flipping mechanism, wherein the sample reaction testing device is mounted to the collection tube, and wherein the flipping mechanism is configured to flip the collection tube (4) to allow the sample in the collection tube (4) to enter the sample reaction testing device for reaction.

37. A sample testing device comprising a sample reaction and detection apparatus according to any of claims 22 to 29, and a sample application mechanism configured to inject a sample into the sample reaction and detection apparatus, and a detector configured to detect a test strip reaction result.