EP1066881A2 - Specimen collection assembly with cap - Google Patents
Specimen collection assembly with cap Download PDFInfo
- Publication number
- EP1066881A2 EP1066881A2 EP00113635A EP00113635A EP1066881A2 EP 1066881 A2 EP1066881 A2 EP 1066881A2 EP 00113635 A EP00113635 A EP 00113635A EP 00113635 A EP00113635 A EP 00113635A EP 1066881 A2 EP1066881 A2 EP 1066881A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- container
- cap
- specimen
- septum
- cap body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
- B01L3/50825—Closing or opening means, corks, bungs
Definitions
- the present invention relates to a collection assembly and more particularly to a microcollection container and cap assembly suitable for collecting small quantities of a specimen such as blood from a patient, that provides access to the interior of the container without the need for removing the cap from the assembly and for maintaining a specimen in secure fashion for subsequent testing.
- Analytical instrumentation has made it possible to carry out a variety of hemological diagnostic procedures on very small quantities of blood.
- the blood may be collected from a small puncture placed in a patient's finger or ear lobe.
- the blood is collected in a microcollection container. Once the small quantities of blood are collected, the container is sealably covered by a cap.
- the cap In order for a laboratory technician to conduct tests on the blood sample which is collected in the container, the cap must be removed from the container so as to provide access to the blood sample. In the alternative, the entire contents of the container may be transferred from the container to an instrument compatible sample holder in order for laboratory analysis to take place.
- microcollection container that is (i) compatible with instruments for laboratory analysis whereby the specimen does not have to be transferred out of the container for analysis to be conducted; (ii) provides a resealable portion for easy access into the container by a needle or probe that also prevents specimen leakage out of the container; (iii) maintains a specimen in secure fashion; and (iv) prevents contamination to the specimen and to the user.
- the present invention is a collection assembly comprising a container and a cap.
- the container includes an open end, a closed end and a cylindrical wall therebetween which preferably comprises the interior of the container for accommodating the specimen.
- the cap comprises a cap body removably sealably secured to the open end of the container.
- the cap body supports a membrane for providing reseable access to the interior of the container.
- the membrane is formed of a material which is capable of being pierced and resealed on a repetitive basis with a needle or instrument probe.
- the membrane is formed of a thermoplastic elastomer.
- Such thermoplastic elastomer includes isoprene propylene, such as MONOPRENE (a trademark of QST, Inc.) sold by QST, Inc., St. Albans, Vermont.
- the membrane is disc-shaped having a concave surface facing away from the container interior which assists in resealing of the membrane.
- the thermoplastic elastomer allows for the resealing of the pierced membrane in a manner which prevents specimen leakage therethrough even when the collection assembly is held in an inverted position.
- the cap body includes a top portion, a bottom portion, a cylindrical sidewall extending from the top portion to the bottom portion having an inner surface and an outer surface, an access passageway at the top portion and a membrane supported across the passageway.
- the cap body may further include a depending annular skirt extending into the interior of the container from the top portion and defining an annular region with the cylindrical sidewall. The open end of the container is accommodated within the annular region.
- the depending skirt includes an access passageway, with the membrane being supported across the passageway.
- the membrane and the cap body may be co-injection molded or insert molded.
- An advantage of the present invention is that it facilitates direct access to a sample for diagnostic instrumentation systems and enables microcollection container compatability with diagnostic instrumentation by providing features such as pierceability and self-resealing of the cap.
- Still another advantage of the present invention is that the self-sealing pierceable cap permits mixing of the specimen in the container without transferring the specimen to another container and providing for direct access to the specimen via the self-sealing pierceable cap by diagnostic instrumentation.
- the present invention permits a specimen to be accessed through the top of the cap without removing the cap from the container, thereby providing minimal exposure of the specimen to the user.
- the present invention permits the assembly to be directly used on instrumentation similar to that used for evacuated collection assemblies.
- Advantages of the membrane of the present invention include that: (i) it can be pierced and resealed many times; (ii) it requires less than 21b. force for a probe or needle to pierce it; and (iii) the concave shape aids in the ability of the membrane to seal properly after the piercing element is removed.
- FIG. 1 is a front plan view of the collection assembly of the present invention.
- FIG. 2 is a perspective view of the collection assembly of FIG. 1 illustrating the container, the cap and the membrane.
- FIG. 3 is a cross sectional view of the collection assembly of FIG. 1.
- FIG. 4 is a side elevational view, partially in section of the collection assembly of FIG. 3.
- FIG. 5 illustrates the collection assembly of FIG. 4, with a probe extending thereinto.
- FIGS. 1-3 illustrate the collection assembly 10 of the present invention.
- Collection assembly 10 includes a container 12 and a cap assembly 14 .
- Cap assembly 14 may be removably secured to the container.
- Container 12 is an elongate member having an open upper end 16 , a lower end 18 including a rounded closed bottom 19 and a cylindrical wall 20 extending therebetween.
- the cylindrical wall 20 defines an interior 17 internally thereof for accommodating a specimen such as a blood specimen.
- the cylindrical wall 20 extends beyond the rounded closed bottom 19 to form an annular extension 22 which permits container 12 to stand upright on a flat surface. Once a liquid specimen, such as blood is collected in interior 17 of the container, the container may be sealingly closed by cap assembly 14 .
- cap assembly 14 includes a cap body 30 and a septum 32 supported by cap body 30 .
- Cap body 30 is preferably an integrally formed molded plastic member generally in the shape of an inverted cup.
- the cap includes a flat upper surface 34 , an opposed open lower surface 36 and a cylindrical sidewall 38 extending therebetween.
- Cylindrical side wall 38 includes a plurality of inwardly directed protrusions 40 which engage an exterior surface of cylindrical wall 20 of the container about open upper end 16 to provide sealed engagement between cap body 30 and container 12 .
- Upper surface 34 includes an open upper extent 44 and a central passageway 45 which provides access through cap body 30 and into interior 17 of container 12 .
- Septum 32 is a disc-like membrane formed of a thermoplastic elastomer. As shown in FIG. 4, septum 32 includes a generally planar portion 50 and an upwardly extending annular ridge 52 . Annular ridge 52 has a diameter which allows it to be force fitted within the open upper extent 44 and retained in sealed engagement therewith. Planar portion 50 of septum 32 defines a flat planar surface which faces towards the interior of container 12 . Annular ridge 52 defines a concave surface 53 in opposition to planar surface 50 . Septum 32 defines a centrally located portion 54 having a thickness of about .028 inches. The central portion allows the septum to be easily pierced by a piercing element to extract a portion of the sample from interior 17 of container 12 .
- a liquid sample is collected in container 12 .
- Cap assembly 14 is sealably secured to the open upper end of container 12 .
- a piercing element 60 is inserted into container 12 by inserting element 60 through passageway 45 defined through cap body 30 .
- Distal tip 62 of element 60 then pierces through septum 32 at central portion 54 . Since the material of septum 32 is a thermoplastic elastomer, septum 32 is easily pierced by low insertion forces whereby even for a relatively wide element 60 having a diameter of about .0625 inches, central portion 54 of septum 32 may be pierced by a force of less than 2 pounds.
- Insertion of element 60 continues until it reaches the sample in interior 17 of container 12 and then element 60 collects a portion of the sample. Element 60 is then removed by withdrawing it back through passageway 45 in cap body 30 . Upon withdrawing element 60 from septum 32, the septum self-seals. Due to the thermoplastic elastomer material and that septum 32 has a flat planar surface 50 facing the interior of container 12 and opposed concave surface 53 facing in opposition thereto, helps reseal a hole placed in septum 32 by element 60 .
- the septum shape defines a concave surface in the direction of the element withdrawal.
- septum 32 reseals after multiple puncture sites have been placed therein.
- the sample in container 12 can be repeatedly sampled with the septum self-sealing upon each portion extraction.
- the collection assembly of the invention may be made of a molded thermoplastic material so that the specimen collected may be readily viewed.
- Representative materials include, for example, polyethylene, polypropylene and polyvinyl chloride.
- the collection container may incorporate a hydrophlic material or a silicon, or a texture may be applied to the internal surface thereof for enhancing the flow and mixing of blood introduced into the container.
- caps which are colored to defined specific forms of fluid collection containers containing materials for one reason or another or for defining the kind of examination to be conducted on the specimen collected, transparent caps may be provided. Also, it should be noted that the dimensions of the container are such as to provide space for labeling which may be important for identifying the collected specimen.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
- The present invention relates to a collection assembly and more particularly to a microcollection container and cap assembly suitable for collecting small quantities of a specimen such as blood from a patient, that provides access to the interior of the container without the need for removing the cap from the assembly and for maintaining a specimen in secure fashion for subsequent testing.
- Analytical instrumentation has made it possible to carry out a variety of hemological diagnostic procedures on very small quantities of blood. The blood may be collected from a small puncture placed in a patient's finger or ear lobe. The blood is collected in a microcollection container. Once the small quantities of blood are collected, the container is sealably covered by a cap.
- In order for a laboratory technician to conduct tests on the blood sample which is collected in the container, the cap must be removed from the container so as to provide access to the blood sample. In the alternative, the entire contents of the container may be transferred from the container to an instrument compatible sample holder in order for laboratory analysis to take place.
- Therefore, there is a need for a microcollection container that is (i) compatible with instruments for laboratory analysis whereby the specimen does not have to be transferred out of the container for analysis to be conducted; (ii) provides a resealable portion for easy access into the container by a needle or probe that also prevents specimen leakage out of the container; (iii) maintains a specimen in secure fashion; and (iv) prevents contamination to the specimen and to the user.
- The present invention is a collection assembly comprising a container and a cap.
- The container includes an open end, a closed end and a cylindrical wall therebetween which preferably comprises the interior of the container for accommodating the specimen.
- Desirably, the cap comprises a cap body removably sealably secured to the open end of the container. The cap body supports a membrane for providing reseable access to the interior of the container. The membrane is formed of a material which is capable of being pierced and resealed on a repetitive basis with a needle or instrument probe. Most preferably, the membrane is formed of a thermoplastic elastomer. Such thermoplastic elastomer includes isoprene propylene, such as MONOPRENE (a trademark of QST, Inc.) sold by QST, Inc., St. Albans, Vermont.
- Preferably, the membrane is disc-shaped having a concave surface facing away from the container interior which assists in resealing of the membrane. The thermoplastic elastomer allows for the resealing of the pierced membrane in a manner which prevents specimen leakage therethrough even when the collection assembly is held in an inverted position.
- Preferably, the cap body includes a top portion, a bottom portion, a cylindrical sidewall extending from the top portion to the bottom portion having an inner surface and an outer surface, an access passageway at the top portion and a membrane supported across the passageway.
- The cap body may further include a depending annular skirt extending into the interior of the container from the top portion and defining an annular region with the cylindrical sidewall. The open end of the container is accommodated within the annular region. The depending skirt includes an access passageway, with the membrane being supported across the passageway.
- Preferably, the membrane and the cap body may be co-injection molded or insert molded.
- An advantage of the present invention is that it facilitates direct access to a sample for diagnostic instrumentation systems and enables microcollection container compatability with diagnostic instrumentation by providing features such as pierceability and self-resealing of the cap.
- Still another advantage of the present invention is that the self-sealing pierceable cap permits mixing of the specimen in the container without transferring the specimen to another container and providing for direct access to the specimen via the self-sealing pierceable cap by diagnostic instrumentation.
- Most notably, is that the present invention permits a specimen to be accessed through the top of the cap without removing the cap from the container, thereby providing minimal exposure of the specimen to the user.
- In addition, the present invention permits the assembly to be directly used on instrumentation similar to that used for evacuated collection assemblies.
- Advantages of the membrane of the present invention include that: (i) it can be pierced and resealed many times; (ii) it requires less than 21b. force for a probe or needle to pierce it; and (iii) the concave shape aids in the ability of the membrane to seal properly after the piercing element is removed.
- FIG. 1 is a front plan view of the collection assembly of the present invention.
- FIG. 2 is a perspective view of the collection assembly of FIG. 1 illustrating the container, the cap and the membrane.
- FIG. 3 is a cross sectional view of the collection assembly of FIG. 1.
- FIG. 4 is a side elevational view, partially in section of the collection assembly of FIG. 3.
- FIG. 5 illustrates the collection assembly of FIG. 4, with a probe extending thereinto.
- Referring to the drawings in which like reference characters refer to like parts throughout the several views thereof, FIGS. 1-3 illustrate the
collection assembly 10 of the present invention. -
Collection assembly 10 includes acontainer 12 and acap assembly 14.Cap assembly 14 may be removably secured to the container. -
Container 12 is an elongate member having an openupper end 16, alower end 18 including a rounded closedbottom 19 and acylindrical wall 20 extending therebetween. Thecylindrical wall 20 defines aninterior 17 internally thereof for accommodating a specimen such as a blood specimen. Thecylindrical wall 20 extends beyond the rounded closedbottom 19 to form anannular extension 22 which permitscontainer 12 to stand upright on a flat surface. Once a liquid specimen, such as blood is collected ininterior 17 of the container, the container may be sealingly closed bycap assembly 14. - Referring to FIG. 4,
cap assembly 14 includes acap body 30 and aseptum 32 supported bycap body 30.Cap body 30 is preferably an integrally formed molded plastic member generally in the shape of an inverted cup. The cap includes a flatupper surface 34, an opposed openlower surface 36 and acylindrical sidewall 38 extending therebetween.Cylindrical side wall 38 includes a plurality of inwardly directedprotrusions 40 which engage an exterior surface ofcylindrical wall 20 of the container about openupper end 16 to provide sealed engagement betweencap body 30 andcontainer 12. -
Upper surface 34 includes an openupper extent 44 and acentral passageway 45 which provides access throughcap body 30 and intointerior 17 ofcontainer 12. - Septum 32 is a disc-like membrane formed of a thermoplastic elastomer. As shown in FIG. 4,
septum 32 includes a generallyplanar portion 50 and an upwardly extendingannular ridge 52.Annular ridge 52 has a diameter which allows it to be force fitted within the openupper extent 44 and retained in sealed engagement therewith.Planar portion 50 ofseptum 32 defines a flat planar surface which faces towards the interior ofcontainer 12.Annular ridge 52 defines aconcave surface 53 in opposition toplanar surface 50. Septum 32 defines a centrally locatedportion 54 having a thickness of about .028 inches. The central portion allows the septum to be easily pierced by a piercing element to extract a portion of the sample frominterior 17 ofcontainer 12. - In use, a liquid sample is collected in
container 12.Cap assembly 14 is sealably secured to the open upper end ofcontainer 12. Then, as shown in FIG 5, apiercing element 60 is inserted intocontainer 12 by insertingelement 60 throughpassageway 45 defined throughcap body 30.Distal tip 62 ofelement 60 then pierces throughseptum 32 atcentral portion 54. Since the material ofseptum 32 is a thermoplastic elastomer,septum 32 is easily pierced by low insertion forces whereby even for a relativelywide element 60 having a diameter of about .0625 inches,central portion 54 ofseptum 32 may be pierced by a force of less than 2 pounds. - Insertion of
element 60 continues until it reaches the sample ininterior 17 ofcontainer 12 and thenelement 60 collects a portion of the sample.Element 60 is then removed by withdrawing it back throughpassageway 45 incap body 30. Upon withdrawingelement 60 fromseptum 32, the septum self-seals. Due to the thermoplastic elastomer material and thatseptum 32 has a flatplanar surface 50 facing the interior ofcontainer 12 and opposedconcave surface 53 facing in opposition thereto, helps reseal a hole placed inseptum 32 byelement 60. - The septum shape defines a concave surface in the direction of the element withdrawal. The compressive forces exerted by such a shape to effect resealing of any hole placed therein as
element 60 is withdrawn from the container. Thus,septum 32 reseals after multiple puncture sites have been placed therein. The sample incontainer 12 can be repeatedly sampled with the septum self-sealing upon each portion extraction. - The collection assembly of the invention may be made of a molded thermoplastic material so that the specimen collected may be readily viewed. Representative materials include, for example, polyethylene, polypropylene and polyvinyl chloride. The collection container may incorporate a hydrophlic material or a silicon, or a texture may be applied to the internal surface thereof for enhancing the flow and mixing of blood introduced into the container.
- Although it is within the purview of the invention to provide caps which are colored to defined specific forms of fluid collection containers containing materials for one reason or another or for defining the kind of examination to be conducted on the specimen collected, transparent caps may be provided. Also, it should be noted that the dimensions of the container are such as to provide space for labeling which may be important for identifying the collected specimen.
Claims (1)
- A specimen collection assembly comprising:an elongate specimen collection tube having an open end, a closed end and a cylindrical wall therebetween defining a tube interior for accommodating said specimen; and;a cap assembly having a cap body removably sealably secured to said open end of said container, said cap body includes an upper surface, an opposed lower surface and a cylindrical side wall therebetween, said cylindrical side wall being sealably engageable with said open upper end of said container and an access passageway located in said upper surface of said cap body and said membrane being supported within said access passageway.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US392867 | 1989-08-11 | ||
US14321499P | 1999-07-09 | 1999-07-09 | |
US143214P | 1999-07-09 | ||
US39286799A | 1999-09-09 | 1999-09-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1066881A2 true EP1066881A2 (en) | 2001-01-10 |
EP1066881A3 EP1066881A3 (en) | 2002-07-03 |
Family
ID=26840800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00113635A Withdrawn EP1066881A3 (en) | 1999-07-09 | 2000-06-28 | Specimen collection assembly with cap |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP1066881A3 (en) |
JP (1) | JP2001161669A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1400283A2 (en) * | 2002-09-20 | 2004-03-24 | Becton Dickinson and Company | Roller bottle |
WO2007090362A1 (en) * | 2006-02-07 | 2007-08-16 | Sarstedt Ag & Co | Sample vessel for accommodating small amounts of liquid for analyses |
EP1950579A1 (en) * | 2007-01-27 | 2008-07-30 | Bruker BioSpin AG | Cap for a NMR sample tube with interior sealing lip |
EP2660163A1 (en) * | 2010-12-28 | 2013-11-06 | Nipro Corporation | Rubber stopper for vial |
US10618049B2 (en) | 2015-05-04 | 2020-04-14 | Greiner Bio-One Gmbh | Sampling assembly, in particular for collecting a relatively small quantity |
US11554894B2 (en) | 2020-12-04 | 2023-01-17 | Sonoco Development, Inc. | Peelable resealable membrane for containers |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20051057A1 (en) * | 2005-06-08 | 2006-12-09 | Copan Innovation Ltd | DEVELOPMENT, COLLECTION AND TRANSPORT OF BIOLOGICAL SAMPLES |
JP6463997B2 (en) * | 2015-03-10 | 2019-02-06 | 株式会社日立ハイテクノロジーズ | Automatic analyzer |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989002399A1 (en) * | 1987-09-10 | 1989-03-23 | Joseph Parsons Nominees Pty. Ltd. | Cap |
EP0454493A2 (en) * | 1990-04-26 | 1991-10-30 | Charles Terrence Macartney | Reinsertable closure for sample tubes |
US5247015A (en) * | 1988-12-22 | 1993-09-21 | The West Company, Incorporated | Molded thermoplastic elastomer |
US5306270A (en) * | 1990-02-11 | 1994-04-26 | Starplex Scientific | Sealing closure cap and biological sample collection tube |
US5779074A (en) * | 1994-07-26 | 1998-07-14 | Becton, Dickinson And Company | Combination stopper-shield closure |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT377907B (en) * | 1983-01-27 | 1985-05-28 | Greiner & Soehne C A | BLOOD SAMPLES |
AT380392B (en) * | 1985-01-24 | 1986-05-12 | C A Greiner & S Hne Ges M B H | BLOOD SAMPLING! |
JPH0397450A (en) * | 1989-09-11 | 1991-04-23 | Yukitaka Furukawa | Vacuum type blood collection tube |
US5494170A (en) * | 1993-05-06 | 1996-02-27 | Becton Dickinson And Company | Combination stopper-shield closure |
-
2000
- 2000-06-28 EP EP00113635A patent/EP1066881A3/en not_active Withdrawn
- 2000-07-05 JP JP2000203790A patent/JP2001161669A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989002399A1 (en) * | 1987-09-10 | 1989-03-23 | Joseph Parsons Nominees Pty. Ltd. | Cap |
US5247015A (en) * | 1988-12-22 | 1993-09-21 | The West Company, Incorporated | Molded thermoplastic elastomer |
US5306270A (en) * | 1990-02-11 | 1994-04-26 | Starplex Scientific | Sealing closure cap and biological sample collection tube |
EP0454493A2 (en) * | 1990-04-26 | 1991-10-30 | Charles Terrence Macartney | Reinsertable closure for sample tubes |
US5779074A (en) * | 1994-07-26 | 1998-07-14 | Becton, Dickinson And Company | Combination stopper-shield closure |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1400283A2 (en) * | 2002-09-20 | 2004-03-24 | Becton Dickinson and Company | Roller bottle |
EP1400283A3 (en) * | 2002-09-20 | 2005-07-06 | Becton Dickinson and Company | Roller bottle |
US7163115B2 (en) | 2002-09-20 | 2007-01-16 | Becton, Dickinson And Company | Roller bottle cap |
WO2007090362A1 (en) * | 2006-02-07 | 2007-08-16 | Sarstedt Ag & Co | Sample vessel for accommodating small amounts of liquid for analyses |
EP1950579A1 (en) * | 2007-01-27 | 2008-07-30 | Bruker BioSpin AG | Cap for a NMR sample tube with interior sealing lip |
EP2660163A1 (en) * | 2010-12-28 | 2013-11-06 | Nipro Corporation | Rubber stopper for vial |
EP2660163A4 (en) * | 2010-12-28 | 2014-06-11 | Nipro Corp | Rubber stopper for vial |
US10131472B2 (en) | 2010-12-28 | 2018-11-20 | Nipro Corporation | Vial rubber stopper |
US10618049B2 (en) | 2015-05-04 | 2020-04-14 | Greiner Bio-One Gmbh | Sampling assembly, in particular for collecting a relatively small quantity |
US11554894B2 (en) | 2020-12-04 | 2023-01-17 | Sonoco Development, Inc. | Peelable resealable membrane for containers |
Also Published As
Publication number | Publication date |
---|---|
EP1066881A3 (en) | 2002-07-03 |
JP2001161669A (en) | 2001-06-19 |
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