CN218627656U - Immunochromatographic test paper production line - Google Patents
Immunochromatographic test paper production line Download PDFInfo
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- CN218627656U CN218627656U CN202223204889.4U CN202223204889U CN218627656U CN 218627656 U CN218627656 U CN 218627656U CN 202223204889 U CN202223204889 U CN 202223204889U CN 218627656 U CN218627656 U CN 218627656U
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
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Abstract
The utility model provides an immunochromatographic detection test paper production line, it includes conveyer belt and control system, is equipped with along the direction of delivery of conveyer belt and pastes subassembly, diolame subassembly spraying subassembly, dry subassembly and tailors the subassembly. The pasting component comprises a film laminating machine which is used for attaching the NC film, the absorbent paper, the gold pad and the sample pad to the set position of the substrate. The film coating assembly comprises a film coating machine used for scribing and coating films on the NC films. The spraying assembly comprises a spraying machine which is used for spraying the colloidal gold immune complex and the sample pad treatment liquid on the gold pad. The drying component is used for drying. The cutting assembly comprises a detection probe and a first cutting machine, the detection probe judges whether the sprayed substrate meets the parameter requirements or not, identification marks are made in unqualified areas, the first cutting machine cuts out the unqualified areas, and the substrate is cut to a preset length. The production line also comprises a slitting assembly, the slitting assembly comprises a second cutting machine, and the substrate after being cut is cut into preset width to be made into the test strip.
Description
Technical Field
The utility model relates to an immunochromatography test paper technical field particularly, relates to an immunochromatography test paper production line.
Background
In order to obtain qualitative results quickly in vitro diagnosis or in vitro detection, an immunochromatographic test strip is usually used as a rapid diagnosis tool or a rapid detection tool. The conventional immunochromatographic test paper comprises a substrate, a sample pad, a gold pad, an NC membrane and absorbent paper, wherein the sample pad, the gold pad, the NC membrane and the absorbent paper are sequentially contacted and arranged on one side of the substrate, and the NC membrane is also provided with a detection line and a quality control line.
The immunochromatographic test strip has the advantages of high sensitivity, strong specificity and the like, can realize on-site rapid detection, can realize quantitative detection, multiple detection and the like along with the development of a labeled solid phase material technology, and has a good application prospect. However, the current immunochromatographic test strip has low production automation degree, most procedures are manually completed, and the production efficiency is low, so that the increasing requirements cannot be met.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide an immunochromatography test paper production line realizes immunochromatography test paper's automated production system, replaces the manual production of current immunochromatography test paper.
In order to solve the technical problem, the utility model adopts the following technical scheme:
according to an aspect of the utility model, the utility model provides an immunochromatography test paper production line, this production line includes: including conveyer belt and control system, follow the direction of delivery of conveyer belt is equipped with in proper order: the device comprises a pasting component, a coating component spraying component, a drying component and a cutting component; the pasting assembly comprises a film laminating machine, and the film laminating machine is used for pasting an NC film, absorbent paper, a gold pad and a sample pad on the set position of the substrate on the conveying belt; the coating assembly comprises a coating machine, the coating machine adjusts the position of a coating machine nozzle relative to the NC film on the substrate under the control of the control system, and lines and coats a coating on the NC film to form a detection line and a quality control line; the spraying component comprises a spraying machine, the spraying machine adjusts the position of a spraying head of the spraying machine relative to the NC film on the substrate under the control of the control system, and the spraying head of the spraying machine sprays the colloidal gold immune complex and the sample pad single treatment liquid on the gold pad; the drying component is used for drying; the cutting assembly comprises a detection probe and a first cutting machine, the detection probe judges whether the sprayed substrate meets the parameter requirement, an identification mark is made in an unqualified area, and the first cutting machine cuts and eliminates the unqualified area so as to cut the dried substrate into a preset length; the production line also comprises a slitting assembly; the strip cutting assembly comprises a second cutting machine, and the second cutting machine cuts the cut substrate into a preset width to manufacture the test strip.
In some embodiments of the present application, the production line further comprises a chucking assembly and a bagging assembly; the card loading assembly loads the test strip into the card box and compresses the test strip through a rubber roller; and the bagging component automatically packs the pressed card box, the drying agent or the dropper into a packaging bag and seals the packaging bag.
Some embodiments of this application, the bagging-off subassembly still includes the visual detection module, the visual detection module is used for right seal detects to reject and seal unqualified product.
Some embodiments of the present application, the laminating machine includes tectorial membrane motor and reel, tectorial membrane motor drive the reel rotates and carries out the tectorial membrane.
In some embodiments of the present application, the drying assembly includes a forced air drying tunnel for drying products passing therethrough.
In some embodiments of the present application, the length of the forced air drying tunnel is not less than 3 meters, the temperature is 25 to 100 degrees, and the transmission speed is 50 to 1000 mm/s.
In some embodiments of the present application, the first cutting machine includes a first cutting motor and a first cutting wheel, and the first cutting motor drives the first cutting wheel to rotate for cutting; the second cutting machine comprises a second cutting motor and a second cutting wheel, and the second cutting motor drives the second cutting wheel to rotate for cutting.
In some embodiments of the present application, the portion of the first cutting machine after the unqualified area is cut and removed is a qualified substrate, and the preset length of the qualified substrate is 1 mm to 100 mm.
In some embodiments of the present application, the control system is a PLC control system.
In some embodiments of the present application, the pasting assembly further includes a first sensor, and the first sensor sends a signal to the control system when detecting that the substrate on the conveying belt passes through, so that the control system controls the laminator to perform laminating; the coating assembly further comprises a second sensor, and the second sensor sends a signal to the control system when detecting that the substrate on the conveying belt passes through the second sensor, so that the control system controls the spray head of the coating machine to perform scribing coating; the spraying assembly further comprises a third sensor, and when the third sensor detects that the substrate on the conveying belt passes through the third sensor, the third sensor sends a signal to the control system so that the control system controls the sprayer nozzle to spray; the cutting assembly further comprises a fourth sensor, and the fourth sensor sends a signal to the control system when detecting that the substrate on the conveying belt passes through, so that the control system controls the first cutting machine to cut.
According to the above technical scheme, the utility model discloses following advantage and positive effect have at least:
the utility model discloses among the immunochromatography test paper production line, through effective decomposition and the flow process to production process, with each process link of immunochromatography test paper production, combine through machine and process optimization back organic, designed the automatic production line of immunochromatography test paper, realize from the auxiliary material to the full production process machine automation of test paper, replace current immunochromatography test paper manual production. The production efficiency is improved, the uncontrollable property in the manual production operation process is avoided, and the defective rate is effectively reduced, so that the production efficiency is improved, the production cost is reduced, and the requirement of mass production is met.
Drawings
FIG. 1 is a schematic structural diagram of an immunochromatographic test strip.
FIG. 2 is a flow chart of the production of the immunochromatographic test strip.
The reference numerals are explained below: 1. a substrate; 2. a sample pad; 3. gold pad; 4. NC film; 41. detecting lines; 42. a quality control line; 5. and (7) absorbent paper.
Detailed Description
While the present invention may be susceptible to embodiment in different forms, there is shown in the drawings and will herein be described in detail only some specific embodiments, with the understanding that the present disclosure is to be considered as an exemplification of the principles of the invention and is not intended to limit the invention to that as illustrated herein.
Thus, a feature indicated in this specification will serve to explain one of the features of an embodiment of the invention, and not to imply that every embodiment of the invention must have the described feature. Further, it should be noted that this specification describes many features. Although some features may be combined to show a possible system design, these features may also be used in other combinations not explicitly described. Thus, the combinations illustrated are not intended to be limiting unless otherwise specified.
In the embodiments shown in the drawings, the indications of directions (such as up, down, left, right, front, and rear) are used for explaining the structure and movement of the various elements of the present invention are not absolute but relative. These descriptions are appropriate when the elements are in the positions shown in the drawings. If the description of the positions of these elements changes, the indication of these directions changes accordingly.
The following description of the preferred embodiments of the present invention will be made with reference to the accompanying drawings.
Referring to fig. 1, the immunochromatographic test strip includes a substrate 1 (PVC plate), a sample pad 2, a gold pad 3, an NC membrane 4 (nitrocellulose membrane), and absorbent paper 5, the sample pad 2 (conjugate pad), the gold pad 3 (polyester film or glass fiber film), the NC membrane 4, and the absorbent paper 5 are sequentially contacted and disposed on one side of the substrate 1, wherein the NC membrane 4 is further provided with a detection line 41 and a quality control line 42,
after the antigen or antibody labeled solid phase carrier fixed on the sample pad 2 and the object to be detected in the sample pad 2 are subjected to specific immunoreaction, a complex is formed, the specific immunoreaction is carried out again at the detection line 41 through the chromatography action on the NC membrane 4, the solid phase carrier is used as a signal amplification marker, and the detection result is obtained through visual observation or corresponding equipment detection.
Referring to fig. 2, an immunochromatography test strip production line provided in an embodiment of the present invention includes a conveyor belt and a control system, and the conveyor belt is sequentially provided with: paste subassembly, diolame subassembly spraying subassembly, dry subassembly and tailor the subassembly. Putting the substrate 1 on a conveyer belt, conveying materials by using the conveyer belt, and positioning and correcting the substrate 1 so as to realize automatic transfer of the substrate 1 among all the working procedures.
The pasting component comprises a film laminating machine, and the film laminating machine is used for attaching the NC film 4, the absorbent paper 5, the gold pad 3 and the sample pad 2 to the set position of the substrate 1 on the conveying belt.
In some embodiments, the laminating machine includes a laminating motor and a winding drum, and the film to be laminated on the substrate 1 is wound on the winding drum, and the winding drum is driven by the laminating motor to rotate, and the film is adhered to the substrate 1 in conjunction with the movement of the substrate 1 on the conveyor belt.
In some embodiments, the pasting assembly further comprises a first sensor, which sends a signal to the control system when detecting that the substrate 1 on the conveyer belt passes by, so that the control system controls the film laminating machine to perform film lamination, i.e. starts the film laminating motor, and respectively attaches the NC film 4, the absorbent paper 5, the gold pad 3 and the sample pad 2 to the set positions of the substrate 1 at appropriate time. By the first sensor, the accuracy of the film covering position is ensured.
The coating assembly comprises a coating machine, the coating machine adjusts the position of a nozzle of the coating machine relative to the NC film 4 on the substrate 1 under the control of the control system, and lines are marked on the NC film 4 for coating to form a detection line 41 and a quality control line 42.
In some embodiments, the coating assembly further comprises a second sensor, and the second sensor sends a signal to the control system when detecting that the substrate 1 on the conveyor belt passes by, so that the control system judges and automatically corrects the position of the nozzle of the coating machine relative to the NC film 4 on the substrate 1. And the marking position of the spray head of the coating machine is ensured to accord with the set technical parameters through the second sensor.
The spraying component comprises a spraying machine, the spraying machine adjusts the position of a spraying head of the spraying machine relative to the NC film 4 on the substrate 1 under the control of the control system, and then the spraying head of the spraying machine sprays the colloidal gold immune complex and the sample pad treatment liquid on the gold pad 3.
In some embodiments, the spraying assembly further comprises a third sensor, and the third sensor sends a signal to the control system when detecting that the substrate 1 on the conveyor belt passes by, so that the control system judges and automatically corrects the position of the sprayer nozzle relative to the NC film 4 on the substrate 1, and then the control system controls the sprayer nozzle to spray. And the third sensor is used for ensuring that the position of the spraying liquid of the sprayer nozzle meets the set technical parameters.
The drying unit is used for drying to cure the glue between the substrate 1, the NC film 4, the absorbent paper 5, the gold pad 3, and the sample pad 2.
In some embodiments, the drying assembly includes a forced air drying tunnel for drying products passing therethrough.
In some embodiments, the length of the forced air drying tunnel is not less than 3 meters, and sufficient drying time is ensured for curing the glue when the coated substrate 1 passes through the longer forced air drying tunnel. The temperature of the forced air drying tunnel is 25-100 ℃, and the transmission speed is 50-1000 mm/s. For example, when the temperature of the forced air drying tunnel is 25 ℃, the transmission speed is 50 mm/s, and the lower temperature needs longer drying time to ensure the drying effect. Or when the temperature of the blast drying channel is 60 ℃, the transmission speed is 520 mm/s, the temperature is moderate, the drying time is moderate, and the drying effect can also be ensured. And when the temperature of the blast drying channel is 100 ℃, the transmission speed is 50 mm/s, the temperature is higher, the drying time is short, and the drying efficiency is improved.
The cutting assembly comprises a detection probe and a first cutting machine, the detection probe judges whether the sprayed substrate 1 meets the parameter requirements or not, identification marks are made in unqualified areas, and the cutting machine cuts out the unqualified areas to cut the attached substrate 1 into preset lengths. The part of the first cutting machine after the unqualified area is cut and removed is a qualified substrate 1, and the preset length of the qualified substrate 1 can be 1 mm to 100 mm. The detection probe may be a CCD vision detection probe.
In some embodiments, the first cutting machine includes a first cutting motor and a first cutting wheel, and the first cutting motor drives the first cutting wheel to rotate to cut.
In some embodiments, the cutting assembly further comprises a fourth sensor, and the fourth sensor sends a signal to the control system when detecting that the substrate 1 on the conveyor belt passes through, so that the control system controls the first cutting machine to cut, rejects the unqualified area, and cuts the substrate 1 to meet the set length. The marking mark may be an inkjet scribing mark of the nozzle on the NC film 4 of the substrate 1.
The production line also includes a slitting assembly. The slitting component comprises a second cutting machine, and the second cutting machine cuts the substrate 1 after cutting into a preset width to manufacture the test strip.
In some embodiments, the second cutter includes a second cutting motor and a second cutting wheel, and the second cutting motor drives the second cutting wheel to rotate to cut.
Through effective decomposition and flow process of production procedures, all procedure links of the production of the immunochromatography test paper are organically combined through machines and procedure optimization, an automatic production line of the immunochromatography test paper is designed, the automation of the machines in the whole production process from auxiliary materials to the test paper is realized, and the manual production of the immunochromatography test paper is replaced. The production efficiency is improved, the uncontrollable property in the manual production operation process is avoided, and the defective rate is effectively reduced, so that the production efficiency is improved, the production cost is reduced, and the requirement of mass production is met.
In some embodiments, the control system employs a PLC control system, i.e., a programmable logic controller. Each component can be controlled by one set of PLC control system, and can also be controlled by respective set of PLC control system.
In some embodiments, the production line further comprises a chucking assembly and a bagging assembly.
The card loading assembly loads the test strip into the card box and compresses tightly the test strip through the rubber roller. The card box comprises a plastic bottom card and a plastic surface card, and the test paper strip is put into the plastic bottom card and then covered on the plastic bottom card to complete the storage of the test paper strip.
It should be noted that after the slitting assembly finishes slitting, the test strip after slitting can be transferred to the card loading assembly for card loading after being fed by the automatic feeding system.
And the bagging component automatically loads the pressed card box, the drying agent or the dropper into a packaging bag and seals the packaging bag. And (5) completing bagging and packaging of the immunochromatographic detection test paper. And then outputting the materials after bagging and sealing, and carrying out external packaging. And finishing the shipment packaging of the immunochromatographic detection test paper.
In some embodiments, the bagging assembly further comprises a visual inspection module for inspecting the seal and rejecting rejected products that fail the seal during the sealing operation. Ensuring the quality and the qualified rate of the final product. The visual detection module can also be a CCD visual detection probe.
Through dress card subassembly and bagging-off subassembly, still realized automatic packing after realizing that the test paper strip is automatic, further improve production efficiency, reduced manufacturing cost. In addition, when manual production is performed, production personnel generally adopt different independent workshops to perform the operations of preparing the gold pad 3, preparing the sample pad 2, preparing the coated sheet, assembling the pasting board, cutting into strips, installing, clamping, bagging and the like, so that the corresponding operations of arranging, packaging, marking, clearing, transferring, unpacking and the like are required to be performed on the processed and prepared products in each procedure, and the risks of additional loss of the processed products, production environment pollution and the like are possibly brought. Compared with a manual mode, the automatic production process can reduce the material loss and pollution.
While the present invention has been described with reference to several exemplary embodiments, it is understood that the terminology used is intended to be in the nature of words of description and illustration, rather than of limitation. As the present invention may be embodied in several forms without departing from the spirit or essential characteristics thereof, it should also be understood that the above-described embodiments are not limited by any of the details of the foregoing description, but rather should be construed broadly within its spirit and scope as defined in the appended claims, and therefore all changes and modifications that fall within the metes and bounds of the claims, or equivalence of such metes and bounds are therefore intended to be embraced by the appended claims.
Claims (10)
1. The utility model provides an immunochromatography test paper production line, its characterized in that, includes conveyer belt and control system, follows the direction of delivery of conveyer belt is equipped with in proper order: the device comprises a pasting component, a coating component spraying component, a drying component and a cutting component;
the pasting assembly comprises a film laminating machine, and the film laminating machine is used for pasting an NC film, absorbent paper, a gold pad and a sample pad on the set position of the substrate on the conveying belt;
the coating assembly comprises a coating machine, the coating machine adjusts the position of a coating machine nozzle relative to the NC film on the substrate under the control of the control system, and lines and coats a coating on the NC film to form a detection line and a quality control line;
the spraying assembly comprises a spraying machine, the spraying machine adjusts the position of a spraying head of the spraying machine relative to the NC film on the substrate under the control of the control system, and the spraying head of the spraying machine sprays the colloidal gold immune complex and the sample pad treatment liquid on the gold pad;
the drying component is used for drying;
the cutting assembly comprises a detection probe and a first cutting machine, the detection probe judges whether the sprayed substrate meets the parameter requirements or not, identification marks are made in unqualified areas, and the first cutting machine cuts out the unqualified areas to cut the dried substrate into preset lengths;
the production line also comprises a slitting assembly; the strip cutting assembly comprises a second cutting machine, and the second cutting machine cuts the cut substrate into a test strip with a preset width.
2. The immunochromatographic test strip production line of claim 1, further comprising a card loading assembly and a bagging assembly;
the card loading assembly loads the test strip into the card box and compresses the test strip through a rubber roller;
and the bagging assembly automatically loads the pressed card box, the drying agent or the dropper into a packaging bag and seals the packaging bag.
3. The immuno-chromatographic test strip production line of claim 2, wherein said bagging assembly further comprises a visual inspection module for inspecting said seal and rejecting products that fail the seal.
4. The production line of immunochromatographic test strip according to claim 1, wherein the laminating machine includes a laminating motor and a reel, and the laminating motor drives the reel to rotate for laminating.
5. The immunochromatographic test strip production line of claim 1, wherein said drying assembly comprises an air-blowing drying tunnel for drying products passing therethrough.
6. The immunochromatographic test strip production line of claim 5, wherein the length of the air-drying tunnel is not less than 3 m, the temperature is 25 to 100 ℃, and the transmission speed is 50 to 1000 mm/s.
7. The immunochromatographic test strip production line of claim 1, wherein the first cutting machine comprises a first cutting motor and a first cutting wheel, and the first cutting motor drives the first cutting wheel to rotate for cutting;
the second cutting machine comprises a second cutting motor and a second cutting wheel, and the second cutting motor drives the second cutting wheel to rotate for cutting.
8. The production line of an immunochromatographic test strip according to claim 1, wherein the portion of the first cutter from which the non-conforming region is cut out is a conforming substrate, and the predetermined length of the conforming substrate is 1 mm to 100 mm.
9. The immunochromatographic test strip production line of claim 1, wherein the control system is a PLC control system.
10. The immunochromatographic test strip production line of claim 1, wherein the pasting component further comprises a first sensor, the first sensor sends a signal to the control system when detecting that the substrate on the conveyor belt passes by, so that the control system controls the laminating machine to carry out laminating;
the coating assembly further comprises a second sensor, and the second sensor sends a signal to the control system when detecting that the substrate on the conveying belt passes through the second sensor, so that the control system controls the spray head of the coating machine to perform scribing coating;
the spraying assembly further comprises a third sensor, and when the third sensor detects that the substrate on the conveying belt passes through the third sensor, the third sensor sends a signal to the control system to enable the control system to control the sprayer nozzle to spray;
the cutting assembly further comprises a fourth sensor, and the fourth sensor sends a signal to the control system when detecting that the substrate on the conveying belt passes through, so that the control system controls the first cutting machine to cut.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223204889.4U CN218627656U (en) | 2022-11-30 | 2022-11-30 | Immunochromatographic test paper production line |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223204889.4U CN218627656U (en) | 2022-11-30 | 2022-11-30 | Immunochromatographic test paper production line |
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| Publication Number | Publication Date |
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| CN218627656U true CN218627656U (en) | 2023-03-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202223204889.4U Active CN218627656U (en) | 2022-11-30 | 2022-11-30 | Immunochromatographic test paper production line |
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- 2022-11-30 CN CN202223204889.4U patent/CN218627656U/en active Active
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