CN218232337U - Nucleic acid extraction device for CD55 variant expression - Google Patents

Abstract

The utility model provides a nucleic acid extraction device for CD55 variation expression, relate to the nucleic acid extraction art field, including the work box, be equipped with chamber door and control box on the work box, work box inside bottom surface symmetry is provided with two sets of cassettes, be equipped with the adjustable aperture in the work box, adjustable aperture department is equipped with the guided way, sliding fit has the removal post on the guided way, the removal post is connected with the cylinder of seeking a position, sliding fit upper slide and lower slider on the removal post, upper link plate and lower link plate are equipped with respectively on upper slide and the lower slider, upper link plate and lower link plate are connected with upper cylinder and lower cylinder respectively, the mounting panel is installed on the upper slide, the mounting panel bottom symmetry is provided with two sets of magnetic rods, install the mounting bracket on the lower slider, the symmetry is provided with two sets of draw-in grooves and is in two sets of bar holes directly over the draw-in grooves on the mounting bracket, the bar hole is in directly under the magnetic rod; the device has the advantages of simple structure, high nucleic acid extraction efficiency, simple operation and good use effect.

Description

Nucleic acid extraction device for CD55 variant expression

Technical Field

The utility model relates to a nucleic acid extraction art field particularly, relates to a nucleic acid extraction device for CD55 variant expression.

Background

The decay-accelerating factor (DAF), CD55, is expressed on the surface of all peripheral blood cells, endothelial cells and various mucosal epithelial cells, and can competitively bind with C2 to C4b, thereby inhibiting the formation and promoting the decomposition of C4b2 b. The dissociation of Bb from the formed C3bBb can also be promoted. The nucleic acid detection comprises qualitative PCR, molecular hybridization, real-time fluorescent quantitative PCR and other technologies, and the first key of the nucleic acid detection technology is to complete the extraction of nucleic acid of a biological sample. The nucleic acid extraction device is an instrument which automatically finishes the work of extracting the nucleic acid of a sample by using a matched nucleic acid extraction reagent. The method is widely applied to various fields of disease control center, clinical disease diagnosis, blood transfusion safety, forensic medicine identification, environmental microorganism detection, food safety detection, animal husbandry, molecular biology research and the like. Therefore, the effective and accurate extraction of the nucleic acid template becomes the premise of subsequent nucleic acid detection.

Nucleic acid extraction mainly adopts nucleic acid extraction equipment to extract, but the tradition generally adopts the manual work to utilize detection tool to detect, along with the development of technique, automatic detection technique also comes with it, but the device structure of current nucleic acid extraction equipment nucleic acid extraction is complicated, the staff need place the kit in extraction equipment in the testing process, the position can't effectively obtain accurate fixed in the placing process of kit, lead to that bar magnet and kit have the deviation in the testing process, the staff operates inconvenience slightly in the testing process, the efficiency of nucleic acid extraction is lower.

SUMMERY OF THE UTILITY MODEL

The object of the present invention is to solve the above problems in the background art, and then to provide a nucleic acid extraction device for the variant expression of CD 55.

The utility model provides a technical scheme that its technical problem adopted is:

the utility model provides a nucleic acid extraction element for CD55 variogram, the device comprises a work box, be equipped with chamber door and control box on the work box, work box inside bottom surface symmetry is provided with two sets of cassettes, be equipped with the spacing groove on the relative face of two cassettes in a set of, be equipped with the movable opening in the work box, movable opening department is equipped with the guided way, sliding fit has the removal post on the guided way, it is connected with the cylinder of seeking a position to remove the post, sliding fit upper sliding block and lower slider on the removal post, be equipped with even board and lower even board on upper sliding block and the lower slider respectively, it is connected with upper cylinder and lower cylinder respectively to go up even board and lower even board, install the mounting panel on the upper sliding block, mounting panel bottom symmetry is provided with two sets of bar magnets, install the mounting bracket on the slider down, the symmetry is provided with two sets of draw-in grooves and is in two sets of bar holes directly over the draw-in groove on the mounting bracket, the bar hole is directly under the bar magnet and the diameter that the width is greater than the bar magnet can pass the bar hole with the permission magnet.

Furthermore, a heater and an ultraviolet disinfection lamp are arranged in the working box to ensure that a good extraction environment exists in the nucleic acid extraction process.

Furthermore, a reagent kit is placed between the two clamping seats, a bottom plate of the reagent kit is matched with the limiting groove, and two sides of the reagent kit are in contact with the clamping seats to ensure stable placement.

Furthermore, the box door is provided with a transparent window which is convenient for workers to observe the nucleic acid extraction process.

Furthermore, a sealing rubber pad for improving the sealing effect of the working box is arranged on the box door.

Furthermore, be equipped with display screen and control button on the control box, staff's accessible operation display screen is controlled information such as nucleic acid extraction time.

Furthermore, a buzzer is arranged on the control box to remind workers of completion of nucleic acid extraction.

Furthermore, the position finding cylinder, the upper cylinder and the lower cylinder are respectively arranged at the back of the working box and are electrically connected with the control box

Compared with the prior art, the beneficial effects of the utility model are that:

1. the utility model has simple structure and high nucleic acid extraction efficiency; the staff accuracy is placed the kit at the cassette and is pushed into the draw-in groove completely with the bar magnet cover, closes a body, and the device starts, looks for a cylinder and drives and remove the post and look for the position to the kit, and under the function of last cylinder and lower cylinder, bar magnet and bar magnet cover can be drawed the sample in the kit afterwards, easy operation, excellent in use effect.

2. The utility model discloses a relate to ultraviolet ray disinfection lamp and heater in the work box, improved the requirement to the environment of nucleic acid extraction in-process, it is better to extract the effect.

Drawings

FIG. 1 is a schematic view of the present invention;

FIG. 2 is a schematic structural view of the mounting bracket;

FIG. 3 is a schematic view of the slider drive;

FIG. 4 is a schematic diagram of the placement of the reagent cartridge;

wherein: 1 work box, 11 movable openings, 12 guide rails, 13 ultraviolet ray disinfection lamps, 14 heaters, 2 box doors, 21 transparent windows, 22 sealing rubber pads, 3 control boxes, 31 display screens, 32 control buttons, 33 buzzers, 4 clamping seats, 41 limiting grooves, 5 moving columns, 51 upper sliding blocks, 511 upper connecting plates, 512 upper cylinders, 52 lower sliding blocks, 521 lower connecting plates, 522 lower cylinders, 53 mounting plates, 54 magnetic rods, 55 mounting frames, 551 clamping grooves, 552 strip-shaped holes, 56 positioning cylinders, 6 magnetic rod sleeves and 7 kits.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention. The invention will be further explained with reference to the accompanying drawings and examples:

as shown in fig. 1 to 4, a nucleic acid extraction device for CD55 variant expression comprises a work box 1, wherein in order to ensure a good extraction environment in the nucleic acid extraction process, a heater 14 and an ultraviolet disinfection lamp 13 are arranged in the work box, a box door 2 and a control box 3 are arranged on the work box, two sets of clamping seats 4 are symmetrically arranged on the bottom surface in the work box, a limiting groove 41 is arranged on the opposite surface of two clamping seats in one set, a reagent box 7 is placed between the two clamping seats, specifically, the bottom plate of the reagent box is matched with the limiting groove, and the two sides of the reagent box are contacted with the clamping seats to ensure stable placement; be equipped with the movable opening 11 in the work box, movable opening department is equipped with guided way 12, sliding fit has removal post 5 on the guided way, it is connected with the cylinder 56 that looks for a position to remove the post, sliding fit upper sliding block 51 and lower slider 52 on the removal post, be equipped with even board 511 and lower even board 521 on upper sliding block and the lower slider respectively, it is connected 522 with upper cylinder 512 and lower cylinder respectively to go up even board and lower even board in order to realize the independent motion of upper sliding block and lower slider, install mounting panel 53 on the upper sliding block, the mounting panel bottom symmetry is provided with two sets of bar 54, install mounting bracket 55 on the lower slider, the symmetry is provided with two sets of draw-in grooves 551 that are used for placing bar cover 5 and is in two sets of bar holes 552 directly over the draw-in groove on the mounting bracket, the bar hole is directly under the bar and the diameter that the width is greater than the bar is in order to allow the bar to pass the bar hole.

Wherein, be equipped with the transparent window 21 that is convenient for the staff to observe the nucleic acid extraction process and improves the sealed rubber pad 22 of the sealed effect of work box on the chamber door.

Wherein, be equipped with display screen 31 and control button 32 on the control box, staff's accessible operation display screen is controlled information such as nucleic acid extraction time, of course, for the result of use that improves the device, still is equipped with bee calling organ 33 on the control box in order to remind staff's nucleic acid extraction to accomplish.

Certainly, look for a position cylinder, go up cylinder and lower cylinder and install respectively at the back of work box and all with control box electric connection.

This device is at the concrete implementation in-process, at first utilize the ultraviolet ray disinfection lamp to carry out disinfection treatment to the work box inside, secondly, the accuracy is placed the kit at the cassette and is pushed into the draw-in groove completely with the bar magnet cover, close the door body, operation control button sets for temperature and extraction time in the work box, the device starts, it drives the removal post to look for the position to the kit to look for the position cylinder, at last cylinder under with the function of cylinder down afterwards, bar magnet and bar magnet cover vibrate the sample in the reagent box, the magnetic bead adsorbs in order to realize the extraction to nucleic acid, sound along with bee calling organ, it formally finishes to draw the work.

The foregoing illustrates and describes the general principles, features and advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments, and the description in the above embodiments and the specification is only for explaining the principle of the present invention, and that the present invention can also have various changes and modifications without departing from the spirit and scope of the present invention, and these changes and modifications all fall into the scope of the present invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (6)

1. The utility model provides a nucleic acid extraction element for CD55 variogram, a serial communication port, including the work box, be equipped with chamber door and control box on the work box, work box inside bottom surface symmetry is provided with two sets of cassettes, be equipped with the spacing groove on the relative face of two cassettes in a set of, be equipped with the dodge gate in the work box, dodge gate department is equipped with the guided way, sliding fit has the removal post on the guided way, it is connected with the cylinder of looking for a position to remove the post, sliding fit top shoe and lower slider on the removal post, be equipped with upper link plate and lower link plate on top shoe and the lower slider respectively, upper link plate and lower link plate are connected with upper cylinder and lower cylinder respectively, install the mounting panel on the top shoe, mounting panel bottom symmetry is provided with two sets of bars, install the mounting bracket on the lower slider, the symmetry is provided with two sets of draw-in grooves and is in two sets of bar holes directly over the draw-in groove on the mounting bracket, the bar hole is in directly under the bar and the width is greater than the diameter of bar.

2. The apparatus for extracting nucleic acid used for variant expression of CD55 as claimed in claim 1, wherein a heater and an ultraviolet disinfection lamp are provided in said work chamber.

3. The apparatus according to claim 1, wherein a transparent window is disposed on the door.

4. The apparatus of claim 1, wherein the door is provided with a rubber gasket.

5. The apparatus of claim 1, wherein the control box is provided with a display and control buttons.

6. The apparatus of claim 1, wherein a buzzer is disposed on the control box.

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