CN218223878U - Liquid transfer workstation - Google Patents

Liquid transfer workstation Download PDF

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Publication number
CN218223878U
CN218223878U CN202220832213.0U CN202220832213U CN218223878U CN 218223878 U CN218223878 U CN 218223878U CN 202220832213 U CN202220832213 U CN 202220832213U CN 218223878 U CN218223878 U CN 218223878U
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China
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reagent
needle
sample
cleaning
driving
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CN202220832213.0U
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Chinese (zh)
Inventor
邹继华
陈宇迪
徐勇
蒋彬瑜
陈文炎
赵达
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Ningbo Medical System Biotechnology Co Ltd
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Ningbo Medical System Biotechnology Co Ltd
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Abstract

The utility model provides a liquid transfer workstation, which comprises a box body, a reagent container, a sample container and a mixing container are placed in the box body, and a reagent arm mechanism is used for automatically transferring a reagent into the mixing container; a sample arm mechanism for automatically transferring a sample into a mixing container; the reagent needle cleaning mechanism is used for cleaning the outer wall of the reagent needle; the sample needle cleaning mechanism is used for cleaning the outer wall of the sample needle; the liquid path mechanism is respectively communicated with the inner cavities of the reagent needle and the sample needle to clean the inner walls of the reagent needle and the sample needle; the liquid path mechanism is also used for providing outer wall cleaning liquid for the reagent needle cleaning mechanism and the sample needle cleaning mechanism; the box body is also provided with a control screen for operating the corresponding motion mechanism. The utility model provides a move liquid workstation possesses automatic washing, imbibition, spits the liquid function, realizes that reagent and sample are automatic to be shifted to mixing container, need not artifical manually operation, reduces manpower intensity of labour, improves and moves liquid efficiency.

Description

Liquid transfer workstation
Technical Field
The utility model belongs to the technical field of medical treatment check out test set technique and specifically relates to a move liquid workstation.
Background
In experiments such as biochemistry and the like, liquid medicines are often required to be transferred, and conventionally, a simple liquid transfer device such as a rubber head dropper is adopted, and a liquid transfer gun is also adopted under the condition that a large number of experimental samples are required.
Most of the existing pipetting work is manually operated, namely, the pipetting pressing rod is manually pressed to push the suction head to suck the reagent, the reagent and the sample are mixed and reacted in a designated headspace bottle, and then the bottle cap is covered and the bottle cap is sent for analysis and test. The liquid transfer workstation is a precise instrument, a correct posture needs to be kept when the liquid transfer workstation is used, the holding force needs to be controlled when the liquid transfer workstation is used, and due to the fact that the number of samples to be tested is large and an operator is not unique, the error probability is increased, and the working efficiency is low; and the manual pipetting mode is also easy to cause pipetting errors, so that the detection result is inaccurate.
SUMMERY OF THE UTILITY MODEL
The utility model provides a problem, in order to overcome the defect among the prior art, provide a move liquid workstation, possess automatic washing, imbibition, spit the liquid function, realize that reagent and sample are automatic to be shifted to mixing container in, need not artifical manually operation, improved degree of automation greatly, reduce manpower intensity of labour, improve and move liquid efficiency.
In order to solve the problems, the utility model provides a liquid transfer workstation, which comprises a box body, wherein a working area is arranged in the box body, a reagent container, a sample container and a mixing container are placed in the working area, and a window for the reagent container, the sample container and the mixing container to enter and exit is arranged on the side wall of the box body; the inside of the box body is also provided with
The reagent arm mechanism comprises a reagent needle, a first driving mechanism and a reagent sucking and spitting module, wherein the first driving mechanism is used for driving the reagent needle to linearly move along three X, Y and Z axes, and the reagent sucking and spitting module is used for driving the reagent needle to automatically transfer the reagent in the reagent container into the mixing container;
a sample arm mechanism comprising a sample needle, a second drive mechanism for driving the sample needle to move linearly along three axes XYZ, and a sample sucking and spitting module for driving the sample needle to automatically transfer the sample in the sample container into the mixing container;
the reagent needle cleaning mechanism is used for cleaning the outer wall of the reagent needle;
the sample needle cleaning mechanism is used for cleaning the outer wall of the sample needle;
the liquid path mechanism is respectively communicated with the reagent needle and the inner cavity of the sample needle and is used for cleaning the inner walls of the reagent needle and the inner wall of the sample needle; the liquid path mechanism is also used for providing an outer wall cleaning liquid for the reagent needle cleaning mechanism and the sample needle cleaning mechanism;
the box body is also provided with a control screen, and the control screen is electrically connected with the reagent arm mechanism, the sample arm mechanism, the reagent needle cleaning mechanism, the sample needle cleaning mechanism and the liquid path mechanism.
The utility model discloses a move liquid workstation and prior art and compare and have following advantage:
the liquid transfer workstation of the utility model is provided with a special box mechanism, and a window is arranged on the side wall of the box body for taking and placing the reagent and the sample, and the reagent and the sample are automatically and rapidly transferred to the corresponding mixing container through the linear motion in the XYZ axial directions of the reagent arm mechanism and the sample arm mechanism in the box body, so that the whole process does not need manual participation, and the working efficiency is effectively improved; a reagent needle cleaning structure and a sample needle cleaning structure which are used for separately and independently cleaning the reagent needle and the sample needle are additionally arranged in the box body, so that different samples or reagents are prevented from being mixed, and the accuracy of a detection result is ensured; in addition, the liquid-transfering workstation structure of the utility model can realize the cleaning of the outer wall of the reagent needle and the cleaning of the inner wall of the sample needle, and can also realize the cleaning of the inner wall, and the structure is simplified by controlling through the same liquid path mechanism, thereby ensuring the cleaning efficiency of the reagent needle and the cleaning efficiency of the sample needle; moreover, the structure can be used for centralized control through the control screen, so that the operation steps are effectively simplified, the operation of detection personnel is facilitated, and the working efficiency is improved.
Furthermore, the liquid path mechanism comprises a liquid supply assembly, a cleaning assembly and a waste discharge assembly, wherein one end of the liquid supply assembly is connected with a water source, and the other end of the liquid supply assembly is communicated with the reagent sucking and spitting module and the sample sucking and spitting module; the reagent sucking and spitting module or the sample sucking and spitting module is used for driving the water source to be discharged from the reagent needle or the sample needle so as to clean the inner wall of the reagent needle or the sample needle; the cleaning assembly is used for conveying a water source to the reagent needle cleaning mechanism or the sample needle cleaning mechanism so as to clean the outer wall of the reagent needle or the sample needle; one end of the waste discharge assembly is communicated with the reagent needle cleaning mechanism or the sample needle cleaning mechanism, and the other end of the waste discharge assembly is communicated to the waste liquid box for recycling the cleaning waste liquid.
As an improvement, the first driving mechanism and the second driving mechanism have the same structure, and both of them include a support beam which extends horizontally along the Y-axis direction and is arranged above the working area and can slide along the X-axis direction of the box body, and a first driving assembly for driving the support beam to move horizontally along the X-axis direction is mounted on the box body; the support beam is provided with a mounting plate capable of sliding along the Y-axis direction and a second driving assembly for driving the mounting plate to slide; the mounting plate is provided with a sliding block capable of sliding along the Z axis and a third driving assembly for driving the sliding block to slide; the reagent needle or the sample needle is connected to the corresponding slide block, and the reagent sucking and spitting module and the sample sucking and spitting module are connected to the box body.
Preferably, the first driving assembly, the second driving assembly and the third driving assembly respectively comprise a driving motor, a driving wheel, a driven wheel and a belt, the belts are tensioned and assembled outside the driving wheel and the driven wheel, and an output shaft of the driving motor is connected with a central shaft of the driving wheel; one end of the supporting beam or the mounting plate or the sliding block is connected to the belt. The horizontal movement of a supporting beam, the front-back movement of the mounting plate and the up-down movement of the sliding block in the structure are all driven through the synchronous belt mechanism, the complexity of the driving structure is reduced, the driving is stable, and the control is convenient.
And the improved structure is characterized in that the upper ends of the front side and the rear side of the inner cavity of the box body are respectively provided with a front fixed beam and a rear fixed beam which horizontally extend along the X-axis direction, the first driving assembly is arranged on the rear fixed beam, the rear end of the supporting beam is connected with a belt of the first driving assembly, and the front end of the supporting beam is connected with the front fixed beam in a sliding manner. In the above-mentioned improvement structure, preceding fixed beam and the stability of a supporting beam horizontal movement is effectively increased in the setting of back fixed beam structure to guarantee reagent needle and sample needle at the three direction rectilinear motion's of XYZ axle stationarity, improve and move liquid the precision.
And the reagent needle cleaning mechanism and the sample needle cleaning mechanism are of the same structure and respectively comprise a cleaning seat arranged on a bottom plate of the box body, a cleaning cavity with an opening at the upper part is arranged on the cleaning seat, and the cleaning cavity is communicated with the cleaning assembly. Among the above-mentioned improvement structure, set up special reagent needle and wash the chamber and sample needle and wash the chamber on box inner chamber bottom plate for independently wash reagent needle and sample needle, at the liquid-transfering in-process of different times, avoid sneaking into non-this sample or different grade type reagent, guarantee testing result's accuracy.
In another improvement, the cleaning cavity comprises a liquid inlet cavity and a liquid outlet cavity, the bottom of the liquid inlet cavity is communicated with the cleaning assembly, and the bottom of the liquid outlet cavity is communicated with the waste discharge assembly; and the upper ends of the liquid inlet cavity and the liquid outlet cavity are provided with communicating grooves; when the reagent needle or the sample needle extends into the liquid inlet cavity, the cleaning assembly supplies liquid into the liquid inlet cavity to wash the outer wall of the reagent needle or the sample needle. In the above-mentioned improvement structure, divide into two cavities with the washing chamber, a cavity is used for supplying reagent needle or sample needle to stretch into and carries out the outer wall washing to waste liquid after the washing can overflow to the flowing back chamber through the intercommunication groove, and discharges through corresponding waste discharge assembly, guarantees the purity of the washing liquid in flowing back chamber, and then guarantees that reagent needle or sample needle can both abluent clean, thorough after using each time.
In a further improvement, the reagent container comprises a reagent rack and a plurality of reagent boxes detachably arranged at the upper end of the reagent rack; the reagent rack is characterized in that a bottom plate of the box body is provided with a first positioning protruding strip extending along the front-back direction of the box body, and the lower end of the reagent rack is provided with a first positioning sliding groove in sliding fit with the first positioning protruding strip. In the above-mentioned improvement structure, carry on spacingly through the cooperation of corresponding location sand grip and location spout structure between the bottom plate of reagent frame and box, simple structure, it is spacing stable, convenient.
In another improvement, the sample container and the mixing container have the same structure, and both comprise a strip-shaped fixing frame, and the fixing frame is provided with a plurality of test tube hole sites which are distributed along the length direction of the fixing frame and used for inserting sample test tubes or mixing test tubes; the bottom plate of the box body is provided with a plurality of second positioning convex strips extending along the front-back direction of the box body, and the lower end of each fixing frame is provided with a second positioning sliding groove in sliding fit with the second positioning convex strips. In the above-mentioned improved structure, carry on spacingly through the cooperation of corresponding location sand grip and location spout structure between the bottom plate of mount and box, simple structure, it is spacing stable, convenient.
And in the improved structure, the positions of the rear side wall of the inner cavity of the box body, which correspond to the working area, are respectively provided with a first magnetic attraction piece, and the rear side walls of the reagent rack and each fixing rack are respectively provided with a second magnetic attraction piece corresponding to each first magnetic attraction piece. Among the above-mentioned improvement structure, when reagent frame or mount from the window position along the location sand grip that corresponds slide to the settlement position, inhale the absorption location of piece through first magnetism and inhale with the second magnetism, further guarantee reagent frame or mount and place accuracy and stability of position.
Drawings
Fig. 1 is a schematic perspective view of a pipetting workstation of the present invention;
fig. 2 is a schematic structural view of the pipetting workstation of the present invention after removing the box body;
FIG. 3 is a schematic view of another angle structure of the pipetting station after removing the box body;
fig. 4 is another schematic structural view of the pipetting workstation after removing the box body;
fig. 5 is a schematic structural diagram of a sample arm mechanism in the present invention;
fig. 6 is a schematic structural diagram of a first driving assembly in the present invention;
FIG. 7 is a schematic structural view of a reagent arm mechanism of the present invention;
fig. 8 is a schematic perspective view of a cleaning seat according to the present invention;
FIG. 9 is a cross-sectional view of a cleaning seat in accordance with the present invention;
fig. 10 is a schematic structural view of the present invention when the working area is empty;
fig. 11 is a schematic structural view of the reagent rack and the fixing frame in the middle working area.
Description of the reference numerals:
1. a box body; 1.1, a window; 2. a reagent needle; 3. a reagent sucking and spitting module; 4. a sample needle; 5. a sample sucking and spitting module; 6. a liquid supply assembly; 7. cleaning the assembly; 8. a waste discharge assembly; 9. a support beam; 10. mounting a plate; 11. a slider; 12. a drive motor; 13. a driving wheel; 14. a driven wheel; 15. a belt; 16. a front fixed beam; 16.1, a guide chute; 17. a rear fixed beam; 18. cleaning a seat; 19. a cleaning chamber; 19.1, a liquid inlet cavity; 19.2, a liquid discharge cavity; 20. a communicating groove; 21. a reagent rack; 21.1, a first positioning chute; 22. a kit; 23. a first positioning convex strip; 24. a fixed mount; 24.1, test tube hole site; 24.2, a second positioning chute; 25. a second positioning convex strip; 26. a first magnetic attraction member; 27. a control screen; 28. an external cleaning pump; 29. a tact switch; 30. a water storage tank; 31. and a code scanner.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention more comprehensible, embodiments accompanied with figures are described in detail below.
In the description of the present invention, it should be noted that the terms "front, back", "left, right", "up and down", "X-axis direction", "Y-axis direction", "Z-axis direction", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the term "connected" is to be interpreted broadly, for example, as a fixed connection, a detachable connection, or an integral connection; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood as a specific case by those skilled in the art.
As shown in fig. 1 and 2, the utility model provides a liquid transfer workstation, which comprises a box body 1 with a rectangular structure, wherein a working area is arranged in the middle of the bottom plate of the inner cavity of the box body 1, a reagent container, a sample container and a mixing container are placed in the working area, and a window 1.1 is arranged on the front side wall of the box body 1 and used for taking and placing the reagent container, the sample container and the mixing container; an operator can manually take, place and replace the reagent container, the sample container and the mixing container from the 1.1 position of the window; in addition, the inner cavity of the box body 1 is also provided with
The reagent arm mechanism comprises a reagent needle 2, a first driving mechanism and a reagent sucking and spitting module 3, wherein the first driving mechanism is used for driving the reagent needle 2 to linearly move along three axes XYZ, and under the driving action of the reagent sucking and spitting module 3, the reagent needle 2 is used for automatically transferring the reagent in the reagent container to the corresponding mixing container;
the sample arm mechanism comprises a sample needle 4, a second driving mechanism and a sample sucking and spitting module 5, wherein the second driving mechanism is used for driving the sample needle 4 to linearly move along three X, Y and Z axes, and the sample sucking and spitting module 5 is used for driving the sample needle 4 to automatically transfer the sample in the sample container to the corresponding mixing container;
the reagent needle cleaning mechanism is used for cleaning the outer wall of the reagent needle 2;
the sample needle cleaning mechanism is used for cleaning the outer wall of the sample needle 4;
the liquid path mechanism is respectively communicated with the inner cavities of the reagent needle 2 and the sample needle 4 and is used for cleaning the inner walls of the reagent needle 2 and the sample needle 4; the liquid path mechanism is also used for providing outer wall cleaning liquid for the reagent needle cleaning mechanism and the sample needle cleaning mechanism; the liquid supply system supplies liquid to the corresponding inner wall cleaning assembly and outer wall cleaning assembly, so that a liquid path mechanism is effectively simplified, the installation is convenient, and the cost is reduced;
on the other hand, in order to facilitate the operation of the whole workstation, a control panel 27 is further disposed on the box body 1, and the control panel 27 is electrically connected to the reagent arm mechanism, the sample arm mechanism, the reagent needle cleaning mechanism, the sample needle cleaning mechanism, and the liquid path mechanism. In this structure, control the screen 27 inner wall and all be connected with this master controller electricity from taking corresponding master controller, each actuating mechanism's drive element, the operation that the operator just should control screen 27 through the touch and can easily realize each actuating mechanism promptly, and is very convenient to make whole move liquid workstation's appearance neat more, pleasing to the eye.
Specifically, in the present embodiment, the liquid path mechanism includes a liquid supply assembly 6, a cleaning assembly 7 and a waste discharge assembly 8, one end of the liquid supply assembly 6 is connected to a water source, and the other end is communicated with the reagent sucking and discharging module 3 and the sample sucking and discharging module 5; the reagent sucking and spitting module 3 or the sample sucking and spitting module 5 is used for driving a water source to be discharged from the reagent needle 2 or the sample needle 4 so as to clean the inner wall of the reagent needle 2 or the sample needle 4; in this configuration, the reagent suction and discharge module 3 and the sample suction and discharge module 5 are used for controlling the suction, discharge and transfer of the reagent and the sample by the reagent needle 2 and the sample needle 4, in addition to the cleaning of the inner walls of the reagent needle 2 and the sample needle 4 by the water source pumping. Specifically, the reagent sucking and spitting module 3 and the sample sucking and spitting module 5 in this embodiment each include a plunger pump, a valve, and a connecting pipeline, and the pressure change in the reagent needle 2 or the sample needle 4 is controlled by the combination of the plunger pump and the valve to realize the suction and spitting of liquid, that is, the reagent in the reagent container or the sample in the sample container is sucked into the inner cavity of the needle tube, and the reagent or the sample is spitted after being transferred to the mixing container; in addition, the structure can also play a role in mixing and stirring the sample and the reagent under the reciprocating sucking and spitting action of the reagent sucking and spitting module 3 or the sample sucking and spitting module 5.
The cleaning assembly 7 is used for delivering a water source to the reagent needle cleaning mechanism or the sample needle cleaning mechanism to clean the outer wall of the reagent needle 2 or the sample needle 4; specifically, supply liquid subassembly 6, washing subassembly 7 and water source to carry out switching control through the three-way valve to external water source can be no water pressure source also can be pressure water source, when putting through pressure water source, in order to guarantee the pressure stability of system, need with it through corresponding solenoid valve and miniature water storage tank 30 step-down back, reconnection to three-way valve prevents that the too high system performance of causing of water pressure is unstable.
In this embodiment, the cleaning assembly 7 further comprises an external cleaning pump 28 capable of continuously pumping a source of clean water to the needle cleaning mechanism or the sample needle cleaning mechanism; specifically, one end of the cleaning component 7 is connected with one interface of the three-way valve, and the other end of the cleaning component 7 is communicated to the agent needle cleaning mechanism or the sample needle cleaning mechanism; when reagent needle 2 or sample needle 4 is moved to the reagent needle washing mechanism or sample needle washing mechanism for the washing operation, washing of the outer wall of reagent needle 2 or sample needle 4 is effected by the external washing pump 28.
One end of the liquid supply assembly 6 is connected with the other interface of the three-way valve, the other end of the liquid supply assembly 6 is communicated to the reagent sucking and spitting module 3 or the sample sucking and spitting module 5, and when the reagent needle 2 or the sample needle 4 realizes the liquid transfer function, a water source does not feed water into the reagent needle 2 or the sample needle 4; the matching of a plunger pump and a corresponding valve realizes that the reagent needle 2 transfers the reagent in the reagent container to the mixing container in a sucking and spitting way, and the sample needle 4 transfers the sample in the sample container to the mixing container in a sucking and spitting way; when the reagent needle 2 or the sample needle 4 is completely pipetted and then moved to the reagent needle cleaning mechanism or the sample needle cleaning mechanism for cleaning operation, the clean water at the water source end is discharged from the reagent needle 2 or the sample needle 4, so that the inner wall of the reagent needle 2 or the sample needle 4 is cleaned by the discharged clean water.
On the other hand, in the above structure, one end of the waste discharge assembly 8 is communicated with the reagent needle cleaning mechanism or the sample needle cleaning mechanism, and the other end is communicated to a waste liquid box (not shown in the figure) for realizing the recovery of the cleaning waste liquid and realizing the cycle operation of the whole cleaning process, pure cleaning water is supplied from a water source end, the cleaned waste liquid is discharged and recovered to the waste liquid box, and the reagent needle 2 or the sample needle 4 can be cleaned and thoroughly after each pipetting.
In the structure, the cleaning component 7 for cleaning the outer walls of the reagent needle 2 and the sample needle 4 and the liquid supply component 6 for cleaning the inner wall are communicated with the same water source through corresponding three-way valve structures, so that the liquid path of the system is effectively simplified; the outer wall cleaning and the inner wall cleaning of the reagent needle 2 and the sample needle 4 can be carried out by adopting a set of water source system, the water supply system has simple structure, and the operation and the control are convenient.
As shown in fig. 3, 8 and 9, the reagent needle cleaning mechanism and the sample needle cleaning mechanism in this embodiment have the same structure, and each of them includes a cleaning seat 18 mounted on the bottom plate of the case 1, and a cleaning cavity 19 with an upper opening is provided at the upper end of the cleaning seat 18 for the reagent needle 2 and the sample needle 4 to extend into and clean, respectively; and the cleaning cavity 19 is communicated with the cleaning assembly 7, and clean water is continuously pumped into the cleaning cavity 19 under the action of the external cleaning pump 28, so that the cleaning of the outer walls of the reagent needle 2 and the sample needle 4 is realized. More specifically, in the present embodiment, the cleaning cavity 19 includes a liquid inlet cavity 19.1 and a liquid outlet cavity 19.2, the bottom of the liquid inlet cavity 19.1 is communicated with the cleaning assembly 7, and the bottom of the liquid outlet cavity 19.2 is communicated with the waste discharge assembly 8; and the upper ends of the liquid inlet cavity 19.1 and the liquid outlet cavity 19.2 are provided with a communicating groove 20; when the reagent needle 2 or the sample needle 4 extends into the liquid inlet cavity 19.1, the cleaning component 7 supplies liquid into the liquid inlet cavity 19.1 to wash the outer wall of the reagent needle 2 or the sample needle 4, the washed waste liquid enters the liquid discharge cavity 19.2 from the communicating groove 20, and under the action of the waste discharge component 8, the waste liquid in the liquid discharge cavity 19.2 is transferred to a waste liquid box for temporary storage, so that the reagent needle 2 or the sample needle 4 can be cleaned completely each time. In this configuration, the waste discharge assembly 8 also includes a corresponding pump assembly for facilitating the flow of waste fluid from the fluid discharge chamber 19.2 into the waste fluid box.
In addition, in the embodiment, in order to realize the rapid sucking, spitting and transferring of the reagent, four reagent needles 2 arranged side by side are arranged in the reagent arm mechanism, so that the reagent arm mechanism can be used for simultaneously sucking a plurality of liquid surfaces with the same height, and the transferring efficiency of the reagent is improved; correspondingly, the sample arm mechanism in this embodiment adopts a single-needle mechanism for realizing independent and sequential aspiration and discharge of sample tubes with different liquid amounts, and the operations of the multi-needle reagent arm mechanism and the single-needle sample arm mechanism are independently controlled, wherein the aspiration and discharge actions of the reagent needle 2 and the sample needle 4 are also independently controlled by the corresponding reagent aspiration and discharge module 3 and the sample aspiration and discharge module 5, and each aspiration and discharge module can also select different accuracies and aspiration and discharge levels according to requirements to achieve the best matching and realize accurate aspiration and discharge control.
As shown in fig. 2 and 3, the specific structures of the first driving mechanism and the second driving mechanism are also substantially the same, and they both include a supporting beam 9 extending horizontally along the Y-axis direction, which is disposed above the working area and is slidable along the X-axis direction (left-right direction) of the box body, and a first driving assembly for driving the supporting beam 9 to move horizontally along the X-axis direction is mounted on the box body 1; the supporting beam 9 is provided with a mounting plate 10 which can slide along the Y-axis direction and a second driving component for driving the mounting plate 10 to slide; a sliding block 11 which can slide along the Z axis and a third driving assembly for driving the sliding block 11 to vertically slide are arranged on the mounting plate 10; the reagent needle 2 or the sample needle 4 is connected to the corresponding slider 11, and the reagent aspirating and discharging module 3 and the sample aspirating and discharging module 5 are connected to the case 1.
More specifically, as shown in fig. 5, 6 and 7, the first driving assembly, the second driving assembly and the third driving assembly are also the same in structure and are all synchronous belt driving structures, and each of them includes a driving motor 12, a driving wheel 13, a driven wheel 14 and a belt 15, and the belt 15 is installed outside the driving wheel 13 and the driven wheel 14 in a tensioned manner, and an output shaft of the driving motor 12 is connected with a central shaft of the driving wheel 13; the reciprocating operation of the belt 15 can be driven by the bidirectional rotation of the driving motor 12; in addition, one end of the support beam 9 or the mounting plate 10 or the slider 11 is attached to the respective belt 15. That is, the two support beams 9 can move left and right along the X-axis direction by the driving of the two corresponding driving motors 12, the mounting plate 10 can move up and down and back and forth along the Y-axis direction by the driving of the corresponding driving motors 12, and the slider 11 can move up and down along the Z-axis direction by the driving of the corresponding driving motors 12, so that the linear movement of the reagent needle 2 and the sample needle 4 in the XYZ-axis direction is finally realized, and the flexible transfer of the reagent or the sample between different containers is realized.
On the other hand, the upper ends of the front side and the rear side of the inner cavity of the box body 1 are respectively provided with a front fixed beam 16 and a rear fixed beam 17 which horizontally extend along the X-axis direction (left-right direction), wherein the first driving assembly is arranged on the rear fixed beam 17, the rear end of the supporting beam 9 is connected with a belt 15 of the first driving assembly, and the front end of the supporting beam 9 is connected with the front fixed beam 16 in a sliding manner, so that the supporting beam 9 can stably move in the left-right direction of the box body 1. More specifically, in this embodiment, a guide slide rail extending along the length direction of the rear fixed beam 17 is further provided on the rear fixed beam, and the rear end of the support beam 9 is slidably fitted on the guide slide rail through the guide slide block; and set up the direction spout 16.1 that extends along its length direction at preceding fixed beam 16 upper end, at the front end of a supporting beam 9 through corresponding gyro wheel roll cooperation in direction spout 16.1 to realize under the drive effect of first drive assembly, a supporting beam 9 can be along the X axle direction (left and right sides direction) of box 1 steady and smooth round trip movement.
Similarly, in the above structure, the slide block 11 and the mounting plate 10 are also slidably connected through a linear guide rail mechanism, so that the slide block 11 is ensured to move smoothly and stably along the Z-axis direction under the action of the corresponding driving motor 12, and the smooth and stable pipetting process is ensured.
Further, as shown in fig. 10 and 11, the reagent vessel in this embodiment includes an elongated reagent rack 21 and a plurality of reagent cartridges 22 detachably attached to the upper end of the reagent rack 21, the reagent cartridges 22 containing standard reagents; the bottom plate of the box body 1 is provided with a first positioning convex strip 23 extending along the front-back direction, and the lower end of the reagent rack 21 is provided with a first positioning sliding groove 21.1 in sliding fit with the first positioning convex strip 23.
The sample container and the mixing container have the same structure, and both comprise a strip-shaped fixing frame 24, and a plurality of test tube hole sites 24.1 which are distributed along the length direction of the fixing frame 24 and used for inserting sample test tubes or mixing test tubes are arranged on the fixing frame; similarly, a plurality of second positioning protruding strips 25 extending in the front-rear direction of the bottom plate of the box body 1 are provided, and a second positioning sliding groove 24.2 in sliding fit with the second positioning protruding strips 25 is provided at the lower end of each fixing frame 24. As shown in fig. 11, three holders 24 are provided on the right side of the working area, in practical applications, one holder 24 on the far right side is used for inserting sample tubes containing samples, and the other two holders 24 are used for inserting empty tubes, that is, mixing tubes, and the reagent in the reagent kit 22 is transferred to the corresponding mixing tube through the reagent arm mechanism, and simultaneously the sample in the sample tube is transferred to the corresponding mixing tube through the sample arm mechanism, so that the reagent and the sample are mixed by pipetting.
In the above structure, in order to ensure the stability of the reagent rack 21 and the fixing rack 24 in the positioning of the working area, in this embodiment, the positions corresponding to the working area on the rear sidewall of the inner cavity of the box body 1 are respectively provided with the first magnetic attraction pieces 26, and the rear sidewalls of the reagent rack 21 and the fixing racks 24 are respectively provided with the second magnetic attraction pieces corresponding to the first magnetic attraction pieces 26. After setting up like this, when reagent frame 21 or mount 24 along window 1.1 propelling movement backward to the settlement position, the second is inhaled the piece and is inhaled piece 26 with first magnetism and adsorb the location, guarantees the stability of kit 22 and sample test tube, mixed test tube position.
As shown in fig. 10, in this embodiment, a plurality of tact switches 29 corresponding to the reagent rack 21 and the fixing rack 24 are further disposed on the rear side wall of the inner cavity of the box body 1 at positions corresponding to the working area, and each tact switch 29 is in signal connection with the control panel 27, when the reagent rack 21 or the fixing rack 24 is mounted to the tact switch 29, the control panel 27 can receive corresponding signals, and the control panel 27 displays readiness information, so as to prevent an operator from performing misoperation when the reagent rack 21 or the fixing rack 24 is not mounted.
In addition, as shown in fig. 1 and 2, a code scanner 31 is further installed on the bottom plate of the inner cavity of the box body 1 near the window 1.1 for scanning and identifying the sample information on the fixing frame 24, so as to ensure that no error occurs in the pipetting process.
Although the present disclosure has been described above, the scope of the present disclosure is not limited thereto. Those skilled in the art can make various changes and modifications without departing from the spirit and scope of the present disclosure, and such changes and modifications will fall within the scope of the present invention.

Claims (10)

1. A pipetting station, comprising: the device comprises a box body (1), wherein a working area is arranged in the box body (1), a reagent container, a sample container and a mixing container are placed in the working area, and a window (1.1) for the reagent container, the sample container and the mixing container to enter and exit is formed in the side wall of the box body (1); the box body (1) is also internally provided with
The reagent arm mechanism comprises a reagent needle (2), a first driving mechanism and a reagent sucking and spitting module (3), wherein the first driving mechanism is used for driving the reagent needle (2) to linearly move along three X, Y and Z axes, and the reagent sucking and spitting module (3) is used for driving the reagent needle (2) to automatically transfer the reagent in the reagent container into the mixing container;
a sample arm mechanism comprising a sample needle (4), a second driving mechanism and a sample sucking and spitting module (5), wherein the second driving mechanism is used for driving the sample needle (4) to linearly move along three X, Y and Z axes, and the sample sucking and spitting module (5) is used for driving the sample needle (4) to automatically transfer the sample in the sample container into the mixing container;
the reagent needle cleaning mechanism is used for cleaning the outer wall of the reagent needle (2);
a sample needle cleaning mechanism for cleaning the outer wall of the sample needle (4);
the liquid path mechanism is respectively communicated with the inner cavities of the reagent needle (2) and the sample needle (4) and is used for cleaning the inner walls of the reagent needle (2) and the sample needle (4); the liquid path mechanism is also used for providing outer wall cleaning liquid for the reagent needle cleaning mechanism and the sample needle cleaning mechanism;
the box body (1) is further provided with a control screen (27), and the control screen (27) is electrically connected with the reagent arm mechanism, the sample arm mechanism, the reagent needle cleaning mechanism, the sample needle cleaning mechanism and the liquid path mechanism.
2. Pipetting station according to claim 1, characterized in that: the liquid path mechanism comprises a liquid supply assembly (6), a cleaning assembly (7) and a waste discharge assembly (8), one end of the liquid supply assembly (6) is connected with a water source, and the other end of the liquid supply assembly is communicated with the reagent sucking and spitting module (3) and the sample sucking and spitting module (5); the reagent sucking and spitting module (3) or the sample sucking and spitting module (5) is used for driving the water source to be discharged from the reagent needle (2) or the sample needle (4) so as to clean the inner wall of the reagent needle (2) or the sample needle (4); the cleaning assembly (7) is used for conveying a water source to the reagent needle cleaning mechanism or the sample needle cleaning mechanism so as to clean the outer wall of the reagent needle (2) or the sample needle (4); one end of the waste discharge assembly (8) is communicated with the reagent needle cleaning mechanism or the sample needle cleaning mechanism, and the other end of the waste discharge assembly is communicated to the waste liquid box for realizing the recovery of the cleaning waste liquid.
3. Pipetting station according to claim 1 or 2, characterized in that: the first driving mechanism and the second driving mechanism are identical in structure and respectively comprise a supporting beam (9) which horizontally extends along the Y-axis direction, is arranged above the working area and can slide along the X-axis direction of the box body, and a first driving assembly for driving the supporting beam (9) to horizontally move along the X-axis direction is mounted on the box body (1); the supporting beam (9) is provided with a mounting plate (10) capable of sliding along the Y-axis direction and a second driving assembly for driving the mounting plate (10) to slide; a sliding block (11) capable of sliding along the Z axis and a third driving assembly for driving the sliding block (11) to slide are arranged on the mounting plate (10); the reagent needle (2) or the sample needle (4) is connected to the corresponding sliding block (11), and the reagent sucking and spitting module (3) and the sample sucking and spitting module (5) are connected to the box body (1).
4. A pipetting station as recited in claim 3 wherein: the first driving assembly, the second driving assembly and the third driving assembly respectively comprise a driving motor (12), a driving wheel (13), a driven wheel (14) and a belt (15), the belt (15) is tightly assembled outside the driving wheel (13) and the driven wheel (14), and an output shaft of the driving motor (12) is connected with a central shaft of the driving wheel (13); one end of the supporting beam (9) or the mounting plate (10) or the sliding block (11) is connected to the belt (15).
5. Pipetting station according to claim 4, characterized in that: the upper end of both sides is equipped with respectively around box (1) inner chamber preceding fixed beam (16) and the back fixed beam (17) of extending along X axle direction level, first drive assembly sets up on back fixed beam (17), the rear end of a supporting beam (9) with first drive assembly's belt (15) are connected, the front end of a supporting beam (9) with preceding fixed beam (16) sliding connection.
6. Pipetting station according to claim 2, characterized in that: the reagent needle cleaning mechanism and the sample needle cleaning mechanism are identical in structure and comprise cleaning seats (18) arranged on a bottom plate of the box body (1), cleaning cavities (19) with openings in the upper portions are formed in the cleaning seats (18), and the cleaning cavities (19) are communicated with the cleaning assembly (7).
7. Pipetting station according to claim 6, characterized in that: the cleaning cavity (19) comprises a liquid inlet cavity (19.1) and a liquid outlet cavity (19.2), the bottom of the liquid inlet cavity (19.1) is communicated with the cleaning component (7), and the bottom of the liquid outlet cavity (19.2) is communicated with the waste discharge component (8); and the upper ends of the liquid inlet cavity (19.1) and the liquid outlet cavity (19.2) are provided with a communicating groove (20); when the reagent needle (2) or the sample needle (4) extends into the liquid inlet cavity (19.1), the cleaning assembly (7) supplies liquid into the liquid inlet cavity (19.1) for washing the outer wall of the reagent needle (2) or the sample needle (4).
8. Pipetting station according to any one of claims 1 to 2 or 4 to 7, characterized in that: the reagent container comprises a reagent rack (21) and a plurality of reagent boxes (22) which are detachably arranged at the upper end of the reagent rack (21); the reagent box is characterized in that a first positioning protruding strip (23) extending along the front-back direction of the box body (1) is arranged on a bottom plate of the box body, and a first positioning sliding groove (21.1) in sliding fit with the first positioning protruding strip (23) is formed in the lower end of the reagent frame (21).
9. Pipetting station according to claim 8, characterized in that: the sample container and the mixing container have the same structure, and both comprise a strip-shaped fixing frame (24), wherein the fixing frame (24) is provided with a plurality of test tube hole sites (24.1) which are distributed along the length direction and used for inserting sample test tubes or mixing test tubes; the bottom plate of the box body (1) is provided with a plurality of second positioning convex strips (25) extending along the front-back direction of the box body, and the lower end of each fixing frame (24) is provided with a second positioning sliding groove (24.2) in sliding fit with the second positioning convex strips (25).
10. Pipetting station according to claim 9, characterized in that: the rear side wall of the inner cavity of the box body (1) is provided with first magnetic attraction pieces (26) at positions corresponding to the working area, and the reagent rack (21) and the rear side wall of each fixing rack (24) are provided with second magnetic attraction pieces corresponding to the first magnetic attraction pieces (26).
CN202220832213.0U 2022-04-12 2022-04-12 Liquid transfer workstation Active CN218223878U (en)

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Application Number Priority Date Filing Date Title
CN202220832213.0U CN218223878U (en) 2022-04-12 2022-04-12 Liquid transfer workstation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202220832213.0U CN218223878U (en) 2022-04-12 2022-04-12 Liquid transfer workstation

Publications (1)

Publication Number Publication Date
CN218223878U true CN218223878U (en) 2023-01-06

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