CN215910503U - Blood sample analyzer - Google Patents

Abstract

A blood sample analyzer relates to the technical field of blood coagulation analyzers, and adopts the technical scheme that the blood sample analyzer comprises a main body frame, a detection module, a reagent cooling disc, a reaction cup incubation disc, a sample frame conveying module, a sampling and sample adding module, an emergency treatment module and a reaction cup conveying module, wherein the reaction cup incubation disc is arranged around the outer side of the reagent cooling disc and is rotatably connected with the main body frame; the detection module, the sample frame conveying module, the emergency treatment module and the reaction cup conveying module are distributed on the main body frame around the reaction cup incubation disc; the sampling and sample adding module comprises a first sample adding device, a second sample adding device and a third sample adding device. The utility model optimizes the layout, ensures that the installation positions of all modules are orderly and clear, not only facilitates the installation, maintenance and upgrade of the instrument, but also reduces the overall size and weight of the instrument.

Description

Blood sample analyzer

Technical Field

The utility model relates to the technical field of blood coagulation analyzers, in particular to a blood sample analyzer.

Background

Three-dimensional motion of present full-automatic blood coagulation analysis appearance inner space does not realize independent motion module, has increased the instrument and has upgraded the optimization degree of difficulty and the maintenance degree of difficulty, for example the utility model patent application of patent application number 201810762104.4 discloses full-automatic blood coagulation analysis appearance and application method, its needle motion module setting that is used for the sampling application of sample is on main inner chamber upper portion, occupation space is great, it is reasonable inadequately still to have inner module overall arrangement design simultaneously, the loaded down with trivial details problem of subregion, the whole size and the weight that lead to the instrument are great, succinct inadequately.

SUMMERY OF THE UTILITY MODEL

The utility model provides a blood sample analyzer, aiming at the problems that a three-dimensional movement mechanism in the prior art occupies a large space and is difficult to maintain and upgrade, and the instrument size is large due to unreasonable layout of all modules in a blood coagulation analyzer.

The utility model provides the following technical scheme: a blood sample analyzer comprises a main body frame, a detection module, a reagent cooling disc, a reaction cup incubation disc, a sample frame conveying module, a sampling and sample adding module, an emergency call module and a reaction cup conveying module, wherein the reagent cooling disc is provided with a reagent position for placing a reagent, the reaction cup incubation disc is provided with a reaction cup position for placing a reaction cup, and the reaction cup incubation disc is arranged around the outer side of the reagent cooling disc and is rotatably connected with the main body frame; the detection module, the sample frame conveying module, the emergency treatment module and the reaction cup conveying module are distributed on the main body frame around the reaction cup incubation disc; the sampling and sample-adding module comprises a first sample-adding device, a second sample-adding device and a third sample-adding device which are distributed around the reaction cup incubation disc and detachably connected to the main body rack, and the first sample-adding device, the second sample-adding device and the third sample-adding device respectively comprise a needle tube, a rotary driving device and an up-and-down driving device, wherein the rotary driving device is used for driving the needle tube and enabling the projection of the moving track of the needle tube on the horizontal plane to be circular, and the up-and-down driving device is used for driving the needle tube to reciprocate up and down; the moving track of the needle tube of the first sample adding device covers the sample rack conveying module, the emergency treatment module, the reaction cup incubation disc and the reagent refrigerating disc; the moving track of the needle tube of the second sample adding device covers the reagent refrigerating disc and the reaction cup conveying module; the moving track of the needle tube of the third sample adding device covers the reaction cup incubation disc and the reagent cooling disc.

Preferably, the main body frame is further provided with a cup dividing and diluting module and a starting reagent adding module, the cup dividing and diluting module comprises at least 2 cup dividing and diluting positions for placing reaction cups, and the starting reagent adding module comprises at least 1 starting reagent adding position for placing reaction cups; the moving track of the needle tube of the first sample adding device also covers a plurality of cup separating dilution positions; the moving track of the needle tube of the third sample adding device also covers the sample adding starting reagent position.

Preferably, the detection module includes a magnetic bead detection device and an optical detection device, the optical detection device is provided with an optical detection position, and the magnetic bead detection device is provided with a plurality of magnetic bead detection positions arranged in an arc shape; the sampling and sample adding module further comprises a fourth sample adding device with the same structure as the first sample adding device, and the moving track of the needle tube of the fourth sample adding device covers the reaction cup incubation disc, the reagent cooling disc, the sample adding starting reagent position and the plurality of magnetic bead detection positions.

Preferably, still be provided with the first rim of a cup of abandoning and abandon the rim of a cup with the second in the main part frame, the first rim of a cup of abandoning sets up divide near cup dilution position, the rim of a cup setting is abandoned to the second between magnetic bead detection device and the optical detection device, the first, second is abandoned the rim of a cup and all is connected with and abandons a cup pipe, it is provided with the waste material bucket to abandon a cup pipe bottom.

Preferably, the first, second, third and fourth sample adding devices comprise spline shafts and supporting arms for connecting the spline shafts and the needle tubes; the rotation driving device comprises a first driven wheel in clearance fit with the spline shaft, a first driving wheel in transmission connection with the first driven wheel through a first synchronous belt, and a first motor for driving the first driving wheel to rotate; the upper and lower driving device comprises a bearing, the bearing is in interference fit with the spline shaft and is far away from one end of the supporting arm, the bearing is connected with a sliding block, the sliding block is connected with a sliding rail in a sliding mode, and the sliding block is further provided with a first linear module for driving the sliding block to slide along the sliding rail in a reciprocating mode.

Preferably, still include the pump station module, the pump station module is including setting up cleaning solution bottle, waste liquid bucket in the main part frame, set up respectively in the needle tubing of the removal orbit coverage of the needle tubing of first, second, third, fourth application of sample device wash the position and respectively with the cleaning pump of the needle tubing connection of first, second, third, fourth application of sample device, the cleaning pump through first input pipeline with the cleaning solution bottle is connected, be provided with a plurality of washing nozzles on the needle tubing washs the position lateral wall, the cleaning solution bottle is connected to through second input pipeline washing nozzle, needle tubing washs the position bottom and is connected to through output pipeline waste liquid bucket, first input pipeline, second input pipeline, output pipeline all are provided with the valve, be provided with the transfer pump on the second input pipeline.

Preferably, the reaction cup conveying module comprises a reaction cup input track, a first cup grabbing device for transferring the reaction cup from the reaction cup input track to the cup dividing dilution position or the reaction cup incubation tray, and a second cup grabbing device for transferring the reaction cup from the reaction cup incubation tray to the reagent adding position or the detection module; the moving track of the needle tube of the second sample adding device covers the input track of the reaction cup; the first cup grabbing device and the second cup grabbing device comprise a three-axis manipulator arranged on the main body rack and a reaction cup gripper arranged at the tail end of the three-axis manipulator.

Preferably, the reaction cup incubation disc and the vicinity of the reagent adding and starting module are provided with a blending device, and the blending device comprises two shaft mechanical arms arranged on the main body rack and a blending head arranged at the tail ends of the two shaft mechanical arms.

Preferably, the sample rack conveying module comprises a sample feeding track, a connecting track, a sample discharging track and a retesting track which surround the reaction cup incubation disc and are connected in sequence, the retesting track is connected to the sample feeding track, and the moving track of the needle tube of the first sample adding device covers the connecting track; advance between appearance track and the connection track go out the appearance track with all be provided with first transfer device between the retest track, between connection track and the play appearance track the retest track all is provided with the second transfer device with advancing between the appearance track.

Preferably, the emergency treatment module comprises an emergency treatment synchronous belt conveyor, and third limiting plates are arranged on two sides of the emergency treatment synchronous belt conveyor; the emergency treatment module is provided with an emergency treatment sample sampling position, and the moving track of the needle tube of the first sample adding device also covers the emergency treatment sample sampling position.

The utility model has the beneficial effects that: redesigned the overall arrangement of inside each module, coiled around reagent refrigeration dish outside with reaction cup incubation, reduced occupation space between them, and disassemble sampling application of sample module into a plurality of independent and dispersed application of sample devices, install according to the function difference in suitable position, on this basis, optimize the overall arrangement of other modules, make the mounted position of each module orderly and clearly, not only made things convenient for the installation, the maintenance and the upgrading of instrument, reduced the overall size and the weight of instrument moreover.

Drawings

FIG. 1 is a top view I of one embodiment of the present invention.

FIG. 2 is a top view II of one embodiment of the present invention.

FIG. 3 is a top view III of one embodiment of the present invention.

Fig. 4 is a schematic three-dimensional view i of an embodiment of the present invention.

FIG. 5 is a schematic three-dimensional diagram II of an embodiment of the present invention.

Fig. 6 is an enlarged view of a portion D of fig. 5.

Fig. 7 is an enlarged view of a portion C of fig. 4.

Fig. 8 is an enlarged view of a portion a of fig. 3.

Fig. 9 is an enlarged view of a portion B of fig. 3.

Reference numerals: 1-a main body frame, 11-a cup dividing dilution position, 12-a starting reagent adding position, 13-a first abandoned cup opening, 14-a second abandoned cup opening, 15-a abandoned cup guide pipe, 16-a waste barrel and 17-a blending device;

2-a detection module, 21-a magnetic bead detection device, 211-a magnetic bead detection position, 22-an optical detection device, 221-an optical detection position, and 222-a light source assembly;

3-reagent cooling disc, 31-reagent site;

4-reaction cup incubation plate, 41-reaction cup position;

5-a sample rack conveying module, 51-a sample feeding track, 511-a bottom plate, 512-a first limiting plate, 513-a crossbeam, 515-a base, 516-a pushing plate, 5161-a first arc, 5162-a second arc, 517-a first limiting plate, 518-a second limiting plate, 52-a connecting track, 521-a synchronous belt conveyor, 522-a second limiting plate, 523-a bar code scanning port, 524-a scanner, 525-a sampling position, 53-a sample discharging track, 54-a retest track, 55-a first transfer device, 551-a screw rod, 552-a pushing block, 56-a second transfer device, 561-a telescopic rod and 57-an online track;

6-sampling sample adding module, 61-first sample adding device, 611-needle tube, 612-spline shaft, 613-supporting arm, 614-first driven wheel, 615-first synchronous belt, 616-first driving wheel, 617-bearing, 618-sliding block, 62-second sample adding device, 63-third sample adding device and 64-fourth sample adding device;

7-an emergency treatment module, 71-an emergency treatment synchronous belt conveyor, 72-a third limiting plate, and 73-an emergency treatment sample sampling position;

8-a reaction cup conveying module, 81-a reaction cup input track, 811-a reaction cup guide rail, 812-a cup conveying trolley, 813-a cup conveying slide rail, 814-a third linear module, 815-a reaction cup taking position, 816-a buffer reagent adding position, 82-a first cup grabbing device, 821-a three-axis manipulator, 822-a reaction cup grabbing hand and 83-a second cup grabbing device;

9-pump station module, 91-waste liquid barrel, 92-needle tube cleaning position.

Detailed Description

The embodiments of the present invention will be described in more detail with reference to the accompanying drawings and reference numerals, so that those skilled in the art can implement the embodiments of the present invention after studying the specification. It should be understood that the specific embodiments described herein are merely illustrative of the utility model and are not intended to limit the utility model.

The utility model provides a blood sample analyzer shown in figure 1, which comprises a main body frame 1, a detection module 2, a reagent cooling disc 3, a reaction cup incubation disc 4, a sample frame conveying module 5, a sampling and sample adding module 6, an emergency treatment module 7 and a reaction cup conveying module 8, wherein the reagent cooling disc 3 is provided with a reagent position 31 for placing a reagent, the reaction cup incubation disc 4 is provided with a reaction cup position 41 for placing a reaction cup, and the reaction cup incubation disc 4 is arranged around the outer side of the reagent cooling disc 3 and is rotatably connected with the main body frame 1; the detection module 2, the sample rack conveying module 5, the emergency treatment module 7 and the reaction cup conveying module 8 are distributed on the main body frame 1 around the reaction cup incubation tray 4; the sampling and sample-adding module 6 comprises a first sample-adding device 61, a second sample-adding device 62 and a third sample-adding device 63 which are distributed around the reaction cup incubation disc 4 and detachably connected to the main body frame 1, wherein each of the first, second and third sample-adding devices comprises a needle tube 611, a rotary driving device for driving the needle tube 611 and enabling the projection of the moving track of the needle tube on the horizontal plane to be circular, and an up-and-down driving device for driving the needle tube to reciprocate up and down; the movement track of the needle tube of the first sample adding device 61 covers the sample rack conveying module 5, the emergency treatment module 7, the reaction cup incubation tray 4 and the reagent cooling tray 3; the moving track of the needle tube of the second sample adding device 62 covers the reagent cooling disk 3 and the reaction cup conveying module 8; the movement locus of the needle of the third sample adding device 63 covers the cuvette incubation plate 4 and the reagent cooling plate 3.

The reagent refrigerating disc is mainly used for various reagents required by refrigeration detection, and comprises a diluting reagent, a buffering reagent, a starting reagent, a special cleaning solution and the like which are commonly used in the prior art; the reagent position is a plurality of grooves which are arranged on the reagent refrigeration disk and matched with the reagent bottles, the detection reagent is generally stored in the reagent bottles, and one reagent bottle corresponds to one reagent position. In particular, the bottom of the reagent refrigeration plate can be provided with Peltier refrigerationA heat sink, a Peltier refrigerator for controlling the temperature of the reagent at 10 deg.C℃Hereinafter, the heat sink is used to dissipate heat for the refrigerator. In one embodiment, the reagent refrigeration disk is rotatably connected to the main frame, and specifically, the reagent refrigeration disk is provided with a rotating shaft and a stepping motor in transmission connection with the rotating shaft through a synchronous belt or a gear transmission structure or the like, and the stepping motor drives the reagent refrigeration disk to rotate, so that the position of the detection reagent is conveniently moved.

The cuvette is a detection device commonly used in a blood sample analyzer in the prior art and is used for accommodating a sample and a reagent. The reaction cup incubation tray is mainly used for storing and incubating reaction cups loaded with blood samples and detection reagents at constant temperature, as shown in figure 1, the reaction cup incubation tray can be of an independent annular structure and can rotate relative to the reagent refrigeration tray, the reaction cup positions are grooves capable of accommodating the reaction cups, and a plurality of reaction cup positions can be uniformly distributed on the reaction cup incubation tray; further, the reaction cup incubation disc is hollow inside, and two sides of the reaction cup position are provided with constant temperature heating belts for controlling the incubation temperature of the reaction cup to be 37 +/-0.5℃Within. The main part frame rotates with reaction cup incubation dish to be connected, specifically, can be provided with the ring formula that is used for spacing and direction in the main part frame and rotate the track, reaction cup incubation dish with rotate track sliding connection, furthermore, reaction cup incubation dish is provided with the step motor who is connected through the transmission of forms such as hold-in range or gear with reaction cup incubation dish, step motor drives reaction cup incubation dish and rotates for main part frame and reagent refrigeration dish, be convenient for remove the position of reaction cup, for example, the reaction cup that finishes with the incubation is rotatory to the position that is close to detection module. Compared with the reaction cup incubation disc and the reagent cooling disc which are not related in the prior art, the reaction cup incubation disc and the reagent cooling disc are surrounded by the reaction cup incubation disc, and the installation mode in the utility model has higher integration level and smaller occupied area.

In the prior art, a blood sample is stored in a sample tube, and a plurality of sample tubes are arranged in a row on a sample rack. The sample rack conveying module is used for conveying and guiding the sample rack to move in the blood sample analyzer according to a designed route. The emergency treatment module is used for inputting a sample rack where a sample needing emergency treatment is located. The reaction cup conveying module is used for transferring the reaction cups. The detection module is an existing detection device adopting an optical method and/or a magnetic bead method and is used for detecting a sample in the reaction cup to obtain detection data.

The sampling and sample adding module is used for transferring samples and reagents and comprises a first sample adding device, a second sample adding device and a third sample adding device. The sample adding devices are mutually independent and have a modular structure and comprise needle tubes, a rotary driving device and an up-and-down driving device; the needle tube is used for sucking and releasing a sample or a reagent; the rotary driving device is used for rotating the needle tubes to change the positions of the needle tubes relative to the main body frame, and simultaneously fixing the projections of the moving tracks of the needle tubes on a horizontal plane into a circle, so that the sampling and sample adding positions are adjusted more regularly, and the moving tracks of the needle tubes of each sample adding device are shown as the dotted line part in figure 1; the up-and-down driving device is used for driving the needle tube to move up and down. In one embodiment, the needle tubes of the first, second and third sample adding devices are connected with high-precision plunger pumps to complete the collection and release of samples or reagents; the needle tube can also be provided with a liquid level detector; the needle tube may be a conventional puncture type and/or heating type sample needle or reagent needle. Compared with the prior art, each sample adding device is independently detachably connected to the main body rack, the occupied space is small, and the installation, the maintenance and the upgrading are convenient.

On the structural basis of the reaction cup incubation disc, the reagent refrigeration disc, the sample frame conveying module and the sampling and sample adding module, the layout of other modules is optimized according to the working flow of the blood sample analyzer, so that the installation positions of the modules are orderly and clearly known.

Specifically, in one embodiment as shown in fig. 1, the detection module, sample rack transport module, emergency treatment module, cuvette transport module and 3 sample addition devices are distributed around the cuvette incubation tray. The first sample adding device can be arranged among the emergency treatment module, the reaction cup incubation disc and the sample frame conveying module, and the moving track of the needle tube of the first sample adding device covers the emergency treatment module, the reaction cup incubation disc, the sample frame conveying module and the reagent cooling disc and is mainly used for sampling on the sample frame conveying module and the emergency treatment module; the second sample adding device can be arranged between the reaction cup conveying module and the reaction cup incubation disc, and the moving track of the needle tube of the second sample adding device covers the reaction cup conveying module and the reagent cooling disc, and is mainly used for collecting the buffer reagent in the reagent position and adding the buffer reagent into the reaction cup in the reaction cup conveying module; the third sample adding device can be arranged near the detection module, and the moving track of the needle tube of the third sample adding device can cover the reaction cup incubation disc and the reagent refrigerating disc, and is mainly used for collecting the starting reagent in the reagent position and adding the starting reagent into the reaction cup or the reaction cup at other positions.

When the first sample adding device is used for sampling, the rotary driving device can be used for driving the needle tube to rotate to the position above the sample frame on the sample frame conveying module, the upper and lower driving devices are used for driving the needle tube to descend into the sample tube to finish sampling, after sampling is finished, the needle tube is moved upwards to leave the sample tube, the sample tube is rotated to the position above the reaction cup, and then the needle tube is driven to move downwards to release the collected sample into the reaction cup; the other sample application devices transfer the sample or reagent in a similar process as the first sample application device.

When the device works, the reaction cups are conveyed to the reaction cup incubation disc, the detection module or other positions by the reaction cup conveying module, and in the process, the second sample adding device adds the buffer reagent to each reaction cup; placing a sample frame into a sample frame conveying module and entering a main body frame, wherein a first sample adding device firstly absorbs a diluted reagent at a reagent position, then moving the sample frame to finish sampling, transferring the collected sample and the diluted reagent together into a reaction cup on a reaction cup incubation tray for incubation, after the incubation is carried out for a period of time, the reaction cup incubation tray rotates the reaction cup to a position close to a detection module, and after a starting reagent is added by a third sample adding device, the reaction cup can be transferred from the reaction cup incubation tray to the detection module by the reaction cup conveying module for detection; the sample rack where the samples needing emergency treatment are located directly enters the emergency treatment module, is sampled by the first sample adding device and is transferred to the reaction cups in the reaction cup incubation tray for incubation.

Preferably, the main body frame 1 is further provided with a cup dividing and diluting module and a starting reagent adding module, the cup dividing and diluting module comprises at least 2 cup dividing and diluting positions 11 for placing reaction cups, and the starting reagent adding module comprises at least 1 starting reagent adding position 12 for placing reaction cups; the moving track of the needle tube of the first sample adding device 61 also covers a plurality of the cup separating dilution positions 11; the movement track of the needle tube of the third sample adding device 63 also covers the sample adding starting reagent position 12.

The cup separating and diluting module is used for assisting in completing the cup separating and diluting step of the sample, and the cup separating and diluting position is a groove used for storing a reaction cup. Specifically, as shown in fig. 1, the cuvette dilution module may be a column with 2 cuvette dilution positions arranged on the top, and is arranged between the cuvette incubation tray and the emergency treatment module, and the plurality of cuvette dilution positions are all located on the moving track of the needle tube of the first sample adding device. When a sample needs to be diluted in a separate cup, the first sample adding device firstly absorbs enough diluting reagent and transfers the diluting reagent into the reaction cup on the first separate cup diluting position, then samples the sample and injects the sample into the reaction cup, the sucking and discharging actions are repeatedly executed to uniformly mix the sample and the diluting reagent, then a certain amount of diluted sample is absorbed and transferred into the reaction cup on the second reaction cup diluting position for detection, and the separate cup dilution is completed. The reaction cup conveying module completes the movement of the reaction cup.

The starting reagent adding module is used for assisting in the step of adding the starting reagent after finishing the incubation of the sample and before the detection, and the starting reagent adding position is a groove for storing the reaction cup. Specifically, the reagent adding and starting module can be a column with 1 reagent adding and starting position arranged on the top, and is arranged between the detection module and the reaction cup incubation disc, and the reagent adding and starting position is located on the moving track of the needle tube of the third sample adding device. The reaction cup conveying module takes out the reaction cup after the incubation is finished from the reaction cup incubation disc and places the reaction cup on the starting reagent adding position, the third sample adding device transfers the starting reagent from the reagent refrigerating disc to the reaction cup on the starting reagent adding position, and then the reaction cup conveying module transfers the reaction cup to the detection module.

Preferably, the detection module 2 includes a magnetic bead detection device 21 and an optical detection device 22, the optical detection device 22 is provided with an optical detection position 221, and the magnetic bead detection device 21 is provided with a plurality of magnetic bead detection positions 211 arranged in an arc shape; the sampling and sample-adding module 6 further comprises a fourth sample-adding device 64 with the same structure as the first sample-adding device, and the moving track of the needle tube of the fourth sample-adding device 64 covers the cuvette incubation plate 4, the reagent cooling plate 3, the start reagent adding position 12 and the plurality of magnetic bead detection positions 211.

The magnetic bead detection device and the optical detection device are similar to the existing equipment which respectively adopts a magnetic bead method and an optical method to detect the sample in the reaction cup and output the detection data. The magnetic bead detection position and the optical detection position are used for placing the reaction cup. In one embodiment as shown in FIGS. 1-2, the optical detection device is disposed at the upper right portion of the main body frame, the magnetic bead detection device is disposed at the lower right portion of the main body frame, the fourth sample adding device is disposed between the magnetic bead detection device and the cuvette incubation plate, and the plurality of magnetic bead detection sites are arranged in a circular arc shape and covered by the moving track of the needle of the fourth sample adding device. The reaction cup conveying module can directly transfer the reaction cup after the incubation to the magnetic bead detection position, then transfer the starting reagent to the reaction cup by the fourth sample adding device, and finally start the detection.

As shown in fig. 2, the optical detection device further includes a light source assembly 222 disposed near the optical detection device 22, where the light source assembly 222 includes a cylindrical light path interface, one end of the light path interface is provided with a light source, and the other end of the light path interface is connected with an optical fiber. The optical fiber is used for guiding the light emitted by the light source to the optical detection device.

Preferably, the main body frame 1 is further provided with a first discarding cup mouth 13 and a second discarding cup mouth 14, the first discarding cup mouth 13 is arranged near the cup separating dilution position 11, the second discarding cup mouth 14 is arranged between the magnetic bead detection device 21 and the optical detection device 22, the first and second discarding cup mouths are both connected with a discarding cup guide pipe 15, and the bottom of the discarding cup guide pipe 15 is provided with a waste material barrel 16.

After the cup separation dilution is completed, one reaction cup is transferred to a reaction cup position on the reaction cup incubation plate by the reaction cup conveying module, and the other reaction cup enters the cup discarding guide pipe from the first cup discarding opening and falls into the waste barrel. After the detection is finished, the reaction cup on the detection module enters the cup abandoning guide pipe from the second cup abandoning opening and falls into the waste barrel.

Preferably, the first, second, third and fourth sample adding devices each comprise a spline shaft 612, a supporting arm 613 connecting the spline shaft 612 and the needle tube 611; the rotary driving device comprises a first driven wheel 614 in clearance fit with the spline shaft, a first driving wheel 616 in transmission connection with the first driven wheel 614 through a first synchronous belt 615, and a first motor for driving the first driving wheel 616 to rotate; the up-down driving device comprises a bearing 617 which is in interference fit with one end of the spline shaft 612 far away from the supporting arm 613, the bearing 617 is connected with a sliding block 618, the sliding block 618 is connected with a sliding rail in a sliding manner, and the sliding block 618 is further provided with a first linear module which drives the sliding block 618 to slide back and forth along the sliding rail.

As shown in fig. 6, the spline shaft is in clearance fit with the first driven wheel, so that the spline shaft is connected with the first driven wheel in a sliding manner, the first driven wheel can drive the spline shaft to rotate, the first motor drives the spline shaft to rotate through the first driving wheel, the first synchronous belt and the first driven wheel, so that the needle tube rotates around the spline shaft, and the movement track of the needle tube on the horizontal plane is circular. Meanwhile, the first linear module can adopt a synchronous belt transmission structure driven by a stepping motor, the sliding block is fixedly connected to the synchronous belt, and the forward rotation and the reverse rotation of the stepping motor drive the sliding block to reciprocate up and down along the sliding rail, so that the spline shaft, the supporting arm and the needle tube are driven to move up and down.

Preferably, still include pump station module 9, pump station module 9 is including setting up cleaning solution bottle, waste liquid bucket 91 on the main part frame 1, set up respectively in the needle tubing of first, second, third, fourth application of sample device wash position 93 and respectively with the scavenging pump of the needle tubing connection of first, second, third, fourth application of sample device, the scavenging pump through first input pipeline with the cleaning solution bottle is connected, be provided with a plurality of washing nozzles on the needle tubing washs the 92 lateral wall of position, the cleaning solution bottle through second input pipeline connect to the washing nozzle, needle tubing washs the 92 bottom and connects to through output pipeline waste liquid bucket 91, first input pipeline, second input pipeline, output pipeline all are provided with the valve, be provided with the transfer pump on the second input pipeline.

As shown in fig. 3-4, the cleaning solution bottle is used for storing the cleaning solution of the needle tube, and the waste liquid barrel is used for storing the waste liquid after the needle tube is cleaned; the needle tube cleaning position can be a container with an opening at the top, and the moving track of the needle tube of each sample adding device is covered with one needle tube cleaning position; the cleaning nozzles can adopt solid conical fog-like nozzles, and a plurality of cleaning nozzles are uniformly distributed on the inner wall of the needle tube cleaning position in an array shape. When the waste liquid barrel needs to be cleaned, the needle tube extends into the needle tube cleaning position, and a valve of the output pipeline can be opened firstly to enable the needle tube cleaning position to be communicated with the waste liquid barrel; secondly, opening valves on the infusion pump and the second input pipeline, and spraying cleaning liquid to the outer surface of the needle tube by using a cleaning nozzle for cleaning; simultaneously opening a cleaning pump and a valve on a first input pipeline, conveying cleaning liquid into the needle tube, and washing the inner wall of the needle tube; waste liquid generated by cleaning the inner wall and the outer wall of the needle tube enters the needle tube cleaning position and then flows into the waste liquid barrel. The scavenging pump and the infusion pump can be integrated on one side of the main frame, so that the device is convenient to install and maintain.

Preferably, the cuvette transport module 8 comprises a cuvette input track 81, a first cup gripping device 82 for transferring cuvettes from the cuvette input track 81 to the cuvette dilution position 11 or the cuvette incubation tray 4, and a second cup gripping device 83 for transferring cuvettes from the cuvette incubation tray 4 to the priming reagent position 12 or the detection module 2; the moving track of the needle tube of the second sample adding device 62 covers the reaction cup input track 81; the first cup gripping device 82 and the second cup gripping device 83 each include a three-axis robot 821 provided on the main body frame 1 and a reaction cup gripper 822 provided at a distal end of the three-axis robot 821.

The cuvette input track 81 is used for inputting cuvettes into the blood sample analyzer, and specifically, as shown in fig. 2 and 7, the cuvette input track 81 includes a cuvette guide 811, a cuvette transport carriage 812 disposed at the bottom of the cuvette guide 811, a cuvette transport rail 813 slidably connected to the cuvette transport carriage 812, a third linear module 814 for driving the cuvette transport carriage 812 to reciprocate along the cuvette transport rail 813, a cuvette taking position 815 and a buffering reagent adding position 816.

The reaction cup track is a strip-shaped through groove, and the reaction cup can slide in the reaction cup guide rail; the third linear module can adopt a synchronous belt transmission structure driven by a stepping motor, the cup conveying trolley is fixedly connected to the synchronous belt, and the reciprocating motion of the cup conveying trolley is realized along with the forward rotation and the reverse rotation of the stepping motor; the cup conveying trolley is provided with a cup conveying groove for fixing the reaction cup; the cup taking position is arranged at the tail end of the reaction cup guide rail and at the bottom of the first cup grabbing device; the buffering reagent adding position is positioned at the intersection point of the reaction cup guide rail and the moving track of the needle tube of the second sample adding device. Under the drive of the third linear module, the cup transporting trolley inputs the reaction cup into the blood sample analyzer along the reaction cup guide rail until the reaction cup is positioned at the buffer reagent adding position, after the second sample adding device adds the buffer reagent into the reaction cup, the third linear module continues to convey the reaction cup forwards until the reaction cup is positioned at the cup taking position, and after the first cup grabbing device takes the reaction cup away, the cup transporting trolley resets.

The first cup grabbing device is used for transferring the reaction cup from the cup taking position to the cup dividing dilution position or the reaction cup position on the reaction cup incubation disc, and the second cup grabbing device is used for transferring the reaction cup on the reaction cup incubation disc to the magnetic bead detection position of the starting reagent adding position or the magnetic bead detection device. Specifically, as shown in fig. 4-6, the three-axis manipulator is used for driving the gripper of the reaction cup to move in a three-dimensional space; the gripper of the reaction cup can adopt an electric clamping jaw for gripping the reaction cup; a rotating motor can be arranged between the reaction cup gripper and the three-axis manipulator and used for rotating the reaction cup gripper on the horizontal plane so as to change the postures of the reaction cup gripper and the reaction cup. The first cup grabbing device and the second cup grabbing device are independently detachably connected to the main body frame, and installation, maintenance and upgrading are facilitated.

Preferably, the mixing devices 17 are arranged near the reaction cup incubation disc 4 and the start reagent adding module, and each mixing device 17 comprises two shaft mechanical arms arranged on the main body rack 1 and a mixing head arranged at the tail ends of the two shaft mechanical arms. As shown in fig. 2 and 6, the two-axis mechanical arm is used for driving the blending head to move in the vertical direction and the horizontal direction, so that the blending head can move to a reaction cup position or a reagent adding and starting position, and is inserted into the reaction cup to complete stirring and then reset. The mixing head can adopt a mechanical or ultrasonic disperser. Furthermore, a mixing head cleaning position with the same structure as the needle tube cleaning position is also arranged near the mixing device.

Preferably, the sample rack transport module 5 comprises a sample feeding track 51, a connecting track 52, a sample discharging track 53 and a sample re-measuring track 54 which surround the cuvette incubation plate 4 and are connected in sequence, the sample re-measuring track 54 is connected to the sample feeding track 51, and the moving track of the needle tube of the first sample adding device 61 covers the connecting track 52; the sample feeding track 51 and the connecting track 52, the sample discharging track 53 and the retest track 54 are provided with first transfer devices 55, the connecting track 52 and the sample discharging track 53, and the retest track 54 and the sample feeding track 51 are provided with second transfer devices 56.

The sample feeding track, the connecting track, the sample discharging track and the re-measuring track can be connected into a square shape, the sample rack enters the blood sample analyzer from the sample feeding track, is pushed into the connecting track by the first transfer device, is pushed into the sample discharging track by the second transfer device, is sent out by the sample discharging track, needs to be re-measured, is pushed into the re-measuring track by the first transfer device, and is pushed into the sample feeding track again by the second transfer device.

Specifically, as shown in fig. 3 and 8, each of the sample inlet rail 51 and the sample outlet rail 53 includes a bottom plate 511, first limiting plates 512 disposed on both sides of the bottom plate 511, a mounting slot disposed between the bottom plate 511 and the first limiting plate 512, and a pushing device for pushing the sample rack; the pushing device comprises a cross beam 513 connected with the bottom plate 511 in a sliding mode, one-way pushing devices arranged at two ends of the cross beam 513 and a second linear module used for pushing the cross beam 513 to do linear reciprocating motion. The unidirectional propulsion device comprises a base 515 arranged on the cross beam 513, a propulsion sheet 516 rotationally connected with the base 515, a torsion spring arranged between the propulsion sheet 516 and the base 515, and a first limiting sheet 517 and a second limiting sheet 518 for limiting the rotation range of the propulsion sheet 516, wherein a first circular arc 5161 is arranged on one side of the propulsion sheet 516, which is far away from the bottom plate 511 and close to the second limiting sheet 518, and a second circular arc 5162 is arranged on one side of the propulsion sheet 516, which is close to the bottom plate 511 and close to the first limiting sheet 517; the pushing piece 516 extends into the space between the two first limiting plates 512 from the mounting slot.

The unidirectional propelling device is used for propelling the sample rack from the inlet end to the outlet end of the sample feeding and discharging track. When the unidirectional propulsion device pushes the sample rack, the two propulsion pieces are respectively clamped at two ends of the sample rack, the first limiting piece and the second limiting piece can clamp the propulsion pieces and prevent the propulsion pieces from rotating under the reaction force of the sample rack, so that the propulsion pieces can push the sample rack under the driving of the second linear module; when the unidirectional propelling device returns to the inlet end, if a sample rack newly entering the inlet end is met, the first arc and the second arc allow the propelling piece to rotate under the pressure of the newly entering sample rack to avoid the newly entering sample rack, and simultaneously enable the torsion spring to generate deformation and accumulate elastic potential energy. The second linear module can adopt a synchronous belt transmission structure driven by a stepping motor, and the beam is fixedly connected on the synchronous belt.

As shown in fig. 3, each of the connecting track 52 and the retest track 54 includes a timing belt conveyor 521 and second limiting plates 522 disposed on two sides of the timing belt conveyor 521; a barcode scanning port 523 is arranged on the second limiting plate 522 connected with the track 52, and a scanner 524 for scanning barcode information on the sample tube is arranged outside the barcode scanning port 523; the connection track 52 is also provided with a sampling bit 525.

The upper edge of the synchronous belt conveyor is flush with the bottom plates of the sample feeding rail and the sample discharging rail. When the sample rack enters the connecting track, one side of the sample tube, which is provided with the bar code, faces the bar code scanning port, and when the sample tubes sequentially pass through the bar code scanning port, the bar code used for representing the sample source on each sample tube can be scanned by the scanner, so that the detection data and the sample source can be conveniently corresponding. The sampling position is located at the intersection point of the moving tracks of the synchronous belt conveyor connected with the track and the needle tube of the first sample adding device, and the plurality of sample tubes on the sample frame sequentially pass through the sampling position and are sampled by the first sample adding device on the sampling position.

As shown in fig. 9, the first transfer device 55 includes a bottom bracket, a screw 551 rotatably connected to the bottom bracket, a pushing block 552 screwed on the screw 551, a slide rail slidably connected to the pushing block 552, and a stepping motor for driving the screw 551 to rotate. The slide rail blocks and promotes the piece and prevent to promote the piece and rotate, and step motor drives the lead screw rotation, turns into the rotation of lead screw through threaded connection and promotes the linear motion along the slide rail soon to promote the piece and promote sample frame and get into the connection track from advancing the appearance track. The second transfer device 56 comprises a telescopic rod 561, by means of which the sample rack on the connecting rail can be pushed into and out of the sample rail.

Furthermore, an existing on-line track 57 for transferring the sample rack between the plurality of medical testing devices can be disposed on the side of the emergency module away from the cuvette incubation tray, and the moving track of the needle tube of the first sample adding device covers the on-line track 57, so that the first sample adding device can also sample the sample rack on the connecting track 57.

Preferably, the emergency treatment module 7 comprises an emergency treatment synchronous belt conveyor 71, and third limiting plates 72 are arranged on both sides of the emergency treatment synchronous belt conveyor 71; the emergency treatment module 7 is provided with an emergency treatment sample sampling position 73, and the moving track of the needle tube of the first sample adding device 61 covers the emergency treatment sample sampling position 73.

The emergency synchronous belt conveyor is used for moving the sample rack. The distance between the third limiting plate of emergency call hold-in range conveyer both sides slightly is greater than the width of sample frame for guarantee the stability of sample frame in the removal process, prevent to turn on one's side. Furthermore, a third limiting plate is provided with a bar code scanning port, and a scanner for scanning bar code information on the sample tube is arranged outside the bar code scanning port; when the sample rack enters, one side of each sample tube, which is provided with the bar code, faces to the third limiting plate with the bar code scanning port, and when the sample rack passes through the bar code scanning port, the scanner can scan the bar code used for representing a sample source on each sample tube, so that detection data and the sample source are conveniently corresponding. The emergency sample sampling position is located at the intersection point of the moving tracks of the synchronous belt conveyor and the needle tubes of the first sample adding device, and the sample tubes on the sample rack sequentially pass through the emergency sample sampling position and are sampled by the third sample adding device on the emergency sample sampling position.

The foregoing is a detailed description of one or more embodiments of the utility model, which is set forth in more detail and is not intended to limit the scope of the utility model. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the spirit of the utility model, which falls within the scope of the utility model. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (10)

1. The utility model provides a blood sample analyzer, includes main part frame (1), detection module (2), reagent refrigeration dish (3), reaction cup incubation dish (4), sample frame transport module (5), sampling application of sample module (6), emergency call module (7), reaction cup transport module (8), reagent refrigeration dish (3) are provided with reagent position (31) that are used for placing the reagent, reaction cup incubation dish (4) are provided with reaction cup position (41) that are used for placing the reaction cup, its characterized in that:

the reaction cup incubation disc (4) is arranged on the outer side of the reagent refrigeration disc (3) in a surrounding mode and is connected with the main body frame (1) in a rotating mode; the detection module (2), the sample rack conveying module (5), the emergency treatment module (7) and the reaction cup conveying module (8) are distributed on the main body rack (1) around the reaction cup incubation disc (4);

the sampling and sample-adding module (6) comprises a first sample-adding device (61), a second sample-adding device (62) and a third sample-adding device (63) which are distributed around the reaction cup incubation disc (4) and detachably connected to the main body frame (1), wherein the first, second and third sample-adding devices respectively comprise a needle tube (611), a rotary driving device for driving the needle tube (611) and enabling the projection of the moving track of the needle tube on the horizontal plane to be circular, and an up-and-down driving device for driving the needle tube to reciprocate up and down;

the movement track of the needle tube of the first sample adding device (61) covers the sample rack conveying module (5), the emergency treatment module (7), the reaction cup incubation disc (4) and the reagent refrigerating disc (3);

the moving track of the needle tube of the second sample adding device (62) covers the reagent refrigerating disc (3) and the reaction cup conveying module (8);

the moving track of the needle tube of the third sample adding device (63) covers the reaction cup incubation disc (4) and the reagent cooling disc (3).

2. A blood sample analyzer according to claim 1, wherein: the main body frame (1) is also provided with a cup dividing and diluting module and a starting reagent adding module, the cup dividing and diluting module comprises at least 2 cup dividing and diluting positions (11) for placing reaction cups, and the starting reagent adding module comprises at least 1 starting reagent adding position (12) for placing the reaction cups;

the moving track of the needle tube of the first sample adding device (61) also covers a plurality of cup dividing and diluting positions (11); the moving track of the needle tube of the third sample adding device (63) also covers the sample adding starting reagent position (12).

3. A blood sample analyzer according to claim 2, wherein: the detection module (2) comprises a magnetic bead detection device (21) and an optical detection device (22), the optical detection device (22) is provided with an optical detection position (221), and the magnetic bead detection device (21) is provided with a plurality of magnetic bead detection positions (211) which are arranged in an arc shape; the sampling and sample-adding module (6) further comprises a fourth sample-adding device (64) with the same structure as the first sample-adding device, and the moving track of the needle tube of the fourth sample-adding device (64) covers the reaction cup incubation disc (4), the reagent cooling disc (3), the sample-adding starting reagent position (12) and the plurality of magnetic bead detection positions (211).

4. A blood sample analyzer according to claim 3, wherein: still be provided with on main part frame (1) that first abandon rim of a cup (13) and second abandon rim of a cup (14), first abandon rim of a cup (13) setting and be in divide cup dilute position (11) near, rim of a cup (14) setting is abandoned to the second is in between magnetic bead detection device (21) and optical detection device (22), first, second abandon the rim of a cup and all are connected with and abandon cup pipe (15), it is provided with waste material bucket (16) to abandon cup pipe (15) bottom.

5. A blood sample analyzer according to claim 3, wherein: the first sample adding device, the second sample adding device, the third sample adding device and the fourth sample adding device respectively comprise a spline shaft (612) and a supporting arm (613) for connecting the spline shaft (612) and the needle tube (611); the rotary driving device comprises a first driven wheel (614) in clearance fit with the spline shaft, a first driving wheel (616) in transmission connection with the first driven wheel (614) through a first synchronous belt (615), and a first motor for driving the first driving wheel (616) to rotate; the up-and-down driving device comprises a bearing (617) which is in interference fit with one end, far away from the supporting arm (613), of the spline shaft (612), the bearing (617) is connected with a sliding block (618), the sliding block (618) is connected with a sliding rail in a sliding mode, and the sliding block (618) is further provided with a first linear module which drives the sliding block (618) to slide in a reciprocating mode along the sliding rail.

6. A blood sample analyzer according to claim 3, wherein: the device also comprises a pump station module (9), wherein the pump station module (9) comprises a cleaning liquid bottle, a waste liquid barrel (91), needle tube cleaning positions (92) and cleaning pumps, the cleaning liquid bottle and the waste liquid barrel are arranged on the main body frame (1), the needle tube cleaning positions are respectively arranged in the moving track coverage range of the needle tubes of the first, second, third and fourth sample adding devices, the cleaning pumps are respectively connected with the needle tubes of the first, second, third and fourth sample adding devices, the cleaning pump is connected with the cleaning solution bottle through a first input pipeline, a plurality of cleaning nozzles are arranged on the side wall of the needle tube cleaning position (92), the cleaning solution bottle is connected to the cleaning nozzle through a second input pipeline, the bottom of the needle tube cleaning position (92) is connected to the waste liquid barrel (91) through an output pipeline, the first input pipeline, the second input pipeline and the output pipeline are all provided with valves, and the second input pipeline is provided with an infusion pump.

7. A blood sample analyzer according to claim 2, wherein: the reaction cup conveying module (8) comprises a reaction cup input track (81), a first cup grabbing device (82) used for transferring the reaction cups from the reaction cup input track (81) to the cup dividing dilution position (11) or the reaction cup incubation tray (4), and a second cup grabbing device (83) used for transferring the reaction cups from the reaction cup incubation tray (4) to the adding starting reagent position (12) or the detection module (2);

the moving track of the needle tube of the second sample adding device (62) covers the reaction cup input track (81);

the first cup grabbing device (82) and the second cup grabbing device (83) respectively comprise a three-axis manipulator (821) arranged on the main body frame (1) and a reaction cup grabbing hand (822) arranged at the tail end of the three-axis manipulator (821).

8. A blood sample analyzer according to claim 2, wherein: reaction cup incubation dish (4) and add near start reagent module all are provided with mixing device (17), mixing device (17) are including setting up diaxon arm on main part frame (1) is in with the setting the terminal mixing head of diaxon arm.

9. A blood sample analyzer according to claim 1, wherein: the sample rack conveying module (5) comprises a sample feeding track (51), a connecting track (52), a sample discharging track (53) and a retest track (54) which surround the reaction cup incubation disc (4) and are connected in sequence, the retest track (54) is connected to the sample feeding track (51), and the moving track of the needle tube of the first sample adding device (61) covers the connecting track (52);

advance between appearance track (51) and connecting track (52) go out appearance track (53) with all be provided with first transfer device (55) between retest track (54), between connecting track (52) and the appearance track (53) go out all be provided with second transfer device (56) between retest track (54) and the appearance track (51).

10. A blood sample analyzer according to claim 1, wherein: the emergency treatment module (7) comprises an emergency treatment synchronous belt conveyor (71), and third limiting plates (72) are arranged on two sides of the emergency treatment synchronous belt conveyor (71); the emergency treatment module (7) is provided with an emergency treatment sample sampling position (73), and the moving track of the needle tube of the first sample adding device (61) also covers the emergency treatment sample sampling position (73).

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