CN113406347A - Blood sample analyzer - Google Patents

Abstract

A blood sample analyzer relates to the technical field of blood coagulation analyzers, and adopts the technical scheme that the blood sample analyzer comprises a main body frame, and a detection module, a reagent cooling disc, a reaction cup incubation disc, a sample frame conveying module, a sampling and sample adding module, an emergency call module, a retest module and a reaction cup conveying module which are arranged on the main body frame, wherein the reaction cup incubation disc is arranged around the outer side of the reagent cooling disc and is rotatably connected with the main body frame; the sampling and sample adding module comprises a first sample adding device, a second sample adding device, a third sample adding device and a fourth sample adding device which surround the reaction cup incubation disc. The invention optimizes the layout, ensures that the installation positions of all modules are orderly and clear, not only facilitates the installation, maintenance and upgrade of the instrument, but also reduces the overall size and weight of the instrument.

Description

Blood sample analyzer

Technical Field

The invention relates to the technical field of blood coagulation analyzers, in particular to a blood sample analyzer.

Background

For example, the invention patent application with the patent application number of 201810762104.4 discloses a full-automatic coagulation analyzer and a use method thereof, wherein a needle motion module for sampling and sample adding is arranged on the upper part of a main inner cavity, so that the occupied space is large, and meanwhile, the problems of unreasonable layout design and complicated partitioning of internal modules exist, so that the whole size and weight of the instrument are large and the instrument is not simple.

Disclosure of Invention

The invention provides a blood sample analyzer, aiming at the problems that a three-dimensional movement mechanism in the prior art occupies a large space and is difficult to maintain and upgrade, and the instrument size is large due to unreasonable layout of all modules in a blood coagulation analyzer.

The invention provides the following technical scheme: a blood sample analyzer comprises a main body frame, and a detection module, a reagent cooling disc, a reaction cup incubation disc, a sample frame conveying module, a sampling and sample adding module, an emergency treatment module, a retest module and a reaction cup conveying module which are arranged on the main body frame, wherein the reagent cooling disc is provided with a reagent position for placing a reagent, the reaction cup incubation disc is provided with a reaction cup position for placing a reaction cup, and the reaction cup incubation disc is arranged around the outer side of the reagent cooling disc and is rotatably connected with the main body frame; the detection module, the emergency treatment module and the reaction cup conveying module are distributed on the main body frame around the reaction cup incubation disc; the sample rack conveying module comprises a sample feeding track, a connecting track and a sample discharging track which surround the reaction cup incubation disc and are connected in sequence; the sampling and sample-adding module comprises a first sample-adding device, a second sample-adding device, a third sample-adding device and a fourth sample-adding device which are distributed around the reaction cup incubation disc and detachably connected to the main body rack, and the first, second, third and fourth sample-adding devices respectively comprise a needle tube, a rotary driving device and an up-and-down driving device, wherein the rotary driving device is used for driving the needle tube and enabling the projection of the moving track of the needle tube on the horizontal plane to be circular, and the up-and-down driving device is used for driving the needle tube to reciprocate up and down; the moving track of the needle tube of the first sample adding device covers the connecting track, the reaction cup incubation disc and the reagent refrigerating disc; the retest module is connected to the sample outlet track, and the moving track of the needle tube of the second sample adding device covers the retest module, the reaction cup incubation disc and the reagent refrigerating disc; the moving track of the needle tube of the third sample adding device covers the emergency treatment module, the reaction cup incubation disc and the reagent refrigerating disc; the fourth sample adding device is arranged near the detection module, and the moving track of the needle tube of the fourth sample adding device covers the reaction cup incubation disc and the reagent refrigerating disc.

Preferably, the main body frame is further provided with at least 2 sample adding positions for placing reaction cups and a starting reagent adding position; the movement track of the needle tube of the first sample adding device also covers the sample adding position; the moving tracks of the needle tubes of the second sample adding device and the fourth sample adding device cover the sample adding starting reagent positions.

Preferably, the blood sample analyzer further comprises a cuvette transport module comprising a cuvette input track, a first cuvette holding device for transferring cuvettes from the cuvette input track to the loading position or the cuvette incubation tray, and a second cuvette holding device for transferring cuvettes from the cuvette incubation tray to the loading-start reagent position or the detection module; the first cup grabbing device and the second cup grabbing device comprise a three-axis manipulator arranged on the main body rack and a reaction cup gripper arranged at the tail end of the three-axis manipulator.

Preferably, still be provided with the first rim of a cup of abandoning and the rim of a cup is abandoned to the second in the main part frame, the first rim of a cup of abandoning sets up near application of sample home position, the second is abandoned the rim of a cup and is set up near detection module, the first, second is abandoned the rim of a cup and all is connected with and abandons a cup pipe, it is provided with the waste material bucket to abandon a cup pipe bottom.

Preferably, a first transfer device for transferring the sample rack from the sample injection track to the connection track is arranged between the sample injection track and the connection track, and a second transfer device for transferring the sample rack from the connection track to the sample outlet track is arranged between the connection track and the sample outlet track.

Preferably, the first, second, third and fourth sample adding devices comprise spline shafts and supporting arms for connecting the spline shafts and the needle tubes; the rotation driving device comprises a first driven wheel in clearance fit with the spline shaft, a first driving wheel in transmission connection with the first driven wheel through a first synchronous belt, and a first motor for driving the first driving wheel to rotate; the upper and lower driving device comprises a bearing, the bearing is in interference fit with the spline shaft and is far away from one end of the supporting arm, the bearing is connected with a sliding block, the sliding block is connected with a sliding rail in a sliding mode, and the sliding block is further provided with a first linear module for driving the sliding block to slide along the sliding rail in a reciprocating mode.

Preferably, the detection module includes a magnetic bead detection device and an optical detection device, the magnetic bead detection device is provided with a magnetic bead detection position, and the optical detection device is provided with an optical detection position.

Preferably, the emergency treatment module comprises an emergency treatment synchronous belt conveyor, and third limiting plates are arranged on two sides of the emergency treatment synchronous belt conveyor; the emergency treatment module is provided with an emergency treatment sample sampling position, and the moving track of the needle tube of the third sample adding device covers the emergency treatment sample sampling position.

Preferably, the retest module comprises a retest bottom plate, a third transfer device for pushing the sample rack onto the retest bottom plate is arranged on the sample outlet track, and fourth limiting plates are arranged on two sides of the retest bottom plate; the retest module also comprises a retest pushing device and a retest sample sampling position, wherein the retest pushing device is used for pushing the sample rack to move, and the moving track of the needle tube of the second sample adding device covers the retest sample sampling.

Preferably, the reaction cup incubation disc and the start reagent adding position are both provided with a blending device, and the blending device comprises two shaft mechanical arms arranged on the main body rack and blending heads arranged at the tail ends of the two shaft mechanical arms.

The invention has the beneficial effects that: redesigned the structure and the overall arrangement of inside each module, coiled around reagent refrigeration dish outside with reaction cup incubation dish, reduced occupation space between them, and disassemble sampling application of sample module into a plurality of independent and dispersed application of sample devices, install according to the function difference in suitable position, on this basis, optimize the overall arrangement of other modules, make the mounted position of each module orderly and distinct, not only made things convenient for the installation of instrument, maintain and upgrade, reduced the overall size and the weight of instrument moreover.

Drawings

FIG. 1 is a top view I of one embodiment of the present invention.

FIG. 2 is a top view II of one embodiment of the present invention.

FIG. 3 is a top view III of one embodiment of the present invention.

Fig. 4 is a schematic three-dimensional view i of an embodiment of the present invention.

FIG. 5 is a schematic three-dimensional diagram II of an embodiment of the present invention.

Fig. 6 is an enlarged view of a portion a of fig. 2.

Fig. 7 is an enlarged view of a portion B of fig. 4.

Fig. 8 is an enlarged view of a portion C of fig. 4.

Fig. 9 is an enlarged view of a portion D of fig. 5.

Fig. 10 is an enlarged view of a portion E of fig. 5.

Reference numerals: 1-a main body frame, 11-a sample adding home position, 12-a sample adding starting reagent position, 13-a first abandoned cup opening, 14-a second abandoned cup opening, 15-a mixing device, 2-a detection module, 21-a magnetic bead detection device, 211-a magnetic bead detection position, 22-an optical detection device, 221-an optical detection position, 222-a light source component, 3-a reagent refrigeration disc, 31-a reagent position, 4-a reaction cup incubation disc, 41-a reaction cup position, 5-a sample frame conveying module, 51-a sample feeding track, 511-a bottom plate, 512-a first limiting plate, 513-a cross beam, 514-a second linear module, 515-a base, 516-a pushing sheet, 5161-a first circular arc, 5162-a second circular arc, 517-a first limiting sheet and 518-a second limiting sheet, 52-connecting track, 521-synchronous belt conveyor, 522-second limiting plate, 523-bar code scanning port, 524-scanner, 525-sampling position, 53-sample outlet track, 54-online track, 55-first transfer device, 551-lead screw, 552-pushing block, 553-sliding rail, 56-second transfer device, 561-telescopic rod, 6-sampling sample adding module, 61-first sample adding device, 611-needle tube, 612-spline shaft, 613-supporting arm, 614-first driven wheel, 615-first synchronous belt, 616-first driving wheel, 617-first motor, 618-bearing, 619-sliding block, 620-sliding rail, 62-second sample adding device, 63-third sample adding device and 64-fourth sample adding device, 7-emergency treatment module, 71-emergency treatment synchronous belt conveyor, 72-third limiting plate, 73-emergency treatment sample sampling position, 8-retest module, 81-retest bottom plate, 82-fourth limiting plate, 83-retest sample sampling position, 9-reaction cup conveying module, 91-reaction cup input track, 911-reaction cup guide rail, 912-cup conveying trolley, 913-cup conveying slide rail, 914-third linear module, 915-reaction cup taking position, 92-first cup grabbing device, 921-three-axis manipulator, 922-reaction cup grabbing hand, 93-second cup grabbing device, 94-cup abandoning guide pipe and 95-waste barrel.

Detailed Description

The embodiments of the present invention will be described in more detail with reference to the accompanying drawings and reference numerals, so that those skilled in the art can implement the embodiments of the present invention after studying the specification. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

The invention provides a blood sample analyzer as shown in fig. 1, which comprises a main body frame 1, and a detection module 2, a reagent cooling disc 3, a reaction cup incubation disc 4, a sample frame conveying module 5, a sampling and sample adding module 6, an emergency treatment module 7, a retest module 8 and a reaction cup conveying module 9 which are arranged on the main body frame 1, wherein the reagent cooling disc 3 is provided with a reagent position 31 for placing a reagent, the reaction cup incubation disc 4 is provided with a reaction cup position 41 for placing a reaction cup, and the reaction cup incubation disc 4 is arranged around the outer side of the reagent cooling disc 3 and is rotatably connected with the main body frame 1; the detection module 2, the emergency treatment module 7 and the reaction cup conveying module 9 are distributed on the main body frame 1 around the reaction cup incubation tray 4; the sample rack conveying module 5 comprises a sample inlet track 51, a connecting track 52 and a sample outlet track 53 which surround the reaction cup incubation disc 4 and are connected in sequence; the sampling and sample-adding module 6 comprises a first sample-adding device 61, a second sample-adding device 62, a third sample-adding device 63 and a fourth sample-adding device 64 which are distributed around the reaction cup incubation disc 4 and detachably connected to the main body frame 1, wherein each of the first, second, third and fourth sample-adding devices comprises a needle tube 611, a rotary driving device for driving the needle tube 611 and enabling the projection of the moving track of the needle tube on the horizontal plane to be circular, and an up-and-down driving device for driving the needle tube to reciprocate up and down; the moving track of the needle tube of the first sample adding device 61 covers the connecting track 52, the reaction cup incubation plate 4 and the reagent cooling plate 3; the retest module 8 is connected to the sample outlet track 53, and the moving track of the needle tube of the second sample adding device 62 covers the retest module 8, the cuvette incubation plate 4 and the reagent cooling plate 3; the moving track of the needle tube of the third sample adding device 63 covers the emergency treatment module 7, the reaction cup incubation disc 4 and the reagent cooling disc 3; the fourth sample adding device 64 is disposed near the detection module 2, and the moving track of the needle tube of the fourth sample adding device 64 covers the cuvette incubation plate 4 and the reagent cooling plate 3.

The reagent refrigerating disc is mainly used for various reagents required by refrigeration detection, and comprises a diluting reagent, a buffering reagent, a starting reagent, a special cleaning solution and the like which are commonly used in the prior art; the reagent position is a plurality of grooves which are arranged on the reagent refrigeration disk and matched with the reagent bottles, the detection reagent is generally stored in the reagent bottles, and one reagent bottle corresponds to one reagent position. Specifically, the bottom of the reagent cooling tray can be provided with a Peltier refrigerator and a radiator, and the Peltier refrigerator is used for controlling the temperature of the reagent to be 10℃Hereinafter, the heat sink is used to dissipate heat for the refrigerator. In one embodiment, the reagent cooling disk is also rotatably connected to the main frame, and specifically, the reagent cooling disk is provided with a rotating shaft and a stepping motor in transmission connection with the rotating shaft through a synchronous belt, a gear and the like, and the stepping motor drives the reagent cooling disk to rotate so as to conveniently move the position of the detection reagent.

The cuvette is a detection device commonly used in a blood sample analyzer in the prior art and is used for accommodating a sample and a reagent. The reaction cup incubation tray is mainly used for storing and incubating reaction cups loaded with blood samples and detection reagents at constant temperature, as shown in figure 1, the reaction cup incubation tray can be in an annular structure independent from the reagent refrigeration tray, the reaction cup incubation tray can rotate relative to the reagent refrigeration tray, the reaction cup positions are grooves capable of containing the reaction cups, and a plurality of reaction cup positions can be uniformly distributed on the reaction cup incubation tray; further, the reaction cup incubation disc is hollow inside and the reaction cup is positionedIs provided with a constant temperature heating belt at both sides for controlling the incubation temperature of the reaction cup to be 37 +/-0.5℃Within. The main part frame rotates with reaction cup incubation dish to be connected, specifically, can be provided with the ring formula rotation track that is used for spacing and direction in the main part frame, reaction cup incubation dish with rotate track sliding connection, and be provided with through hold-in range, the step motor that forms such as gear and reaction cup incubation dish transmission are connected, step motor drives reaction cup incubation dish and rotates for main part frame and reagent refrigeration dish, be convenient for remove reaction cup's position, for example, the reaction cup that finishes with the incubation is rotatory to the position that is close to detection module, be convenient for subsequent the transfer. Compared with the reaction cup incubation disc and the reagent cooling disc which are not related in the prior art, the reaction cup incubation disc and the reagent cooling disc are surrounded by the reaction cup incubation disc, and the installation mode in the invention has higher integration level and smaller occupied area.

In the prior art, a blood sample is stored in a sample tube, and a plurality of sample tubes are arranged in a row on a sample rack. The sample rack conveying module is used for conveying and guiding the sample rack to move in the blood sample analyzer according to a designed route, and comprises a sample introduction track, a connecting track and a sample outlet track. The sample rack enters the blood sample analyzer from the sample inlet track, enters the sample outlet track through the connecting track and is sent out by the sample outlet track. Furthermore, the existing on-line rail 54 for transferring the sample rack between the plurality of medical examination apparatuses may be provided on the side of the first sample application device away from the cuvette incubation plate, and the on-line rail 54 may be covered with the movement locus of the needle tube of the first sample application device, so that the first sample application device can also sample the sample rack on the connection rail 54.

The retest module sets up in the detection module towards the one side of connecting the track, and is connected to out the appearance track, and the sample frame that the sample that needs the retest is located can be followed out the appearance track and got into the retest module and kept in, prevents to influence the normal operating of other sample framves. The emergency treatment module is used for inputting a sample rack where a sample needing emergency treatment is located. The retest module is used for receiving and temporarily storing the sample rack where the retest sample is needed from the sample outlet track. The reaction cup conveying module is used for transferring the reaction cups. The detection module is an existing detection device adopting an optical method and/or a magnetic bead method and is used for detecting a sample in the reaction cup to obtain detection data.

The sampling and sample adding module is used for transferring samples and reagents and comprises a first sample adding device, a second sample adding device, a third sample adding device and a fourth sample adding device. The sample adding devices are mutually independent and have a modular structure and comprise needle tubes, a rotary driving device and an up-and-down driving device; the needle tube is used for sucking and releasing a sample or a reagent; the rotary driving device is used for rotating the needle tubes to change the positions of the needle tubes relative to the main body frame, and simultaneously fixing the moving tracks of the needle tubes on the horizontal plane into a circle, so that the sampling and sample adding positions are adjusted more regularly, and the moving tracks of the needle tubes of each sample adding device are shown as the dotted line part in figure 1; the up-and-down driving device is used for driving the needle tube to move up and down. In one embodiment, the needle tubes of the first, second, third and fourth sample adding devices are connected with a high-precision plunger pump to complete the collection and release of samples or reagents; the needle tube can also be provided with a liquid level detector; the needle tube may be a conventional puncture type and/or heating type sample needle or reagent needle. Compared with the prior art, each sample adding device is independently detachably connected to the main body rack, and installation, maintenance and upgrading are facilitated.

When the first sample adding device is used for sampling, the needle tube can be driven to rotate to the position above the sample frame on the connecting track, then the needle tube is driven to descend into the sample tube to finish sampling, after sampling is finished, the needle tube is moved upwards to leave the sample tube, the needle tube is rotated to the position above the reaction cup, then the needle tube is driven to move downwards, and the collected sample is released into the reaction cup; the other sample application devices transfer the sample or reagent in a similar process as the first sample application device.

On the structural basis of the reaction cup incubation disc, the reagent refrigerating disc, the sample frame conveying module and the sample adding device, the layout of other modules is optimized according to the working flow of the blood sample analyzer, so that the installation positions of the modules are ordered and distinct.

Specifically, as shown in fig. 1, the sample inlet track, the connecting track and the sample outlet track can be connected into a U shape to surround the reaction cup incubation disc; the detection module, the retest module and the emergency treatment module can be arranged between the sample rack conveying module and the reaction cup incubation disc, the emergency treatment module is positioned on the left side of the reaction cup incubation disc, and the detection module and the retest module are positioned on the right side of the reaction cup incubation disc; the reaction cup conveying module is mainly arranged on one side of the connecting track far away from the reaction cup incubation plate. 4 sample adding devices are distributed around the reaction cup incubation disc; the first sample adding device is arranged on one side, far away from the reaction cup incubation disc, of the connecting track, the movement track of the needle tube of the first sample adding device covers the connecting track, the reaction cup incubation disc and the reagent refrigeration disc, and is mainly used for sampling on the connecting track and transferring the sample into a reaction cup of the reaction cup incubation disc, and if the sample needs to be diluted conventionally, the first sample adding device firstly absorbs the diluted reagent in the reagent refrigeration disc and then samples; the second sample adding device is arranged near the retest module, the moving track of a needle tube of the second sample adding device covers the retest module, the reaction cup incubation disc and the reagent refrigerating disc, and the second sample adding device is mainly used for sampling a sample to be retested and transferring the sample to a reaction cup on the reaction cup incubation disc; the third sample adding device is arranged near the emergency treatment module, the moving track of a needle tube of the third sample adding device can cover the emergency treatment module, the reaction cup incubation disc and the reagent refrigerating disc, the third sample adding device is mainly used for sampling an emergency treatment sample and transferring the sample into a reaction cup on the reaction cup incubation disc, and the buffer reagent is transferred from the reagent refrigerating disc into the reaction cup of the reaction cup incubation disc; the fourth sample adding device is arranged near the detection module and the reaction cup incubation disc, the moving track of the needle tube of the fourth sample adding device covers the reaction cup incubation disc and the reagent cooling disc, and the fourth sample adding device is mainly used for transferring the starting reagent required by detection to the reaction cup after incubation.

When the device works, the reaction cup is conveyed to the reaction cup incubation disc or other positions by the reaction cup conveying module; the sample rack enters the connecting track through the sample introduction track, is sampled on the connecting track by the first sample adding device, enters the sample outlet track after sampling is finished, enters the retest module if retest is needed, and is directly sent out if retest is not needed; the sample collected by the first sample adding device is loaded into a reaction cup on a reaction cup incubation tray for incubation, the reaction cup incubation tray drives the reaction cup to rotate anticlockwise, if buffer reagents need to be added, the buffer reagents are added into the reaction cup by a third sample adding device, the reaction cup rotates to a position close to the detection device after being incubated for a period of time, and after starting reagents are added by a fourth sample adding device, the reaction cup can be transferred to the detection module from the reaction cup incubation tray for detection by a reaction cup conveying module; the sample rack where the sample needing emergency treatment or retest is located respectively enters the emergency treatment module and the retest module, and the sample is transferred to the reaction cup in the reaction cup incubation tray by the third sample adding device and the second sample adding device respectively.

Preferably, the main body frame 1 is further provided with at least 2 sample adding positions 11 for placing reaction cups and a starting reagent adding position 12; the moving track of the needle tube of the first sample adding device 61 also covers the sample adding position 11; the moving tracks of the needle tubes of the second sample adding device and the fourth sample adding device cover the sample adding starting reagent position 12.

The sample adding position is a groove for storing the reaction cup and is used for assisting in completing the steps of sampling and cup-dividing dilution. Specifically, the sample adding position can be a cylindrical part with a groove at the top, can be arranged on one side of the connecting track far away from the reaction cup incubation plate, and is positioned on the moving track of the needle tube of the first sample adding device, and the reaction cup can be arranged in the groove. When a sample needs to be diluted in a cup-divided manner, the first sample adding device firstly absorbs enough diluted reagent in the reagent cooling disc and transfers the diluted reagent to the reaction cup on the first sample adding position, then sampling of the sample is completed, then suction and discharge actions are repeatedly executed to uniformly mix the sample and the diluted reagent, then a certain amount of diluted sample is absorbed and transferred to the reaction cup on the second sample adding position, cup-divided dilution is completed, and the reaction cup conveying module transfers the reaction cup on the second sample adding position to the reaction cup incubation disc.

The starting reagent adding position is a groove for storing the reaction cup and is used for assisting in the step of adding the starting reagent after the sample incubation is finished and before the detection is carried out. Specifically, the reagent adding and starting position can be a column with a groove at the top, is arranged between the detection module and the reaction cup incubation disc, and is positioned on the moving tracks of the needle tubes of the second sample adding device and the fourth sample adding device. The reaction cup conveying module takes out the reaction cup after the incubation is finished from the reaction cup incubation disc and places the reaction cup on the starting reagent adding position, and after the second or fourth sample adding device transfers the starting reagent from the reagent refrigerating disc to the reaction cup on the starting reagent adding position, the reaction cup conveying module transfers the reaction cup to the detection module.

Preferably, as shown in fig. 3-5, the blood sample analyzer further comprises a reaction cup transport module 9, the reaction cup transport module 9 comprising a reaction cup input track 91, a first cup gripping device 92 for transferring reaction cups from the reaction cup input track 91 to the loading position 11 or the reaction cup incubation tray 4, and a second cup gripping device 93 for transferring reaction cups from the reaction cup incubation tray 4 to the loading start reagent position 12 or the detection module 2; the first cup grabbing device 92 and the second cup grabbing device 93 respectively comprise a three-axis manipulator 921 arranged on the main body frame 1 and a reaction cup grabbing hand 922 arranged at the tail end of the three-axis manipulator 921.

The cuvette input track is used for inputting cuvettes into the blood sample analyzer, and specifically, as shown in fig. 10, the cuvette input track 91 includes a cuvette guide rail 911, a cuvette transportation trolley 912 disposed at the bottom of the cuvette guide rail 911, a cuvette transportation slide rail 913 slidably connected to the cuvette transportation trolley 912, a third linear module 914 for driving the cuvette transportation trolley 912 to reciprocate along the cuvette transportation slide rail 913, and a cuvette taking position 915. The reaction cup can slide in the guide rail of the reaction cup; the third linear module can adopt a synchronous belt transmission structure driven by a stepping motor, the cup conveying trolley is fixedly connected to the synchronous belt, and the reciprocating motion of the cup conveying trolley is realized along with the forward rotation and the reverse rotation of the stepping motor; the cup conveying trolley is provided with a cup conveying groove for placing the reaction cup; the reaction cup taking position is arranged at the tail end of the reaction cup input track and at the bottom of the first cup grabbing device. Under the drive of the third linear module, the cup transporting trolley inputs the reaction cup into the blood sample analyzer along the reaction cup guide rail until the reaction cup gets the cup position, the third linear module stops running, and after the first cup grabbing device takes the reaction cup away, the cup transporting trolley resets and transports the reaction cup again.

As shown in fig. 4, 5 and 8, the three-axis manipulator is used for driving the gripper of the reaction cup to move in a three-dimensional space; the gripper of the reaction cup can adopt an electric clamping jaw for gripping the reaction cup; a rotating motor can be arranged between the reaction cup gripper and the three-axis manipulator and used for rotating the reaction cup gripper on the horizontal plane so as to change the postures of the reaction cup gripper and the reaction cup. The first cup grabbing device and the second cup grabbing device are independently arranged on the main body frame, and installation, maintenance and upgrading are facilitated.

Preferably, as shown in fig. 3 and 4, the main body frame 1 is further provided with a first discarding cup mouth 13 and a second discarding cup mouth 14, the first discarding cup mouth 13 is disposed near the sample addition position 11, the second discarding cup mouth 14 is disposed near the detection module 2, the first and second discarding cup mouths are both connected to a discarding cup guide tube 94, and a waste barrel 95 is disposed at the bottom of the discarding cup guide tube 94. After the cup separation dilution or the detection is finished, the reaction cup conveying module transfers the waste reaction cups to a waste barrel through the first cup abandoning opening and the second cup abandoning opening respectively through the respective cup abandoning guide pipes.

Preferably, a first transfer device 55 for transferring the sample rack from the sample inlet track to the connecting track is arranged between the sample inlet track 51 and the connecting track 52, and a second transfer device 56 for transferring the sample rack from the connecting track to the sample outlet track is arranged between the connecting track 52 and the sample outlet track 53.

Specifically, as shown in fig. 2, 6 and 7, each of the sample inlet rail 51 and the sample outlet rail 53 includes a bottom plate 511, first limiting plates 512 disposed at both sides of the bottom plate 511, a mounting slot disposed between the bottom plate 511 and the first limiting plates 512, and a pushing device for pushing the sample rack; the pushing device comprises a cross beam 513 connected with the bottom plate 511 in a sliding manner, one-way pushing devices arranged at two ends of the cross beam 513 and a second linear module 514 used for pushing the cross beam 513 to do linear reciprocating motion. The unidirectional propulsion device comprises a base 515 arranged on the cross beam 513, a propulsion sheet 516 rotationally connected with the base 515, a torsion spring arranged between the propulsion sheet 516 and the base 515, and a first limiting sheet 517 and a second limiting sheet 518 for limiting the rotation range of the propulsion sheet 516, wherein a first circular arc 5161 is arranged on one side of the propulsion sheet 516, which is far away from the bottom plate 511 and close to the second limiting sheet 518, and a second circular arc 5162 is arranged on one side of the propulsion sheet 516, which is close to the bottom plate 511 and close to the first limiting sheet 517; the pushing piece 516 extends into the space between the two first limiting plates 512 from the mounting slot.

The unidirectional propelling device is used for propelling the sample rack from the inlet end to the outlet end of the sample feeding and discharging track. When the unidirectional propulsion device pushes the sample rack, the two propulsion pieces are respectively clamped at two ends of the sample rack, the first limiting piece and the second limiting piece can clamp the propulsion pieces and prevent the propulsion pieces from rotating under the reaction force of the sample rack, so that the propulsion pieces can push the sample rack under the driving of the second linear module; when the unidirectional propelling device returns to the inlet end, if a sample rack newly entering the inlet end is met, the first arc and the second arc allow the propelling piece to rotate under the pressure of the newly entering sample rack to avoid the newly entering sample rack, and simultaneously enable the torsion spring to generate deformation and accumulate elastic potential energy. The second linear module can adopt a synchronous belt transmission structure driven by a stepping motor, and the beam is fixedly connected on the synchronous belt. Furthermore, a yielding gap allowing the pushing device to pass through is arranged between the retest module and the sample outlet track, the width of the yielding gap is far smaller than the length of the sample rack, and the sample rack is not influenced to be transferred to the retest track from the sample outlet track.

As shown in fig. 2, the connecting track 52 includes a synchronous belt conveyor 521 and second limiting plates 522 arranged at two sides of the synchronous belt conveyor 521, a barcode scanning port 523 is arranged on the second limiting plate 522, and a scanner 524 for scanning barcode information on the sample tube is arranged outside the barcode scanning port 523; the connecting track 52 is further provided with a sampling position 525, and the moving track of the needle tube of the first sample adding device 61 covers the sampling position 525. The upper edge of the synchronous belt conveyor is flush with the bottom plates of the sample feeding rail and the sample discharging rail. The sampling position is located the point of intersect of the removal orbit of the needle tubing of first application of sample device and hold-in range conveyer, and a plurality of sample tubes on the sample frame pass through the sampling position in proper order to by first application of sample device sampling on the sampling position.

As shown in fig. 9, the first transfer device 55 includes a bottom bracket, a screw 551 rotatably connected to the bottom bracket, a pushing block 552 screwed on the screw 551, a slide 553 slidably connected to the pushing block 552, and a stepping motor for driving the screw 551 to rotate. The slide rail blocks and promotes the piece and prevent to promote the piece and rotate, and step motor drives the lead screw rotatory, turns into the rotation of lead screw through threaded connection and promotes the linear motion along the slide rail soon to promote the piece and promote sample frame and get into the connection track from advancing the appearance track. The second transfer device 56 comprises a telescopic rod 561, by means of which the sample rack on the connecting rail can be pushed into and out of the sample rail.

Preferably, the first, second, third and fourth sample adding devices each comprise a spline shaft 612, a supporting arm 613 connecting the spline shaft 612 and the needle tube 611; the rotary driving device comprises a first driven wheel 614 in clearance fit with the spline shaft, a first driving wheel 616 in transmission connection with the first driven wheel 614 through a first synchronous belt 615, and a first motor 617 for driving the first driving wheel 616 to rotate; the up-and-down driving device comprises a bearing 618 which is in interference fit with one end, far away from the supporting arm 613, of the spline shaft 612, the bearing 618 is connected with a sliding block 619, the sliding block 619 is connected with a sliding rail 620 in a sliding manner, and the sliding block 619 is further provided with a first linear module which drives the sliding block 619 to slide along the sliding rail 620 in a reciprocating manner.

Specifically, as shown in fig. 8, the spline shaft is in clearance fit with the first driven wheel, so that the spline shaft is connected with the first driven wheel in a sliding manner, the first driven wheel can drive the spline shaft to rotate, the first motor drives the spline shaft to rotate through the first driving wheel, the first synchronous belt and the first driven wheel, so that the needle tube rotates around the spline shaft, and the movement track of the needle tube on the horizontal plane is circular. Meanwhile, the first linear module can adopt a synchronous belt transmission structure driven by a stepping motor, the sliding block is fixedly connected to the synchronous belt, and the forward rotation and the reverse rotation of the stepping motor drive the sliding block to reciprocate up and down along the sliding rail, so that the spline shaft, the supporting arm and the needle tube are driven to move up and down.

Preferably, the detection module 2 includes a magnetic bead detection device 21 and an optical detection device 22, the magnetic bead detection device 21 is provided with a magnetic bead detection site 211, and the optical detection device 22 is provided with an optical detection site 221. The magnetic bead detection device and the optical detection device are similar to the existing equipment which respectively adopts a magnetic bead method and an optical method to detect the sample in the reaction cup and output the detection data. The magnetic bead detection position and the optical detection position are grooves for placing reaction cups. As shown in fig. 2, the optical detection device further includes a light source assembly 222 disposed between the second sample adding device 62 and the connecting rail 52, the light source assembly 222 includes a cylindrical light path interface, one end of the light path interface is provided with a light source, and the other end of the light path interface is connected with an optical fiber. The optical fiber is used for guiding the light emitted by the light source to the optical detection device.

Preferably, the emergency treatment module 7 comprises an emergency treatment synchronous belt conveyor 71, and third limiting plates 72 are arranged on both sides of the emergency treatment synchronous belt conveyor 71; the emergency treatment module is provided with an emergency treatment sample sampling position 73, and the moving track of the needle tube of the third sample adding device 63 covers the emergency treatment sample sampling position 73.

The emergency synchronous belt conveyor is used for moving the sample rack. The distance between the third limiting plate of emergency call hold-in range conveyer both sides slightly is greater than the width of sample frame for guarantee the stability of sample frame in the removal process, prevent to turn on one's side. Furthermore, a third limiting plate on one side is provided with a bar code scanning port, and a scanner for scanning bar code information on the sample tube is arranged outside the bar code scanning port; when the sample rack enters, one side of each sample tube, which is provided with the bar code, faces to the third limiting plate with the bar code scanning port, and when the sample rack passes through the bar code scanning port, the scanner can scan the bar code used for representing a sample source on each sample tube, so that detection data and the sample source are conveniently corresponding. The emergency sample sampling position is located at the intersection point of the moving track of the needle tube of the third sample adding device and the emergency synchronous belt conveyor, and the plurality of sample tubes on the sample frame sequentially pass through the emergency sample sampling position and are sampled by the third sample adding device on the emergency sample sampling position.

Preferably, the retest module 8 includes a retest bottom plate 81, a third transfer device for pushing the sample rack onto the retest bottom plate 81 is disposed on the sample outlet track 53, and fourth limiting plates 82 are disposed on both sides of the retest bottom plate 81; the retest module 8 further includes a retest pushing device for pushing the sample rack to move and a retest sample sampling position 83, and the moving track of the needle tube of the second sample adding device 62 covers the retest sample sampling position 83.

The retest module is used for receiving from the orbit that produces a appearance and temporarily store the sample frame that the sample that needs the retest is located. Specifically, the retest bottom plate is flush with the bottom plate of the sample outlet rail, and a yield gap allowing the pushing device of the sample outlet rail to pass through is arranged between the retest bottom plate and the sample outlet rail; the distance between the two fourth limiting plates is slightly larger than the width of the sample rack. The third transfer device comprises an electric telescopic rod and a retest position sensor, wherein the electric telescopic rod and the retest position sensor are arranged on one side, away from the retest module, of the sample outlet rail. The retest pushing device is used for transferring the sample rack from the retest module to the sample outlet track, and the structure of the retest pushing device is similar to that of the first transfer device.

After the sample rack is sampled by the first sample adding device, the sample rack enters the sample outlet track, and after the retest position sensor detects the sample rack, the sample outlet track stops running and waits for a detection result; and if the detection personnel judge that the sample on the sample rack needs to be retested, starting the third transfer device to push the sample rack into the retesting module. The retest sample sampling position is located at the intersection point of the moving track of the needle tube of the second sample adding device and the retest bottom plate, and the plurality of sample tubes on the sample frame sequentially pass through the retest sample sampling position and are sampled by the second sample adding device on the retest sample sampling position.

Preferably, the reaction cup incubation disc 4 and the start reagent adding position 12 are both provided with a blending device 15, and the blending device 15 comprises two shaft mechanical arms arranged on the main body rack 1 and blending heads arranged at the tail ends of the two shaft mechanical arms. As shown in fig. 2 and 3, the two-axis mechanical arm is used for driving the blending head to move in the vertical direction and the horizontal direction, so that the blending head can move to a reaction cup position or a reagent adding and starting position, and is inserted into the reaction cup to complete stirring and then reset. The mixing head can adopt a mechanical or ultrasonic disperser.

The foregoing is a detailed description of one or more embodiments of the invention, which is set forth in more detail and is not intended to limit the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the spirit of the invention, which falls within the scope of the invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (10)

1. The utility model provides a blood sample analyzer, includes main part frame (1) and sets up detection module (2), reagent refrigeration dish (3), reaction cup incubation dish (4), sample frame transport module (5), sampling application of sample module (6), emergency call module (7), retest module (8), reaction cup transport module (9) on main part frame (1), reagent refrigeration dish (3) are provided with reagent position (31) that are used for placing the reagent, reaction cup incubation dish (4) are provided with reaction cup position (41) that are used for placing the reaction cup, its characterized in that:

the reaction cup incubation disc (4) is arranged on the outer side of the reagent refrigeration disc (3) in a surrounding mode and is connected with the main body frame (1) in a rotating mode; the detection module (2), the emergency treatment module (7) and the reaction cup conveying module (9) are distributed on the main body frame (1) around the reaction cup incubation disc (4);

the sample rack conveying module (5) comprises a sample inlet track (51), a connecting track (52) and a sample outlet track (53) which surround the reaction cup incubation disc (4) and are connected in sequence;

the sampling and sample-adding module (6) comprises a first sample-adding device (61), a second sample-adding device (62), a third sample-adding device (63) and a fourth sample-adding device (64) which are distributed around the reaction cup incubation disc (4) and detachably connected to the main body frame (1), wherein the first, second, third and fourth sample-adding devices respectively comprise a needle tube (611), a rotary driving device for driving the needle tube (611) and enabling the projection of the moving track of the needle tube on the horizontal plane to be circular, and an up-and-down driving device for driving the needle tube to reciprocate up and down;

the moving track of the needle tube of the first sample adding device (61) covers the connecting track (52), the reaction cup incubation disc (4) and the reagent refrigerating disc (3);

the retest module (8) is connected to the sample outlet track (53), and the moving track of the needle tube of the second sample adding device (62) covers the retest module (8), the reaction cup incubation disc (4) and the reagent refrigerating disc (3);

the moving track of the needle tube of the third sample adding device (63) covers the emergency treatment module (7), the reaction cup incubation disc (4) and the reagent refrigerating disc (3);

the fourth sample adding device (64) is arranged near the detection module (2), and the moving track of the needle tube of the fourth sample adding device (64) covers the reaction cup incubation disc (4) and the reagent refrigerating disc (3).

2. A blood sample analyzer according to claim 1, wherein: the main body frame (1) is also provided with at least 2 sample adding positions (11) for placing reaction cups and a starting reagent adding position (12);

the moving track of the needle tube of the first sample adding device (61) also covers the sample adding position (11); the moving tracks of the needle tubes of the second sample adding device and the fourth sample adding device cover the sample adding starting reagent position (12).

3. A blood sample analyzer according to claim 2, wherein: the blood sample analyzer further comprises a cuvette transport module (9), the cuvette transport module (9) comprising a cuvette input track (91), a first cuvette holding device (92) for transferring cuvettes from the cuvette input track (91) to the loading location (11) or the cuvette incubation tray (4), and a second cuvette holding device (93) for transferring cuvettes from the cuvette incubation tray (4) to the loading start reagent location (12) or the detection module (2); first grab a glass device (92) and second and grab a glass device (93) and all be in including setting up triaxial manipulator (921) on main part frame (1) and setting are in reaction cup tongs (922) that triaxial manipulator (921) are terminal.

4. A blood sample analyzer according to claim 2, wherein: still be provided with on main part frame (1) that first abandon rim of a cup (13) and second abandon rim of a cup (14), first abandon rim of a cup (13) setting and be in near sample addition position (11), rim of a cup (14) setting is abandoned to the second is in near detection module (2), first, second abandon the rim of a cup and all be connected with and abandon cup pipe (94), it is provided with waste material bucket (95) to abandon cup pipe (94) bottom.

5. A blood sample analyzer according to claim 1, wherein: a first transfer device (55) used for transferring the sample rack from the sample feeding track to the connecting track is arranged between the sample feeding track (51) and the connecting track (52), and a second transfer device (56) used for transferring the sample rack from the connecting track to the sample discharging track is arranged between the connecting track (52) and the sample discharging track (53).

6. A blood sample analyzer according to claim 1, wherein: the first sample adding device, the second sample adding device, the third sample adding device and the fourth sample adding device respectively comprise a spline shaft (612) and a supporting arm (613) for connecting the spline shaft (612) and the needle tube (611); the rotary driving device comprises a first driven wheel (614) in clearance fit with the spline shaft, a first driving wheel (616) in transmission connection with the first driven wheel (614) through a first synchronous belt (615), and a first motor (617) for driving the first driving wheel (616) to rotate; the upper and lower drive device comprises an interference fit, the spline shaft (612) is far away from a bearing (618) at one end of the supporting arm (613), the bearing (618) is connected with a sliding block (619), the sliding block (619) is connected with a sliding rail (620) in a sliding manner, and the sliding block (619) is further provided with a drive to follow the sliding block (619) along a first linear module of the reciprocating sliding of the sliding rail (620).

7. A blood sample analyzer according to claim 1, wherein: the detection module (2) comprises a magnetic bead detection device (21) and an optical detection device (22), the magnetic bead detection device (21) is provided with a magnetic bead detection position (211), and the optical detection device (22) is provided with an optical detection position (221).

8. A blood sample analyzer according to claim 1, wherein: the emergency treatment module (7) comprises an emergency treatment synchronous belt conveyor (71), and third limiting plates (72) are arranged on two sides of the emergency treatment synchronous belt conveyor (71); the emergency treatment module (7) is provided with an emergency treatment sample sampling position (73), and the moving track of the needle tube of the third sample adding device (63) covers the emergency treatment sample sampling position (73).

9. A blood sample analyzer according to claim 1, wherein: the retest module (8) comprises a retest bottom plate (81), a third transfer device for pushing the sample rack into the retest bottom plate (81) is arranged on the sample outlet rail (53), and fourth limiting plates (82) are arranged on two sides of the retest bottom plate (81); the retest module (8) further comprises a retest pushing device and a retest sample sampling position (83), the retest pushing device is used for pushing the sample rack to move, and the moving track of the needle tube of the second sample adding device (62) covers the retest sample sampling position (83).

10. A blood sample analyzer according to claim 1, wherein: reaction cup incubation dish (4) with add start reagent position (12) and all be provided with mixing device (15), mixing device (15) are including setting up diaxon arm on main part frame (1) is in with the setting the terminal mixing head of diaxon arm.

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