CN218157925U - Double-function immunity analyzer - Google Patents

Abstract

The utility model relates to an immunity check out test set technical field especially relates to a difunctional immunoassay appearance, including the pedestal, be equipped with liquid chip detection module on the pedestal, chemiluminescence detection module, sample storehouse, reagent storehouse, reaction disc and arm, place the sample in the sample storehouse, place liquid chip detection reagent and chemiluminescence detection reagent in the reagent storehouse, the reaction disc is used for carrying out the sample reaction, and the arm is transferred the sample after reaction of reaction disc department sample is accomplished to liquid chip detection module and is carried out liquid chip method and detect or transfer to chemiluminescence detection module and carry out chemiluminescence method and detect. The method realizes the free selection of two detection methods of liquid chip detection and chemiluminescence detection on one instrument, so that one instrument has the functions of multi-index parallel analysis of liquid chip detection and single-index ultrahigh sensitivity and wide linear range of chemiluminescence detection.

Description

Double-function immunity analyzer

Technical Field

The utility model relates to an immunodetection equipment technical field especially relates to a difunctional immunoassay appearance.

Background

The liquid chip detection technology is also called flow fluorescence method, which is a multi-index parallel analysis technology platform integrating a plurality of technologies such as encoding microspheres as a core, a current-collecting principle, laser analysis, high-speed digital signal processing and the like, can simultaneously and accurately detect a plurality of different biomolecules at one time, can theoretically detect more than 100 indexes at most, and has the characteristics of high flux, high sensitivity, parallel detection and the like.

The chemiluminescence detection technology is another common immunoassay method, which is a method for fixing bioactive substances such as enzyme, antigen, antibody and the like on the surface of a magnetic particle through the magnetic particle, reacting with a sample, adding a substrate, detecting a luminescence signal, and performing immunoassay, and generally comprises the steps of filling, uniformly mixing, incubating, washing, detecting and the like.

At present, an immunoreagent for liquid chip detection can only be matched with a special liquid chip immunoassay analyzer for detection, and an immunoreagent for chemiluminescence detection can only be matched with a special chemiluminescence immunoassay analyzer for detection, so that the defect that the available detection technology of one immunoassay analyzer is single exists.

SUMMERY OF THE UTILITY MODEL

The to-be-solved technical problem of the utility model is to provide a compatible liquid chip detects and two kinds of detection methods's of chemiluminescence difunctional immunoassay appearance to overcome prior art's above-mentioned defect.

In order to solve the technical problem, the utility model adopts the following technical scheme: the utility model provides a difunctional immunoassay appearance, includes the pedestal, be equipped with liquid chip detection module on the pedestal, chemiluminescence detection module, the sample storehouse, the reagent storehouse, reaction dish and arm, place the sample in the sample storehouse, place liquid chip detection reagent and chemiluminescence detection reagent in the reagent storehouse, the reaction dish is used for carrying out the sample reaction, the arm is transferred the sample after the sample reaction of reaction dish department and is accomplished to liquid chip detection module and carry out liquid chip method detection or transfer to chemiluminescence detection module and carry out chemiluminescence method detection.

Preferably, the reaction disc and the mechanical arm are both arranged between the liquid chip detection module and the chemiluminescence detection module.

Preferably, the robot arm is disposed above the reaction tray.

Preferably, the sample is transferred by the mechanical arm in an XYZ axial moving mode or a swing arm type.

Preferably, the pedestal is further provided with a garbage can, and garbage generated in the detection process is placed in the garbage can.

Preferably, the test device further comprises a control module, the liquid chip detection module, the chemiluminescence detection module and the mechanical arm are all connected with the control module, the control module controls the mechanical arm to transfer a sample after the reaction of the sample at the reaction disc to the liquid chip detection module or the chemiluminescence detection module according to a project to be tested, and controls the liquid chip detection module or the chemiluminescence detection module to perform detection and output a detection result.

Compared with the prior art, the utility model discloses the progress that has showing:

the utility model discloses a difunctional immunoassay appearance has integrated liquid chip detection module and chemiluminescence detection module in an instrument, one set of sample storehouse of both sharing, reagent storehouse and reaction disc, sample after the sample reaction is accomplished can be according to the detection project type, it is selectively transferred to liquid chip detection module or chemiluminescence detection module to carry out corresponding detection with it by the arm, thereby two kinds of detection methods of free choice liquid chip detection and chemiluminescence detection have been realized on an instrument, make an instrument have the parallel analysis function of many indexs that liquid chip detected and the single index ultrahigh sensitivity and the wide linear range function that chemiluminescence detected concurrently.

Drawings

Fig. 1 is a schematic front view of a bifunctional immunoassay analyzer according to an embodiment of the present invention.

Fig. 2 is a schematic side view of a dual function immunoassay analyzer according to an embodiment of the present invention.

Fig. 3 is a schematic top view of a dual function immunoassay analyzer according to an embodiment of the present invention.

Wherein the reference numerals are as follows:

1. pedestal

2. Liquid chip detection module

3. Chemiluminescence detection module

4. Sample bin

5. Reagent storehouse

6. Reaction disc

7. Mechanical arm

8. Garbage can

Detailed Description

The following describes the present invention in further detail with reference to the accompanying drawings. These embodiments are only for illustrating the present invention and are not to be construed as limiting the present invention.

In the description of the present invention, it should be noted that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for convenience of description and simplification of the description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected" and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.

In addition, in the description of the present invention, "a plurality" means two or more unless otherwise specified.

As shown in fig. 1 to 3, an embodiment of the present invention is a dual function immunoassay analyzer. The bifunctional immunoassay analyzer of the present embodiment includes a pedestal 1, and the pedestal 1 is provided with a liquid chip detection module 2, a chemiluminescence detection module 3, a sample chamber 4, a reagent chamber 5, a reaction tray 6, and a mechanical arm 7.

Wherein, pedestal 1 is the whole support rack of difunctional immunoassay appearance, and liquid chip detection module 2, chemiluminescence detection module 3, sample storehouse 4, reagent storehouse 5, reaction plate 6 and arm 7 integration are on pedestal 1.

The liquid chip detection module 2 is used for realizing liquid chip method detection on a sample. The liquid chip method mainly utilizes the flow principle to realize one-tube multi-index detection through the coding microspheres, and the index number of parallel detection is related to the variety number of the coding microspheres. The encoding microspheres can be selected from fluorescent encoding microspheres or quantum dot encoding microspheres and the like. The laser can be selected from different configurations such as single laser, double laser or triple laser. Therefore, the liquid chip detection module 2 can select any one of single-laser three-color flow type, double-laser four-color flow type, double-laser six-color flow type and other similar flow type devices with different configuration parameters. The configuration of the liquid chip detection module 2 capable of realizing liquid chip method detection is the prior art, and is not described herein again.

The chemiluminescence detection module 3 is used for realizing chemiluminescence method detection on a sample. The chemiluminescence method detection is a trace analysis method for determining the content of an object to be detected by detecting the chemiluminescence intensity of a system by using an instrument according to the principle that the concentration of the object to be detected in a chemical detection system and the chemiluminescence intensity of the system are in a linear quantitative relation under a certain condition. Chemiluminescence is classified into direct chemiluminescence, indirect chemiluminescence, electrochemiluminescence, light-activated chemiluminescence, and the like. Therefore, the chemiluminescence detection module 3 can be any one of acridinium ester chemiluminescence, alkaline phosphate enzymatic chemiluminescence, horseradish peroxidase enzymatic chemiluminescence, electrochemiluminescence, light-activated chemiluminescence and the like similar to different luminescence detection modules. The configuration of the chemiluminescence detection module 3 capable of realizing chemiluminescence detection is prior art and is not described in detail herein.

The sample is placed in the sample chamber 4. The sample is a serum or plasma or whole blood sample, placed on a sample rack, and inserted into the sample compartment 4.

Liquid chip detection reagent and chemiluminescence detection reagent are placed in the reagent bin 5. The liquid chip detection reagent is contained in the liquid chip detection reagent box, the chemiluminescence detection reagent is contained in the chemiluminescence detection reagent box, and the liquid chip detection reagent box and the chemiluminescence detection reagent box are both placed in the reagent bin 5.

The reaction tray 6 is used for carrying out a sample reaction. The main process of sample reaction includes grabbing a cuvette, sucking a sample, adding a detection reagent (liquid chip detection reagent/chemiluminescence detection reagent), incubating and washing, which is the prior art and is not described herein again. The sample after the reaction is completed can be detected (liquid chip method detection/chemiluminescence method detection).

The mechanical arm 7 transfers the sample after the reaction of the sample on the reaction disk 6 to the liquid chip detection module 2 for liquid chip method detection or transfers the sample to the chemiluminescence detection module 3 for chemiluminescence detection.

Therefore, the bifunctional immunoassay analyzer of the embodiment integrates the liquid chip detection module 2 and the chemiluminescence detection module 3 in one instrument, the two instruments share one set of the sample bin 4, the reagent bin 5 and the reaction tray 6, and a sample after sample reaction can be selectively transferred and configured to the liquid chip detection module 2 or the chemiluminescence detection module 3 by the mechanical arm 7 according to the detection item type for corresponding detection, so that two detection methods of liquid chip detection and chemiluminescence detection can be freely selected on one instrument, and the instrument has the functions of multi-index parallel analysis function of liquid chip detection and single-index ultrahigh sensitivity and wide linear range of chemiluminescence detection.

In this embodiment, referring to fig. 1, preferably, the reaction tray 6 and the mechanical arm 7 are both disposed between the liquid chip detection module 2 and the chemiluminescence detection module 3, so that the mechanical arm 7 transfers the sample after the reaction of the sample on the reaction tray 6 to the liquid chip detection module 2 or the chemiluminescence detection module 3. Preferably, the robot arm 7 is disposed above the reaction tray 6.

In this embodiment, the structural form of the robot arm 7 is not limited, and a conventional robot arm structure in the prior art may be adopted. For example, in one embodiment, the robot arm 7 may transfer the sample in an XYZ-axis movement manner, that is, the robot arm 7 moves in an X-direction, a Y-direction, and a Z-direction, thereby transferring the sample between the reaction tray 6 and the liquid chip detection module 2 or between the reaction tray 6 and the chemiluminescence detection module 3. In another embodiment, the mechanical arm 7 may move the sample in a swing arm type, that is, the mechanical arm 7 moves in a swing manner between the reaction tray 6 and the liquid chip detection module 2, and between the reaction tray 6 and the chemiluminescence detection module 3, so as to realize the movement of the sample between the reaction tray 6 and the liquid chip detection module 2, or between the reaction tray 6 and the chemiluminescence detection module 3.

The sample after the reaction of the sample on the reaction disk 6 is finished is contained in the reaction cup, and the mechanical arm 7 transfers the sample and realizes the transfer of the reaction cup by grabbing. In this embodiment, the manner of gripping the reaction cup by the mechanical arm 7 is not limited, and for example, a mechanical gripper gripping manner may be adopted, and a vacuum suction gripping manner may also be adopted.

In this embodiment, the mechanical arm 7 participates in the sample reaction process at the reaction disk 6 to realize actions of grabbing a reaction cup, sucking a sample, adding a detection reagent, and the like in the sample reaction process.

In this embodiment, referring to fig. 1, preferably, a trash can 8 is further disposed on the pedestal 1, and trash generated in the detection process is placed in the trash can 8.

Preferably, the dual-function immunoassay analyzer of the present embodiment further includes a control module (not shown in the figure), the liquid chip detection module 2, the chemiluminescence detection module 3, and the mechanical arm 7 are all connected to the control module, and the control module controls the mechanical arm 7 to transfer the sample after the reaction of the sample on the reaction disk 6 to the liquid chip detection module 2 or the chemiluminescence detection module 3 according to the item to be tested, and controls the liquid chip detection module 2 or the chemiluminescence detection module 3 to perform detection and output the detection result, thereby implementing the automatic detection of the dual-function immunoassay analyzer of the present embodiment. The control module can comprise a display interface and a controller, the display interface is used for displaying parameter settings of detection items and detection results, and the controller is used for controlling the liquid chip detection module 2, the chemiluminescence detection module 3 and the mechanical arm 7 to work. The form of the controller is not limited, and the existing controller, such as a PLC controller or a single chip microcomputer, can be adopted.

The detection process of the bifunctional immunoassay analyzer of the present embodiment is as follows:

1. a serum or plasma or whole blood sample is placed on the sample holder and inserted into the sample chamber 4.

2. The liquid chip detection kit and the chemiluminescence detection kit are placed in the reagent bin 5.

3. Entering a display interface of the control module, setting items to be tested of the current sample, and after the setting is finished, controlling the action of the mechanical arm 7 by a controller of the control module to perform a sample reaction process at the reaction disc 6.

4. According to the set items to be tested, the controller controls the mechanical arm 7 to grab the reaction cup after the reaction of the sample on the reaction disk 6 is completed and transfer the reaction cup to the detection module (the liquid chip detection module 2 or the chemiluminescence detection module 3) required by the test items for detection. And outputting the detection result after the detection is finished to a display interface of the control module.

Thus, the sample detection is completed.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of modifications and replacements can be made without departing from the technical principle of the present invention, and these modifications and replacements should also be considered as the protection scope of the present invention.

Claims (6)

1. The utility model provides a difunctional immunoassay appearance, its characterized in that includes pedestal (1), be equipped with liquid chip detection module (2), chemiluminescence detection module (3), sample storehouse (4), reagent storehouse (5), reaction disc (6) and arm (7) on pedestal (1), place the sample in sample storehouse (4), place liquid chip detection reagent and chemiluminescence detection reagent in reagent storehouse (5), reaction disc (6) are used for carrying out the sample reaction, arm (7) will sample after reaction disc (6) department sample reaction is accomplished is transferred extremely liquid chip detection module (2) carry out liquid chip method and detect or transfer extremely chemiluminescence detection module (3) carry out the chemiluminescence method and detect.

2. The apparatus according to claim 1, wherein said reaction disk (6) and said robotic arm (7) are disposed between said liquid chip detection module (2) and said chemiluminescent detection module (3).

3. The apparatus according to claim 2, wherein said robotic arm (7) is disposed above said reaction disk (6).

4. The apparatus according to claim 1, wherein the robotic arm (7) is configured to move the sample in an XYZ-axis mobile manner or a swing arm type.

5. The apparatus according to claim 1, wherein a garbage can (8) is further disposed on the pedestal (1), and garbage generated during the detection process is placed in the garbage can (8).

6. The bifunctional immunoassay analyzer of any one of claims 1 to 5, further comprising a control module, wherein the liquid chip detection module (2), the chemiluminescence detection module (3) and the mechanical arm (7) are all connected to the control module, the control module controls the mechanical arm (7) to transfer the sample after the reaction of the sample on the reaction tray (6) to the liquid chip detection module (2) or the chemiluminescence detection module (3) according to the item to be tested, and controls the liquid chip detection module (2) or the chemiluminescence detection module (3) to perform detection and output the detection result.

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