CN214473391U - Homogeneous phase immunoassay appearance - Google Patents
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- CN214473391U CN214473391U CN202022778166.XU CN202022778166U CN214473391U CN 214473391 U CN214473391 U CN 214473391U CN 202022778166 U CN202022778166 U CN 202022778166U CN 214473391 U CN214473391 U CN 214473391U
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Abstract
The utility model discloses a homogeneous phase immunoassay appearance, include: an operation table; the sample storage and conveying module, the reaction container storage and loading module, the reagent storage and conveying module, the incubation module and the detection module are arranged above the operating platform; the sample storage and conveying module is located at one end of the operating platform, the reagent storage and conveying module is located at the other side end of the operating platform, the incubation module is located in the middle of the operating platform, and the reaction container storage and loading module and the detection module are both arranged at the side of the incubation module. According to the utility model discloses, it need not solid carrier and solid phase probe, need not to separate antigen-antibody complex and free antigen-antibody, can wait to detect the sample and directly survey, compact structure simultaneously, easy operation is swift, and degree of automation is high, has wide market using value.
Description
Technical Field
The utility model relates to a medical science inspection field. More specifically, the utility model relates to a homogeneous phase immunoassay appearance.
Background
In the field of medical testing, it is well known to use analytical devices of different configurations to perform the detection and analysis of a sample. In the process of researching and implementing detection analysis of samples, the inventor finds that the analysis device in the prior art has at least the following problems:
most of the existing analysis devices adopt a chemiluminescence immunoassay technology, and the existing analysis devices have the defects of complex structure, complex technology, complex operation and easy error occurrence, such as: the main technology adopted by the chemiluminescence immunoassay technology is magnetic particle chemiluminescence, and the core hypothesis is that the separation of a specific immune compound and a biological matrix can be realized certainly through magnetic separation, but in the clinical practical application, due to the diversity of clinical samples, the cases of magnetic separation failure cannot be avoided, such as the phenomenon of 'jump value' caused by nonspecific adsorption caused by fibrin adhesion, false positive caused by heterophilic antibodies and the like, meanwhile, due to the fact that magnetic cleaning faults are easy to occur in the cleaning process of an analysis device, the magnetic separation failure can also be caused, the analysis device cannot be accurately analyzed, the analysis and detection cost is high, the analysis and detection device cannot be widely applied to the immediate detection fields of emergency treatment and the like, and meanwhile, the existing immediate detection immunoassay device has the common problem of poor precision, such as a colloidal gold immunoassay device, a fluorescence chromatography immunoassay device, a fluorescence detection device and the like, Colloidal turbidimetric immunoassays, etc., are only used as an auxiliary primary screening detection means, and are ultimately confirmed by chemiluminescence immunoassay.
The homogeneous fluoroimmunoassay can directly perform the determination without separating the antigen-antibody complex from the free antigen-antibody after the antigen-antibody characteristic reaction is completed.
In view of the above, there is a need to develop a homogeneous immunoassay analyzer to solve the above problems.
SUMMERY OF THE UTILITY MODEL
To the weak point that exists among the prior art, the utility model discloses a main objective provides a homogeneous phase immunoassay appearance, and it stores the loading module through reaction vessel and loads reaction vessel to hatching the module, and through sample storage transport module will wait to detect the sample and load to be located the reaction vessel on hatching the module in, through reagent storage transport module with detect reagent transport to be located the reaction vessel on hatching the module in for detect reagent and wait to detect the sample and mix, measure through the mixed liquid of detection module in to reaction vessel and detect; homogeneous phase immunoassay appearance need not solid carrier and solid phase probe, need not to separate antigen-antibody complex and free antigen-antibody, can wait to detect the sample and directly survey, compact structure simultaneously, easy operation is swift, degree of automation is high, has wide market using value.
Another object of the utility model is to provide a homogeneous phase immunoassay appearance, it is equipped with emergency call loading unit, and the user can wait to detect the sample with needs emergency treatment and place emergency call loading unit is carried extremely by emergency call loading unit the emergency call material loading station of sample transfer chain is being carried through the sample transfer chain, can avoid waiting to detect the sample with needs emergency call treatment and place first sample buffer zone and line up waiting for conveying and detecting, has improved work efficiency, has practiced thrift operating time to adapt to instant measuring such as current emergency call.
To achieve these objects and other advantages in accordance with the purpose of the invention, there is provided a homogeneous immunoassay analyzer comprising: an operation table; and
the sample storage and conveying module, the reaction container storage and loading module, the reagent storage and conveying module, the incubation module and the detection module are arranged above the operating platform;
the sample storage and conveying module is positioned at one end of the operating platform, the reagent storage and conveying module is positioned at the other side end of the operating platform, the incubation module is positioned in the middle of the operating platform, and the reaction container storage and loading module and the detection module are both arranged at the side of the incubation module;
the reaction container storage and loading module loads the reaction container to the incubation module, the sample storage and conveying module conveys a sample to be detected to the reaction container on the incubation module, the reagent storage and conveying module conveys a detection reagent to the reaction container on the incubation module, so that the detection reagent is mixed with the sample to be detected, and the detection module measures and detects mixed liquid in the reaction container.
Preferably, the sample storage and delivery module comprises: the sample conveying line is sequentially provided with an emergency call feeding station, a sample identification station, a sample adding station and a sample recovery station along the conveying direction of the sample conveying line;
the sample conveying unit is arranged beside the sample conveying line and is positioned at a sample feeding station;
the sample identification module is arranged beside the sample conveying line and is positioned at a sample identification station; and
the sample recovery unit is arranged beside the sample conveying line and is positioned at a sample recovery station;
the sample conveying unit is used for conveying a sample to be detected to a sample feeding station, the sample identification module is used for identifying the sample to be detected, and the sample recovery unit is used for recovering the sample.
Preferably, the sample storage and delivery module further comprises: the emergency loading unit is positioned at the emergency feeding station; and
and the sample loading unit is positioned at the sample loading station and used for conveying a sample positioned at the sample loading station to the reaction container on the incubation module.
Preferably, the reaction vessel storage load module comprises: a reaction vessel storage tray having at least two reaction vessels stored thereon; and
the movable grabbing module is arranged beside the reaction vessel storage disk;
the movable grabbing module is used for sequentially grabbing and placing the reaction containers stored on the reaction container storage disc onto the incubation module.
Preferably, the reagent storage delivery module comprises: the reagent turntable is provided with at least two reagent containers above, a detection reagent is stored in each reagent container, and the reagent turntable is sequentially provided with a reagent identification station and a reagent sample adding station along the rotation direction of the reagent turntable;
the reagent identification module is arranged beside the reagent rotary table and is positioned at the reagent identification station; and
the reagent sample adding module is arranged beside the reagent turntable and is positioned at the reagent sample adding station;
the reagent identification module identifies the reagent container positioned at the reagent identification station, so as to identify the detection reagent in the reagent container, and the reagent loading module loads the detection reagent in the reagent container positioned at the reagent loading station into the reaction container.
Preferably, the incubation module is an incubation rotating disc, at least two placing parts are arranged above the incubation rotating disc, each placing part is regularly arrayed along the periphery of the incubation rotating disc, and the placing parts are used for placing reaction containers;
the rotary disc is provided with a reaction container feeding station, a sample feeding station, a reagent feeding station, an incubation station and a detection station along the rotation direction of the rotary disc;
the reaction container storage and loading module is located at the reaction container loading station, the sample loading unit is located at the sample loading station, the reagent loading module is located at the reagent loading station, and the detection module is located at the detection station.
Preferably, the lower part of incubating the module is equipped with temperature control module, temperature control module to the incubation temperature of incubating the module carries out accurate control.
Preferably, the detection module includes: the device comprises a photon counting unit, an optical filter assembly, a two-way mirror, a light source and a light source optical filter;
the two-way mirror is obliquely arranged and is positioned right above the detection station, the light source is arranged at the side of the two-way mirror, the light source optical filter is arranged between the light source and the two-way mirror, the photon counting unit and the optical filter are both arranged above the two-way mirror, and the optical filter is arranged between the photon counting unit and the two-way mirror;
the light source provides a detection light source, the optical filter component and the light source optical filter are used for selecting light with specific wavelength, and the photon counting unit collects final photon signals.
One of the above technical solutions has the following advantages or beneficial effects: loading the reaction container to the incubation module through the reaction container storage and loading module, loading a sample to be detected to the reaction container on the incubation module through the sample storage and conveying module, conveying a detection reagent to the reaction container on the incubation module through the reagent storage and conveying module, mixing the detection reagent and the sample to be detected, and measuring and detecting the mixed liquid in the reaction container through the detection module; the homogeneous phase immunoassay analyzer of the utility model does not need a solid phase carrier and a solid phase probe, does not need to separate an antigen-antibody compound from free antigen-antibody, can directly measure a sample to be detected, and has the advantages of compact structure, simple and rapid operation, high automation degree and wide market application value;
another technical scheme in the above technical scheme has the following advantages or beneficial effects: the utility model discloses be equipped with emergency call loading unit, the user can be with waiting to detect that needs emergency treatment treat that the sample is placed emergency call loading unit is carried extremely by emergency call loading unit the emergency call material loading station of sample transfer chain is being carried through the sample transfer chain, can avoid waiting to detect that the sample is placed first sample buffer area and is queued for the conveying and detect that will need emergency treatment, has improved work efficiency, has practiced thrift operating time to adapt to instant measuring such as current emergency call.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.
Drawings
In order to illustrate the technical solutions of the embodiments of the present invention more clearly, the drawings of the embodiments will be briefly described below, and it is obvious that the drawings in the following description only relate to some embodiments of the present invention, and are not intended to limit the present invention, wherein:
fig. 1 is a schematic structural diagram of a homogeneous immunoassay analyzer according to an embodiment of the present invention;
fig. 2 is a schematic diagram of an optical path of the detection module in an embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
In the drawings, the shape and size may be exaggerated for clarity, and the same reference numerals will be used throughout the drawings to designate the same or similar components.
Unless defined otherwise, technical or scientific terms used herein shall have the ordinary meaning as understood by one of ordinary skill in the art to which this invention belongs. The use of "first," "second," and similar terms in the description and in the claims does not indicate any order, quantity, or importance, but rather is used to distinguish one element from another. Also, the use of the terms "a," "an," or "the" and similar referents do not denote a limitation of quantity, but rather denote the presence of at least one. The word "comprise" or "comprises", and the like, means that the element or item listed before "comprises" or "comprising" covers the element or item listed after "comprising" or "comprises" and its equivalents, and does not exclude other elements or items. "upper", "lower", "left", "right", and the like are used merely to indicate relative positional relationships, and when the absolute position of the object being described is changed, the relative positional relationships may also be changed accordingly.
In the following description, terms such as center, thickness, height, length, front, back, rear, left, right, top, bottom, upper, lower, etc., are defined with respect to the configurations shown in the respective drawings, and in particular, "height" corresponds to a dimension from top to bottom, "width" corresponds to a dimension from left to right, "depth" corresponds to a dimension from front to rear, which are relative concepts, and thus may be varied accordingly depending on the position in which it is used, and thus these or other orientations should not be construed as limiting terms.
Terms concerning attachments, coupling and the like (e.g., "connected" and "attached") refer to a relationship wherein structures are secured or attached, either directly or indirectly, to one another through intervening structures, as well as both movable or rigid attachments, unless expressly described otherwise.
According to an embodiment of the present invention, in combination with the illustrations of fig. 1 and 2, it can be seen that a homogeneous immunoassay analyzer includes: the sample storage and conveying module 1, the reaction container storage and loading module 2, the reagent storage and conveying module 3, the incubation module 4 and the detection module 5 are arranged above the operation table;
the sample storage and conveying module 1 is positioned at one end of the operating platform, the reagent storage and conveying module 3 is positioned at the other side end of the operating platform, the incubation module 4 is positioned in the middle of the operating platform, and the reaction vessel storage and loading module 2 and the detection module 5 are both arranged at the side of the incubation module 4;
the reaction container storage and loading module 2 loads the reaction container to the incubation module 4, the sample storage and conveying module 1 conveys the sample to be detected to the reaction container on the incubation module 4, the reagent storage and conveying module 3 conveys the detection reagent to the reaction container on the incubation module 4, so that the detection reagent is mixed with the sample to be detected, and the detection module 5 measures and detects the mixed liquid in the reaction container.
In a preferred embodiment, the homogeneous immunoassay analyzer further comprises a waste storage module, wherein the waste storage module comprises a solid waste storage unit and a waste liquid storage unit, the solid waste storage unit is used for storing the reaction container after the analysis and detection, and the waste liquid storage unit is used for storing the mixed liquid after the analysis and detection.
The solid waste storage unit and the waste liquid storage unit respectively prevent the reaction container and the mixed liquid after analysis and detection from being discharged randomly to cause environmental pollution.
Further, the sample storage and delivery module 1 comprises: the sample conveying line 12 is sequentially provided with an emergency call feeding station, a sample identification station, a sample adding station and a sample recovery station along the conveying direction of the sample conveying line 12;
the sample conveying unit 11 is arranged beside the sample conveying line 12, and the sample conveying unit 11 is positioned at a sample feeding station;
the sample identification module 14 is arranged beside the sample conveying line 12, and the sample identification module 14 is positioned at a sample identification station; and
the sample recovery unit 13 is arranged beside the sample conveying line 12, and the sample recovery unit 13 is positioned at a sample recovery station;
the sample conveying unit 11 is used for conveying a sample to be detected to a sample feeding station, the sample identification module 14 is used for identifying the sample to be detected, and the sample recovery unit 13 is used for recovering the sample.
In a preferred embodiment, the sample delivery unit 11 comprises: the sample loading area is butted with the sample conveying line 12, a sample rack is placed in the first sample buffer area, and a sample to be detected is placed in the sample rack; the sample rack is placed in the first sample buffer area, transported to the sample loading area in the first sample buffer area, and then transported to the sample loading station of the sample transport line 12.
The sample recovery unit 13 includes: the sample unloading area is butted with the sample conveying line 12, and the sample rack which is completely taken is conveyed to a recovery station through the sample conveying line 12 and conveyed to the second sample buffer area for recovery and storage through the sample unloading area.
In a preferred embodiment of the present invention, the sample identification module 14 is a code scanner, the surface of the sample holder is provided with an identification code, and the code scanner scans the identification code on the surface of the sample holder to identify the information of the sample to be detected.
Further, the sample storage and delivery module 1 further comprises: an emergency loading unit 15 located at the emergency loading station; and
and the sample loading unit 16 is positioned at the sample loading station, and the sample loading unit 16 conveys the sample positioned at the sample loading station into the reaction container on the incubation module 4.
In an embodiment of the present invention, the sample loading unit 16 is a mechanical arm structure, and in another embodiment of the present invention, the sample loading unit 16 is a linear guide mechanism.
The sample adding unit 16 specifically selects a mechanical arm structure or a linear guide rail mechanism, and a user can select the mechanical arm structure or the linear guide rail mechanism according to actual needs.
The utility model discloses a sample transfer chain 12 is equipped with emergency call material loading station, emergency call material loading station department is equipped with emergency call loading unit 15, and the user can wait to detect the sample with the urgent processing and place emergency call loading unit 15, carry by emergency call loading unit 15 extremely the emergency call material loading station of sample transfer chain 12 is carrying through sample transfer chain 12, can avoid waiting to detect the sample with the urgent processing of needs and place first sample buffer area and queue up and wait for the conveying and detect, has improved work efficiency, has practiced thrift operating time.
It can be understood that the sample rack containing the sample to be detected is placed in the first sample buffer area, conveyed to the sample loading station of the sample conveying line 12 through the sample loading area, and then conveyed to the sample identification station through the sample conveying line 12, the sample to be detected is identified by the sample identification module 14 at the sample identification station for relevant information of the sample to be detected, after identification is completed, the sample to be detected is conveyed to the sample loading station, the sample at the sample loading station is conveyed to the reaction container on the incubation module 4 by the sample loading unit 16, the sample rack is conveyed to the recovery station, and is conveyed to the second sample buffer area through the sample unloading area at the recovery station for recovery and storage.
Further, the reaction vessel storage and loading module 2 includes: a reaction vessel storage tray 21 on which at least two reaction vessels are stored; and
a movable grabbing module 22 arranged beside the reaction vessel storage disk 21;
the movable grabbing module 22 sequentially grabs and places the reaction containers stored on the reaction container storage tray 21 onto the incubation module 4.
In a preferred embodiment, a material presence sensor is disposed on the movable grabbing module 22, and the material presence sensor is used for detecting whether a reaction container is stored in the reaction container storage tray 21,
the reaction vessel storage disk 21 is provided with an idle alarm, and when the reaction vessel storage disk 21 is judged to be in an idle state, the idle alarm gives an idle alarm.
The vacant alarm may be light, sound, image, text, etc., and in a preferred embodiment of the present invention, the vacant alarm is sound.
It can be understood that the movable grabbing module 22 detects the reaction container storage tray 21 through a material sensor, when the material sensor senses that no reaction container exists in the reaction container storage tray 21, the reaction container storage tray 21 is judged to be in an idle state, the idle alarm gives an idle alarm, and when the material sensor senses that a reaction container exists in the reaction container storage tray 21, the movable grabbing module 22 clamps and places the reaction container on the incubation module 4.
Further, the reagent storage and delivery module 3 includes: the reagent turntable 31 is provided with at least two reagent containers above, detection reagents are stored in the reagent containers, and the reagent turntable 31 is sequentially provided with a reagent identification station and a reagent sample adding station along the rotation direction;
the reagent identification module 33 is arranged beside the reagent rotary table 31, and the reagent identification module 33 is positioned at the reagent identification station; and
the reagent sample adding module 32 is arranged beside the reagent turntable 31, and the reagent sample adding module 32 is positioned at the reagent sample adding station;
the reagent identification module 33 identifies the reagent containers located at the reagent identification station, and further identifies the detection reagents in the reagent containers, and the reagent loading module 32 loads the detection reagents in the reagent containers located at the reagent loading station into the reaction containers.
In a preferred embodiment, the reagent identification module 33 is a code scanner, and the surface of the reagent container is provided with an identification code, and the code scanner scans the identification code on the surface of the reagent container to identify the information of the detection reagent in the reagent container.
The reagent identification module 33 identifies the relevant information of the detection reagent, so that the reagent sample adding module 32 can select different detection reagents for detection according to different samples to be detected, the reagent identification module 33 is prevented from being mixed with the sample to be detected when the wrong detection reagent is loaded, waste is prevented, and the detection time is prolonged.
The bottom end of the reagent rotating disc 31 is provided with a rotating disc driver, and the rotating disc driver drives the reagent rotating disc 31 to rotate.
The utility model discloses an in implementing, reagent application of sample module 32 is mechanical arm structure the utility model discloses in another embodiment, reagent application of sample module 32 is linear guide mechanism.
The reagent sample adding module 32 specifically selects a mechanical arm structure or a linear guide rail mechanism, and a user can select the mechanical arm structure or the linear guide rail mechanism according to actual needs.
It can be understood that different detection reagents are stored in different reagent containers, the reagent turntable 31 drives the reagent container with the detection reagent to the reagent identification station, the reagent identification module 33 identifies relevant information of the detection reagent, the reagent container with the detection reagent is driven to the reagent loading station by the reagent turntable 31, and the reagent loading module 32 loads the detection reagent in the reagent container at the reagent loading station into the reaction container on the incubation module 4 to be mixed with the sample to be detected in the reaction container.
Further, the incubation module 4 is an incubation turntable, at least two placing parts are arranged above the incubation turntable, each placing part is regularly arrayed along the periphery of the incubation turntable, and the placing parts are used for placing reaction containers;
the rotary disc is provided with a reaction container feeding station, a sample feeding station, a reagent feeding station, an incubation station and a detection station along the rotation direction of the rotary disc;
the reaction container storage and loading module 2 is located at the reaction container loading station, the sample loading unit 16 is located at the sample loading station, the reagent loading module 32 is located at the reagent loading station, and the detection module 5 is located at the detection station.
Further, the below of incubating module 4 is equipped with temperature control module, temperature control module is in the temperature of incubating module 4 carries out accurate control for wait to detect the mixed liquid of sample and detect reagent and have better incubation effect, the follow-up detection module of being convenient for detects.
In a preferred embodiment of the present invention, the temperature control module employs peltier.
It can be understood that the reaction container is placed on the placing portion of the incubation module 4 by the movable grasping module 22 at the reaction container loading station, the incubation module 4 is conveyed to the sample loading station, the sample to be detected is conveyed into the reaction container located at the sample loading station by the sample loading unit 16, the reaction container containing the sample to be detected is conveyed to the reagent loading station, the corresponding detection reagent is loaded into the reaction container containing the sample to be detected at the reagent loading station by the reagent loading module 32, the reaction container is mixed with the sample to be detected, the reaction container containing the mixed liquid to be detected is conveyed to the incubation station, incubation is performed at the incubation station, and after incubation is completed, the reaction container containing the mixed liquid to be detected is conveyed to the detection station and is detected by the detection module 5.
Further, the detection module 5 includes: a photon counting unit 51, a filter assembly 52, a dichroic mirror 53, a light source 54, and a light source filter 55;
the two-way mirror 53 is obliquely arranged, the two-way mirror 53 is positioned right above the detection station, the light source is arranged at the side of the two-way mirror 53, the light source optical filter 55 is arranged between the light source 54 and the two-way mirror 53, the photon counting unit 51 and the optical filter assembly 52 are both arranged above the two-way mirror 53, and the optical filter assembly 52 is arranged between the photon counting unit 51 and the two-way mirror 53;
the light source 54 provides a detection light source, the optical filter assembly 52 and the light source optical filter 55 are used for selecting light with a specific wavelength, and the photon counting unit 51 collects a final photon signal.
In a preferred embodiment of the present invention, the filter assembly 52 includes: the optical filter switcher is driven by a rotating motor to complete the switching of the first optical filter and the second optical filter so as to realize the detection of the luminous intensity of the sample to be detected with two different wavelengths.
In a preferred embodiment of the present invention, the central wavelength of the light source filter 55 is 320nm, the central wavelength of the first filter is 620nm, and the central wavelength of the second filter is 655 nm.
It can be understood that, at the inspection station, the light source 54 emits an inspection light source, the inspection light source passes through the light source filter 55, the light source filter 55 selects light with a specific wavelength to the dichroic mirror 53, a part of the light is refracted by the dichroic mirror 53 to the reaction vessel of the inspection station, another part of the light is refracted by the dichroic mirror 53 to the first filter, and the photon counting unit 51 collects corresponding photon signals after passing through the first filter to the photon counting unit 51; after the collection is completed, the optical filter switcher switches the first optical filter into a second optical filter, the operations are repeated, the photon counting unit 51 collects photon signals corresponding to the second optical filter, and after the photon counting unit 51 collects two different photon signals, the photon signals are processed through a corresponding algorithm to obtain corresponding detection information of the sample to be detected.
To sum up, the homogeneous phase immunoassay appearance's theory of operation does:
the movable grabbing module 22 detects the reaction container storage tray 21 through a material sensor, when the material sensor senses that no reaction container exists in the reaction container storage tray 21, the reaction container storage tray 21 is judged to be in an idle state, the idle alarm gives an idle alarm, and when the material sensor senses that a reaction container exists in the reaction container storage tray 21, the movable grabbing module 22 clamps the reaction container to a reaction container feeding station on the incubation module 4 and conveys the reaction container to a sample feeding station through the incubation module 4;
the sample rack containing the sample to be detected is placed in the first sample buffer area, is conveyed to the sample loading station of the sample conveying line 12 through the sample loading area, is conveyed to the sample identification station through the sample conveying line 12, the sample to be detected is identified by the sample identification module 14 at the sample identification station, the sample to be detected is conveyed to the sample loading station after identification is finished, the sample positioned at the sample loading station is loaded into the reaction container positioned at the sample loading station of the incubation module 4 through the sample loading unit 16, the reaction container containing the sample to be detected is conveyed to the reagent loading station through the incubation module 4, and the sample rack is conveyed to the recovery station, conveying the sample to a second sample buffer area for recovery and storage through the sample unloading area at a recovery station;
the reagent turntable 31 drives the reagent container filled with the detection reagent to the reagent identification station, the reagent identification module 33 identifies the relevant information of the detection reagent, the reagent container filled with the detection reagent is driven to the reagent loading station by the reagent turntable 31, and the reagent loading module 32 loads the detection reagent in the reagent container positioned at the reagent loading station into the reaction container positioned at the reagent loading station of the incubation module 4 to be mixed with the sample to be detected in the reaction container;
conveying the reaction container filled with the mixed solution to be detected to an incubation station, incubating at the incubation station, after incubation is finished, conveying the reaction container filled with the mixed solution to be detected to a detection station, and detecting by a detection module 5;
at the detection station, the light source 54 emits a detection light source, the detection light source passes through the light source filter 55, the light source filter 55 selects light with a specific wavelength to the two-way mirror 53, one part of the light is refracted to the reaction container of the detection station through the two-way mirror 53, the other part of the light is refracted to the first filter through the two-way mirror 53, and the photon counting unit 51 collects corresponding photon signals after passing through the first filter to the photon counting unit 51; after the collection is completed, the optical filter switcher switches the first optical filter into a second optical filter, the operations are repeated, the photon counting unit 51 collects photon signals corresponding to the second optical filter, and after the photon counting unit 51 collects two different photon signals, the photon signals are processed through a corresponding algorithm to obtain corresponding detection information of the sample to be detected.
The number of apparatuses and the scale of the process described here are intended to simplify the description of the present invention. Applications, modifications and variations of the present invention will be apparent to those skilled in the art.
While embodiments of the invention have been disclosed above, it is not intended to be limited to the applications listed in the specification and the examples. It can be applicable to various and be fit for the utility model discloses a field completely. Additional modifications will readily occur to those skilled in the art. The invention is therefore not to be limited to the specific details and illustrations shown and described herein, without departing from the general concept defined by the claims and their equivalents.
Claims (8)
1. A homogeneous immunoassay analyzer, comprising: an operation table; and
the sample storage and conveying module (1), the reaction container storage and loading module (2), the reagent storage and conveying module (3), the incubation module (4) and the detection module (5) are arranged above the operating platform;
the sample storage and conveying module (1) is positioned at one end of the operating platform, the reagent storage and conveying module (3) is positioned at the other side end of the operating platform, the incubation module (4) is positioned in the middle of the operating platform, and the reaction vessel storage and loading module (2) and the detection module (5) are both arranged at the side of the incubation module (4);
the reaction container storage and loading module (2) loads the reaction container to the incubation module (4), the sample storage and conveying module (1) conveys the sample to be detected to the reaction container on the incubation module (4), the reagent storage and conveying module (3) conveys the detection reagent to the reaction container on the incubation module (4), so that the detection reagent is mixed with the sample to be detected, and the detection module (5) measures and detects the mixed liquid in the reaction container.
2. The homogeneous immunoassay analyzer of claim 1, wherein the sample storage and delivery module (1) comprises: the sample conveying line (12) is sequentially provided with an emergency call feeding station, a sample identification station, a sample adding station and a sample recovery station along the conveying direction of the sample conveying line (12);
the sample conveying unit (11) is arranged beside the sample conveying line (12), and the sample conveying unit (11) is positioned at a sample feeding station;
the sample identification module (14) is arranged beside the sample conveying line (12), and the sample identification module (14) is positioned at a sample identification station; and
the sample recovery unit (13) is arranged beside the sample conveying line (12), and the sample recovery unit (13) is positioned at a sample recovery station;
the sample conveying unit (11) is used for conveying a sample to be detected to a sample feeding station, the sample identification module (14) is used for identifying the sample to be detected, and the sample recovery unit (13) is used for recovering the sample.
3. The homogeneous immunoassay analyzer of claim 2, wherein the sample storage and delivery module (1) further comprises: an emergency loading unit (15) located at the emergency loading station; and
and the sample loading unit (16) is positioned at the sample loading station, and the sample loading unit (16) conveys the sample positioned at the sample loading station to the reaction container on the incubation module (4).
4. The homogeneous immunoassay analyzer of claim 1, wherein the reaction vessel storage loading module (2) comprises: a reaction vessel storage tray (21), the reaction vessel storage tray (21) having at least two reaction vessels stored thereon; and
the movable grabbing module (22) is arranged beside the reaction vessel storage disc (21);
the movable grabbing module (22) is used for sequentially grabbing and placing the reaction containers stored on the reaction container storage disc (21) onto the incubation module (4).
5. The homogeneous immunoassay analyzer of claim 1, wherein the reagent storage and delivery module (3) comprises: the reagent rotating disc (31) is provided with at least two reagent containers above, detection reagents are stored in the reagent containers, and the reagent rotating disc (31) is sequentially provided with a reagent identification station and a reagent sample adding station along the rotating direction;
the reagent identification module (33), the reagent identification module (33) is arranged beside the reagent turntable (31), and the reagent identification module (33) is positioned at the reagent identification station; and
the reagent sample adding module (32) is arranged beside the reagent rotating disc (31), and the reagent sample adding module (32) is positioned at the reagent sample adding station;
the reagent identification module (33) identifies the reagent containers positioned at the reagent identification station, so as to identify the detection reagents in the reagent containers, and the reagent loading module (32) loads the detection reagents in the reagent containers positioned at the reagent loading station into the reaction containers.
6. The homogeneous immunoassay analyzer of claim 1, wherein the incubation module (4) is an incubation carousel, and at least two placement portions are arranged above the incubation carousel, each placement portion is arranged along the periphery of the incubation carousel in a regular array, and the placement portions are used for placing reaction containers;
the rotary disc is provided with a reaction container feeding station, a sample feeding station, a reagent feeding station, an incubation station and a detection station along the rotation direction of the rotary disc;
the reaction vessel storage and loading module (2) is located at the reaction vessel loading station, the sample loading unit (16) is located at the sample loading station, the reagent loading module (32) is located at the reagent loading station, and the detection module (5) is located at the detection station.
7. The homogeneous immunoassay analyzer of claim 1, wherein a temperature control module is disposed below the incubation module (4), and the temperature control module precisely controls the incubation temperature of the incubation module (4).
8. The homogeneous immunoassay analyzer of claim 6, wherein the detection module (5) comprises: a photon counting unit (51), a filter assembly (52), a dichroic mirror (53), a light source (54), and a light source filter (55);
the two-way mirror (53) is obliquely arranged, the two-way mirror (53) is positioned right above the detection station, the light source is arranged at the side of the two-way mirror (53), the light source optical filter (55) is arranged between the light source (54) and the two-way mirror (53), the photon counting unit (51) and the optical filter assembly (52) are both arranged above the two-way mirror (53), and the optical filter assembly (52) is arranged between the photon counting unit (51) and the two-way mirror (53);
the light source (54) provides a detection light source, the optical filter component (52) and the light source optical filter (55) are used for selecting light with specific wavelength, and the photon counting unit (51) collects final photon signals.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022778166.XU CN214473391U (en) | 2020-11-26 | 2020-11-26 | Homogeneous phase immunoassay appearance |
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|---|---|---|---|
| CN202022778166.XU CN214473391U (en) | 2020-11-26 | 2020-11-26 | Homogeneous phase immunoassay appearance |
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| CN214473391U true CN214473391U (en) | 2021-10-22 |
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