CN213517172U

CN213517172U - Full-automatic chemiluminescence immunoassay analyzer

Info

Publication number: CN213517172U
Application number: CN202022308067.5U
Authority: CN
Inventors: 张海峰; 牟胜军; 张勇立; 王斌利
Original assignee: Jiaxing Kaishi Biotechnology Co ltd
Current assignee: Jiaxing Kaishi Biotechnology Co ltd
Priority date: 2020-10-16
Filing date: 2020-10-16
Publication date: 2021-06-22
Anticipated expiration: 2030-10-16

Abstract

The utility model belongs to the technical field of the medical equipment technique and specifically relates to a full-automatic chemiluminescence immunoassay appearance. The full-automatic chemiluminescence immunoassay analyzer comprises a host and a track, wherein the host comprises a shell, a frame body, a reagent disk, a reaction disk, a reagent needle module, a magnetic separation module, a manipulator module, a sample needle module, a photometry module, a cup arranging module and a control module, the reagent disk, the reaction disk, the reagent needle module, the magnetic separation module, the manipulator module, the sample needle module, the photometry module and the cup arranging module are all arranged on the frame body, and is electrically connected with the control module, the outer shell covers the outside of the frame body, the control module is arranged on the frame body, and is positioned in the shell, the cup arranging module comprises an arranging and transferring mechanism, a hopper and a slideway, the slideway is fixed on the frame body, a plurality of reaction cups are arranged in the hopper, one end of the sorting and transferring mechanism is arranged in the hopper and positioned in the reaction cups, and the other end of the sorting and transferring mechanism is erected at the upper end of the slide way.

Description

Full-automatic chemiluminescence immunoassay analyzer

Technical Field

The utility model belongs to the technical field of the medical equipment technique and specifically relates to a full-automatic chemiluminescence immunoassay appearance.

Background

The reagent matched with the full-automatic chemiluminescence immunoassay analyzer is an enzymatic chemiluminescence method reagent, and refers to a technology that a known antibody is coated on a magnetic bead microsphere, a sample to be detected and an enzyme-labeled secondary antibody are added for immunoreaction, and finally a substrate is added to generate glow which is captured by a detector. The full-automatic chemiluminescence immunoassay analyzer is used for analyzing the serum, the plasma and the analytes in other human body fluids, quantitative patient serum and horse radish peroxide are added to the magnetic bead microspheres coated with antibodies, and molecules to be detected in the serum are specifically combined with conjugates of horse radish peroxidase and the antibodies on the carriers. The unreacted free components are separated and washed. And then adding a Luminol luminescent substrate, exciting the intermediate by utilizing free energy released by chemical reaction, returning to an excited state from a ground state, releasing energy in a photon form, reading the photon number of each micropore cup by a photon counter, and quantitatively analyzing the concentration of the molecules to be detected in the sample according to a mathematical model established by a standard substance.

SUMMERY OF THE UTILITY MODEL

The utility model provides a simple structure, cross contamination are few, detection speed is fast, the consumptive material does not shut down the loading, detect the full automatization chemiluminescence immunoassay appearance that the rate of accuracy is high, detection efficiency is high.

The utility model discloses a realize through following technical scheme:

a full-automatic chemiluminescence immunoassay analyzer comprises a host and a track, wherein the host comprises a shell, a frame body, a reagent disc, a reaction disc, a reagent needle module, a magnetic separation module, a manipulator module, a sample needle module, a photometry module, a cup arranging module and a control module, the reagent disc, the reaction disc, the reagent needle module, the magnetic separation module, the manipulator module, the sample needle module, the photometry module and the cup arranging module are all arranged on the frame body, and is electrically connected with the control module, the outer shell covers the outside of the frame body, the control module is arranged on the frame body, and is positioned in the shell, the cup arranging module comprises an arranging and transferring mechanism, a hopper and a slideway, the slideway is fixed on the frame body, a plurality of reaction cups are arranged in the hopper, one end of the sorting and transferring mechanism is arranged in the hopper and positioned in the reaction cups, and the other end of the sorting and transferring mechanism is erected at the upper end of the slide way.

The slide includes left slide and right slide of mutual symmetry, splices each other about left slide and the right slide and forms a slide, and the upper end of slide is the attitude adjustment section, is equipped with first plane on the attitude adjustment section, and first plane has certain angle alpha with the horizontal plane, and the lower extreme of slide is the section of sequencing, and left slide and right slide respectively are equipped with an inclined plane at the section of sequencing department, and the section of sequencing has certain angle beta with the horizontal plane, be provided with the spout on the inclined plane, the lower part of reaction cup is absorbed in the spout.

The following still is connected with the section of snatching of the sequencing section of slide, snatchs the section top and is provided with and snatchs the mechanism, it is the setting of level form to snatch the section.

Alpha ranges between 20 deg. -60 deg., beta ranges between 20 deg. -60 deg..

The arrangement and transmission mechanism is arranged in an up-down inclined mode and comprises a mounting frame, a driving motor and a chain, the driving motor is arranged on the upper portion of the mounting frame, a driving chain wheel is arranged at the output end of the driving motor, a driven chain wheel is arranged on the lower portion of the mounting frame through a driven shaft, the chain is used for connecting the driving chain wheel and the driven chain wheel, and a plurality of lifting blocks are arranged on the chain.

Reason cup module still includes rabbling mechanism, and rabbling mechanism includes stirring piece, pendulum rod and cam, the cam is located on the driven shaft, be equipped with the bearing on the pendulum rod, one side that the cam is close to the pendulum rod is equipped with the cam groove, the bearing outer end is located in the cam groove, the pendulum rod is close to the one end of stirring piece and is connected with stirring piece through the round pin axle.

And the mounting frame is provided with a coded disc and a clamping cup sensor, and the clamping cup sensor is arranged on one side of the coded disc through a clamping cup sensor mounting piece.

And the mounting frame is provided with a tensioning piece.

The upper surface of the grabbing section is provided with a limiting block.

The lateral wall of the left slide or the right slide is provided with at least one sensor, and the sensor is fixed on the lateral wall through a sensor mounting piece and is electrically connected with the control module.

And a baffle is arranged on the upper surface of the sorting section of the slide way.

An invalid cup channel is arranged below the slideway.

The track includes an injector module and a pre-bin module.

The utility model discloses the beneficial effect who brings is:

in the utility model, the full-automatic chemiluminescence immunoassay analyzer comprises a host and a track, the host comprises a shell, a frame body, a reagent tray, a reaction tray, a reagent needle module, a magnetic separation module, a manipulator module, a sample needle module, a photometric module, a cup processing module and a control module, the cup processing module can orderly transmit a plurality of disordered reaction cups in a hopper to a slide way through a processing and transmitting mechanism, and send the reaction cups to the lower part of a grabbing mechanism through the slide way, so as to orderly use the reaction cups, the track is used for sending samples in test tubes to the reaction cups on the reaction tray, the reaction tray finishes operations of sample adding, reagent adding, diluting, incubating and the like, then carries out magnetic separation through the magnetic separation module, and then carries out detection, the above processes effectively avoid cross contamination, ensure the detection result, the reagent needs to be added into the reaction cups through the reagent needle module in the reaction process, the detection module is used for detecting the sample after the reaction is finished and then obtaining a conclusion, and the control module is used for controlling various actions of the whole instrument.

Drawings

The present invention will be described in further detail with reference to the accompanying drawings.

Fig. 1 is a schematic structural diagram of the full-automatic chemiluminescence immunoassay analyzer of the present invention.

Fig. 2 is a schematic structural diagram of the housing of the full-automatic chemiluminescence immunoassay analyzer.

Fig. 3 is a schematic view of a first structure of the arranging and transferring mechanism of the present invention.

Fig. 4 is a second schematic structural diagram of the arranging and transferring mechanism of the present invention.

Fig. 5 is a schematic structural view of the slide of the present invention.

Fig. 6 is a schematic structural view of the right slide of the present invention.

Fig. 7 is a side view of the slide of the present invention.

Fig. 8 is a schematic structural view of the stirring mechanism of the present invention.

Fig. 9 is a schematic structural view of the sorting and transferring mechanism for removing the hopper of the present invention.

The corresponding reference numbers for the component names in the figures are as follows:

1. a housing; 2. a frame body; 3. a reagent tray; 4. a reaction disc; 5. a reagent needle module; 6. a magnetic separation module; 7. a cup arranging module; 71. a left slideway; 72. a right slideway; 7201. a high-level sensor; 7202. a low-level sensor; 7203. a sensor mount; 73. an attitude adjusting section; 74. a first plane; 75. a sequencing section; 751. a baffle plate; 76. a bevel; 77. a chute; 78. a grabbing section; 781. a limiting block; 79. a grabbing mechanism; 710. a hopper; 711. a mounting frame; 712. a drive motor; 713. a chain; 714. a drive sprocket; 715. a driven shaft; 716. a driven sprocket; 717. a lifting block; 718. a stirring block; 719. a swing rod; 720. a cam; 721. a bearing; 722. a cam slot; 723. a pin shaft; 724. a tensioning member; 725. an invalid cup channel; 8. a manipulator module; 9. a sample needle module; 10. a light measuring module; 11. a reaction cup; 12. an injector module; 13. a pre-bin module; 14. a touch screen; 15. code disc; 16. a card cup sensor; 17. a card cup sensor mount.

Detailed Description

The present invention will be described in detail with reference to the accompanying drawings and embodiments:

as an embodiment of the full-automatic chemiluminescence immunoassay analyzer of the invention, as shown in fig. 1 to 9, the analyzer comprises a host and a track, the host comprises a housing 1, a frame 2, a reagent disk 3, a reaction disk 4, a reagent needle module 5, a magnetic separation module 6, a manipulator module 8, a sample needle module 9, a photometric module 10, a cup sorting module 7 and a control module (not shown in the figure), the reagent disk 3, the reaction disk 4, the reagent needle module 5, the magnetic separation module 6, the manipulator module 8, the sample needle module 9, the photometric module 10 and the cup sorting module 7 are all arranged on the frame 2 and are electrically connected with the control module, the housing 1 covers the frame 2, the control module is arranged on the frame 2 and is located inside the housing 1, the cup sorting module 7 comprises a sorting and transferring mechanism 71, a hopper 710 and a slide, the slide is fixed on the frame 2, a plurality of reaction cups 11 are placed in the hopper 710, one end of the sorting and transferring mechanism is arranged in the hopper 710 and is positioned among the reaction cups 11, and the other end is arranged at the upper end of the slide way. Disordered reaction cups 11 are arranged and transferred by the arranging and transferring mechanism, then slide into the slide way one by one from the upper end of the slide way, stand up vertically after being arranged by the slide way, are clamped in the slide way, and are used after being grabbed 11 by the grabbing mechanism 79.

In this embodiment, the slide includes a left slide 71 and a right slide 72 that are symmetrical to each other, the left slide 71 and the right slide 72 are spliced to each other from left to right to form a slide, the upper end of the slide is a posture adjustment section 73, a first plane 74 is arranged on the posture adjustment section 73, an angle α between the first plane 74 and the horizontal plane is 31.5 °, the lower end of the slide is a sorting section 75, the left slide 71 and the right slide 72 are respectively provided with an inclined plane 76 at the sorting section 75, an angle β between the sorting section 74 and the horizontal plane is 40 °, a slide groove 77 is arranged on the inclined plane 76, and the lower portion of the reaction cup 11 sinks into the slide groove 77. The slide way is formed by splicing a left slide way 71 and a right slide way 72, so that the slide way is convenient to install and debug. When the reaction cup 11 slides into the entrance at the upper end of the slide way from the lifting block 717 of the arranging and transferring mechanism, the first plane 74 on the posture adjusting section 73 arranged at the upper end of the slide way can make the reaction cup 11 lie down, the opening of the reaction cup 11 has a protruding edge and is flat, the section is rectangular, when the reaction cup 11 lies down, the opening of the reaction cup 11 is above, the side with large surface area contacts with the first plane 74, because the first plane 74 and the horizontal plane have an included angle, the reaction cup 11 slides onto the sequencing section 75 along the first plane 74, the inclined plane 76 and the chute 77 on the sequencing section 75 facilitate the reaction cup 11 to slide into the chute 77 smoothly, the edge at the opening of the reaction cup 11 is just clamped at the upper part of the chute 77 and is not easy to drop, if the reaction cup 11 enters into the posture adjusting section, the side with small surface area contacts with the first plane 74, when entering the sequencing section 75, since the width of the chute 77 is larger than the short side of the cuvette 11, the cuvette 11 is an invalid cuvette 11 and falls into the invalid cuvette channel 725 below. Beta is slightly larger than alpha, the reaction cup can slide downwards more smoothly.

In this embodiment, a grabbing section 78 is further connected below the sorting section 75 of the slide way, a grabbing mechanism 79 is arranged above the grabbing section 78, and the grabbing section 78 is arranged horizontally. The gripping section 78 is provided to facilitate the gripping mechanism 79 to smoothly grip the cuvette 11.

In this embodiment, the cup sorting module 7 further includes a hopper 710, a plurality of reaction cups 11 are placed in the hopper 710, and one end of the sorting and transferring mechanism is disposed inside the hopper 710 and located among the plurality of reaction cups 11. The arrangement of the hopper 710 can centralize the reaction cups 11 together, and is convenient for the arrangement and transmission mechanism to smoothly transmit the reaction cups 11 to the slide way.

In this embodiment, the sorting and transferring mechanism is arranged in an up-down inclined manner, and includes a mounting bracket 711, a driving motor 712 and a chain 713, the driving motor 712 is arranged on the upper portion of the mounting bracket 711, a driving sprocket 714 is arranged at the output end of the driving motor 712, a driven sprocket 716 is arranged on the lower portion of the mounting bracket 711 through a driven shaft 715, the chain 713 is used for connecting the driving sprocket 714 and the driven sprocket 716, and a plurality of lifting blocks 717 are arranged on the chain 713. The arrangement and transmission mechanism transmits disordered reaction cups 11 to the upper end of the slide way through a lifting block 717, the lifting block 717 is installed on the outer surface of the chain 713, and the lifting block 717 is provided with a certain inclination, so that the reaction cups 11 can smoothly slide into the slide way when rising to an inlet at the upper end of the slide way.

In this embodiment, the cup sorting module 7 further includes a stirring mechanism, the stirring mechanism includes a stirring block 718, a swing rod 719 and a cam 720, the cam 720 is disposed on the driven shaft 715, a bearing 721 is disposed on the swing rod 719, a cam groove 722 is disposed on one side of the cam 720 close to the swing rod 719, an outer end of the bearing 721 is disposed in the cam groove 722, and one end of the swing rod 719 close to the stirring block 718 is connected to the stirring block 718 through a pin 723. The reaction cups 11 in the hopper 710 are easy to be taken out after being sorted for a period of time, and the stirring mechanism can be arranged to stir the reaction cups 11 in the hopper 710 periodically, so that the lifting block 717 is convenient for extracting the reaction cups 11. The driven shaft 715 rotates to drive the cam 720 to rotate along with the driven shaft 715, the fixed bearing 721 on the swinging rod 719 moves in the cam groove 722 of the cam 720 to drive the swinging rod 719 to move, and the stirring block 718 is connected with the swinging rod 719 through the shaft pin 723 to drive the stirring block 718 to move at the bottom of the hopper 710, so that the reaction cups 11 are stacked again.

In this embodiment, the mounting bracket 711 is provided with a code wheel 15 and a cup sensor 16, and the cup sensor 16 is provided on one side of the code wheel 15 through a cup sensor mounting member 17. The coded disc 15 and the cup clamping sensor 16 can monitor whether the reaction cup 11 in the hopper is clamped or not in real time.

In this embodiment, the mounting frame 711 is provided with an expanding member 724. The chain 713 is easily loosened after a period of use and the tensioning member 724 is used to tension the chain 713.

In this embodiment, the upper surface of the grabbing section 78 is provided with a limit block 781. If there is no limit block 781, when a plurality of cuvettes 11 reach the grabbing section 78, the grabbing mechanism 79 grabs the first cuvette 11, and then the second cuvette 11 will be brought out under the action of frictional resistance, and the limit block 781 can prevent the second cuvette 11 from being brought out upwards.

In this embodiment, a high-level sensor 7201 and a low-level sensor 7202 are provided on the side wall of the right chute 72, and are fixed on the side wall of the right chute 72 by a sensor mounting member 7203, and are electrically connected to the control module. The high-level sensor 7201 and the low-level sensor 7202 can effectively monitor the number of reaction cups in the slide way, and the control module can timely control the reaction cups.

In this embodiment, the upper surface of the sorting section 75 of the chute is provided with a blocking piece 751. The blocking piece 751 is arranged to prevent the reaction cup 11 from being excessively accumulated in the slide channel.

In this embodiment, an invalid cup channel 725 is provided below the slide. The invalid cup passage 725 is for collecting the invalid reaction cups 11 dropped in the slide.

In this embodiment, the track includes an injector module 12 and a pre-chamber module 13, and a touch screen 14 is disposed above the injector module 12. The sample injector module 12 and the pre-chamber module 13 are sample injection, and can realize the functions of high detection speed and non-stop consumable loading.

In the present invention, the value of α can be any value between 20 ° and 60 °, and the value of β can be any value between 20 ° and 60 °. The slope of the lifting block 717 may be various angles as long as the cuvette may be inclined on the upper surface of the lifting block 717. Therefore, the present invention is also within the protection scope of the present invention.

Claims

1. A full-automatic chemiluminescence immunoassay analyzer is characterized by comprising a host and a track, wherein the host comprises a shell, a frame body, a reagent disc, a reaction disc, a reagent needle module, a magnetic separation module, a manipulator module, a sample needle module, a photometry module, a cup sorting module and a control module, the reagent disc, the reaction disc, the reagent needle module, the magnetic separation module, the manipulator module, the sample needle module, the photometry module and the cup sorting module are all arranged on the frame body and are electrically connected with the control module, the shell covers the outside of the frame body, the control module is arranged on the frame body and is positioned inside the shell, the cup sorting module comprises a sorting and transmitting mechanism, a hopper and a slide way, the slide way is fixed on the frame body, a plurality of reaction cups are placed in the hopper, one end of the sorting and transmitting mechanism is arranged inside the hopper and is positioned among the reaction cups, the other end is arranged at the upper end of the slideway.

2. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein the slide comprises a left slide and a right slide which are symmetrical to each other, the left slide and the right slide are spliced to form a slide from left to right, the upper end of the slide is a posture adjustment section, the posture adjustment section is provided with a first plane, the first plane and the horizontal plane have a certain angle α, the lower end of the slide is a sequencing section, the left slide and the right slide are respectively provided with an inclined plane at the sequencing section, the sequencing section and the horizontal plane have a certain angle β, the inclined planes are provided with slide grooves, and the lower parts of the reaction cups sink into the slide grooves.

3. The full-automatic chemiluminescence immunoassay analyzer of claim 2, wherein a grabbing section is further connected below the sequencing section of the slide, a grabbing mechanism is arranged above the grabbing section, and the grabbing section is arranged horizontally.

4. The fully automated chemiluminescent immunoassay analyzer of claim 2 wherein α ranges between 20 ° -60 ° and β ranges between 20 ° -60 °.

5. The full-automatic chemiluminescence immunoassay analyzer of claim 1, wherein the sorting and transmitting mechanism is arranged in an inclined manner, and comprises a mounting rack, a driving motor and a chain, wherein the driving motor is arranged at the upper part of the mounting rack, a driving sprocket is arranged at the output end of the driving motor, a driven sprocket is arranged at the lower part of the mounting rack through a driven shaft, the chain is used for connecting the driving sprocket and the driven sprocket, and a plurality of lifting blocks are arranged on the chain.

6. The full-automatic chemiluminescence immunoassay analyzer of claim 5, wherein the cup sorting module further comprises a stirring mechanism, the stirring mechanism comprises a stirring block, a swing rod and a cam, the cam is arranged on the driven shaft, a bearing is arranged on the swing rod, a cam groove is arranged on one side of the cam close to the swing rod, the outer end of the bearing is arranged in the cam groove, and one end of the swing rod close to the stirring block is connected with the stirring block through a pin shaft.

7. The full-automatic chemiluminescence immunoassay analyzer of claim 6, wherein the mounting rack is provided with a code wheel and a card cup sensor, and the card cup sensor is arranged on one side of the code wheel through a card cup sensor mounting piece.

8. The fully automated chemiluminescent immunoassay analyzer of claim 5 wherein the mounting frame is provided with a tensioning member.

9. The fully automated chemiluminescent immunoassay analyzer of claim 3 wherein the upper surface of the grasping section is provided with a stop.

10. The full-automatic chemiluminescence immunoassay analyzer of claim 2, wherein the side wall of the left slide or the right slide is provided with at least one sensor, and the sensor is fixed on the side wall through a sensor mounting piece and is electrically connected with the control module.

11. The fully automated chemiluminescent immunoassay analyzer of claim 2 wherein the top surface of the sequencing section of the slide is provided with a stop.

12. The fully automated chemiluminescent immunoassay analyzer of claim 1 wherein a non-use cup channel is provided below the slide.

13. The fully automated chemiluminescent immunoassay analyzer of claim 1 wherein the track comprises an injector module and a pre-chamber module.