CN218012859U - Test tube rack - Google Patents

Abstract

The utility model provides a test-tube rack, test-tube rack include first holding surface and second holding surface the test-tube rack on still including the first hole that is used for inserting the test tube, wherein, first and second support can fold. By the test tube rack, the test tube can be folded and shrunk and packaged when packaged, and can be unfolded when used, so that the test tube can be inserted for operation.

Description

Test tube rack

Technical Field

The utility model relates to a test-tube rack for preventing the test tube, especially the pipe support that is used for placing the schizolysis pipe in the quick diagnosis field.

Background

The following background description is only an introduction to the general knowledge in the background and should not be taken as limiting the invention.

Currently, a large number of test devices for detecting whether a sample contains an analyte are used in hospitals or homes, and these test devices for rapid diagnosis include one or more test reagent strips, such as an early pregnancy test, a drug abuse test, and the like. The rapid diagnosis test device is convenient, and can obtain the test result on the test reagent strip within one minute or at most ten minutes.

Currently, infectious disease detection, particularly viral detection, is becoming more common and more commonplace. Such tests are not only necessary for professional testing institutions to perform daily tests, but also become more popular for home-based operations. Like early pregnancy tests, infectious disease detection is becoming more popular and moves to home detection. For the home-based detection of infectious diseases, such as influenza and new corona, and of course, including other home-based detections in daily life, it is usually necessary to lyse viruses or bacteria in advance, or to pre-process a sample and then perform subsequent detection. For infectious disease detection, an important component is the lysis of viruses or bacteria in a sample, thereby detecting the lysed fragment antigens. Of course, in the case of other samples, it may be necessary to subject the sample to a pre-treatment, such as treatment with some buffer solution. In a home test or in some small office environments, it is necessary to place a tube of lysis solution or solution for sample treatment in a timely manner, place the tube vertically on a table, such as a small test stand or a table in the home, and then place the sample, which has a sample holder, such as a swab for collecting the sample, in the tube or in the body of the tube, so that the liquid in the tube and the sample come into contact with each other to treat or dispose of the sample. After the treatment is completed, the lysate or the solution for treating the sample is subjected to subsequent detection or the like.

For a table top to hold test tubes, a rack is typically required to hold the test tubes upright, which is typically provided to the user by the supplier of the reagent, and the user is not typically prepared for such a rack. Traditional test-tube rack all is plastics one-time molding, occupies the volume on making the packing, has weight moreover, and the transportation is inconvenient, has increased the cost moreover, and a large amount of plastic products cause the pollution that can the environment, have increased follow-up environmental protection and have handled the cost.

In view of the above technical problems, it is desirable to improve the above and provide an alternative way to overcome the shortcomings of the conventional technologies.

SUMMERY OF THE UTILITY MODEL

In order to change the improvement to current test-tube rack, the utility model relates to a test-tube rack adopts this test-tube rack, and it is very little to take up space in the packing, is folding compressed state basically, when needs use, opens the test-tube rack that is a spatial structure for place test tube, centrifuging tube or any body that has solution, when using up the back, disposable abandons. In some forms, the tube racks are made of rigid paper, and in some forms, are made of paper that can be degraded.

Therefore, the utility model discloses a first aspect provides a test-tube rack, the test-tube rack include first holding surface and second holding surface the test-tube rack on still including the hole that is used for driving into the body, wherein, first and second support can fold. In some embodiments, the test tube rack further comprises a first face connecting the first and second support faces, the first face including the aperture. In some forms, the first face is connected to the first support face and the second support face by a fold line, a crease, respectively.

In some embodiments, the support surface comprises a first support surface and a second support surface, and the connection between the support surface and the first surface comprises a folding line, or two support surfaces are connected with two ends of the first surface through the folding line. Folding between holding surface and the first face can be realized through the folding line to reduce the volume, when needs, open through the folding line, then form a solid, can place the support body structure of body. A fold line is here understood to mean a crease, a fold, a crease line, a fold line etc. Therefore, the first and second support surfaces are used to support the first surface when in an open standing position, allowing the first surface to have an operational full or support surface at a distance from the bottom, such that when a test tube or tube is inserted into the well, the tube is maintained in an upright or standing position. When the tube body is taken out from the hole after the tube body is used up, the tube body is collected by the folding line.

In some embodiments, the test tube rack further comprises a base surface, the base surface being connected to the support surface, the base surface being located below the first surface. In some forms, the base surface is connected to the support surface by a fold, crease line. In some forms, one end of the base surface is connected to one end of the support surface by a fold line and a crease, and the other end of the support surface is connected to the first surface by a fold line and a crease. In some embodiments, one end of the base face is connected to one end of the first support face by a fold line, and the other end of the first support face is connected to the first face by a fold line, or permanently. Like this, base face and two holding surfaces and first face have constituted a three-dimensional shape, and first face is used for inserting the body, and the base face is used for stabilizing the distance of holding surface to the stability of pipe support has been increased. In some modes, the supporting surface is trapezoidal, so that a three-dimensional body shape is formed, the short surface serves as a surface inserted into a test tube hole, and the long surface serves as a base, so that the stability of the test tube rack is improved. Of course, this is only preferred, but any other way is possible, such as a cube, a cuboid, where the first and support faces and the base face form a solid.

In some forms the base surface is parallel or substantially parallel to the first surface when open. In some embodiments, the base surface has a length greater than the length of the first surface, and the cut surface forms a trapezoidal shape when the tube rack is unfolded from the folded shape, thereby increasing the stability of the test tube. In some forms the width of the base surface is the same or substantially the same as the width of the first surface.

In some modes, still set up a firm face between base face and first face, first holding surface or second holding surface are connected respectively to the both ends of this firm face, like this, can let whole test-tube rack when standing again, and more stable and difficult turnover. In some forms the stabilizing surface also includes a receptacle, the receptacle being substantially co-axial with the receptacle on the first surface. Like this, in the test tube inserted the jack, there are two holes to receive the insertion of test tube, it is more stable when the test tube body.

In some modes, one or more of the first surface, the base surface, the stabilizing surface or the first surface further comprises a folding line, and the first surface, the base surface or the stabilizing surface is not folded by virtue of folding of the folding line, so that the whole test tube rack is not folded and contracted, and the thickness of the whole test tube rack is small and basically has no thickness except the sum of the thicknesses of the surfaces. The thickness of the folded test tube rack is the thickness of the superposition of the two supporting surfaces. In some forms the fold line is located at a midline of the first face. In some embodiments, the fold lines of the base and stabilizing surfaces are both located at their respective midline locations. In some embodiments, the first side is folded inward in a direction close to the fixing side or the base by a folding line, and when the fixing side or the base side exists, if the fixing side or the base side does not exist, the first side is folded downward by a folding line. Therefore, the length of the test tube in the vertical direction when the test tube is folded is reduced, and the space is saved in packaging and transportation. In some embodiments, for the same reason, when the base surface is folded by the folding line, the folding direction is also inward, or the folding direction is close to the first surface, so that the length of the whole test tube rack in the vertical direction when the test tube rack is folded is also reduced. These folding directions are only some preferred directions, but of course, either the first or the second face may be folded outwardly. The two states of opening and contraction are realized by folding and opening of the folding line.

In some embodiments, the entire test tube rack is folded by a fold line, through a single plane or through a single plane. Thus, the processing and the design are convenient. A three-dimensional structure is formed by folding from a plane, and the three-dimensional structure can be contracted and unfolded through a folding line. In some aspects, the entire plane is formed by folding a rigid paper or sheet. In some modes, in order to let whole structure more stable, can set up some faces of bonding, through first face, the base face or firm the connecting between the face, set up the face of bonding and bond each other. In some forms, the base surface is further connected to an adhesive surface, the adhesive surface being adhered to the second support surface, the adhesive surface and the base edge also being connected by a crease line. In some modes, the two ends of the stabilizing surface are respectively provided with bonding surfaces which are respectively bonded inside the two supporting surfaces, so that the test tube rack with a fixed structure is formed. Of course, the first surface, the supporting surface, the base surface, the stabilizing surface and the bonding surface are all areas which are divided into different areas on the whole plane, and a three-dimensional test tube rack structure is formed by the folding lines.

In some embodiments, when the first side has a receptacle, a test tube can be inserted, and when multiple test tubes need to be inserted simultaneously, it is desirable to have multiple different receptacles to receive the insertion of multiple tubes. This is the case, and a single body in which a plurality of insertion holes are repeatedly arranged in different directions is desirable. For example, in the longitudinal direction of the first surface, it is possible to adopt a manner of extending the first surface toward both ends so that the width of the first surface is constant, and so that the length of the first surface is extended to extend toward the connecting section, so that a plurality of insertion holes can be provided in the first surface. In the same way, when the base is included, or when the fixing surface is included, the fixing surface integrally extends towards two ends, so that a plurality of jacks can be arranged.

In other directions, lateral expansion, i.e. expansion in the direction of the support surface, is desired. When the supporting surface is vertical or vertical to the first surface, the supporting surface is actually in a cubic or rectangular structure, and the extension mode is the same as the mode of longitudinal extension along the first surface, so that the extension in the transverse direction is realized.

Advantageous effects

Adopt above-mentioned structure, can provide folding body frame, this pipe support can fold and contract, also can open and expand to be three-dimensional shape to be used for supporting the test tube. Therefore, the test tube rack has the advantages of light weight and small packaging space, and if the test tube rack is made of paper materials, the test tube rack is simple and convenient to manufacture and low in cost, and reduces environmental pollution (compared with a plastic support).

Drawings

Fig. 1 is a schematic structural view of a cardboard sheet for manufacturing a collapsible tube body frame according to an example of the present invention in the embodiment.

Fig. 2 is a test tube rack according to an embodiment of the present invention, fig. 2A is a folded state, fig. 2B is an unfolded state, fig. 2C is another opened state, fig. 2D is a paperboard for manufacturing the test tube rack shown in fig. 2A, and fig. 2E is a schematic structural view for expanding a plurality of test tube racks.

Fig. 3 is a test tube rack according to another embodiment of the present invention, fig. 3A is a folded state, fig. 3B is an unfolded state, fig. 3C is another unfolded state, fig. 3D is a cardboard for manufacturing the test tube rack shown in fig. 2A, fig. 3E is another state structure diagram for folding and unfolding, fig. 3F is another state diagram for folding and unfolding, and fig. 3G is a three-dimensional structure diagram of a fixing surface located at the middle position of a supporting surface.

Fig. 4 is a schematic view of the process of folding the blank of fig. 1 by a fold line. Fig. 4A is a schematic view of the folding at the third step, fig. 4B is a schematic view of the folding at the fourth step, fig. 4C is a schematic view of the folding at the fifth step, and fig. 4D is a schematic view of the folding at the sixth step.

Fig. 5 is a perspective view of the paperboard of fig. 1 formed by folding.

Fig. 6 is a perspective view of the paperboard of fig. 1 formed by folding.

Fig. 7 is a left side view of the blank of fig. 1 formed by folding.

Fig. 8 is a schematic structural view of the tube body frame shown in fig. 5 undergoing a folding process or a process from folding to unfolding.

Fig. 9 is a schematic structural view of the tube body frame shown in fig. 5 after being folded and contracted.

Fig. 10 is a schematic diagram of the structure of fig. 5 in which a single test tube rack is longitudinally expanded into a plurality of test tube racks.

Fig. 11 is a schematic diagram of the structure of fig. 5 in which a single test tube rack is longitudinally expanded into a plurality of test tube racks.

Fig. 12 is a schematic perspective view of the tube, the sealing film and the drip plug, wherein fig. 12A is a schematic structural view of the test tube sealed by the sealing film, fig. 12B is a schematic structural view of the sealing film, and fig. 12C is a schematic structural view of the drip plug.

FIG. 13 is a schematic diagram of a test apparatus.

Fig. 14 is a schematic view of a single tube body frame shown in fig. 5 being laterally expanded.

Fig. 15 is a diagram of a process of folding two single tube racks from a single piece of cardboard.

FIG. 16 is a schematic view of another embodiment of a paperboard planar structure with fold line demarcations.

Fig. 17 is a tubular structure formed by folding the flat surfaces shown in fig. 16.

Figure 18 is a schematic view of the structure of figure 17 showing the single tube body frame longitudinally expanded into a plurality of tube body connections.

Fig. 19 is a schematic view of the tube rack shown in fig. 17 undergoing a folding process or a process from folding to unfolding.

Fig. 20 is a schematic structural view of the tube body frame shown in fig. 17 after being folded and contracted.

Fig. 21 is a schematic structural view of a foldable tube according to another embodiment of the present invention, fig. 21A is a schematic structural view of unfolding, fig. 21B is a schematic structural view of containing a base, fig. 21C is a schematic structural view of setting a stable surface between the base and a hole, and fig. 21D is a schematic structural view of lacking a base surface.

Detailed Description

The structures referred to in the present invention or these terms of art used are further described below, if not otherwise indicated, in accordance with the common general terminology used in the art.

Detection of

Detection refers to assaying or testing for the presence of a substance or material, such as, but not limited to, a chemical, organic compound, inorganic compound, metabolic product, drug or drug metabolite, organic tissue or metabolite of organic tissue, nucleic acid, protein, or polymer. In addition, detection indicates the amount of the test substance or material. Further, the assay means immunodetection, chemical detection, enzyme detection, and the like.

Sample(s)

The test device or collected sample of the present invention includes a biological fluid (e.g., a case fluid or a clinical sample). Liquid or liquid samples, or fluid samples, may be derived from solid or semi-solid samples, including fecal, biological tissue and food samples. The solid or semi-solid sample may be converted to a liquid sample by any suitable method, such as mixing, triturating, macerating, incubating, dissolving, or enzymatically digesting a solid sample in a suitable solution (e.g., water, phosphate solution, or other buffered solution). "biological samples" include samples of animal, plant and food origin, including for example urine, saliva, blood and components thereof, spinal fluid, vaginal secretions, sperm, feces, sweat, secretions, tissues, organs, tumors, cultures, cell cultures and media of tissues and organs derived from humans or animals. Preferably, the biological sample is urine and preferably, the biological sample is saliva. Food samples include food processing materials, end products, meat, cheese, wine, milk and drinking water. Plant samples include those derived from any plant, plant tissue, plant cell culture and medium. An "environmental sample" is derived from the environment (e.g., a liquid sample from a lake or other body of water, a sewage sample, a soil sample, groundwater, seawater, and a waste liquid sample). Environmental samples may also include sewage or other wastewater.

Utilize the utility model discloses suitable detecting element or test element can detect any analyte. Preferably utilizes the utility model discloses detect the drugs micromolecule in saliva, urine. Of course, any of the above forms of samples, whether initially solid or liquid, may be collected using the collector of the present invention, provided that the liquid or liquid sample is absorbed by the absorbent member. Absorbent members herein are generally made of an absorbent material that is initially dry and capable of absorbing a liquid or fluid sample by capillary or other properties of the absorbent member material. The absorbent material may be any material capable of absorbing liquid, such as sponge, filter paper, polyester fiber, gel, nonwoven, cotton, polyester film, yarn, etc. The absorbent member need not be made of absorbent material, and may be made of non-absorbent material, but rather has apertures, threads, cavities in the absorbent member, on which structures samples, typically solid or semi-solid samples, can be collected, which are filled between the threads, holes, or pores.

Downstream and upstream

Downstream or upstream is divided with respect to the direction of liquid flow, typically liquid flows from upstream to downstream regions. The downstream region receives liquid from the upstream region, and liquid may also flow along the upstream region to the downstream region. It is also generally divided in the direction of liquid flow, for example, on materials that use capillary forces to urge liquid flow, the liquid may flow by gravity in the opposite direction to gravity, and in this case, the upstream and downstream are also divided in the direction of liquid flow.

Gas or liquid communication

By gas or liquid communication is meant that liquid or gas can flow from one place to another, possibly guided by some physical structure during the flow. By physical structures is generally meant that the liquid flows passively or actively to another place through the surface of the physical structures or the space inside the physical structures, and passively is generally a flow caused by external force, such as a flow under capillary action. The flow here can also be a liquid or a gas, because of its own effect (gravity or pressure), or a passive flow. Communication herein does not necessarily mean that a liquid or gas is required to be present, but merely that in some cases a connection or condition between two objects, if any, may flow from one object to the other. This is a state in which two objects are connected, and conversely, if there is no liquid communication or gas communication between the two objects, if there is liquid in or on one object, the liquid cannot flow into or on the other object, and such a state is a state of non-communication, non-liquid or gas communication.

Test element

The term "test element" as used herein refers to an element that can detect whether a sample or specimen contains an analyte of interest, and the detection can be based on any technical principles, such as immunology, chemistry, electricity, optics, molecular, nucleic acid, physics, etc. The test element may be a lateral flow test strip which detects a plurality of analytes. Of course, other suitable test elements may be used in the present invention,

various test elements may be combined and used in the present invention. One form is a test strip. Test strips for the analysis of an analyte (e.g., a drug or a metabolite indicative of a physical condition) in a sample may be in various forms, such as immunoassay or chemical assay. The test strip may be used in a non-competitive or competitive assay format. Test strips generally comprise a bibulous material having a sample application area, a reagent area, and a test area. The sample is added to the sample application zone and flows by capillary action to the reagent zone. In the reagent zone, the sample binds to the reagent if the analyte is present. The sample then continues to flow to the detection zone. Other reagents, such as molecules that specifically bind to the analyte, are immobilized at the detection zone. These reagents react with the analyte (if present) in the sample and bind the analyte to the zone, or to one of the reagents of the reagent zone. The label for indicating the detection signal is present in the reagent zone or in a separate label zone.

A typical non-competitive assay format is one in which a signal is generated if the sample contains the analyte and no signal is generated if the sample does not contain the analyte. In a competition method, a signal is generated if the analyte is not present in the sample and no signal is generated if the analyte is present.

The test element can be a test paper, and can be made of water-absorbing or non-water-absorbing materials. The test strip may include a variety of materials for liquid sample delivery. One of the test strips may be coated with another material, such as a nitrocellulose membrane coated with filter paper. One region of the test strip may be selected from one or more materials and another region may be selected from a different one or more materials. The test strip may be adhered to some support or hard surface for improved strength of the pinch test strip.

The analyte is detected by a signal producing system, such as one or more enzymes that specifically react with the analyte, and one or more compositions of the signal producing system are immobilized on the analyte detection zone of the test strip by a method such as that described above for the immobilization of a specific binding substance on the test strip. The signal-producing substance can be on the sample addition zone, reagent zone, or detection zone, or the entire test strip, and the substance can be impregnated on one or more materials of the test strip. A solution containing the signal is applied to the surface of the strip or one or more materials of the strip are immersed in the solution containing the signal. The strip to which the solution containing the signal was added was dried.

The various regions of the test strip may be arranged in the following manner: a sample adding area, a reagent area, a detection area, a control area, a sample adulteration area and a liquid sample absorption area. The control zone is located behind the detection zone. All zones may be arranged on a strip of test paper using only one material. It is also possible to use different materials for the different zones. The zones may be in direct contact with the liquid sample, or different zones may be arranged according to the direction of flow of the liquid sample, with the ends of each zone being contiguous with and overlapping the ends of the other zone. The material used can be material with good water absorption such as filter paper, glass fiber or nitrocellulose membrane. The test strip may take other forms.

A commonly used reagent strip is a nitrocellulose membrane reagent strip, i.e., a detection area comprises a nitrocellulose membrane, and a specific binding molecule is fixed on the nitrocellulose membrane to display the detection result; and may be a cellulose acetate film, a nylon film, or the like. Such as the reagent strips or devices containing the reagent strips described in some of the following patents: US 4857453; US 5073484; US 5119831; US 5185127; US 5275785; US 5416000; US 5504013; US 5602040; US 5622871; US 5654162; US 5656503; US 5686315; US 5766961; US 5770460; US 5916815; US 5976895; US 6248598; US 6140136; US 6187269; US 6187598; US 6228660; US 6235241; US 6306642; US 6352862; US 6372515; US 6379620; and US 6403383. The test strip disclosed in the above patent documents and similar devices with test strips can be applied to the test element or the test device of the present invention for detecting an analyte, such as an analyte in a sample.

The test strips used in the present invention may be so-called Lateral flow test strips (Lateral flow test strips), and the specific structure and detection principle of these test strips are well known in the art. A typical test strip includes a sample collection area or application area, a labeling area, a detection area and a wicking area, wherein the sample collection area includes a sample receiving pad, the labeling area includes a label pad, and the wicking area may include a wicking pad, and wherein the detection area includes the necessary chemicals to detect the presence of the analyte, such as an immunological reagent or an enzymatic reagent. A commonly used detection reagent strip is a nitrocellulose membrane reagent strip, that is, a detection area comprises a nitrocellulose membrane, and a specific binding molecule is fixed on the nitrocellulose membrane to display a detection result; it may also be cellulose acetate film, nylon film, etc., and of course, it may also include a detection result control region downstream of the detection region, and usually, the control region and the detection region are in the form of transverse lines, which are detection lines or control lines. Such test strips are conventional, but other types of test strips that utilize capillary action for testing are also contemplated. In addition, typically, the test strip has a dry chemical reagent component, such as an immobilized antibody or other reagent, which when exposed to a liquid, flows along the test strip by capillary action, and as it flows, the dry reagent component is dissolved in the liquid, and the next zone is processed to react the dry reagent in that zone, thereby performing the necessary test. The liquid flow is mainly by capillary action. The present invention can be applied to a test device, or can be disposed in a test chamber to contact a liquid sample, or can be used to detect the presence or quantity of an analyte in a liquid sample entering the test chamber. The test element is typically disposed in a test chamber, and when the test chamber has a fluid sample, the fluid sample contacts the test element and is assayed or detected.

In addition to the test strips described above or the lateral flow test strip itself being used to contact a fluid sample to determine whether the fluid sample contains an analyte. In some preferred forms, the test elements may also be provided on some carriers, as shown in fig. 13, for example some carriers having one or more recesses in which the test elements are located. The carrier 900 may be a combination of two plates, one above the other, with test elements positioned between the two plates, the combined plates having a window 901 through which the results of the test areas on the test elements can be read visually or by machine, and a sample application well 902 for applying a sample, such as a liquid sample or a liquid or solid sample treated with a liquid reagent, thereto, although optionally, a grip 903 may be included for applying a hand to the test device.

Analyte substance

Examples of analytes that can be used in the present invention include small molecule substances, including drugs of abuse (e.g., drugs of abuse). By "drug of abuse" (DOA) is meant the use of a drug (usually acting to paralyze nerves) at a non-medical destination. Abuse of these drugs can result in physical and mental damage, dependence, addiction and/or death. Examples of drug abuse include cocaine; amphetamine AMP (e.g., black mermaid, white amphetamine tablets, dextroamphetamine tablets, beans); methamphetamine MET (crank, methamphetamine, crystal, speed); barbiturate BAR (e.g., valium, roche Pharmaceuticals, nutley, new Jersey); sedatives (i.e., sleep-aid drugs); lysergic acid diethylamide (LSD); inhibitors (downs, goofballs, barbs, blue devils, yellow jacks, hypnones); tricyclic antidepressants (TCAs, i.e., imipramine, amitriptyline and doxepin); dimethyldioxymethylaniline MDMA; phencyclidine (PCP); tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); opiates (i.e., morphine, or opiates, cocaine, COC; heroin, dihydrocodeinone); anxiolytics, which are mainly used for relieving anxiety, tension, fear, stabilizing mood, and having hypnotic and sedative effects, and sedative hypnotic agents, include benzodiazepines BZO (benzodiazepines), atypical BZ, fused dinitrogen NB23C, benzazepines, ligands of BZ receptor, open-ring BZ, diphenylmethane derivatives, piperazine carboxylates, piperidine carboxylates, quinazolone, thiazine and thiazole derivatives, other heterocycles, imidazole-type sedative/analgesic agents (such as hydroxydihydrocodeinone OXY, methadone MTD), propylene glycol derivatives-carbamates, aliphatic compounds, anthracene derivatives, etc. The detection device of the utility model can also be used for detecting the detection which belongs to the medical purpose and is easy to take excessive medicine, such as tricyclic antidepressants (imipramine or analogues) and acetaminophen, etc. After being absorbed by human body, the medicines are metabolized into small molecular substances, and the small molecular substances exist in body fluids such as blood, urine, saliva, sweat and the like or exist in partial body fluids.

For example, analytes detected with the present invention include, but are not limited to, creatinine, bilirubin, nitrite, protein (non-specific), hormones (e.g., human chorionic gonadotropin, progesterone hormone, follicle stimulating hormone, etc.), blood, leukocytes, sugars, heavy metals or toxins, bacterial material (e.g., proteins or carbohydrate material directed against specific bacteria, such as e.g., e.coli 0157; any other clinical urine chemistry analysis can all utilize the cooperation of side direction crossing current detection mode the utility model discloses the device detects. The analyte may also be any virus, such as influenza virus, new corona virus, etc., or any other type of virus or cleaved virus fragments, such as antigenic fragments, etc., that are clinically considered to be detectable by the test strips of the present invention.

Type of sample

Any type of sample can be tested with the device or treated with the test tube rack of the present invention, including body fluids (e.g., urine and other body fluids, as well as clinical samples). Liquid samples may be derived from solid or semi-solid samples, including stool, biological tissue, and food samples. These solid and semi-solid samples may be converted to liquid samples by any suitable method, such as mixing in a suitable liquid, mincing, macerating, incubating, dissolving, or enzymatically hydrolyzing the solid sample (e.g., water, phosphate buffer, or other buffer). "biological samples" include samples derived from living animals, plants and food, and also include urine, saliva, blood and blood components, cerebrospinal fluid, vaginal swabs, pharyngeal swabs, nasal swabs, semen, feces, sweat, secretions, tissues, organs, tumors, cultures of tissues and organs, cell cultures and conditioned media therein, whether human or animal. Food samples include processed food ingredients and end products, meat, cheese, wine, milk and drinking water. Plant samples include samples derived from any plant, plant tissue, plant cell culture, and conditioned medium therein. "environmental samples" are those samples derived from the environment (e.g., lake water samples or samples of other bodies of water, sewage samples, soil samples, groundwater samples, seawater samples, samples of waste water). Sewage and associated waste may also be included in the environmental sample.

Flow of liquid

The flow of liquid usually refers to a flow from one place to another, and in general, the natural liquid flow mostly depends on gravity from high to low, and the flow here also depends on external force, i.e. the flow under the external gravity condition, and can be the natural gravity flow. In addition to gravity, the flow of liquid may also overcome gravity and move from low to high. For example, the liquid is pumped, or the liquid is compressed, or the liquid is pressurized and flows from the bottom to the top, or the liquid flows against the gravity of the liquid itself by the pressure.

Detailed Description

The following presents a simplified summary of the invention in order to provide a more complete understanding of the invention, and is not intended to limit the scope of the invention.

Referring to fig. 2, an embodiment of the present invention is described, in which the test tube rack includes a first surface 203 and a first supporting surface 201 and a second supporting surface 202 supporting the first surface, and a hole is provided on the first surface, the hole being a container for receiving or placing a tube, such as a test tube or a tube with a solution, as shown in fig. 12A.

This is in fact a simple collapsible tube rack. The term "test tube" is used herein only as a general term and is not intended to limit the rack to receive test tubes in the general sense, but to receive any container, such as test tubes (fig. 12A), centrifuge tubes, or containers. The container may be any type of container, such as a plastic, glass, metal container. These containers may contain solutions or solid reagents in advance. In some cases, the wells of the rack may be inserted into containers such as tip tubes, PCR tubes, and contain sample processing solutions, such as lysis solutions or any other liquids, which contain certain chemical reagents that can process the sample. For example, a reagent that lyses the virus in solution, when the virus is present in the sample, the virus is cleaved into fragments, typically antigenic fragments. These antigenic fragments can then be detected by subsequent steps, for example by means of immunization. In some embodiments, the tube contains a liquid reagent and the tube is sealed. When it is desired to treat the sample, the sealing film is removed, for example when the seal is an aluminium foil seal, and the sample is contacted with the liquid reagent by tearing the aluminium foil seal. The sample may be any sample, such as a swab from a cotton swab, a sample from the inside of the mouth or a sample from the inside of the nasal cavity, which, when removed, is inserted directly through the tube and into contact with the liquid reagent, thereby allowing the liquid reagent to process the sample, for example to lyse viruses or bacteria, or analytes therein. After the treatment is completed, the subsequent detection or assay can be performed directly with the liquid reagent (which may contain the analyte). For example, after the sample processing is completed, the swab head may be directly left in the tube, the swab head may be attached to the tube, the tube may be removed, the tube may be inverted, and the drop may be dropped by pressing the tube with a finger. Typically, the dripping liquid may drip onto the test element, for example onto a sample application area on the test element.

Thus, on the first face 203 there are provided holes 207 (one or more depending areas) which holes 207 are intended to insert or receive containers, such as the test tube-like containers described above. Fold lines 204 and 205 are provided at the junction of the first surface and the support surface, and the fold lines are not artificially provided, but may be a boundary or dividing line formed by folding the first surface and the support surface, so as to distinguish the two surfaces. In the initial state, the first and second support surfaces 201, 202 and the first surface 203 may be a flat sheet of paper or cardboard which is mechanically cut and perforated on the first surface 203 with holes of a size corresponding to the size of the tubular bodies to be placed. When it is needed, it is folded downwards by the folding lines 204 and 205 to form a "U" shape, so that the shelf stands up (fig. 2B). At this time, the tube containing the solution is checked into the hole 207, so that the tube is kept in an upright state, thereby facilitating the next operation, such as processing a sample. This is particularly convenient in home self-testing, but is very easy to operate, while these small accessories are disposable and can be discarded at hand after testing. When such a frame is made of paper material or is very easy to handle, it is less harmful to the environment. On the other hand, for manufacturers or sellers who provide the detection reagent, the traditional plastic support is not needed, the frame bodies are paper before being used, the package basically does not occupy a large space, the frame bodies are light, the cost is greatly saved, the plastic support is manufactured by opening the die after all, the plastic product can cause environmental pollution, and the plastic support is not easy to process. For example, such a form may be in the form of fig. 2D, which is a piece of cardboard, with crease lines indicated thereon, and according to the instructions of the instruction manual, the operator folds the crease lines, for example, downward along crease lines 205 and 206, and folds the first support 201 and the second support 202 into the form of fig. 2B, so that the operator can place the support on the operation surface for operation. In some embodiments, if the first side also includes a fold line 206, the first side may not be planar when folded, but may be curved, such as in the configuration of FIG. 2C, and also include a tube insertion aperture 207. Of course, the curved surface may be curved downward or upward, for example, a curved surface opposite to the curved direction of the first surface shown in fig. 2C. Of course, it is also possible to arrange a plurality of consecutive cells, such as fig. 2A or 2B, by consecutive folding, in a similar manner to fig. 2E, each of which is folded in a manner according to fig. 2A and unfolded in a manner according to fig. 2E when unfolded.

In some embodiments, instead of a flat sheet of cardboard, the initial folded and collapsed form (such as shown in fig. 2A) may be used, and the collapsed tube holder may be left open when desired. For example, when not opened for use, by folding and collapsing fold lines 204 and 205 and 206 together (as shown in fig. 2A, for example), when desired, support surfaces 202 and 201 are opened, allowing the racks to be supported and placed on an operating surface, such as a test stand or home table, to begin self-test operations. At this time, the first surface 203 is supported by the support surface so as to be spaced from the operation surface, so that the test tube can be inserted into the hole 207 in a standing posture, the tube body is located above the hole 207 near the nozzle, and the bottom of the tube can directly lean on the operation surface. Of course, in order to fold more compactly, the folding line 206 is also arranged on the first face, and when the folding line is folded, the folding line 206 is folded, so that the folding line is more compactly folded and is small, and when the folding line is packaged with a detection reagent, the packaging space is hardly occupied, the manufacturing and production are convenient, and meanwhile, the cost is saved.

When making, for example as shown in fig. 2D, a sheet of paper having a certain thickness is selected, the first and second support surfaces 201 and 202, and the first surface 203 are formed by machine cutting, and a hole 207 is formed in the first surface, while the first and second straight surfaces and the first surface are provided with folding lines 111 and 112, the method of forming the folding lines is to form the contracted lines 111 and 112 at the positions of the folding lines by punching at the positions of the folding lines by a machine, and the lines are not necessarily present, but when folding is required, the lines can be folded together and kept contracted by the folding lines 111 and 112, when placed on the operating surface, the lines can stand on the operating surface by means of the support surface, and further for example, continuous perforations are made at the positions of the folding lines, with a space between each hole, for example, 1 mm or 2 mm, so that an easy folding form can also be realized. It will be readily appreciated by those skilled in the art that other ways of achieving folding may be used in the present invention as a way of folding. In this embodiment, the base surface, adhesive surface and stabilizing surface described below are not included. In the following manner, when the base surface, the bonding surface and the fixing surface are provided, the folding line and the specific size of the paperboard can be formed by stamping and pressing the paperboard.

In some embodiments, to make the rack more stable, a base surface 305 is further included on the rack, the base surface is connected to the second support surface 302 by a fold line 308, and the base surface 305 can be connected to the first support surface. When in the folded and contracted state, the first side 303 and the base side are folded inward, thereby being in the contracted state (fig. 3A). The base surface is connected with the supporting surface through a folding line. The base surface may also be in the form of a curved surface when in the open position, with the first surface 303 being curved, and the apex 304 of the curved surface of the base surface being substantially collinear with the center of the hole 311 of the first surface 303, although it is possible that it is not collinear. For example, as shown in FIG. 3B, when the tube body is inserted into the hole 311, the bottom of the tube is dragged by the highest point of the base surface. In addition, when the base surface is a curved surface, the two support surfaces or legs 314, 315 contacting the operating surface make the entire support frame more stable due to the tension between the base surface and the support surfaces. This arch bridge-like principle can withstand heavier forces on arch bridges. The base surface resembles an arched bridge, and the entire force of gravity is distributed over the two feet. When made of a piece of paperboard which is not very thick, the weight of the tube body can still be borne.

In general, when the folded and collapsed stent is in the unfolded state, the first side 303 and the base side 305 may not be a standard curve due to the existence of the crease, but also in the form of a "V", for example, as shown in fig. 3E and 3F, the first side 303 and the base side 305 are still in the folded state due to the existence of the folding line when in the unfolded state, which is only a matter of the size of the angle. Of course, the first surface may be straight when the tube is inserted, or the included angle formed may be increased or almost flat. In the same way, the base surface is pressed by the bottom of the pipe body or the force given by the operator inserting the pipe body, so that the included angle of the base surface is enlarged or is almost in a straight surface form.

In some embodiments, in order to allow the base surface 305 to be coupled to the first supporting surface, an adhesive surface 306 is provided on the base surface, and when manufactured, the adhesive surface is directly adhered to the inner surface of the first supporting surface 301, so that the base surface is coupled to the first supporting surface, and the base surface 305 and the adhesive surface 306 are coupled by a folding line or a folding line 313.

In another embodiment, as shown in fig. 16-17 for example, the first surface 403 is provided with an insertion hole 411 for the pipe body, the first surface 403 is provided with a crease line 410, and the first surface is connected with a first supporting surface 401 and a second supporting surface 402, which are connected by crease lines 409 and 412. Also attached to the second support surface 402 is a base surface 414, and an adhesive surface 406 attached to the base surface, each of which is connected by a crease or fold line 408,413. When assembled into a product, the folds are made according to the fold lines to form the final product as shown in fig. 17 and fig. 19 and 20. Due to the bonding of the adhesive layer, the packaging is only folded, so that when the operation is performed, the folded and contracted manner is unfolded to form the bracket. For ease of folding, a fold line 407 is also provided in the base face, the fold line being generally positioned at a full or substantial bisector of the base, and preferably at a bisector of the first face 403, and the fold line 410 is positioned at the same location. After folding, as shown in figure 20, the first side 403 is folded inwardly by the fold line, the base side 414 is folded inwardly by the fold line, and the two support sides are folded by the fold lines 410 and 4071, thus forming a collapsed form. When it is desired to open, the support surfaces 401 and 402 are opened by hand to allow the first panel 403 and base surface 414 to unfold in a manner similar to an isosceles trapezoid to allow the stand to stand. Of course, after the shelf body is used, the shelf body can be contracted and folded again.

The figure 20 position shows the folded collapsed position, when in the collapsed position, the fold lines are at a minimum angle, or the sides of the fold lines are nearly close together or at a minimum distance. When the mask is folded and contracted for a long time and needs to be unfolded to be in a natural state, the two masks separated by the crease have the natural unfolding force, for example, two surfaces of the first surface separated by the crease 410, and the supporting surface and the first surface connected by the crease lines 409 and 412 also have the natural unfolding capability. For the same reason, the two sides of the base surface separated by the fold lines also have the ability to unfold, as do the folds formed by the fold lines 408,413 connecting the base surface and the support surface, thus creating a unfolded support as seen at 20 when naturally unfolded. As previously mentioned, the first face and the base face are not substantially planar, but form an included angle, as depicted, for example, in fig. 3E and 3F. Of course, it is also possible to form a planar structure as shown in fig. 17, i.e. the first face and the base face are both in the form of planes.

To form the condition shown in fig. 17, the operator can manually align the support surface or the first surface and the base surface to be a flat surface. The length of the base face at this time is generally the distance between the edges of the two support faces when open, which is the distance that the base face lies between the edges of the support faces (which can be considered as the fold line 408 between the base face and the second support face and the edge 413 of the first support face). When these faces are of a paper structure of relative thickness, for example 1 mm, 2 mm, the base face can serve to fix the distance between the edges of the first and second support faces, allowing the rack to stand without easily falling or tipping over, thus being easily stable when the test tube is inserted into the hole 411. The purpose of the base is to keep the distance of the supporting surface and increase the contact area with the operating surface, so that the frame body is more stable. In terms of manufacturing mode, the paper packaging bag can also be formed by arranging different folding lines on one piece of bobble paper, and can be packaged in a paper sheet mode or a folding mode. It is understood that the natural state may be the state shown in fig. 19 if no additional collation is performed. The two states, from folded to retracted to naturally extended and manually finished by the operator, can be used to insert the tube supporting test tube, to perform sample processing or some other operation.

As shown in fig. 1,5-9, in some aspects, in addition to the tube rack including the first side and the support side, the tube rack further includes a stabilizing surface 300 disposed between the first support surface 101 and the second support surface 102 and between the first side 103 and the base surface 200. Of course, it is conceivable that there is no base surface, it is also possible to provide a stabilizing surface only between the two support surfaces, and this stabilizing surface 300 may be provided at any location on the two support surfaces, in some ways, at a location intermediate or near the first surface 103, or near the support surface from the worktop surface. The purpose of the stabilizing surface is to increase the stability of the bracket and also to increase the bearing capacity between the brackets. In a preferred manner, the stabilizing surface 300 is joined to the first adhesive surface 106 by a fold line 116. It will be appreciated that fold line 117 may also be provided in the stabilizing surface in a preferred manner, although fold line 117 may be provided at the location of scoring stabilizing surface 300. When folded, the anchoring surface is folded and retracted by means of a fold line 117, as shown in fig. 9, and when unfolded, it is unfolded to form a shelf, which may be a natural unfolding or an artificial unfolding, such as the one shown in fig. 8. In some forms, the stabilizing surface may also be provided with an aperture 119, which aperture 119 and aperture 120 of the first surface 103 cooperate to receive a tube. So that the position of the tube body on the test tube rack is fixed and cannot swing, and after all, the tube body is limited by the upper hole 119 and the lower hole 120.

Thus, when folded back, either the stabilizing surface 200, the base surface 300, or the first surface 103 can be folded in the same direction, e.g., both upward, or both downward, or both the first surface 103 and the base surface 200 can be folded inward (in embodiments with a base), and the stabilizing surface can be folded up or down. In short, the folding and shrinking manner is possible, and the direction in which each side is folded is not limited.

For example, in the folding direction shown in fig. 6, the first side is folded downward, along the folding line 110, the fastening side can be folded downward or upward along the folding line 117, and the base side is folded upward along the folding line 114, and the folding process brings the support sides into closed contraction, which is accomplished by means of the crease lines connected with the respective sides, and the crease lines act like hinges. The arrows in FIG. 7 can be seen as the direction in which the respective faces are contracted inward by the folds, and the contracted state is formed after the respective faces are folded (FIG. 9)

In another preferred mode, the second bonding surface 107 connected to the stabilizing surface 300 is bonded to the inner surface 201 of the first supporting surface through the second bonding surface. The stabilizing surface 300 and the second bonding surface 107 are connected together by a fold line 118 (shown in fig. 2 as a complete frame structure). Through the bonding of two bonding faces like this, and the broken line connection through each face connection, just formed the structure of whole test-tube rack, such structure can the folding shrinkage, also can expand and form the support body structure, is used for pegging graft test tube or container, aspect sample operation and utilizes the solution in the test tube to handle the sample on placing the operation face.

The manufacturing process is also easy to manufacture, and the manufacturing structure of the complete frame structure shown in fig. 2 is described in detail through the complete paperboard. First, a paperboard with a certain thickness, for example, a paperboard with a thickness of 1 or 2 mm, is selected, and a shape as shown in fig. 1 is formed by punching, and the paperboard shape is divided into several functional areas as follows. The support surface is divided into a first support surface 102 and a second support surface 101, which are connected to a first surface 103, respectively, where a hole 120 is provided for inserting the tube container. Here the first support surface 102 is a single surface and in connection with the second support surface there is also a base surface 200, the middle of which base surface 200 is also provided with a folding line or crease line 114, which divides the base into two parts 104 and 105, the two parts 104 and 105 being divided by the crease line. Similarly, the first side 103 is provided with a fold line 110 and divides the first side into two parts 103 and 400, the two parts 103 and 400 being connected together by the fold line 110. Attached to the base surface is a first adhesive surface 106 that is adhered to the first support surface inner surface 202. Then connected to the first adhesive surface 106 is a stabilizing surface 300, which is likewise provided with a fold line 117 dividing the stabilizing surface into two parts 109 and 108, the two stabilizing surfaces 109 and 108 being connected together by the fold line 117. Holes 119 are also provided in the anchoring surface, holes 119 in the anchoring surface 300 and holes 120 in the first surface being used to secure the tube. A second adhesive surface 107 connected to the anchoring surface, the adhesive surface 107 being adhered to the inner surface 201 of the second support surface 101. First face, holding surface, the base face, the face that bonds, division between the firm face is divided through the crease line, and when the preparation support body, the place that just carries out the folding is just carried out to the crease line of the same line to form like the support body structure of figure 2, when this support body structure shrink, form like figure 9 shrink state. The first and second support surfaces are trapezoidal in shape, the first surface 103 is rectangular in shape, the long sides of the rectangle are defined by the fold lines 111 and 112, and the sides 203 of the first support surface 102 and the sides 113 of the second support surface 101 are longer than the fold lines 111 and 112, so that when unfolded, the tube stand can stand on the operation surface. Of course, not all the surfaces need to be rectangular or trapezoidal, and may be any other surface having any shape as long as it can support all the surfaces and has a hole into which the pipe can be inserted. For example, the support surface may be rectangular, the first surface may be square, and the shape of the stabilizing surface or the base surface is not particularly limited, and may be any combination of any of rectangular, square, triangular, trapezoidal, and the like. The length of the supporting surface can be designed at will, and the length of the supporting surface can be designed at will according to the needs, for example, 3-20 cm can be enough. In some embodiments, the stabilizing surface 300 is disposed near the base surface 200, such that the gravity of the base surface increases and the center of gravity moves downward, which may also increase the stability of the frame. It may be generally located near the base surface and at a third of the height of the support surface, counting from the base surface facing upwards.

The process of forming the frame using the folding as shown in fig. 1 is as follows. First, the two support surfaces and the first surface are made into a skeleton structure by folding the support surfaces 101 and 102 and the crease lines 112 and 111 with the first surface 103), as shown in fig. 4A, then the base surface 200 is folded downward by the crease line 113 to form the base surface 105, then the base surface is made substantially parallel to the first surface 103, and then the first adhesive surface 106 is brought into contact with and adhered to the inner surface 202 of the first support surface 102 by folding the crease lines 115 and 116. Stabilizing surface 300 is then folded down via crease line 116 to lie between first surface 103 and base surface 200. And then folded downwardly by the fold line 118 to bond the second adhesive side 107 to the inner surface 201 of the second support side 101. This forms a frame structure as shown in fig. 2. The general ease of manufacture and folding is described herein, but any other conceivable method of manufacture is within the spirit of the invention. The direction of folding is not the only direction for this embodiment. The folding mode can be formed by manual folding or automatically by a machine, and the bonding of the bonding layer can be paperboard with a glue coating layer, bonding formed by hot processing or laser welding. Preferably, a layer of glue is coated on the surfaces of the bonding surface 106 and the second bonding surface 107, and during the manufacturing process, the first bonding surface 106 and the second bonding surface 107 are bonded to the inner surface of the supporting surface through hot compress or mechanical pressure.

It will be appreciated that the frame structure shown in figure 2 is only one embodiment of the invention, and as previously described, the base surface, bonding surface and stabilizing surface may be absent, and only the two support surfaces and the first surface and the holes thereon are retained, thus forming a simple tubular frame structure that can also be collapsed and expanded. Of course, the base surface, the bonding surface, the stabilizing surface and the like are provided, and one of the purposes is to increase the supporting capability and stability of the frame body.

In other ways, it is possible to achieve a tube rack that can be folded in both the retracted and the open states with only two support surfaces, without the first surface. For example, as shown in fig. 21, two sides of the support 801.802 are folded, and the insertion holes 803 are provided on both sides of the folding line, if a relatively thick or hard cardboard is used, the test tube can stand on the operation surface, for example, the test tube shown in fig. 12A is in a posture that the test tube can be inserted into the hole and stand. Where the first support surface and the second support surface are folded (in phantom in fig. 11), each is notched in a semicircular manner so that the combination is a well into which a test tube can be inserted. In this embodiment, there is no first face, but a hole for inserting the test tube is formed by the combination of notches made in the support face. Of course, in this manner, a base surface 804 may be provided to connect the two support surfaces (FIG. 21B), a stabilizing surface 805 may be provided to connect the two support surfaces (FIG. 21D), or a support surface may be provided with a base surface and a stabilizing surface, as in the manner of FIG. 21C. Of course, the method described with reference to fig. 1 or 16 can be used to fabricate the optical fiber with the first side absent, according to the foregoing fabrication method.

The expressions "crease line", "folding line" and "folding line" herein are interchangeable, and do not mean that there is a line drawn here, but mean that there is a position where two faces can be folded, or bent relatively, or mean that there is a hinge, and mean that two faces are folded or changed in relative position by the hinge. Any sheet, rigid material, such as thin plastic sheets, metal sheets, cardboard, may be used to make such a frame structure. The preferred embodiment is paperboard. The thickness of the cardboard is typically 1 or 2 mm, or even thicker. In addition, the cardboard can be covered with a film. Preferably, the material is a thick, rigid cardboard. As for the crease lines, the folding lines, the manner of the crease lines may take the form of machine punching, or may take the form of punching holes at successive intervals at the location of the crease lines. The known methods are easy to implement wherever folding is desired. The folding here may also be such that, when folded, the test tube rack is foldable along a fold from a piece of cardboard, or may be in the form of a rack that already has a solid body by the fold. When the test tube rack is in a three-dimensional tube rack form, the test tube rack can be folded, contracted and unfolded. The stretching also comprises natural stretching and manual stretching or natural stretching combined with manual stretching. The so-called natural unfolding refers to that after the folding, the pipe frame which is folded and contracted by external force is unfolded into a three-dimensional form by means of internal force of natural unfolding when the pipe frame is in a natural state. The form of contraction is a form compressed by an external force, such as fig. 2A, fig. 3A, fig. 9, fig. 21, and the like.

The above-mentioned frame body structure with only a single hole is introduced, when a plurality of holes are needed, a plurality of different tubes can be inserted at one time, and the utility model can also be realized. Such a tube rack may also be folded in both a collapsed and an expanded state.

In some forms, the width of the board being manufactured may be enlarged in multiples, such as in the transverse direction (actually the longitudinal extension), such as in multiples of 1, 2, 3, 4, 5 or 10, such as in multiples of 2-10 (longitudinal extension) of the edge 203 of the first support surface, and the first surface 103 is also proportioned such that the first surface 103 extends in the longitudinal direction, such that 2-10, or more, holes may be provided in the longitudinal direction of the first surface (arrows in fig. 1; arrow direction in fig. 10). Accordingly, if there is no base surface or stabilizing surface, it is also elongated in the longitudinal direction, in such a way that multiple tube structures can be placed. For example, fig. 2B, fig. 2C, fig. 3B, and fig. 3E may extend along the longitudinal direction, and a plurality of holes may be provided, so that insertion or insertion holes of a plurality of tubes may also be realized.

In another embodiment, as shown in fig. 14 to 16, the test tube rack may be expanded from the lateral direction, for example, as shown in fig. 15, the test tube rack may be formed as two single bodies, but the two single bodies may be formed as one sheet of paper at a time, and folded along a predetermined folding line in the direction indicated by the arrow shown in fig. 15, and the test tube rack may be formed as two foldable test tube racks inserted into the tube body at a time from nos. 1 to 14, each serial number representing one surface, and the surface represented by the next serial number and the surface represented by the previous serial number may be folded. The two surfaces can also be folded, contracted and unfolded according to the method. Simultaneously, guaranteed that two monomers can the stable connection, set up a connection face between two replacements, should connect first monomer of face one end connection, another one monomer is connected to another one end, connects face 602 and holding surface adhesive joint. The joint surface is also provided with fold lines or creases so as to divide the joint surface into two faces 606 and 603. The connecting surface and the two single bodies can be connected in a mode that: the connecting surface 602 has two adhesive surfaces 604 and 605, which are adhered to the supporting surfaces of the two single bodies 60 and 601 respectively. This ensures that after the two cells are folded, each cell is maintained at a suitable distance when free to unfold. It is conceivable that in this form, a further 2 monomers can be connected via the connecting face, which is increased by a factor of 2. This is also an extended way. In other ways, a collapsible tube rack like that shown in fig. 18 or fig. 3 may also be expanded and added in the manner described above. The collapsible tube rack of fig. 2 may also be laterally augmented, for example laterally expanded in the manner of fig. 2E.

In some embodiments, there is another way of lateral expansion, which is to expand the lateral length of the first face. For example, as shown in FIG. 17, the lateral width of the first surface is enlarged such that the area of the first surface is enlarged, which may be in an equal scale, without changing the size of the support surface, with the base surface being extended laterally, with the stabilizing surface being extended laterally (the arrow shown in FIG. 17 is enlarged laterally). This allows one or more rows of test tube insertion holes to be formed in the first face. In some modes, in order to make the test-tube rack of many rows of holes can fold, then set up one or more broken lines or crease on first face, along broken line or crease, can let first face folding shrink, if contain base face or firm face, then set up one or more broken lines or creases with first face according to the same mode or same position, the folding of first face also lets base face or firm folding of face horizontal direction simultaneously like this. Thereby allowing the test tube rack inserted into the holes to be folded and contracted.

In fact, by extending the area of the first surface from two directions, the first surface can be provided with a plurality of holes, and the plurality of holes can be inserted into a plurality of test tubes, so as to perform different virus detection.

Detection device

The detection device is a device for detecting whether or not an analyte is contained in a sample. The detection device may simply comprise a detection chamber and a test element arranged therein, and thus may be referred to as a detection device. For example, the detection device comprises a detection chamber comprising a test element or a test element comprising a carrier. In some embodiments, the detection chamber has a fluid inlet through which the fluid sample flows into the detection chamber into contact with the test element. In some embodiments, the sample application zone of the test element is positioned adjacent to the fluid inlet such that fluid flowing from the inlet into the detection chamber is contacted by the sample application zone, such that fluid sample flows along the application zone to the detection zone, thereby performing an assay and detection of an analyte.

In some embodiments, the test device resembles a test board, although a separate test element may be used as an embodiment of the invention. FIG. 13 shows a detecting unit in an embodiment, which includes a window for applying a liquid and a window for reading a test result. An example of how this is done is described below.

For example, as shown in fig. 18 in conjunction with fig. 13, a test device, such as the test device shown in fig. 14, is removed from the package with the test device. The foldable support is then also taken out, which is folded and then packed, either in the form of a folded-up and collapsed form, as in fig. 21, or in the form of a semi-compressed and semi-collapsed form, as in fig. 20. Taking out the test tube from the packaging box, or taking out a sampling cotton swab or other samplers matched with the test tube. The test tube rack is placed on the operation surface, if at home, on the desktop that can place, if in the laboratory, just put on the test bench, if outdoor, can place on any plane. The test tube rack is in a standing posture. The test tube 70 is inserted into the well 411 and is sealed with a solution for processing the sample, which solution includes reagents, which can process the sample, such as diluting, eluting, or lysing the analyte, for example, virus particles into fragments, etc. Since the tube is sealed, the seal 701 is torn open (fig. 12B), the tube 70 is inserted into the hole 411 and then a sample is taken, for example by detecting a new crown, the nasal or oral cavity is taken with a cotton swab, and the swab head is inserted into the treatment solution of the tube and waits for treatment. After the treatment is finished, the cotton swab head is broken off and left in the test tube, or the cotton swab is taken away. The tube is then fitted with a dripper 702 (fig. 12C) which is inserted at one end 34, 30 into the mouth of the tube and at the other end 31 exposed, by means of a projecting flange 33 to define the depth of insertion of the dripper into the mouth of the tube. And then taking the test tube with the dripper away from the test tube rack, and dripping liquid drops into a liquid applying window of the detection device through the dripper so as to finish the whole detection. And after the detection is finished, the paper test tube rack is contracted again for storage, or is directly discarded, or is packaged by adopting a special bag, and is treated by a special environment-friendly mechanism. The folding test tube rack is made of paper materials, is easy to degrade and treat, and can be folded on a package, so that the packaging space is reduced, and the manufacturing cost is lower.

All patents and publications mentioned in the specification of the invention are indicative of the state of the art to which this invention pertains and of the technology disclosed herein as being applicable. All patents and publications cited herein are hereby incorporated by reference to the same extent as if each individual publication were specifically and individually indicated to be incorporated by reference. The invention described herein may be practiced in the absence of any element or elements, limitation or limitations, which limitation is not specifically disclosed herein. For example, the terms "comprising", "consisting essentially of 8230; …" consisting of 8230; \8230; and "consisting of 8230;" may be substituted with the remaining 2 terms of either one of the two in each of the examples herein. The word "a" or "an" herein means only "one", and does not exclude only one, but may mean more than 2. The terms and expressions which have been employed herein are used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described, but it is recognized that various modifications and changes may be made within the scope of the invention and the claims which follow. It is to be understood that the embodiments described herein are preferred embodiments and features and that modifications and variations may be made by one skilled in the art in light of the teachings of the present disclosure, and are to be considered within the purview of this disclosure and scope of the invention as defined by the appended claims and the independent claims.

Claims (22)

1. A test tube rack, the test tube rack includes the first support surface and the second support surface, also include the first hole used for inserting the test tube on the said test tube rack, wherein, said first and second support can be folded; the test tube rack further comprises a first surface, the first surface is connected with the first supporting surface and the second supporting surface, the first surface comprises a first hole for inserting a test tube, and the connection comprises connection through a broken line or a crease line; or, first face pass through broken line, crease and be connected with first holding surface and second holding surface respectively, first face include the hole.

2. The test tube rack according to claim 1, wherein one end of the first support surface is connected to one end of the first surface by a fold line or a crease, and one end of the second support surface is connected to the other end of the first surface by a fold line or a crease.

3. The test tube rack according to claim 1, wherein the test tube rack further comprises a base surface, one end of the base surface is connected with the other end of the first supporting surface through a folding line or a crease, and the other end of the base surface is connected with the other end of the second supporting surface through a folding line or a crease.

4. The test tube rack according to claim 1, wherein the first and second support surfaces are trapezoidal, square or rectangular in shape; or, the first surface is in a trapezoidal shape,

square or rectangular shape.

5. The test tube rack according to claim 1, wherein the first and second support surfaces are trapezoidal in shape, wherein the first surface has an area smaller than the area of the base surface; or the width of the first surface is the same as that of the base surface; alternatively, the length of the first face is less than the length of the base face.

6. The test tube rack according to claim 5, wherein the width of the first base face and the width of the first face are the same or substantially the same.

7. The test tube rack according to claim 1, further comprising a stabilizing surface, wherein one end of the stabilizing surface is connected to the first supporting surface, and the other end of the stabilizing surface is connected to the second supporting surface.

8. The test tube rack according to claim 1, further comprising a stabilizing surface, wherein one end of the stabilizing surface is connected to the first supporting surface, the other end of the stabilizing surface is connected to the second supporting surface, and the stabilizing surface is located below the first surface.

9. The test tube rack according to claim 8, wherein the stabilizing surface includes a second hole for inserting a test tube, the first and second holes being vertically aligned.

10. The test tube rack according to claim 9, wherein a first adhesive surface and a second adhesive surface are further connected to two ends of the stabilizing surface, the first adhesive surface is adhered to the first supporting surface, and the second adhesive surface is adhered to the second supporting surface.

11. The test tube rack according to claim 8, wherein the stabilizing surface is located between the first surface and the base surface.

12. The test-tube rack according to claim 8, wherein the first surface, the first supporting surface, the second supporting surface, the stabilizing surface, the first pasting surface or the second pasting surface of the test-tube rack are connected through a folding line or a crease, or the first surface, the first supporting surface, the second supporting surface, the stabilizing surface, the first pasting surface or the second pasting surface of the test-tube rack are folded through a connected folding line or crease.

13. The test tube rack according to claim 12, wherein the first, first support, second support, stabilizing, first adhesive or second adhesive surface of the test tube rack is formed by folding a flat sheet of paper.

14. The test tube rack according to claim 1, wherein the rack is collapsible in both a collapsed and an open state.

15. The test tube rack according to claim 4, wherein the base face and the first face also include a fold line or crease, by which both the base face and the first face can be folded.

16. The test tube rack according to claim 1, wherein the first face extends longitudinally or transversely, so that a plurality of first holes for test tube insertion are provided on the first face.

17. A test tube rack, comprising:

a first face having a first end and a second end, said first face having one or more wells for receiving test tubes;

the first supporting surface and the second supporting surface are respectively connected with the first end and the second end of the first surface at one end, and the connection is realized through creases or broken lines;

a base surface connecting the first support surface and the second support surface; wherein the base surface is located below the first surface.

18. The test tube rack according to claim 16, wherein the base surface is connected to the first support surface and the second support surface by a fold or crease line.

19. The test-tube rack of claim 17, the base surface further comprises a pasting surface for pasting with the first supporting surface or the second supporting surface, and the pasting surface is connected with the base surface through a folding line or a crease.

20. The test tube rack according to claim 16, wherein the base face and the first face each include respective fold lines or folds by which the first face and the base face can be folded and collapsed.

21. A test tube rack, comprising:

a plane cardboard, wherein the cardboard is divided into a first surface by a crease line or a fold line; the test tube fixing device comprises a base surface, a first supporting surface, a second supporting surface, a stabilizing surface, a first pasting surface and a second pasting surface, wherein the first surface comprises a first end and a second end, and one or more holes for inserting test tubes are formed in the first surface; one end of each of the first supporting surface and the second supporting surface is respectively connected with the first end and the second end of the first surface;

the base surface is connected with a first pasting surface, the first pasting surface is connected with a stabilizing surface, and the stabilizing surface is connected with a second pasting surface; wherein, the connection of each surface is connected by the crease or the folding line.

22. The test tube rack according to claim 20, wherein the base surface and the first surface each include respective fold lines or folds by which the first surface and the base surface can be folded and collapsed.

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