CN115999673A - Foldable test tube rack - Google Patents

Abstract

The invention provides a test tube rack, which comprises a first supporting surface and a second supporting surface, and further comprises a first hole for inserting test tubes, wherein the first supporting surface and the second supporting surface can be folded. Through such test-tube rack, can fold shrink-wrapping when packing, thereby open when using and be used for inserting the test tube and operate.

Description

Foldable test tube rack

Technical Field

The invention relates to a test tube rack for preventing test tubes, in particular to a tube rack for placing cracking tubes in the field of rapid diagnosis.

Background

The following background description is only an illustration of some of the general background knowledge and is not intended to limit the invention in any way.

Currently, detection devices for detecting whether a sample contains an analyte are used in a large number of hospitals or homes, and these detection devices for rapid diagnosis contain one or more detection reagent strips, such as early pregnancy detection, drug abuse detection, and the like. The rapid diagnostic test device is very convenient and can obtain test results on the test reagent strips in one minute or at most ten minutes.

Currently, infectious disease detection, particularly virus detection, is increasingly common and everyday. Such tests are not only the necessary test items for routine tests by professional testing institutions, but also the household operations are becoming popular. As with early pregnancy tests, infectious disease tests are becoming more popular and are going to be a family test. For the household detection of infectious diseases, such as virus detection of influenza, and other household detection including daily household detection, it is generally required to lyse viruses or bacteria in advance or to pre-treat a sample and then perform subsequent detection. For infectious disease detection, an important component is the lysis of viruses or bacteria in a sample, thereby detecting the lysed fragment antigen. Of course, if other samples are present, it may be desirable to pre-treat the sample, such as with some buffer solution. In home testing or in small clinic environments, it is desirable to place a tube of lysate or sample-handling solution, place the tube vertically on a table, such as a bench or a table in a home, and then place the sample, the latter with a sample format, such as a sample-taking swab, in the tube, or in the tube, and allow the fluid in the tube to contact the sample, thereby handling or handling the sample. After the treatment is completed, the lysate or the solution of the treated sample is subjected to subsequent detection or the like.

For a tabletop to place test tubes, a rack is typically required to allow the test tubes to be placed vertically, which is typically required for the user to be provided by the supplier of the reagents, and the user will typically not be ready for such a rack. The traditional test tube rack is formed by plastic at one time, occupies volume on manufacturing package, has weight, is inconvenient to transport, increases cost, is a large number of plastic products, causes environmental pollution, and increases cost of subsequent environment-friendly treatment.

In view of the above-mentioned problems, improvements are needed to solve the shortcomings of the conventional techniques.

Disclosure of Invention

In order to improve the existing test tube rack, the test tube rack provided by the invention occupies a small space in package, is basically in a folded and compressed state, is unfolded to be a three-dimensional structure when needed for use, and is used for placing test tubes, centrifuge tubes or any tube body with solution, and is disposable after being used up. In some embodiments, the tube rack is made of hard paper, and in some embodiments, paper that can be degraded.

Accordingly, in a first aspect of the present invention, there is provided a test tube rack comprising a first support surface and a second support surface, the test tube rack further comprising an aperture for accessing a tube body, wherein the first and second supports are foldable. In some embodiments, the rack further comprises a first surface, the first surface connecting the first and second support surfaces, the first surface comprising the aperture. In some aspects, the first face is connected to the first and second support faces by fold lines, folds, respectively.

In some embodiments, the support surface includes a first support surface and a second support surface, and the junction between the support surface and the first surface includes a fold line, or the two support surfaces are connected to two ends of the first surface by the fold line. The folding between the supporting surface and the first surface can be realized through the folding line, so that the volume is reduced, and when the folding line is opened, a three-dimensional frame structure capable of placing the pipe body is formed. Fold lines are herein understood to be folds, crease lines, fold lines, etc. The first support surface and the second support surface are thus adapted to support the first surface, when in an open standing position, with the first surface having an operational fullness or the support surface being at a distance from the bottom, such that the tube or body is held in an upright or standing position when inserted into the hole. When the tube is used up, the tube is taken out of the hole and is folded by the folding line.

In some modes, the test tube rack further comprises a base surface, wherein the base surface is connected with the supporting surface and is positioned below the first surface. In some aspects, the base surface is connected to the support surface by folds, fold lines, and the like. In some modes, one end of the base surface is connected with one end of the supporting surface through a folding line and a crease, and the other end of the supporting surface is connected with the first surface through the folding line and the crease. In some embodiments, one end of the base surface is connected to one end of the first support surface by a fold line, and the other end of the first support surface is connected to the first surface by a fold line, or is permanently connected to the first surface. Thus, the base surface, the two supporting surfaces and the first surface form a three-dimensional shape, the first surface is used for being inserted into the pipe body, and the base surface is used for stabilizing the distance between the supporting surfaces, so that the stability of the pipe rack is improved. In some modes, the supporting surface is trapezoidal, so that a three-dimensional body shape is formed, the short surface is used as a surface inserted into the test tube hole, and the long surface is used as a base, so that the stability of the test tube rack is improved. Of course, this is only a preferred way, but it is also possible in virtually any way, such as a cube, a cuboid, where the first face and the support face as well as the base face constitute a solid.

In some aspects, the base surface is parallel or substantially parallel to the first surface when opened. In some modes, the length of the base surface is greater than that of the first surface, and when the test tube rack is unfolded from the folded mode, the tangent plane forms a trapezoid mode, so that the stability of the test tube is improved. In some aspects, the width of the base surface is the same or substantially the same as the width of the first surface.

In some modes, still set up a firm face between base face and first face, first holding surface or second holding surface are connected respectively to the both ends of this firm face, like this, can let whole test-tube rack when standing again, more stable and be difficult to the upset. In some embodiments, the stabilizing surface also includes a receptacle, the receptacle being on substantially the same axis as the receptacle on the first surface. Thus, when a test tube is inserted into the jack, there are two holes to receive the insertion of the test tube, and the tube body is more stable.

In some embodiments, one or more of the first side, the base side, the stability side, or the first side further comprises a fold line, and the first side, the base side, or the stability side is unfolded by folding the fold line, so that the entire test tube rack is folded in a non-folded manner, and the entire test tube rack has a small thickness when folded, and has no thickness basically unless the sum of the thicknesses of the sides is equal. The thickness of the test tube rack after being folded is the thickness of the superposition of the two supporting surfaces. In some aspects, the fold line is located at a midline of the first face. In some aspects, the fold lines of the base and stabilizing surfaces are each located at a respective midline position. In some embodiments, the first side is folded inwardly by a fold line in a direction toward the stabilizing side or base, and when the stabilizing side or base is present, the first side is folded downwardly by a fold line if the stabilizing side or base is not present. Thus, the length of the test tube in the vertical direction when the test tube is folded is reduced, and the space is saved in package and transportation. In some modes, when the base surface is provided with the base surface, the base surface is folded by the fold line, and the folding direction is also inwards folded or is folded towards the direction close to the first surface, so that the length of the whole test tube rack in the vertical direction when being folded is also reduced. These fold directions are only some preferred directions and of course either the first or second faces may be folded outwardly. For both the open and collapsed states, this is achieved by folding and unfolding of the fold line.

In some modes, the whole test tube rack is formed by folding through a whole or a whole plane through folding lines. Thus, the processing and the design are convenient. A three-dimensional structure is formed by folding from a plane, and can be retracted and opened by folding lines. In some aspects, the integral plane is formed by folding a plurality of hard papers and sheets. In some embodiments, in order to make the whole structure more stable, bonding surfaces may be provided, and the bonding surfaces may be bonded to each other by the connection between the first surface, the base surface or the fixing surface. In some embodiments, the base surface is further connected to an adhesive surface, the adhesive surface being adhered to the second support surface, the adhesive surface and the base edge also being connected by a crease line. In some modes, two ends of the stabilizing surface are respectively provided with bonding surfaces, and the bonding surfaces are respectively bonded in the two supporting surfaces, so that the test tube rack with a fixed structure is formed. Of course, the first surface, the supporting surface, the base surface, the stabilizing surface and the bonding surface are all divided into different areas on a whole plane, and a three-dimensional test tube rack structure is formed through folding lines.

In some embodiments, where the first face has a receptacle, a test tube may be inserted, and where multiple test tubes are to be inserted simultaneously, it may be desirable to have multiple different receptacles to receive the insertion of multiple tubes. In this case, it is desirable to repeatedly arrange the monomers of the plurality of insertion holes in different directions. For example, the first surface may be arranged in the longitudinal direction, in such a manner that the first surface is elongated toward both ends, the width of the first surface is constant, and the length of the first surface is elongated to extend toward the continuous section, so that a plurality of insertion holes may be provided in the first surface. In the same manner, when the base is included, or when the stabilizing surface is included, the whole extends toward both ends, so that a plurality of insertion holes can be provided.

In other directions, lateral expansion is desired, i.e. in the direction along the support surface. When the supporting surface is vertical or is perpendicular to the first surface, the supporting surface is actually a cube or cuboid structure, and the extension mode is the same as the longitudinal extension mode along the first surface, so that the extension in the transverse direction is realized.

Advantageous effects

By adopting the structure, the folding tube body frame can be provided, and can be folded and contracted, and can be unfolded and unfolded to be in a three-dimensional shape so as to be used for supporting the test tube. Therefore, the test tube rack has the advantages of light weight and reduced packaging space, and is simple and convenient to manufacture and low in cost if made of paper materials, and environmental pollution is reduced (compared with the plastic bracket).

Drawings

FIG. 1 is a schematic illustration of a paperboard structure used to make a collapsible tube frame in accordance with one example of the present invention, in accordance with an embodiment.

Fig. 2 is a diagram showing a test tube rack according to an embodiment of the present invention, fig. 2A is a folded and contracted state, fig. 2B is an unfolded state, fig. 2C is another unfolded state, fig. 2D is a cardboard for manufacturing the test tube rack shown in fig. 2A, and fig. 2E is a schematic diagram showing a structure for expanding a plurality of test tube rack units.

Fig. 3 is a diagram showing a test tube rack according to another embodiment of the present invention, fig. 3A is a folded and contracted state, fig. 3B is an unfolded state, fig. 3C is another unfolded state, fig. 3D is a board for manufacturing the test tube rack shown in fig. 2A, fig. 3E is a structure diagram showing another folded and unfolded state, fig. 3F is another folded and unfolded state, and fig. 3G is a schematic perspective view showing a stable surface positioned at a middle position of a supporting surface.

Fig. 4 is a schematic view of the process of folding the paperboard shown in fig. 1 by a fold line. Fig. 4A is a schematic view of the third step, fig. 4B is a schematic view of the fourth step, fig. 4C is a schematic view of the fifth step, and fig. 4D is a schematic view of the sixth step.

Fig. 5 is a schematic perspective view of the paperboard of fig. 1 formed by folding.

Fig. 6 is a schematic perspective view of the paperboard of fig. 1 formed by folding.

Fig. 7 is a left side view of the paperboard of fig. 1 formed by folding.

Fig. 8 is a schematic view showing a structure of the tube frame shown in fig. 5 in which the tube frame is folded and contracted or contracted to expanded.

Fig. 9 is a schematic structural view of the tube frame shown in fig. 5 after being folded and contracted.

Fig. 10 is a schematic view showing a structure in which a single tube rack shown in fig. 5 is longitudinally expanded to a plurality of tube racks.

Fig. 11 is a schematic view showing a structure in which a single tube rack shown in fig. 5 is longitudinally expanded to a plurality of tube racks.

Fig. 12 is a schematic perspective view of a tube body, a sealing film and a droplet plug, wherein fig. 12A is a schematic view of a structure of a test tube sealed by the sealing film, fig. 12B is a schematic view of the sealing film, and fig. 12C is a schematic view of a structure of the droplet plug.

FIG. 13 is a schematic diagram of a bit testing apparatus.

Fig. 14 is a schematic view of a laterally expanded structure of the single tube rack shown in fig. 5.

Fig. 15 is a process diagram of folding a single piece of paperboard into two unitary tube frames.

Fig. 16 is a schematic view of a planar structure of another embodiment of a paperboard with fold line demarcation zones.

Fig. 17 is a tube structure in which the plane shown in fig. 16 is formed by folding.

The single tube rack shown in fig. 17 is longitudinally expanded into a structural schematic of a plurality of tube connections.

Fig. 19 is a schematic view showing a structure of the tube frame shown in fig. 17, in which the tube frame is folded and contracted or contracted to expanded.

Fig. 20 is a schematic view of the tube frame shown in fig. 17 after being folded and contracted.

Fig. 21 is a schematic structural view of a foldable pipe body according to another embodiment of the present invention, fig. 21A is a schematic structural view of an unfolded structure, fig. 21B is a schematic structural view of a base, fig. 21C is a schematic structural view of a fixing surface provided between the base and a hole, and fig. 21D is a schematic structural view of a lack of a base surface.

Detailed Description

The structures and terms of art to which the present invention pertains are further described below, as understood and interpreted in accordance with the general terms of art unless otherwise specified.

Detection of

Detection indicates the assay or testing for the presence of a substance or material, such as, but not limited to, a chemical substance, an organic compound, an inorganic compound, a metabolic product, a drug or drug metabolite, an organic tissue or a metabolite of an organic tissue, a nucleic acid, a protein or a polymer. In addition, the detection indicates the amount of the test substance or material. Further, assays also refer to immunoassays, chemical assays, enzymatic assays, and the like.

Sample of

The detection device or collected sample of the present invention includes biological fluids (e.g., case fluids or clinical samples). The liquid or liquid sample, or fluid sample, may be derived from solid or semi-solid samples, including fecal matter, biological tissue, and food samples. The solid or semi-solid sample may be converted to a liquid sample using any suitable method, such as mixing, mashing, macerating, incubating, dissolving, or digesting the solid sample with enzymatic digestion in a suitable solution (e.g., water, phosphate solution, or other buffer solution). "biological samples" include animal, plant and food samples, including, for example, urine, saliva, blood and components thereof, spinal fluid, vaginal secretions, sperm, feces, sweat, secretions, tissues, organs, tumors, cultures of tissues and organs, cell cultures and media derived from humans or animals. Preferably the biological sample is urine, preferably the biological sample is saliva. Food samples include food processed materials, end products, meats, cheeses, wines, milks and drinking water. Plant samples include plants, plant tissues, plant cell cultures and media derived from any plant. An "environmental sample" is derived from the environment (e.g., a liquid sample from a lake or other body of water, a sewage sample, an earth sample, groundwater, seawater, and a waste liquid sample). The environmental sample may also include sewage or other wastewater.

Any analyte may be detected using a suitable detection element or test element of the present invention. Preferably, the invention is used for detecting drug small molecules in saliva and urine. Of course, any of the above forms of sample, whether initially solid or liquid, may be collected using the collector of the present invention, provided that such liquid or liquid sample is absorbed by the absorbent element. The absorbent member is typically made of a water absorbent material, and is initially dry, and is capable of absorbing a liquid sample or fluid sample by capillary or other properties of the absorbent member material. The absorbent material may be any material capable of absorbing liquid, such as sponge, filter paper, polyester fiber, gel, nonwoven, cotton, polyester film, yarn, etc. Of course the absorbent member need not be made of absorbent material, but may be made of non-absorbent material, but may have holes, threads, cavities in the absorbent member, and samples may be collected on these structures, typically solid or semi-solid samples, which are filled between threads, holes, or holes.

Downstream and upstream

Downstream or upstream is divided with respect to the direction of liquid flow, typically liquid flowing from upstream to downstream regions. The downstream region receives liquid from the upstream region and liquid may also flow along the upstream region to the downstream region. Here, the flow direction of the liquid is generally divided, for example, on some materials that use capillary force to promote the flow of the liquid, the liquid may flow in a direction opposite to the gravity, and at this time, the upstream and downstream are also divided according to the flow direction of the liquid.

Gas or liquid communication

Gas or liquid communication refers to the ability of a liquid or gas to flow from one location to another, where the flow may be directed through some physical structure. By physical structures is generally meant that liquid flows passively or actively to another place through the surfaces of the physical structures, or through the spaces within the structures, the passive being generally flow caused by external forces, such as capillary action. The flow may be liquid or gas, or may be passive, due to its own action (gravity or pressure). Communication herein does not necessarily require the presence of a liquid or gas, but merely in some cases indicates a connection or state between two objects, and if a liquid is present, may flow from one object to another. Here, it refers to a state where two objects are connected, but conversely, if there is no liquid communication or gas communication between the two objects, if there is liquid in or on one object, the liquid cannot flow into or on the other object, and such a state is a non-communication, non-liquid or gas communication state.

Test element

The term "test element" as used herein refers to an element that can detect whether a sample or specimen contains an analyte of interest, and can be referred to as a test element, regardless of the principle of technology, immunological, chemical, electrical, optical, molecular, nucleic acid, physical, etc. The test element may be a lateral flow test strip that detects multiple analytes. Of course, other suitable test elements may be used with the present invention,

various test elements may be combined together for use in the present invention. One form is test paper. Test strips for analyzing analytes in a sample, such as drugs or metabolites indicative of a physical condition, may be in various forms, such as immunoassay or chemical analysis. The test strip can adopt an analysis mode of a non-competition method or a competition method. The test strip generally comprises a bibulous material having a sample application area, a reagent area and a test area. Sample is applied to the sample application region and flows to the reagent region by capillary action. In the reagent zone, the sample binds to the reagent if the analyte is present. The sample then continues to flow to the detection zone. Other reagents, such as molecules that specifically bind to the analyte, are immobilized in the detection zone. These reagents react with and bind the analyte (if present) in the sample to the region, or to a reagent in the reagent region. The label for displaying the detection signal is present in a separate label zone from the reagent zone.

A typical non-competitive assay format is one in which a signal is generated if the sample contains an analyte and no signal is generated if the sample does not contain an analyte. In competition methods, a signal is generated if the analyte is not present in the sample, and no signal is generated if the analyte is present.

The test element can be a test paper, and can be made of a material which absorbs or does not absorb water. The test strip may comprise a variety of materials for liquid sample transfer. One of the test strips may be coated with another material, such as a filter paper, on a nitrocellulose membrane. One region of the test strip may be of one or more materials and another region of the test strip of a different material or materials. The test strip may be adhered to a support or hard surface for improving the strength of the pinch test strip.

The analyte is detected by the signal generating system, e.g., using one or more enzymes that specifically react with the analyte, and the composition of the one or more signal generating systems is immobilized on the analyte detection zone of the test strip using the method of immobilizing a specific binding material on the test strip as described previously. The signal generating substance may be on the sample application zone, reagent zone, or test zone, or the entire test strip, and the substance may be impregnated with one or more materials of the test strip. The solution containing the signal is applied to the surface of the test strip or one or more materials of the test strip are immersed in the solution containing the signal. The test paper added with the signal-containing substance solution is dried.

The various zones of the test strip may be arranged in the following manner: the sample adding zone, the reagent zone, the detection zone, the control zone, the liquid sample absorbing zone and the liquid sample absorbing zone. The control zone is located behind the detection zone. All zones may be arranged on a strip of paper of only one material. Different materials may be used for the different regions. Each zone may be in direct contact with the liquid sample or the different zones may be arranged in accordance with the direction of flow of the liquid sample, with the ends of each zone being connected to and overlapping the front end of the other zone. The material used may be a material with good water absorption such as filter paper, glass fiber or nitrocellulose membrane. The test strip may take other forms.

The commonly used reagent strip is a nitrocellulose membrane reagent strip, namely the detection area comprises a nitrocellulose membrane, and specific binding molecules are immobilized on the nitrocellulose membrane to display the detection result; but also cellulose acetate film or nylon film, etc. Such as reagent strips or devices containing reagent strips as described in some of the following patents: US 4857453; US 5073484; US 5119831; US 5185127; US 5275785; US 5416000; US 5504013; US 5602040; US 5622871; US 5654162; US 5656503; US 5686315; US 5766961; US 5770460; US 5916815; US 5976895; US 6248598; US 6140136; US 6187269; US 6187598; US 6228660; US 6235241; US 6306642; US 6352862; US 6372515; US 6379620; and US 6403383. The test strips disclosed in the above patent documents and similar devices with test strips can be used in the test element or test device of the present invention for the detection of an analyte, for example in a sample.

The test strips used in the present invention may be so-called lateral flow test strips (Lateral flow test strip), the specific construction and detection principles of which are well known to those of ordinary skill in the art. A typical test strip comprises a sample collection area or sample application area, a label area, a detection area and a bibulous area, wherein the sample collection area comprises a sample receiving pad, the label area comprises a label pad, and the bibulous area may comprise a bibulous pad, wherein the detection area comprises a necessary chemical, such as an immunological or enzymatic chemical, capable of detecting the presence of an analyte. The common detection reagent strip is a nitrocellulose membrane reagent strip, namely the detection area comprises a nitrocellulose membrane, and specific binding molecules are immobilized on the nitrocellulose membrane to display the detection result; and may also be a cellulose acetate film or nylon film, etc., of course, a detection result control region may be included downstream of the detection region, and typically, the control region and the detection region appear in the form of transverse lines, which are detection lines or control lines. Such test strips are conventional, although other types of strips that utilize capillary action for testing are possible. In addition, the test strip typically carries a dry reagent component, such as an immobilized antibody or other reagent, which, upon encountering the liquid, flows along the strip with capillary action, and with the flow, dissolves the dry reagent component in the liquid, thereby allowing the dry reagent in the zone to react to the next zone for the necessary test. The liquid flow is mainly by capillary action. May be used in the detection device of the present invention, or may be disposed in the detection chamber in contact with the liquid sample, or may be used to detect the presence or amount of analyte in the liquid sample entering the detection chamber. The test element is typically disposed in a test chamber that is in contact with the test element and performs an assay or test when the test chamber has a fluid sample.

In addition to the above-described test strips or the lateral flow test strips themselves are used to contact a liquid sample to test the liquid sample for the presence of an analyte. In some preferred forms, the test elements may also be provided on carriers, such as those shown in FIG. 13, for example, carriers having one or more recesses therein in which the test elements are located. The carrier 900 may also be a combination of two plates, one above the other, with the test element between the plates, the combined plates having a window 901 through which the result of the detection area on the test element can be read with the naked eye or by machine, and a sample drop hole 902 for dropping a sample, such as a liquid sample or a liquid or solid sample treated with a liquid reagent, and of course, optionally, a grip 903 for holding the test device by hand.

Analyte substance

Examples of analytes that can be used in the present invention include small molecule substances, including drugs (e.g., drugs of abuse). "drug of abuse" (DOA) refers to the use of drugs (typically acting to paralyze nerves) in non-medical destinations. Abuse of these drugs can lead to physical and mental impairment, dependence, addiction and/or death. Examples of drug abuse include cocaine; amphetamine AMP (e.g., black americans, white amphetamine tablets, dextroamphetamine tablets, beans); methamphetamine MET (crank, methamphetamine, crystal, speed); barbiturate BAR (e.g., valium, roche Pharmaceuticals, nutley, new Jersey); sedatives (i.e. sleep aid drugs); lysergic acid diethylamide (LSD); inhibitors (downs, goofball, barbs, blue devils, yellow sockets, hypnone); tricyclic antidepressants (TCAs, i.e., imipramine, amitriptyline, and doxepin); dimethyl dioxy methylaniline MDMA; phencyclidine (PCP); tetrahydrocannabinol (THC, point, rope, hash, wet, etc.); opiates (i.e., morphine MOP or, opiates, cocaine COC; heroin, hydroxycodeinone); anxiolytics and sedative hypnotics, which are a class of drugs that are mainly used to relieve anxiety, stress, fear, stabilize mood, and have hypnotic sedative effects, including benzodiazepines BZO (benzodiazepines), atypical BZ, fused diazepines NB23C, benzoazepine, ligands of BZ receptors, ring-opened BZ, diphenylmethane derivatives, piperazine carboxylates, piperidine carboxylates, quinizolinones, thiazine and thiazole derivatives, other heterocycles, imidazole sedative/analgesic drugs (e.g., hydroxyhydrocodone OXY, methadone MTD), propylene glycol derivatives-carbamates, aliphatic compounds, anthracene derivatives, and the like. The detection device can also be used for detecting medical application and is easy to take excessive medicines, such as tricyclic antidepressants (promethazine or analogues), acetaminophen and the like. These drugs are metabolized into small molecular substances after being absorbed by the human body, and these small molecular substances exist in body fluids such as blood, urine, saliva, sweat, etc. or some body fluids exist in these small molecular substances.

For example, analytes detected with the present invention include, but are not limited to, creatinine, bilirubin, nitrite, proteins (non-specific), hormones (e.g., human chorionic gonadotropin, progesterone hormone, follicular stimulating hormone, etc.), blood, leukocytes, sugars, heavy metals or toxins, bacterial substances (e.g., proteins or carbohydrate substances directed against specific bacteria, such as e.g., E.coli 0157: H7, staphylococci, salmonella, clostridium, campylobacter, L.unicytogenes, vibrio, or Cactus) and substances associated with physiological characteristics in urine samples, such as pH and specific gravity; any other clinical urine chemistry analysis can be tested using lateral flow testing in combination with the device of the present invention. The analyte may also be some virus, such as any virus like influenza virus, or any other type of virus or cleaved virus fragment, such as an antigenic fragment, etc., which is clinically recognized as a test strip of the present invention.

Type of sample

Any type of sample can be tested with the device of the present invention or processed with the tube rack of the present invention, including body fluids (e.g., urine and other body fluids, as well as clinical samples). Liquid samples may be derived from solid or semi-solid samples, including fecal, biological tissue and food samples. These solid and semi-solid samples may be converted into liquid samples by any suitable method, such as mixing, stamping, macerating, incubating, dissolving or enzymatic hydrolysis of the solid samples (e.g., water, phosphate buffer or other buffers) in a suitable liquid. "biological samples" include samples derived from living animals, plants and foods, as well as urine, saliva, blood and blood components, cerebrospinal fluid, vaginal swabs, pharyngeal swabs, nasal swabs, semen, faeces, sweat, secretions, tissues, organs, cultures of tumors, tissues and organs, cell cultures and conditioned media therein, whether human or animal. Food samples include processed food ingredients and final products, meat, cheese, wine, milk and drinking water. Plant samples include samples derived from any plant, plant tissue, plant cell culture and conditioned medium therein. "environmental samples" are those derived from the environment (e.g., lake or other water, sewage, soil, groundwater, seawater, waste water). Sewage and related waste may also be contained in the environmental sample.

Flow of liquid

The flow of liquid generally refers to the flow from one place to another, and in general, the flow of liquid in nature mostly flows from high place to low place by gravity, and the flow here also depends on external force, namely, the flow under the external gravity condition, and can be the flow of natural gravity. In addition to gravity, the flow of liquid may also take over gravity, moving from low to high. For example, the liquid is pumped, or the liquid is pressed, and flows from the bottom to the high place, or flows against the gravity of the liquid by the relation of the pressure.

Detailed Description

The following description sets forth how the invention may be carried out in a specific manner, which is a limited list of embodiments of the invention, and in which additional embodiments will be readily apparent to those of ordinary skill in the art in view of this disclosure, are also within the scope of the invention as hereinafter claimed, which is particularly pointed out and defined by the claims of the invention.

An embodiment of the present invention will be described with reference to fig. 2, in which a test tube rack includes a first face 203 on which a hole is provided for receiving or housing a container such as a test tube or a tube with a solution, as shown in fig. 12A, and a first support face 201 and a second support face 202 supporting the first face.

In fact this is a simple foldable test tube rack. The term "tube" is used herein as a generic, readily understood designation and is not intended to limit the scope to use in the usual sense of tubes, but rather to use in any container, such as a tube (fig. 12A), tube or container. The container may be any type of container, such as plastic, glass, metal containers. These containers can hold solutions or solid reagents therein in advance. In some examples, the wells of the holder may be inserted into a receptacle, such as a tip tube, a PCR tube, and a sample processing solution, such as a lysate or any other liquid containing a chemical reagent that may process the sample. For example, when a solution contains a reagent for cleaving a virus, the virus is cleaved into fragments, typically antigen fragments, when the virus is contained in a sample. These antigen fragments can be detected by subsequent steps, for example by immunization. In some embodiments, the test tube contains a liquid reagent and is sealed. When it is desired to process the sample, the sealing film is removed, for example when the seal is an aluminum foil seal, and the sealing aluminum foil is torn off to allow the sample to be contacted with the liquid reagent. The sample may be any sample, such as a swab from a pharynx, a sample from the mouth or a sample from the nasal cavity, and after removal of the sample, the swab is inserted directly into the tube and contacted with the liquid reagent, thereby allowing the liquid reagent to treat the sample, such as to lyse viruses or bacteria, or the analyte therein. After waiting for the end of the treatment, the subsequent detection or assay may be performed directly with the liquid reagent (which may contain the analyte at this time). For example, after the end of the sample treatment, the swab head may be left in the test tube, the dropper may be attached, the test tube may be removed, the test tube may be inverted, and the test tube may be squeezed with a finger to drop out the droplet for detection. Typically, the dripping liquid may drip onto a test element, such as a sample application area on the test element.

Thus, the first face 203 is provided with an aperture 207 (depending on the area may be one or more), which aperture 207 is intended for insertion or placement of a container, such as the tube-like container described above. Fold lines 204 and 205 are provided at the junction of the first face and the support face, where the fold lines are not intended to be human, but may be a dividing or dividing line formed by folding the first face and the support face, so as to distinguish the two faces. When in the initial state, the first support surface 201 and the second support surface 202 and the first surface 203 may be a flat piece of paper or cardboard that is mechanically cut and perforated with holes of a size comparable to the size of the tube body to be placed. When needed, the frame is folded down via fold lines 204 and 205 to form a "n" shape, allowing the frame to stand (fig. 2B). At this time, the test tube containing the solution is allowed to look into the hole 207, thereby allowing the test tube to be kept in a vertical state, thereby facilitating the subsequent operations such as handling the sample. This is particularly convenient in home self-testing, but is very easy to operate, while these small accessories are disposable and can be discarded after testing. When such a frame is made of paper material or is very easy to handle, it is less harmful to the environment. On the other hand, for the manufacturer or the seller providing the detection reagent, the traditional plastic support is not needed, the support body is a piece of paper before being used, the package is basically small and exquisite, the cost is greatly saved, after all, the plastic support is used for opening the mold, and the plastic product can cause environmental pollution and is not easy to process. For example, such a form may be in the form of fig. 2D, which is a sheet of cardboard with indications of crease lines thereon, and according to the instructions of the operating instructions, the operator folds according to the crease lines, for example downwards according to crease lines 205 and 206, the first support 201 and the second support surface 202 being folded to form the form of fig. 2B, so that they can be placed on the operating surface for operation. In some embodiments, if the first side also has fold line 206, the first side is not necessarily planar when folded, but may be curved, such as in the pattern of fig. 2C, with tube insertion aperture 207. Of course, the curved surface may be curved downward or upward, for example, a curved surface opposite to the curved direction of the first surface shown in fig. 2C. Of course, in a manner similar to fig. 2E, a plurality of continuous single bodies such as fig. 2A or 2B may be provided by continuous folding, each of which is folded and contracted in the manner of fig. 2A and unfolded in the manner of fig. 2E.

In some embodiments, rather than a planar sheet of paperboard, it may be initially in a folded collapsed form (e.g., as shown in fig. 2A), with the collapsed tube rack being in an open position when desired. For example, when not in use, the support surfaces 202 and 201 are opened when needed by folding and collapsing together the fold lines 204 and 205 and the fold line 206 (e.g., as shown in fig. 2A), and the stand is supported and placed on an operating surface, such as a bench or a home table, to begin the self-test operation. At this time, the first surface 203 is supported by the support surface and thus is spaced from the operation surface, so that the test tube can be inserted into the hole 207 in a standing posture, the tube body is positioned above the hole 207 near the tube opening, and the bottom of the tube can directly depend on the operation surface. Of course, for the purpose of folding more compactly, the folding line 206 is also arranged on the first surface, so that when the reagent packaging box is folded, the reagent packaging box is folded through the folding line 206, is more compactly and small, almost occupies no packaging space when being packaged with the detection reagent, is convenient to manufacture and produce, and saves cost.

When made, for example, as shown in fig. 2D, a sheet of paper having a certain thickness is selected, the first and second support surfaces 201 and 202, and the first surface 203 are formed by cutting the sheet by a machine, and a hole 207 is provided in the first surface, and folding lines 111 and 112 are provided between the first and second straight surfaces and the first surface. Those skilled in the art will readily appreciate that other ways of achieving folding may be used in the present invention as a way of folding. In this embodiment, the base surface, the bonding surface and the stabilizing surface described below are not included. In the following manner, when having a base surface, an adhesive surface and a stabilizing surface, the fold lines and specific size dimensions of the paperboard can still be formed by stamping and pressing the paperboard.

In some embodiments, to make the frame more stable, the frame further includes a base surface 305, where the base surface is connected to the second support surface 302 by a fold line 308, and the base surface 305 may be connected to the first support surface. When in the collapsed condition, both the first side 303 and the base side are folded inwardly, thereby being in the collapsed condition (fig. 3A). The base surface is connected with the supporting surface through a folding line. The base surface may also be in the form of a curved surface when in the open position, with the first surface 303 being curved, and the highest point 304 of the curved surface of the base surface and the centre of the aperture 311 of the first surface 303 being substantially in the same straight line, although it is also possible that they are not. For example, as shown in FIG. 3B, when the tube body is inserted into the hole 311, the bottom of the tube is pulled by the highest point of the base surface. In addition, when the base surface is curved, the two support surfaces or feet 314, 315 contacting the operating surface are more stable due to the tension between the base surface and the support surfaces. This arch-like bridge-like principle allows the arch-like bridge to withstand heavier forces. The base surface resembles an arched bridge, while the entire gravity is dispersed over the two feet. When made of paperboard which is not very thick, the weight of the tube can still be borne.

Generally, when the folded and contracted stent is in an unfolded state, the first side 303 and the base side 305 may not be standard curved surfaces due to the presence of folds, but may also be in the form of "V", for example, as shown in fig. 3E and 3F, the first side 303 and the base side 305 are still in a folded state due to the presence of fold lines, and are merely a problem of the size of angles when in an unfolded state. Of course, when the pipe body is inserted, the first surface may also be in a linear state, or the included angle formed is increased or almost a plane. In the same way, the base surface has compression on the bottom of the pipe body or force given by an operator inserting the pipe body, so that the included angle of the base surface becomes larger or almost takes the form of a straight surface.

In some embodiments, to enable the base surface 305 to be coupled to the first support surface, an adhesive surface 306 is provided on the base surface, and when manufactured, the adhesive surface is directly adhered to the inner surface of the first support surface 301, thereby enabling the base surface to be coupled to the first support surface, and the base surface 305 and the adhesive surface 306 are coupled by a fold line or fold line 313.

In another embodiment, as shown in fig. 16-17, for example, the first side 403 is provided with a tube insertion hole 411, the first side 403 is provided with a crease line 410, and the first side is connected to the first support surface 401 and the second support surface 402, and the connection between the two sides is through crease lines 409 and 412. Also attached to the second support surface 402 is a base surface 414, and an adhesive surface 406 attached to the base surface, each of which is attached by a crease or fold line 408,413. When assembled into a product, folding is performed along fold lines to form the final product as shown in fig. 17 and fig. 19 and 20. The package forms are folded only due to the bonding of the bonding layers, so that when the operation is performed, the folded and contracted mode is unfolded to form the bracket. For ease of folding, a fold line 407 is also provided in the base surface, typically at a location that is generally the full or substantial bisector of the base, and the fold line 410 of the first surface 403 may be coincident, or may be the bisector of the first surface. After folding, as shown in fig. 20, the first side 403 is folded inwardly by the fold line, the base side 414 is folded inwardly by the fold line, and the two support sides are folded by the fold lines 410 and 4071, thus forming a collapsed form. When it is desired to open, the support surfaces 401 and 402 are opened by hand, allowing the first sheet 403 and the base surface 414 to spread apart, forming an isosceles trapezoid-like shape, thereby allowing the stand to stand. Of course, after the frame body is used, the frame body can be contracted and folded again.

Figure 20 shows the folded collapsed position in which the fold lines are at a minimum angle or the sides of the fold lines are nearly all close together or at a minimum distance. When in the folded and contracted state for a long period of time, when it is desired to perform the opening in the natural state, the two masks separated by the fold have a natural stretching force, for example, the two faces of the first face separated by the fold 410, and the support face and the first face to which the fold lines 409 and 412 are connected have a natural stretching ability. The same reason is that the two sides of the base surface separated by the crease line also have the ability to unfold, as does the crease formed by crease line 408,413, which also includes the connection of the base surface and the support surface, so that when unfolded naturally, a unfolded stand is formed as seen at 20. As previously mentioned, the first and base surfaces are not substantially planar, but are formed with an included angle, as described in fig. 3E and 3F, for example. Of course, it is also possible to form a planar structure as shown in fig. 17, i.e. both the first face and the base face are planar.

If the condition shown in fig. 17 is to be formed, the operator may manually arrange the support surface or the first surface and the base surface so as to be in a planar condition. The length of the seating surface at this time is typically the distance between the edges of the two support surfaces when opened, and the seating surface at this time is located at the distance between the edges of the support surfaces (which can be considered as the fold line 408 of the seating surface and the second support surface and the edge 413 of the first support surface). When the surfaces are of a sheet construction having a relative thickness, for example 1 mm, 2 mm, the base surface serves to fix the distance between the edges of the first and second support surfaces so that the stand is not prone to falling or tipping over and is thus stable when the test tube is inserted into the aperture 411. The purpose of the base is to keep the distance between the supporting surfaces and increase the contact area with the operating surface, so that the frame body is more stable. In the manufacturing mode, the packaging machine can be formed by arranging a piece of paper sheet through different folding lines, and can be packaged in a paper sheet mode or a folding mode. It will be appreciated that the natural state may be the state shown in fig. 19, if no additional finishing is performed. Both the above states, from folded collapsed to natural unfolded and manually finished by the operator, can be used to insert the tube body supporting test tube, to perform sample handling or some other operation.

As shown in fig. 1,5-9, in some embodiments, in addition to the body frame including a first face and a support face, the test tube rack includes a stabilizing face 300 disposed between the first support face 101 and the second support face 102 and between the first face 103 and the base face 200. Of course, it is contemplated that it is possible that no seating surface is provided, and that only a stabilizing surface is provided between the two support surfaces, and that this stabilizing surface 300 may be provided at any location on the two support surfaces, in some aspects, in the middle or near the first surface 103, or near the support surface from the operating surface. The purpose of the stabilizing surface is to enhance the stability of the bracket and also increase the bearing capacity between the brackets. In a preferred form, the stabilizing surface 300 is joined to the first adhesive surface 106 by the fold line 116. It will be appreciated that in a preferred manner, fold lines 117 may also be provided on the stabilizing surface, although fold lines 117 may be provided at the location of scoring the stabilizing surface 300. When folded, the stabilizing surface is folded and contracted by fold line 117, as shown in fig. 9, and when unfolded, expands to form a frame, which may be in a naturally expanded or manually expanded state, such as the one shown in fig. 8. In some ways, a hole 119 may also be provided in the stabilizing surface, the hole 119 and the hole 120 in the first surface 103 together receiving the tube. So that the tube body is fixed in position on the test tube rack without shaking, and after all, the upper and lower holes 119 and 120 are limited.

Thus, upon collapse, either the stabilizing surface 200, the base surface 300, or the first surface 103 may all be folded in the same direction, e.g., all up, all down, or both the first surface 103 and the base surface 200 may be folded inwardly (in the embodiment with a base), while the stabilizing surface may be folded up or down. In short, the folding and contracting can be performed, and the direction of folding of each surface is not limited.

For example, in the folding orientation shown in fig. 6, the first side is folded downwardly and the stabilizing side is folded downwardly along fold line 117 and also folded upwardly along fold line 114. This folding action brings the support sides into inward closing contraction which is accomplished by virtue of the fold lines connecting the sides, which acts like a hinge. The arrows of fig. 7 can be regarded as the direction in which the faces shrink inwards by the folds, so that after folding, a contracted state is created (fig. 9)

In another preferred form, the second bonding surface 107, which is coupled to the stabilizing surface 300, is bonded to the inner surface 201 of the first support surface by the second bonding surface. The stabilizing surface 300 and the second adhesive surface 107 are joined together by fold line 118 (shown in fig. 2 as a complete frame structure). The structure of the whole test tube rack is formed by bonding the two bonding surfaces and connecting the two bonding surfaces by the folding lines connected with the surfaces, and the structure can be folded and contracted, can be unfolded to form a rack body structure, is placed on an operation surface for inserting a test tube or a container, and is used for sampling operation and processing samples by utilizing solution in the test tube.

The manufacturing process is easy to manufacture, and the manufacturing structure of the complete frame structure shown in fig. 2 is described in detail through the complete paperboard. Firstly, a paperboard with a certain thickness, such as a paperboard with a thickness of 1 or 2 mm, is selected, and is formed into a shape as shown in fig. 1 by stamping, and is divided into the following functional areas in the paperboard shape. The support surface is divided into a first support surface 102 and a second support surface 101, which are respectively connected to the first surface 103, and the first surface is provided with a hole 120 for inserting the tube container. The first support surface 102 is here a single surface, while also connected to the second support surface is a base surface 200, a fold line or crease line 114 being provided in the middle of the base surface 200, which crease line fully divides the base into two parts 104 and 105, the two parts 104 and 105 being divided by the crease line. In the same way, the first face 103 is also provided with a fold line 110 and is divided into two parts 103 and 400, the two parts 103 and 400 being connected together by the fold line 110. Attached to the base surface is a first bonding surface 106 that bonds to the first support surface inner surface 202. Then connected to the first adhesive surface 106 is a stabilizing surface 300, which is likewise provided with a fold line 117 dividing the stabilizing surface into two parts 109 and 108, the two stabilizing surfaces 109 and 108 being connected together by means of the fold line 117. A hole 119 is also provided in the stabilizing surface, and the hole 119 in the stabilizing surface 300 and the hole 120 in the first surface are used to secure the pipe body. And a second bonding surface 107 connected to the stabilizing surface, the bonding surface 107 being bonded to the inner surface 201 of the second support surface 101. The first surface, the supporting surface, the base surface, the bonding surface and the division between the stabilizing surfaces are divided through crease lines, when the frame body is manufactured, the same-line crease lines are folded, so that the frame body structure shown in fig. 2 is formed, and when the frame body structure is contracted, the contracted state shown in fig. 9 is formed. The first support surface and the second support surface are trapezoidal, the first surface 103 is rectangular, the long sides of the rectangle are defined by fold lines 111 and 112, and the sides 203 of the first support surface 102 and the sides 113 of the second support surface 101 are longer than the fold lines 111 and 112, so that the tube stand can stand on the operation surface when the tube stand is unfolded. Of course, not all the faces need be rectangular or trapezoidal, and any other shape can be used as long as it can support all the faces and has a face into which the hole can be inserted. For example, the support surface may be rectangular, the first surface may be square, and the shape of the stabilizing surface or the base surface is not particularly limited, and may be any previous combination of any shape, such as rectangular, square, triangular, trapezoidal, etc. The length of the support surface can be designed arbitrarily, and the length of the insertion tube body can be designed arbitrarily according to the requirement, for example, 3-20 cm. In some embodiments, the stabilizing surface 300 is positioned adjacent to the base surface 200, thereby increasing the weight of the base surface and the center of gravity of the base surface. Generally, it may be positioned close to the base surface and at one third of the height of the support surface, counting from the base surface facing upwards.

The process of forming the frame using the folding as in fig. 1 is described below. First, the two support surfaces and the first surface are formed into a skeletal structure by folding the support surfaces 101 and 102 and the crease lines 112 and 111 with the first surface 103), as shown in fig. 4A, then the base surface 200 is folded down by the crease line 113 to form the base surface 105, then the base surface is substantially parallel to the first surface 103, and then the first adhesive surface 106 and the inner surface 202 of the first support surface 102 are brought into contact and bonded together by folding the crease lines 115 and 116. The stabilizing surface 300 is then folded downwardly by crease line 116 such that the stabilizing surface is between the first side 103 and the base side 200. And then folded downwardly by fold line 118 to bond the second bonding surface 107 to the inner surface 201 of the second support surface 101. This forms the frame structure shown in fig. 2. Only the general simple manufacturing method and folding method are described here, but of course any other manufacturing method conceivable is within the scope of the extensions or improvements of the gist of the present invention. The direction of folding is not the only direction of this embodiment. The folding mode can be formed by manual folding or automatic machine, and the bonding of the bonding layer can be the self-adhesive coated paperboard, the bonding formed by hot working or the laser welding mode. Preferably, a layer of glue is coated on the surfaces of the bonding surface 106 and the second bonding surface 107, and the first bonding surface 106 and the second bonding surface 107 are bonded with the inner surface of the supporting surface through hot compress or mechanical pressure during manufacturing.

It will be appreciated that the frame structure shown in fig. 2 is merely an example of an implementation of the present invention, and that the base surface, the bonding surface and the stabilizing surface may be absent, and that only the two support surfaces and the first surface and the holes therein may be left to form a simple tube frame structure, and may also be collapsed and expanded, as previously described. Of course, it is an object to increase the support capacity and stability of the frame body to have a base surface or an adhesive surface, or a stabilizing surface, etc.

In other ways, the test tube rack in two states of folding and shrinking and unfolding can be realized by only two supporting surfaces without the first surface. For example, as shown in fig. 21, two supports 801.802 are folded, and insertion holes 803 are provided on both sides of the crease line, and if a relatively thick or hard cardboard is used, the test tube can stand on the operation surface, for example, the test tube shown in fig. 12A is in a posture in which it can be inserted into the hole and stand. A semicircular notch is formed in each of the first support surface and the second support surface where they are folded (the position of the broken line in fig. 21A), so that the combination is a hole into which a test tube can be inserted. In this embodiment, no first face is present, but rather the holes for inserting the test tubes are formed by the combination of the indentations made in the support face. Of course, in this manner, the base surface 804 may be provided to connect two support surfaces (fig. 21B), the stabilizing surface 805 may be provided to connect two support surfaces (21D), or the base surface and the stabilizing surface may be provided as in the manner of fig. 21C. Of course, according to the previous manufacturing method, reference may be made to fig. 1 or fig. 16, so that the method described is made without the first side.

The expressions "crease line", "fold line" and "fold line" here mean interchangeably and do not mean that there is a drawn line here, but that there is a position where two faces can be folded or doubled or folded or the like relative to each other, or that there is a hinge by which the two faces are folded or the relative position is changed. Any sheet, rigid material such as thin plastic sheet, metal sheet, cardboard, etc. may be used to make such a frame structure. The preferred solution is cardboard. The thickness of the cardboard is typically 1 or 2 mm, or more is also possible. In addition, the cardboard may be covered with a film. Preferably, the material is cardboard having a thickness and being rigid. As for the crease lines, the folding lines and the folding lines can be in the form of machine punching or in the form of punching holes at intervals continuously at the positions of the folding lines. The known method can be easily implemented wherever folding is desired. The folding can also be that the test tube rack can be folded along the crease from a piece of paperboard when being folded, and can also be in the form of a three-dimensional pipe rack which is provided with the crease. When the three-dimensional tube rack is in the form of a three-dimensional tube rack, the test tube rack can be folded, contracted and unfolded. Stretching also includes natural stretching and stretching by hand or natural stretching in combination with hand stretching. The term "natural stretching" refers to a process in which after a crease is formed, an internal force is present to naturally stretch the tube, and the term "manual" refers to a process in which the tube is stretched into a three-dimensional form by folding the tube by external force. The contracted form is a form in which it is compressed by an external force, for example, fig. 2A, 3A, 9, 21, etc.

The above-described frame structure of only a single hole, when a plurality of holes are required, it is desirable to insert a plurality of different pipes at a time, can also be realized by the present invention. Such a rack can also be folded in two states, collapsed and expanded.

In some embodiments, the width of the paperboard may be made in a multiple of the width of the paperboard, such as a lateral expansion (in effect a longitudinal expansion), such as a 1-fold expansion, 2-fold expansion, 3-fold expansion, 4-fold expansion, 5-fold expansion, or 10-fold expansion, such as a 2-10-fold expansion (longitudinal expansion) of the side 203 of the first support surface, the first surface 103 may also be scaled up such that the first surface 103 extends longitudinally, such that 2-10, or more, apertures (arrows shown in fig. 1; arrow directions shown in fig. 10) may be provided in the longitudinal direction of the first surface. Accordingly, if there is no base or stabilizing surface, it is also elongated in the longitudinal direction, in such a way that multiple tubular structures can be placed. For example, fig. 2B, fig. 2C, fig. 3B, fig. 3E, etc., may extend in the longitudinal direction, and a plurality of holes may be provided, so that insertion or insertion of a plurality of tubes may be also achieved.

In another embodiment, as shown in fig. 14-16, the two single bodies can be expanded from the transverse direction, for example, as shown in fig. 15, but the two single bodies are formed by one single paper plate, and are folded along a set folding line according to the direction shown by an arrow in fig. 15, so that two foldable test tube racks capable of being inserted into a tube body can be formed at one time from serial numbers 1-14, each serial number represents one surface, and the surfaces represented by the next serial number and the last serial number are formed by folding. The two faces can also be folded, contracted and unfolded as described above. Meanwhile, the two monomers are guaranteed to be stably connected, a connecting surface is arranged between the two substitutes, one end of the connecting surface is connected with the first monomer, the other end of the connecting surface is connected with the other monomer, and the connecting surface 602 is in adhesive connection with the supporting surface. The connection face is also provided with a fold line or crease, dividing the connection face into two faces 606 and 603. The connection surface and the two monomers can be connected by: the connection surface 602 has two adhesive surfaces 604 and 605, which are respectively adhered to the support surfaces of the two units 60 and 601. This also ensures that after folding of the two monomers, each remains a suitable distance when free to unfold. It is conceivable that another 2 monomers can be joined by a junction surface, thus increasing by a factor of 2. This is also an extension. In other ways, a foldable test tube rack like that shown in fig. 18 or fig. 3 can be expanded and added in the manner described above. The foldable tube rack shown in fig. 2 may also be laterally enlarged, for example, by the manner of fig. 2E.

In some embodiments, there is another lateral expansion that expands the lateral length of the first face. For example, as shown in fig. 17, the lateral width of the first surface is enlarged, so that the area of the first surface is enlarged, and the size of the supporting surface is not changed, and if the supporting surface is provided with the base surface, the base surface is also laterally elongated, and if the supporting surface is provided with the fixing surface, the fixing surface is also laterally elongated (the arrow direction shown in fig. 17 is laterally enlarged). Thus, one or more rows of holes for inserting test tubes can be formed in the first face. In some modes, in order to enable the test tube rack with multiple rows of holes to be folded, one or more folding lines or folds are arranged on the first surface, the first surface can be folded and contracted along the folding lines or folds, if the test tube rack comprises a base surface or a stable surface, one or more folding lines or folds are arranged on the first surface in the same mode or at the same position, and therefore the folding of the first surface also enables the folding of the base surface or the stable surface in the transverse direction. Thereby allowing the test tube rack of the plurality of insertion holes to collapse.

In practice, if the area of the first surface is extended from both the longitudinal direction and the transverse direction, a plurality of holes may be provided in the first surface, and a plurality of holes may be inserted into the multi-feed tube, thereby performing different virus tests.

Detection device

The detection device is a device for detecting whether or not the sample contains an analyte. The detection device may here simply comprise a detection chamber and a test element arranged therein, which may thus be referred to as a detection device. For example, the detection device comprises a detection chamber comprising a test element or a test element comprising a carrier. In some embodiments, the detection chamber has a liquid inlet through which the liquid sample flows into the detection chamber into contact with the test element. In some embodiments, the sample application region of the test element is adjacent to the fluid inlet such that fluid flowing from the inlet into the detection chamber is contacted by the sample application region such that the fluid sample flows along the application region to the detection region for assaying and detecting the analyte.

In some embodiments, the test device resembles a test plate, although a separate test element may be used as an embodiment of the invention. Fig. 13 shows a detection device in an embodiment, which includes a window for applying a liquid and a window for reading test results. An example of an implementation is used to illustrate how this may be done.

For example, as shown in fig. 18, in combination with fig. 13, the test device, for example, the test device shown in fig. 14, is removed from the package with the test device. The foldable stand is then also removed, which is previously folded for packaging, possibly in the form of a fold shrink as in fig. 21, or in the form of a half-compression half-shrink as in fig. 20. The test tube is taken out from the packaging box, or a sampling cotton swab or other samplers matched with the test tube are adopted. The test tube rack is placed on an operation surface, a tabletop which can be placed if the test tube rack is at home, a test stand if the test tube rack is at a laboratory, and any plane if the test tube rack is at the outdoors. Let the test-tube rack take a standing posture. The test tube 70 is inserted into the well 411 and the sample is processed by diluting, eluting, or lysing the analyte, e.g., by lysing the virus particles, etc., with a solution containing reagents. Since the tube is sealed, the sealing sheet 701 may be torn first (fig. 12B), then the tube 70 may be inserted into the hole 411, and then sampling may be performed, for example, for detecting influenza virus, and sampling of the nasal cavity or oral cavity may be performed with a cotton swab, and then the cotton swab head may be inserted into the treatment solution of the tube to wait for treatment. After the treatment is completed, the cotton swab head is broken off and left in the test tube, or the cotton swab is taken away. A dripper 702 (fig. 12C) is then placed on the test tube, with one end 34, 30 of the dripper inserted into the nozzle and the other end 31 exposed, by means of a protruding flange 33 defining the depth of the dripper insertion gate. Then, the test tube with the dripper is taken out from the test tube rack, and liquid drops are dripped into a window for applying liquid of the detection device through the dripper, so that the whole detection is completed. After the detection is finished, the paper test tube rack is contracted again for storage, or is directly discarded, or is packaged by a special bag, and is processed by a special environmental protection organization. The folding test tube rack is generally made of paper materials, is easy to degrade and process, and can be folded on the package, so that the packaging space is reduced, and the manufacturing cost is lower.

All patents and publications mentioned in the specification are indicative of those of ordinary skill in the art to which this invention pertains and which may be applied. All patents and publications cited herein are hereby incorporated by reference to the same extent as if each individual publication were specifically and individually indicated to be incorporated by reference. The invention described herein may be practiced in the absence of any element or elements, limitation or limitations, not specifically disclosed herein. For example, the terms "comprising," "consisting essentially of … …," and "consisting of … …" in each instance herein may be replaced with the remaining 2 terms of either. The term "a" or "an" as used herein means "one" only, and does not exclude that only one is included, and may also mean that more than 2 are included. The terms and expressions which have been employed herein are used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described, but it is recognized that various modifications are possible within the scope of the invention and of the claims. It is to be understood that the embodiments described herein are illustrative of the preferred embodiments and features and that modifications and variations may be made by those skilled in the art in light of the teachings of this invention and are to be considered as falling within the scope of the invention and the appended claims.

Claims (23)

1. A test tube rack comprising a first support surface and a second support surface, said rack further comprising a first hole for inserting a test tube, wherein said first and second supports are foldable.

2. The rack of claim 1, wherein the rack further comprises a first face, the first face connecting the first support face and the second support face, the first face comprising the first hole for inserting test tubes, the connecting comprising connecting by a fold line or crease; or the first surface is respectively connected with the first supporting surface and the second supporting surface through fold lines and folds, and the first surface comprises the holes.

3. The test tube rack of claim 2, wherein one end of the first support surface is connected to one end of the first surface by a fold line or crease, and one end of the second support surface is connected to the other end of the first surface by a fold line or crease.

4. A test tube rack according to claim 1 or 3, wherein the test tube rack further comprises a base surface, one end of the base surface is connected with the other end of the first supporting surface through a fold line or a crease, and the other end of the base surface is connected with the other end of the second supporting surface through a fold line or a crease.

5. The rack of any one of claims 1-4, wherein the first support surface and the second support surface are trapezoidal, square or rectangular in shape; alternatively, the first surface is trapezoidal, square or rectangular.

6. The rack of any one of claims 2-5, wherein the first support surface and the second support surface are trapezoidal in shape, wherein the area of the first surface is smaller than the area of the base surface; alternatively, the width of the first face is the same as the width of the base face; alternatively, the length of the first face is less than the length of the base face.

7. The rack of any of claims 4-6, wherein the width of the first seating surface is the same or substantially the same as the width of the first surface.

8. The rack of any one of claims 1-7, further comprising a stabilizing surface, wherein one end of the stabilizing surface is connected to the first support surface and the other end is connected to the second support surface.

9. The test tube rack of claim 2, further comprising a stabilizing surface, wherein one end of the stabilizing surface is connected to the first support surface, and the other end is connected to the second support surface, and wherein the stabilizing surface is located below the first surface.

10. The rack of any of claims 8-9, wherein the stabilizing surface comprises a second hole for inserting a test tube, the first and second holes being arranged in a vertical orientation.

11. A test tube rack according to any one of claims 8-10, wherein the two ends of the stabilizing surface are further connected with a first adhesive surface and a second adhesive surface, the first adhesive surface being adhered to the first support surface, and the second adhesive surface being adhered to the second support surface.

12. A rack according to any of claims 8-11, wherein the stabilizing surface is located between the first surface and the base surface.

13. The test tube rack of claims 1-11, wherein two of the first face, the first support face, the second support face, the stabilizing face, the first adhesive face or the second adhesive face of the test tube rack are connected by a fold line or a crease, or two of the first face, the first support face, the second support face, the stabilizing face, the first adhesive face or the second adhesive face of the test tube rack are foldable by a connected fold line or crease.

14. The rack of claim 12, wherein the first face, the first support face, the second support face, the stabilizing face, the first adhesive face, or the second adhesive face of the rack is formed by folding a planar sheet of paper.

15. A rack as claimed in any one of claims 1 to 13, wherein the rack is foldable between collapsed and open positions.

16. The rack of claim 4, wherein the base and first sides also include fold lines or creases through which both the base and first sides can be folded.

17. The rack of claim 2, wherein the first face extends longitudinally or transversely to provide a plurality of first holes in the first face for insertion of test tubes.

18. A test tube rack comprising:

a first face having a first end and a second end, said first face having one or more apertures for insertion of test tubes;

the first support surface and the second support surface are respectively connected with the first end and the second end of the first surface at one end respectively, and the connection is realized through crease lines or fold lines;

the base surface is connected with the first supporting surface and the second supporting surface; wherein the base surface is located below the first surface.

19. The rack of claim 16, wherein the base surface is connected to the first support surface and the second support surface by folds or crease lines.

20. The test tube rack of claim 17, wherein the base surface further comprises an adhesive surface for adhering to the first support surface or the second support surface, and the adhesive surface is connected to the base surface by a fold line or a crease.

21. A test tube rack according to claim 16, wherein the base and first faces each comprise a respective fold line or crease by which the first and base faces are foldable.

22. A test tube rack comprising:

a planar sheet of paper, said sheet of paper being divided into a first side by folds or crease lines; the test tube fixing device comprises a base surface, a first supporting surface, a second supporting surface, a stabilizing surface and a first adhesive surface and a second adhesive surface, wherein the first surface comprises a first end and a second end, and one or more holes for inserting test tubes are formed in the first surface; one end of each of the first supporting surface and the second supporting surface is connected with the first end and the second end of the first surface respectively;

the base surface is connected with the first adhesive surface, the first adhesive surface is connected with the stable surface, and the stable surface is connected with the second adhesive surface; wherein the connection of the surfaces is through the crease or fold line.

23. A test tube rack according to claim 20, wherein the base and first faces each comprise a respective fold line or crease by which the first and base faces are foldable.

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