CN217628424U - Novel cell culture device for continuously collecting cell exosomes - Google Patents
Novel cell culture device for continuously collecting cell exosomes Download PDFInfo
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- CN217628424U CN217628424U CN202221191056.6U CN202221191056U CN217628424U CN 217628424 U CN217628424 U CN 217628424U CN 202221191056 U CN202221191056 U CN 202221191056U CN 217628424 U CN217628424 U CN 217628424U
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- bucket
- inner barrel
- interior bucket
- cell culture
- filter bag
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- 238000004113 cell culture Methods 0.000 title claims abstract description 21
- 210000001808 exosome Anatomy 0.000 title claims abstract description 11
- 230000028327 secretion Effects 0.000 claims abstract description 8
- 238000009434 installation Methods 0.000 claims abstract description 6
- 238000007789 sealing Methods 0.000 claims abstract description 5
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 239000007788 liquid Substances 0.000 description 18
- 238000000855 fermentation Methods 0.000 description 13
- 230000004151 fermentation Effects 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 230000002349 favourable effect Effects 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 6
- 238000000034 method Methods 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 235000014101 wine Nutrition 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000019990 fruit wine Nutrition 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000011514 vinification Methods 0.000 description 1
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Abstract
The utility model discloses a novel cell culture device of cell exosome is collected to continuous type, it includes interior bucket and outer bucket, the bottom of outer bucket is equipped with the slide, the slide be located outer bucket and with outer bucket sliding connection, demountable installation has waterproof motor on the slide, interior bucket is located outer bucket, the output of waterproof motor is connected with the bottom of interior bucket, interior bucket rotates with outer bucket under waterproof motor's drive and is connected, the open end lid of interior bucket has closed the lid, lid and interior bucket sealing connection, interior intraductal being equipped with cultivates the filter bag, it can dismantle with interior bucket and be connected to cultivate the filter bag, be equipped with a plurality of apopore on the lateral wall of interior bucket, the bottom of outer bucket is equipped with drainage channel, drainage channel is linked together through the inside of apopore with interior bucket, demountable installation has the ooff valve on the drainage channel. The utility model has the advantages that: the culture solution is favorably shaken and uniformly mixed, the extracellular secretion can be continuously collected, the time is saved, and the inside of the culture tank is not required to be cleaned.
Description
Technical Field
The utility model relates to a culture tank correlation technique field especially indicates a novel cell culture device of cell exosome is collected to continuous type.
Background
A fermentation tank for culturing cells continuously collects exosomes secreted by the cells, and the traditional collection method needs two devices, namely a fermentation tank and a centrifuge.
Cell culture apparatus: the materials are stirred by mechanical stirring to generate axial and radial flow, so that the materials in the tank are well mixed, and solid matters in the liquid keep a suspension state, thereby being beneficial to full contact of the solid matters and the nutrient substances. On the other hand, the gas bubbles can be broken, the gas-liquid contact area is increased, the mass transfer rate between gas and liquid is improved, the oxygen transfer effect is enhanced, and the foams are eliminated. While sterile air is introduced to maintain oxygen requirements.
The continuous collection extracellular secretion device comprises: a mechanism for separating components of liquid from solid particles or a mixture of liquid and liquid by centrifugal force. The centrifugation is to accelerate the sedimentation velocity of particles in liquid by using the strong centrifugal force generated by the high-speed rotation of a centrifuge rotor, and separate substances with different sedimentation coefficients and buoyancy densities in a sample.
The prior art cultures mammalian cells, collects cells or supernatant liquid by column or membrane filtration, and needs two devices of a fermentation tank and a centrifuge, so that the time is long, the space is occupied, the cost is high, and the large-scale production cannot be realized.
In order to solve the technical problems, the Chinese patent publication No. CN201172660 discloses a centrifugal fruit wine fermentation tank, the publication date of which is 2008 12.31.A centrifugal fermentation sieve cylinder is arranged in the tank body, a central shaft is arranged above and below the sieve cylinder and is connected with a motor and a tank body central shaft bearing, and during use, wine making raw materials, namely fruits and yeast are put into the fermentation sieve cylinder to be fermented. After the fermentation is mature, the motor is started to drive the centrifugal fermentation sieve drum to rotate, and the finished wine is discharged to the wine outlet through sieve holes of the sieve drum and flows out under the action of centrifugal force. The fermentation and centrifugation are integrated, so that the space is not occupied and the time is saved.
However, the above patent has disadvantages that the inside of the fermentation tank (i.e., the culture tank) is usually cleaned after the fermentation is completed, which is inconvenient and time-saving.
SUMMERY OF THE UTILITY MODEL
The utility model relates to an overcome among the prior art fermentation cylinder fermentation and accomplish the back, need carry out abluent not enough to the culture tank inside usually, provide one kind and need not to carry out abluent continuous type to the culture tank inside and collect the novel cell culture device of cell exosome.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
the utility model provides a novel cell culture device of cell exosome is collected to continuous type, it includes interior bucket and outer bucket, the bottom of outer bucket is equipped with the slide, the slide be located outer bucket and with outer bucket sliding connection, demountable installation has waterproof motor on the slide, interior bucket is located outer bucket, the output of waterproof motor is connected with the bottom of interior bucket, interior bucket rotates with outer bucket under waterproof motor's drive and is connected, the open end lid of interior bucket has closed the lid, lid and interior bucket sealing connection, be equipped with in the interior bucket and cultivate the filter bag, cultivate the filter bag and can dismantle with interior bucket and be connected, be equipped with a plurality of apopore on the lateral wall of interior bucket, the bottom of outer bucket is equipped with drainage channel, drainage channel is linked together through the inside of apopore with interior bucket, demountable installation has the ooff valve on the drainage channel.
The bottom of the outer barrel is provided with a sliding seat, the sliding seat is positioned in the outer barrel and is in sliding connection with the outer barrel, a waterproof motor is detachably mounted on the sliding seat, the inner barrel is positioned in the outer barrel, the output end of the waterproof motor is connected with the bottom of the inner barrel, the inner barrel is rotationally connected with the outer barrel under the driving of the waterproof motor, the open end of the inner barrel is covered with a cover body, the cover body is hermetically connected with the inner barrel, a culture filter bag is arranged in the inner barrel and is detachably connected with the inner barrel, the side wall of the inner barrel is provided with a plurality of water outlet holes, the bottom of the outer barrel is provided with a drainage channel, the drainage channel is communicated with the inside of the inner barrel through the water outlet holes, and a switch valve is detachably mounted on the drainage channel. The liquid to be cultured is directly cultured in the culture filter bag, the liquid in the culture filter bag does not obviously seep in a natural state, and the sliding seat is positioned in the outer barrel and is in sliding connection with the outer barrel, so that the sliding seat is favorable for driving the culture solution in the inner barrel to uniformly mix by balanced left-right shaking; when the culture is finished, the switch valve is opened, the waterproof motor drives the inner barrel to rotate at high speed to generate centrifugal force, the culture solution is dried, cells are adsorbed on the wall of the culture filter bag, and the liquid in the culture filter bag seeps out of the culture filter bag under the action of the centrifugal force and is discharged through the water outlet hole and the water drainage channel in sequence; when the cell culture is complete, only the culture filter bag needs to be taken out, and the other culture filter bag needs to be replaced, so that the time is saved, and the aim of cleaning the inside of the culture tank is fulfilled.
Preferably, a flange is fixed at the opening end of the inner barrel, the flange is positioned outside the inner barrel, the top side of the flange is hermetically connected with the cover body, a first annular groove matched with the opening end of the outer barrel is formed in the bottom side of the flange, and the opening end of the outer barrel is positioned in the first annular groove. The annular groove is favorable for limiting the inner barrel when the inner barrel slides under the driving of the sliding seat one by one, and the inner barrel is favorable for rotating at a high speed relative to the outer barrel under the driving of the waterproof motor.
Preferably, the width of the first annular groove is larger than the thickness of the opening end of the outer barrel. The design is favorable for the inner barrel to slide relative to the outer barrel, thereby being favorable for the balanced left-right shaking and uniform mixing of the culture solution.
Preferably, the bottom of the outer barrel is provided with an air cylinder, the air cylinder is detachably connected with the outer side wall of the outer barrel, the output end of the air cylinder penetrates through the side wall of the outer barrel and is connected with a sliding seat in the outer barrel, the sliding seat is in sliding connection with the outer barrel under the driving of the air cylinder, the part of the output end of the air cylinder, which penetrates through the side wall of the outer barrel, is in sealing connection with the outer barrel, and the influence on the normal use of the air cylinder due to the seepage of liquid in the inner part is favorably prevented, so that the air cylinder is arranged outside the outer barrel and is favorable for preventing the air cylinder from contacting with the liquid, and the service life of the air cylinder is favorably prolonged; the slide drives the inner barrel to slide relative to the outer barrel under the driving of the cylinder, and the balanced left-right shaking and uniform mixing of the culture solution is favorably realized.
Preferably, a rubber band is fixed at the opening end of the culture filter bag, a limit groove matched with the rubber band is arranged at the opening end of the inner barrel, the limit groove is positioned outside the inner barrel and on the top side of the flanging, and the limit groove is positioned in the cover body. The cultivation filter bag is matched with the limiting groove through the rubber band, so that the limitation of the cultivation filter bag in the working process is improved, and meanwhile, the cultivation filter bag is convenient to mount and dismount.
Preferably, the open end of the inner barrel is provided with an arc-shaped edge, and the inner side wall of the inner barrel is in uniform transition with the outer side wall of the inner barrel through the arc-shaped edge. The arc edge plays a good role in protecting the culture filter bag and prevents the culture filter bag from being damaged to influence cell culture.
Preferably, the bottom of the inner barrel is provided with a second annular groove, a ball bearing is arranged in the second annular groove, a support ring matched with the second annular groove is fixed on the sliding seat, the support ring is matched with the second annular groove and is rotationally connected with the inner barrel through the ball bearing, the waterproof motor is positioned in the support ring, and the output end of the waterproof motor is connected with the center of the bottom of the inner barrel. The design is favorable for improving the balance of the inner barrel, and the inner barrel is convenient to rotate at high speed under the driving of the waterproof motor.
Preferably, the aperture of the culture filter bag is 10-100 μm. The design makes the liquid in the culture filter bag have no obvious seepage phenomenon under no external force, and under the effect of certain centrifugal force, the inside liquid can seep through the culture filter bag, spin-dries the culture solution for the cell is adsorbed on the culture filter bag wall.
The utility model has the advantages that: the culture solution is shaken and uniformly mixed; the time is saved, and the interior of the culture tank does not need to be cleaned; the service life of the cylinder is prolonged; the limit of the culture filter bag in the working process is improved, and the culture filter bag is convenient to mount and dismount; the arc-shaped edge plays a good role in protecting the culture filter bag and prevents the culture filter bag from being damaged to influence cell culture; the balance of the inner barrel is improved, and the inner barrel can rotate at high speed under the driving of the waterproof motor.
Drawings
Fig. 1 is a schematic structural diagram of the present invention;
FIG. 2 is a schematic view of the internal structure of FIG. 1;
FIG. 3 isbase:Sub>A cross-sectional view A-A of FIG. 2;
fig. 4 is an enlarged view of the structure at B in fig. 2.
In the figure: 1. an inner barrel, 2 an outer barrel, 3 a slide seat, 4 a waterproof motor, 5 a cover body, 6 a culture filter bag, 7 a water outlet hole, 8 a drainage channel, 9 a switch valve, 10 a flanging, 11, a first annular groove, 12 cylinders, 13 rubber bands, 14 limiting grooves, 15 arc edges, 16 second annular grooves, 17 ball bearings, 18 support rings.
Detailed Description
The invention is further described with reference to the accompanying drawings and the detailed description.
In the embodiment shown in fig. 1 and 2, a novel cell culture device for continuously collecting cell exosomes comprises an inner barrel 1 and an outer barrel 2, a slide seat 3 is arranged at the bottom of the outer barrel 2, the slide seat 3 is positioned in the outer barrel 2 and is in sliding connection with the outer barrel 2, a waterproof motor 4 is detachably mounted on the slide seat 3, the inner barrel 1 is positioned in the outer barrel 2, the output end of the waterproof motor 4 is connected with the bottom of the inner barrel 1, the inner barrel 1 is rotationally connected with the outer barrel 2 under the driving of the waterproof motor 4, a cover body 5 is covered at the open end of the inner barrel 1, the cover body 5 is in sealing connection with the inner barrel 1, a culture filter bag 6 is arranged in the inner barrel 1, the culture filter bag 6 is detachably connected with the inner barrel 1, a plurality of water outlet holes 7 are arranged on the side wall of the inner barrel 1, a drainage channel 8 is arranged at the bottom of the outer barrel 2, the drainage channel 8 is communicated with the inside of the inner barrel 1 through the water outlet holes 7, and a switch valve 9 is detachably mounted on the drainage channel 8.
As shown in fig. 2, fig. 3 and fig. 4, a flange 10 is fixed at the opening end of the inner barrel 1, the flange 10 is located outside the inner barrel 1, the top side of the flange 10 is hermetically connected with the cover 5, an annular groove 11 matched with the opening end of the outer barrel 2 is arranged at the bottom side of the flange 10, and the opening end of the outer barrel 2 is located in the annular groove 11.
As shown in fig. 3, the width of the annular groove one 11 is greater than the thickness of the open end of the outer tub 2.
As shown in fig. 2, the bottom of the outer tub 2 is provided with a cylinder 12, the cylinder 12 is detachably connected with the outer side wall of the outer tub 2, the output end of the cylinder 12 penetrates through the side wall of the outer tub 2 to be connected with a slide seat 3 in the outer tub 2, the slide seat 3 is slidably connected with the outer tub 2 under the driving of the cylinder 12, and the part of the output end of the cylinder 12 penetrating through the side wall of the outer tub 2 is hermetically connected with the outer tub 2.
As shown in fig. 2 and fig. 4, a rubber band 13 is fixed at the opening end of the culture filter bag 6, a limit groove 14 matched with the rubber band 13 is arranged at the opening end of the inner barrel 1, the limit groove 14 is positioned outside the inner barrel 1 and at the top side of the flanging 10, and the limit groove 14 is positioned in the cover body 5.
As shown in fig. 4, the open end of the inner barrel 1 is provided with an arc-shaped edge 15, and the inner side wall of the inner barrel 1 is uniformly transited to the outer side wall thereof through the arc-shaped edge 15.
As shown in fig. 2, the bottom of the inner barrel 1 is provided with a second annular groove 16, the second annular groove 16 is internally provided with a ball bearing 17, a support ring 18 matched with the second annular groove 16 is fixed on the sliding seat 3, the support ring 18 is matched with the second annular groove 16 and is rotatably connected with the inner barrel 1 through the ball bearing 17, the waterproof motor 4 is positioned in the support ring 18, and the output end of the waterproof motor 4 is connected with the center of the bottom of the inner barrel 1. The aperture of the culture filter bag 6 is 10 to 100 mu m.
Before operation, an operator firstly matches the clean culture filter bag 6 with the limit groove 14 through the rubber band 13 so as to install the culture filter bag in the inner barrel 1; then directly putting the liquid to be cultured into the culture filter bag 6 for culturing, wherein the culture filter bag 6 ensures that the liquid in the culture filter bag has no obvious seepage phenomenon in a natural state; the sliding seat 3 drives the inner barrel 1 to slide relative to the outer barrel 2 under the driving of the cylinder 12, which is beneficial to realizing balanced left-right shaking and uniform mixing of the culture solution; when the culture is finished, the switch valve 9 is opened to drive the inner barrel 1 to rotate at a high speed to generate centrifugal force, the culture solution is dried, cells are adsorbed on the wall of the culture filter bag 6, and the liquid in the culture filter bag 6 seeps out of the culture filter bag 6 under the action of the centrifugal force and is discharged through the water outlet hole 7 and the water drainage channel 8 in sequence; when the cell culture is complete, only the culture filter bag 6 needs to be taken out, and the other culture filter bag 6 needs to be replaced, so that the time is saved, and the inside of the culture tank does not need to be cleaned.
Claims (8)
1. The utility model provides a novel cell culture device of cell exosome is collected to continuous type, characterized by, including interior bucket (1) and outer bucket (2), the bottom of outer bucket (2) is equipped with slide (3), slide (3) be located outer bucket (2) and with outer bucket (2) sliding connection, demountable installation has waterproof motor (4) on slide (3), interior bucket (1) is located outer bucket (2), the output of waterproof motor (4) is connected with the bottom of interior bucket (1), interior bucket (1) rotates with outer bucket (2) under the drive of waterproof motor (4) and is connected, the open end lid of interior bucket (1) has closed lid (5), lid (5) and interior bucket (1) sealing connection, be equipped with in interior bucket (1) and cultivate filter bag (6), cultivate filter bag (6) and interior bucket (1) demountable connection, be equipped with a plurality of apopore (7) on the lateral wall of interior bucket (1), the bottom of outer bucket (2) is equipped with drainage passageway (8), drainage passageway (8) are linked together through apopore (7) and interior bucket (1) demountable installation on the drainage valve (9).
2. The novel cell culture device for continuously collecting the cell exosomes according to claim 1, characterized in that a flanging (10) is fixed at an opening end of the inner barrel (1), the flanging (10) is positioned outside the inner barrel (1), the top side of the flanging (10) is hermetically connected with the cover body (5), an annular groove I (11) matched with the opening end of the outer barrel (2) is arranged at the bottom side of the flanging (10), and the opening end of the outer barrel (2) is positioned in the annular groove I (11).
3. The novel cell culture device for continuously collecting extracellular secretion as claimed in claim 2, wherein the width of the annular groove I (11) is larger than the thickness of the opening end of the outer barrel (2).
4. The novel cell culture device for continuously collecting the extracellular secretion as claimed in claim 1, 2 or 3, wherein a cylinder (12) is disposed at the bottom of the outer tub (2), the cylinder (12) is detachably connected to the outer sidewall of the outer tub (2), the output end of the cylinder (12) penetrates through the sidewall of the outer tub (2) to be connected to a slide seat (3) in the outer tub (2), the slide seat (3) is slidably connected to the outer tub (2) under the driving of the cylinder (12), and the part of the output end of the cylinder (12) penetrating through the sidewall of the outer tub (2) is hermetically connected to the outer tub (2).
5. The novel cell culture device for continuously collecting the extracellular secretion, according to the claim 2 or 3, is characterized in that a rubber band (13) is fixed at the opening end of the culture filter bag (6), a limiting groove (14) matched with the rubber band (13) is arranged at the opening end of the inner barrel (1), the limiting groove (14) is positioned outside the inner barrel (1) and at the top side of the flanging (10), and the limiting groove (14) is positioned in the cover body (5).
6. The novel cell culture device for continuously collecting the cell exosomes according to claim 5, characterized in that an arc-shaped edge (15) is arranged at the opening end of the inner barrel (1), and the inner side wall of the inner barrel (1) is uniformly transited with the outer side wall of the inner barrel through the arc-shaped edge (15).
7. The novel cell culture device for continuously collecting the extracellular secretion, according to the claim 1, the novel cell culture device for continuously collecting the extracellular secretion is characterized in that a second annular groove (16) is formed in the bottom of the inner barrel (1), a ball bearing (17) is arranged in the second annular groove (16), a support ring (18) matched with the second annular groove (16) is fixed on the sliding seat (3), the support ring (18) is matched with the second annular groove (16) and is rotatably connected with the inner barrel (1) through the ball bearing (17), the waterproof motor (4) is located in the support ring (18), and the output end of the waterproof motor (4) is connected with the center of the bottom of the inner barrel (1).
8. The novel cell culture device for continuously collecting extracellular secretion of a human body according to claim 1, 2 or 3, wherein the aperture of the culture filter bag (6) is 10 to 100 μm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221191056.6U CN217628424U (en) | 2022-05-18 | 2022-05-18 | Novel cell culture device for continuously collecting cell exosomes |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202221191056.6U CN217628424U (en) | 2022-05-18 | 2022-05-18 | Novel cell culture device for continuously collecting cell exosomes |
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| CN217628424U true CN217628424U (en) | 2022-10-21 |
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| CN202221191056.6U Active CN217628424U (en) | 2022-05-18 | 2022-05-18 | Novel cell culture device for continuously collecting cell exosomes |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115404153A (en) * | 2022-11-01 | 2022-11-29 | 迈赛凯尔(山东)生命科学有限公司 | Cell culture exosome collection device |
| CN115926956A (en) * | 2023-02-07 | 2023-04-07 | 山东灵犀生物科技有限公司 | Cell culture exosome collection device |
-
2022
- 2022-05-18 CN CN202221191056.6U patent/CN217628424U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115404153A (en) * | 2022-11-01 | 2022-11-29 | 迈赛凯尔(山东)生命科学有限公司 | Cell culture exosome collection device |
| CN115926956A (en) * | 2023-02-07 | 2023-04-07 | 山东灵犀生物科技有限公司 | Cell culture exosome collection device |
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Effective date of registration: 20231126 Address after: 311599 room 208, No. 899, daqishan Road, Tonglu County, Hangzhou City, Zhejiang Province Patentee after: Zhejiang Huayi Health Industry Development Co.,Ltd. Address before: No. 8888, Hunan Road, Pudong New Area, Shanghai, 200135 Patentee before: Yang Guanghua |