CN216458988U

CN216458988U - Magnetic rack for efficiently extracting nucleic acid

Info

Publication number: CN216458988U
Application number: CN202121925070.XU
Authority: CN
Inventors: 周力成; 方利; 张彦林
Original assignee: Changzhou Smart Lifesciences Co ltd
Current assignee: Changzhou Smart Lifesciences Co ltd
Priority date: 2021-08-17
Filing date: 2021-08-17
Publication date: 2022-05-10
Anticipated expiration: 2031-08-17

Abstract

The utility model relates to the technical field of biological experiment equipment, in particular to a magnetic rack for efficiently extracting nucleic acid, which comprises a support, a test tube rack and magnetic block groups, wherein the support comprises a large bottom plate and a middle column, the middle column is provided with a magnetic block mounting cavity, the magnetic block groups are detachably inserted into the magnetic block mounting cavity, clamping strips are arranged at the bottoms of the front side and the rear side of the test tube rack, four sliding grooves are correspondingly arranged at the front side and the rear side of the support, the clamping strips are all inserted into the sliding grooves, the test tube rack is provided with a test tube mounting plate, the test tube mounting plate is provided with at least one test tube sleeve for fixing a test tube, a plurality of test tubes at one side can be conveniently taken down at the same time by arranging the test tube rack and the support with a separation structure, the magnetic force of only one side can be conveniently cut off, meanwhile, test tube racks with different specifications can be used according to test tubes, the side walls of the test tubes abut against the side walls of the middle column, and the magnetic block groups stacked with the magnetic blocks are designed to provide enough magnetic force for the test tubes, and the magnetic force distribution and the magnetic force of the magnetic frame can be adjusted according to the processing requirements, so that the experimental requirements are met.

Description

Magnetic rack for efficiently extracting nucleic acid

Technical Field

The utility model relates to the technical field of biological experiment equipment, in particular to a magnetic rack for efficiently extracting nucleic acid.

Background

In recent years, due to the development of high and new technologies, the progress of scientific technologies and efficient and fast-paced working modes, the field rapid inspection with the advantages of miniaturization of experimental instruments, simplicity in operation and timeliness of report results is more and more favored by people. The point-of-care testing (POCT) is named by the POCT Equipment technical Committee of the China Association for medical Equipment, POCT, and is defined as: the method is a detection mode which is carried out on a sampling site and can quickly obtain a detection result by utilizing a portable analytical instrument and a matched reagent. POCT is mainly standardized in that no fixed detection site is required, reagents and instruments are portable and can be operated in a timely manner without the need for special clinical detection services. Superparamagnetic nano magnetic beads are widely used in the field of nucleic acid extraction and purification as a novel functional material, and have the advantages of no need of using a centrifugal machine, capability of being matched with a high-flux nucleic acid extraction instrument, and the like, and have the advantages of no substitution in the traditional organic reagent extraction and centrifugal column membrane extraction. The magnetic bead method is adopted to pre-pack the reagent, the pre-packed reagent pre-packs lysis solution, washing solution, eluent and magnetic bead solution in the nucleic acid extraction reagent, and the finished product is packaged by a heat sealing film so as to be conveniently brought to a detection field. The defects that the whole bottle of the traditional kit needs to be brought into the field, the solution is taken separately on the field, the time is wasted, and the whole bottle of the reagent is easily polluted by opening the cover on the field are overcome.

The magnet of current magnetic force frame has certain distance with the magnetic bead of test tube bottom, and adsorption effect is not good, also absorbs the magnetic bead easily when absorbing the waste liquid with the pipettor, causes in the disengaging process, and the magnetic bead probably is emptyd along with the supernatant together, and this can produce a series of problems to follow-up experiment. Since the magnetic beads used in the magnetic bead purification technology are generally small in particle size, after the magnetic beads are poured out together with the supernatant, the magnetic beads can cause blockage and even rejection of the chromatographic resin or ultrafiltration membrane used in the subsequent column chromatography purification or ultrafiltration concentration step. In addition, since a part of the magnetic beads is dumped with the supernatant, the magnetic beads are wasted, and thus, the magnetic beads need to be continuously monitored and replenished when repeatedly used for a long time, which causes high costs of labor and materials. Various test tubes also require the use of magnetic racks of different sizes. Meanwhile, in the process of extracting nucleic acid by the magnetic bead method, the magnetic influence of the magnetic beads and the magnetic frame needs to be isolated, and the magnetic beads are eluted.

SUMMERY OF THE UTILITY MODEL

In order to overcome the defects of the prior problems, the utility model provides a magnetic rack for efficiently extracting nucleic acid.

The technical scheme adopted by the utility model for solving the technical problems is as follows: the utility model provides a high-efficient magnetic frame of drawing nucleic acid, includes support, test-tube rack and magnetic block group, the support includes big bottom plate and intermediate column, be equipped with the magnetic block installation cavity on the intermediate column, magnetic block group can dismantle and insert the magnetic block installation cavity, both sides bottom is equipped with the card strip around the test-tube rack, both sides correspondence is equipped with four spouts around the support, the card strip all inserts in the spout, be equipped with the test tube mounting panel on the test-tube rack, be equipped with at least one test tube cover that is used for fixed test tube on the test tube mounting panel, the left and right sides at intermediate column top is equipped with the first groove of dodging that is used for dodging the test tube cover, the test-tube rack passes through locking structure detachably and fixes the left and right sides at the intermediate column, the lateral wall of the equal butt intermediate column of lateral wall of test tube.

The test-tube rack of both sides is fixed a position through the draw-in groove of card strip with the support, and is fixed through locking structure and support and forms integratively, and the test-tube rack can be dismantled and the exclusive use, and the installation of pegging graft is slided to the test-tube rack of both sides, and easy dismounting is swift. Meanwhile, the wall of the test tube is tightly close to the magnetic block group in the middle column, so that the required magnetic force is provided for the magnetic beads in the solution.

According to another embodiment of the utility model, the locking structure comprises a lock catch and a lock tongue, the lock catch is fixed on the top of the middle column and comprises a partition plate and an elastic strip, a jack is formed below the lock catch, a boss extends from the test tube mounting plate, the lock tongue is fixed on the side wall of the boss and comprises a convex part and a suspension plate, the lock tongue is inserted into the jack, and the rear side of the convex part abuts against the side wall of the partition plate. Push type locking structure easy dismounting, disect insertion accomplishes the installation, only needs to press the elasticity strip when taking out the test-tube rack from the support, and the boss sinks the back naturally, pulls out the test-tube rack from support one side.

According to another embodiment of the utility model, the test tube mounting plate of the test tube rack is provided with a second avoidance groove on the side adjacent to the elastic strip. Through setting up the second and dodge the groove, further make things convenient for the operation of pressing of elasticity strip.

According to another embodiment of the utility model, the test tube sleeve further comprises a positioning part and a clamping part, the clamping part is provided with at least three clamping grooves, a middle hole of the positioning part is matched with the outer diameter of the test tube, and a middle hole at the lower end of the clamping part is smaller than the outer diameter of the test tube. Through setting up the clamping part, after inserting the test tube, strut clamping part, the test tube closely combines with the test tube cover, makes test tube and test-tube rack fixed an organic whole, makes things convenient for the whole operation of empting in batches of solution, and it is all more convenient that the test tube is packed into and is taken out simultaneously.

According to another embodiment of the utility model, the test tube rack is provided with a bottom supporting plate, a supporting hole is arranged below a position, corresponding to the test tube sleeve, on the bottom supporting plate, and the aperture of the supporting hole is smaller than the outer diameter of the test tube. Through setting up bottom fagging and propping the hole, when inserting the test tube, for the bottom of test tube provides effective location support, the test tube is fixed more stable.

According to another embodiment of the utility model, the test tube rack is further provided with a back plate, the back plate is provided with a plurality of back plate holes, and one side of the test tube mounting plate, which is close to the back plate, is provided with an upward bent handle part in an extending manner. Through setting up backplate hole and stalk portion, snatch when making things convenient for the test-tube rack dismouting, convenient operation.

According to another embodiment of the utility model, the magnetic block group comprises a base plate and magnetic blocks which are consistent in size and appearance, the base plate and the magnetic blocks are symmetrically stacked to form the magnetic block group, and the middle column is provided with at least two magnetic block mounting cavities which are arranged up and down. Through setting up a plurality of magnetic paths installation cavity and the magnetic path group that can assemble, adjust the magnetic force distribution and the magnetic force size of magnetic frame according to the processing needs, satisfy the experiment demand.

The utility model has the advantages that the test tube rack and the support with the separation structures are arranged, so that a plurality of test tubes on one side can be conveniently and simultaneously taken down, the solution in the test tubes can be conveniently treated, the magnetic force on one side can be conveniently cut off, meanwhile, the test tube racks with different specifications can be used according to the test tubes with different specifications, the side walls of the test tubes are abutted against the side walls of the middle columns, and the magnetic block group design of the stacked magnetic blocks is adopted, so that the sufficient magnetic action is provided for the test tubes, the magnetic force distribution and the magnetic force of the magnetic rack can be adjusted according to the treatment requirements, and the experimental requirements are met.

Drawings

The utility model is further illustrated with reference to the following figures and examples.

FIG. 1 is a schematic view of the present invention;

FIG. 2 is a schematic cross-sectional view taken at A-A in FIG. 1;

FIG. 3 is an enlarged view at X in FIG. 2;

FIG. 4 is a schematic right-view of the present invention;

FIG. 5 is a schematic top view of the stand;

FIG. 6 is a schematic right view of the stand;

fig. 7 is a schematic view of a test tube rack;

FIG. 8 is a schematic left side view of the test tube rack with test tubes inserted therein;

fig. 9 is a schematic view of a test tube rack adapted for other test tubes.

In the figure, the bracket 1, the large bottom plate 11, the middle column 12, the magnetic block mounting cavity 13, the first avoiding groove 14, the lock catch 15, the partition plate 151, the elastic strip 152, the insertion hole 153, the sliding groove 16, the test tube rack 2, the clamping strip 21, the bottom supporting plate 22, the supporting hole 221, the test tube mounting plate 23, the test tube sleeve 24, the positioning portion 241, the clamping portion 242, the clamping groove 243, the boss 25, the lock tongue 26, the suspension plate 261, the convex portion 262, the second avoiding groove 27, the back plate 28, the back plate hole 281, the handle portion 29, the test tube 3, the magnetic block group 4, the backing plate 41, the magnetic block 42 and the locking structure 6.

Detailed Description

As shown in fig. 1-9, which are schematic structural diagrams of the present invention, a magnetic rack for efficiently extracting nucleic acid comprises a rack 1, a test tube rack 2, and a magnetic block group 4, wherein the rack 1 comprises a large bottom plate 11 and a middle column 12, the middle column 12 is provided with a magnetic block installation cavity 13, the magnetic block group 4 is detachably inserted into the magnetic block installation cavity 13, the front and back bottoms of the test tube rack 2 are provided with clamping strips 21, the front and back sides of the rack 1 are correspondingly provided with four sliding grooves 16, the clamping strips 21 are all inserted into the sliding grooves 16, the test tube rack 2 is provided with a test tube installation plate 23, the test tube installation plate 23 is provided with at least one test tube sleeve 24 for fixing a test tube 3, the left and right sides of the top of the middle column 12 are provided with first avoidance grooves 14 for avoiding the test tube sleeve 24, the test tube rack 2 is detachably fixed on the left and right sides of the middle column 12 through locking structures 6, the side walls of the test tubes 3 all abut against the side walls of the middle column 12.

Preferably, locking structure 6 includes hasp 15 and spring bolt 26, hasp 15 is fixed at the top of intermediate column 12, and includes baffle 151 and elastic strip 152, and its below is formed with jack 153, test tube mounting panel 23 extends and is equipped with boss 25, spring bolt 26 is fixed on the lateral wall of boss 25, and includes convex part 262 and hanger plate 261, spring bolt 26 inserts in the jack 153, just the rear side butt baffle 151's of convex part 262 lateral wall for the hasp 15 of both sides test-tube rack 2 is central symmetry setting at the top of intermediate column 12.

The partition 151 and the elastic strip 152 are disposed in parallel, and the elastic strip 152 has a small thickness and elasticity.

Preferably, the test tube mounting plate 23 of the test tube rack 2 is provided with a second avoidance groove 27 on the adjacent side of the elastic strip 152. The elastic strip 152 may extend into the second escape groove 27, increasing the width of the elastic strip 152.

Preferably, the test tube holder 24 includes a positioning portion 241 and a clamping portion 242, the clamping portion 242 is provided with at least three clamping grooves 243, a central hole of the positioning portion 241 matches with the outer diameter of the test tube 3, and a central hole at the lower end of the clamping portion 242 is smaller than the outer diameter of the test tube 3.

Preferably, the test tube rack 2 is provided with a bottom supporting plate 22, a supporting hole 221 is formed in the bottom supporting plate 22 below the position corresponding to the test tube sleeve 24, and the aperture of the supporting hole 221 is smaller than the outer diameter of the test tube 3.

Preferably, the test tube rack 2 is further provided with a back plate 28, the back plate 28 is provided with a plurality of back plate holes 281, and one side of the test tube mounting plate 23 close to the back plate 28 extends to be provided with a handle part 29 which is bent upwards.

Preferably, the magnet block group 4 includes a backing plate 41 and magnets 42 with the same size and shape, the backing plate 41 and the magnets 42 are symmetrically stacked to form the magnet block group 4, and the middle column 12 is provided with at least two magnet mounting cavities 13 arranged up and down. The backing plate 41 may be a common plastic plate.

The foregoing description is intended to be illustrative rather than limiting, and it will be appreciated by those skilled in the art that many modifications, variations or equivalents may be made without departing from the spirit and scope of the utility model as defined in the appended claims.

Claims

1. The utility model provides a high-efficient magnetic rack who draws nucleic acid, characterized by, includes support (1), test-tube rack (2) and magnetic block group (4), support (1) is including big bottom plate (11) and intermediate column (12), be equipped with magnetic block installation cavity (13) on intermediate column (12), magnetic block group (4) can be dismantled and insert in magnetic block installation cavity (13), both sides bottom is equipped with card strip (21) around test-tube rack (2), the correspondence of both sides is equipped with four spout (16) around support (1), card strip (21) all insert in spout (16), be equipped with test tube mounting panel (23) on test-tube rack (2), be equipped with at least one test tube cover (24) that are used for fixed test tube (3) on test tube mounting panel (23), the left and right sides at intermediate column (12) top is equipped with and is used for dodging first dodging groove (14) of dodging test tube cover (24), test-tube rack (2) are fixed in the left and right sides of middle post (12) through locking structure (6) detachably, the lateral wall of test tube (3) all butts the lateral wall of middle post (12).

2. The magnetic rack for efficiently extracting nucleic acid according to claim 1, characterized in that the locking structure (6) comprises a lock catch (15) and a lock tongue (26), the lock catch (15) is fixed at the top of the middle column (12) and comprises a partition plate (151) and an elastic strip (152), a jack (153) is formed below the lock catch (15), a boss (25) is arranged on the test tube mounting plate (23) in an extending manner, the lock tongue (26) is fixed on the side wall of the boss (25) and comprises a convex portion (262) and a suspension plate (261), the lock tongue (26) is inserted into the jack (153), the rear side of the convex portion (262) abuts against the side wall of the partition plate (151), and the lock catches (15) of the two-side test tube racks (2) are arranged in a central symmetry manner at the top of the middle column (12).

3. The magnetic rack for efficiently extracting nucleic acid according to claim 2, wherein the test tube mounting plate (23) of the test tube rack (2) is provided with a second avoiding groove (27) on the side adjacent to the elastic strip (152).

4. The magnetic rack for efficiently extracting nucleic acid according to claim 1, wherein the test tube holder (24) comprises a positioning part (241) and a clamping part (242), the clamping part (242) is provided with at least three clamping grooves (243), the middle hole of the positioning part (241) is matched with the outer diameter of the test tube (3), and the middle hole at the lower end of the clamping part (242) is smaller than the outer diameter of the test tube (3).

5. The magnetic rack for efficiently extracting nucleic acid according to claim 1, wherein the test tube rack (2) is provided with a bottom support plate (22), a support hole (221) is formed below a position of the bottom support plate (22) corresponding to the test tube sleeve (24), and the diameter of the support hole (221) is smaller than the outer diameter of the test tube (3).

6. The magnetic rack for efficiently extracting nucleic acid according to claim 1, wherein the test tube rack (2) is further provided with a back plate (28), the back plate (28) is provided with a plurality of back plate holes (281), and one side of the test tube mounting plate (23) close to the back plate (28) is provided with an upward bent handle part (29) in an extending manner.

7. The magnetic rack for efficiently extracting nucleic acid according to claim 1, wherein the magnetic block set (4) comprises a base plate (41) and magnetic blocks (42) with the same size and shape, the base plate (41) and the magnetic blocks (42) are symmetrically stacked to form the magnetic block set (4), and the middle column (12) is provided with at least two magnetic block mounting cavities (13) arranged up and down.