CN216404373U

CN216404373U - A combination formula test tube for cell filtration

Info

Publication number: CN216404373U
Application number: CN202122133453.XU
Authority: CN
Inventors: 杨俊�; 刘开泰; 童庆超; 祝杭燕; 应静; 葛丛姗; 岑幼青; 刘露; 周俊杰
Original assignee: Ningbo Clinic Pathology Diagnosis Center
Current assignee: Ningbo Clinic Pathology Diagnosis Center
Priority date: 2021-09-06
Filing date: 2021-09-06
Publication date: 2022-04-29
Anticipated expiration: 2031-09-06

Abstract

The embodiment of the utility model discloses a combined test tube for cell filtration, which comprises: the first test tube is provided with a first end and a second end which are opposite, and the first end is communicated with the second end to form a hollow pipeline; the second test tube is provided with an accommodating cavity with a first opening, and the second test tube enables the accommodating cavity to be connected with the pipeline through the opening; a filter assembly removably connected between the opening and the second end. The embodiment of the utility model effectively solves the problem that cell clusters at the bottom of the test tube are difficult to extract after the centrifugal tube is centrifuged.

Description

A combination formula test tube for cell filtration

Technical Field

The utility model relates to the field of medical instruments, in particular to a combined test tube.

Background

The preparation of cell mass is one of important cytopathology inspection techniques, the cell mass not only helps pathologists to observe the structure of cell mass under a microscope, but also can further determine the quality and malignancy of exfoliated cells through immunocytochemistry inspection and molecular pathology detection, and has important significance for disease diagnosis, and the technique is increasingly applied to various body fluid cytopathology inspection.

When the existing combined test tube is used for manufacturing cell blocks, cell samples are centrifugally separated until centrifugal sediments are less, supernatant liquid is removed, cell components in the remaining cell suspension are collected into a cell collecting ring to form solid cell blocks with fixed sizes and shapes, 1-2 drops of agar liquid (heated to 50-60 ℃) are dripped from the upper part of the cell collecting ring, the cell blocks are cooled at room temperature, and the cell blocks are wrapped by dewatering paper together with the collecting ring and then placed into a dewatering box to form the cell blocks.

After the existing centrifugal tube is centrifuged at high speed, effective cell components in body fluid of a patient are gathered at the bottom of the test tube, and the upper part of the test tube is liquid. When the effective cell components at the bottom are extracted, the supernatant must be discarded, and the cells gathered at the bottom are loose during the step of discarding the supernatant, so that the cell sediments are difficult to extract, and the steps are very complicated.

SUMMERY OF THE UTILITY MODEL

Therefore, the embodiment of the utility model provides a combined test tube, which effectively solves the problem that cell masses at the bottom of the traditional test tube are difficult to extract after centrifugation.

In one aspect, an embodiment of the present invention provides a combined test tube, including: the first test tube is provided with a first end and a second end which are opposite, and the first end is communicated with the second end to form a hollow pipeline; the second test tube is provided with an accommodating cavity with a first opening, and the accommodating cavity is communicated with the pipeline through the first opening; the first test tube and the second test tube are connected with each other, and the outer side of the filter assembly mounting position is provided with an external thread; the filter assembly, be equipped with the internal thread on the filter assembly inner wall, through the internal thread with the external screw thread cooperation will filter assembly threaded connection to filter assembly installation position.

In one embodiment of the utility model, the filter assembly attachment location is an inwardly angled channel and the filter assembly attachment location is disposed on and extends beyond the second end.

In one embodiment of the utility model, the filter assembly mounting location is an outwardly inclined channel and the filter assembly mounting location is disposed in and extends out of the first opening.

In one embodiment of the present invention, the filtering apparatus includes: the filtering device body is internally provided with a filtering cavity with a filtering membrane; the second opening is arranged at one end of the filtering device body and communicated with the filtering cavity; and the third opening is arranged at the other end of the filtering device body and communicated with the filtering cavity.

In one embodiment of the present invention, the second opening, the third opening, and the first test tube and the second test tube are all coaxially disposed.

In one embodiment of the utility model, the third opening extends into the receiving cavity.

In one embodiment of the utility model, the third opening is arranged to be inclined inwardly.

In one embodiment of the utility model, the pore size of the filter membrane is 10 μm.

In one embodiment of the present invention, further comprising: and the sealing cover is arranged at the first end in a covering manner.

In one embodiment of the present invention, a mounting base is disposed on an end of the second test tube away from the first opening.

In summary, the above embodiments of the present application may have one or more of the following advantages or benefits: i) when the tissue sample storage device is put into the tissue sample storage device, one part of the tissue sample storage device is positioned at the bottle mouth, and the rest part of the tissue sample storage device is positioned at the bottle body, so that the storage body can be conveniently taken out of the storage body; ii) the storage body is in open-close type buckle connection, so that the tissue sample to be detected can be conveniently stored; iii) the storage body is provided with a first protruding member and a second protruding member for facilitating opening and closing of the storage body.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

Fig. 1 is a schematic structural diagram of a combined test tube 100 according to the present invention.

Fig. 2 is an exploded view of the modular test tube 100 shown in fig. 1.

Fig. 3 is a schematic structural view of the first test tube 10 shown in fig. 1.

Fig. 4 is a schematic view of the filter assembly 30 shown in fig. 1.

Fig. 5 is an exploded view of the filter assembly 30 shown in fig. 4.

Fig. 6 is another schematic view of the filter assembly 30 shown in fig. 1.

Fig. 7 is a schematic structural view of the second test tube 20 shown in fig. 1.

Description of the main element symbols:

100 is a combined test tube; 10 is a first test tube; 11 is a sealing cover connecting position; 12 is a second test tube mounting position; 13 is a filter component mounting position; 20 is a second test tube; 21 is a first opening; 22 is a mounting base; 23 is a base; 30 is a filter assembly; 31 is a first filter assembly; 32 is a second filter assembly; 33 is a second opening; 34 a filter membrane; 35 is a third opening; 40 is a sealing cover.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

[ first embodiment ] A method for manufacturing a semiconductor device

Referring to fig. 1, a schematic structural diagram of a modular test tube 100 according to a first embodiment of the present invention is shown. Specifically, the modular test tube 100 includes, for example: a first test tube 10, a second test tube 20, and a sealing cap 40. The first test tube 10 is provided with a first end and a second end which are opposite to each other, and the first end is communicated with the second end to form a hollow pipeline; the second test tube 20 is provided with an accommodating cavity with a first opening, and the accommodating cavity is communicated with the pipeline through the first opening 21 of the second test tube 20.

Specifically, referring to fig. 2, a sealing cover connecting position 11 is arranged on the first end, and an external thread is arranged on the sealing cover connecting position 11; on the contrary, the sealing cover 40 is internally provided with external threads; the external screw thread on the sealed lid hookup location 11 and the external screw thread cooperation on the sealed lid 40 make sealed lid 40 can seal the setting lid locate first end prevents that cell specimen liquid from following flow out in the first end. The connection mode of the sealing cover 40 and the sealing cover connection position 11 may also be other sealing connection modes, and is not limited herein.

Further, a second test tube mounting position 12 is arranged on the second end, and an external thread is arranged on the second test tube mounting position 12; correspondingly, an external thread is arranged on the outer wall of the first opening 21; external screw thread on second test tube installation position 12 and the external screw thread cooperation of first opening 21 department make first test tube 10 and second test tube 20 sealing connection each other, prevent that cell specimen liquid from oozing out in the clearance between first test tube 10 and the second test tube 20. The connection mode of the first test tube 10 and the second test tube 20 may also be other sealing connection modes, and is not limited herein.

Preferably, referring to fig. 3, a filter assembly mounting location 13 is further disposed on the second end, the filter assembly mounting location 13 is an inwardly inclined channel, and one side close to the second end is larger than one side far away from the second end, and the channel is communicated with the pipeline. For example, when the combination tube 100 is centrifuged, the cell sample liquid inside is swirled, so the large-bottom shape facilitates the separation of the cells and the body fluid in the cell sample liquid.

Further, still be equipped with filter assembly installation position 13 on the first opening 21, filter assembly installation position 13 is the passageway that leans out, and is close to one side of first opening 21 and is less than the one side of keeping away from first opening 21, just the passageway intercommunication the pipeline. For example, when the combination tube 100 is centrifuged, the cell sample liquid inside is swirled, so the large-bottom shape facilitates the separation of the cells and the body fluid in the cell sample liquid. Where the filter assembly attachment location 13 may be attached to and/or the second end and the first opening 21.

Specifically, with reference to fig. 4 and 5, the filter assembly 30 includes: a filter body, a second opening 33 and a third opening 35. Wherein a filtering cavity with a filtering membrane 34 is arranged in the filtering device body; the second opening 33 is arranged at one end of the filtering device body and communicated with the filtering cavity; and a third opening 35 provided at the other end of the filter device body and communicating with the filter cavity. For example, the filter assembly 30 is disposed between the first test tube 10 and the second test tube 20, and the cells in the cell sample solution are separated from the body fluid by the filter assembly 30, and the cells are attached to the filter membrane, thereby making a preliminary cell mass.

Further, the filter device body includes: a first filter assembly 31 and a second filter assembly 32. Wherein the first filter assembly 31 and the second filter assembly 32 are connected by screw threads to form a sealed filter cavity therein. In particular, the filter membrane 34 is arranged on the first filter assembly 31. For example, when the cell sample liquid is blocked by the second filter assembly 32, the first filter assembly 31 and the second filter assembly 32 can be separated, the second filter assembly 32 can be unclogged, and then the first filter assembly 31 and the second filter assembly 32 can be combined to continue the filtration of the cell sample liquid.

Specifically, referring to fig. 6, a groove is formed on a side of the second filter assembly 32 away from the first filter assembly 31, and the third opening 35 is formed on the groove. Further, the third opening 35 is a channel inclined outward, and a side away from the second filter element 32 is smaller than a side close to the second filter element 32. When the cell specimen liquid is separated, the cell serum can slowly flow out from the third opening 35 having a large top and a small bottom.

Further, a third opening 35 extends out of the recess and into the receiving cavity. For example, when the cell specimen liquid is separated, the cell serum flows out from the third opening 35, and the cell serum is prevented from remaining on the upper end side wall of the second test tube 20.

Preferably, the pore size of the filtration membrane 34 is 10 μm. The pore size of the filtration membrane can be changed here according to the size of the retained cells.

In particular, referring to fig. 7, a base 23 is disposed on a side of the second test tube 20 away from the first opening 21. Further, the base 23 is a reverse circular truncated cone shaped base 23 having a large top and a small bottom. For example, when the cell sample liquid is separated, the inverted circular truncated cone-shaped base 23 having a large top and a small bottom can be more preferably centrifugally rotated and fixed.

Further, a mounting base 22 is disposed on a side of the second test tube 20 away from the first opening 21. For example, since the base 23 is in the shape of a truncated cone with a large top and a small bottom, the stability of the base 23 is poor, and therefore the mounting bases 22 are arranged around the base 23, so that the second test tube 20 can be conveniently and independently fixed, and can be prevented from being placed on a table top.

Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims

1. A modular tube for cell filtration, comprising:

the first test tube is provided with a first end and a second end which are opposite, and the first end is communicated with the second end to form a hollow pipeline;

the second test tube is provided with an accommodating cavity with a first opening, and the accommodating cavity is communicated with the pipeline through the first opening;

the first test tube and the second test tube are connected with each other, and the outer side of the filter assembly mounting position is provided with an external thread;

a filter assembly, be equipped with the internal thread on the filter assembly inner wall, through the internal thread with the external screw-thread fit will filter assembly threaded connection to the filter assembly installation position, filter assembly includes:

the filter equipment body is equipped with the filtration cavity who has filtration membrane in, the filter equipment body includes: a first filter assembly and a second filter assembly; wherein the first filter assembly and the second filter assembly are connected through screw threads to form a sealed filter cavity inside; the filtering membrane is arranged on the first filtering assembly;

the second opening is arranged at one end of the filtering device body and communicated with the filtering cavity;

the third opening is arranged at the other end of the filtering device body and communicated with the filtering cavity;

the third opening extends into the accommodating cavity, and the third opening is arranged in an inward inclined mode.

2. The modular cuvette for cell filtration according to claim 1, wherein the filter assembly mounting site is an inwardly inclined channel and the filter assembly mounting site is located at and extends beyond the second end.

3. The modular cuvette for cell filtration according to claim 1, wherein the filter assembly mounting site is an outwardly inclined channel and the filter assembly mounting site is located at and extends out of the first opening.

4. The modular cuvette for cell filtration according to claim 1, wherein the second opening, the third opening and the first and second cuvettes are all coaxially arranged.

5. The modular cuvette for cell filtration according to claim 1, wherein the pore size of the filtration membrane is 10 μm.

6. The modular cuvette for cell filtration according to claim 1, further comprising: and the sealing cover is arranged at the first end in a covering manner.

7. The modular tube for cell filtration according to claim 1, wherein a mounting base is provided on an end of the second tube distal to the first opening.