KR101862991B1 - Sealed type Rapid Diagnostic Kit for Prevention of Secondary Infection - Google Patents

Abstract

The present invention relates to a sealed type rapid diagnostic kit for prevention of secondary infection. More specifically, an overflow phenomenon does not occur since a kit part is uprightly transported, and a kit can be stably supported with a structure which can raise a strip by using an injection material (housing). All procedures except sample collection are performed in a sealed structure, so that second infection of a diagnostic tester can be prevented. The sealed type rapid diagnostic kit can be conveniently used because troublesome steps can be reduced, and completes transportation and rapid diagnosis within 3 to 5 minutes by the sealed structure which is not influenced by an external environment. Also, a cover part, an adapter and a connection part are connected in multi-step and can correspond to two-liquid type and three-liquid type solutions, thereby increasing efficiency. The sealed type rapid diagnostic kit comprises: the cover part; the adapter; the connection part; the kit part; and a tube part.

Description

{Sealed type Rapid Diagnostic Kit for Prevention of Secondary Infection}

The present invention relates to a sealed type rapid diagnostic kit capable of preventing secondary infection, and more particularly, to a kit that can reliably carry a kit without a overhead phenomenon, And all the procedures except the sampling are done in a closed structure. Therefore, it is possible to prevent the secondary infection of the diagnostic tester, to reduce troublesome steps and to use it conveniently, , And it is possible to complete diagnosis of transportation and rapid diagnosis within 3 to 5 minutes, and to cover the cover part, the adapter and the connection part in multiple stages, and to cope with the two-liquid type and three-liquid type solutions, And a diagnostic kit.

The existing strip-type rapid diagnostic kit can be mass-produced and supplied at low cost without separate package, and it is possible to save storage efficiency due to its small volume. However, In order to immerse the sample in a specimen, it is necessary to secure a tube conforming to the standard. When the specimen is put in, there is a fear that it is necessary to place a separate support to prevent contamination of the periphery of the test and infection due to exposure of the specimen.

Another Rapid Diagnostic Kit is a cassette type Rapid Diagnostic Kit that has a strip in the housing structure that is less susceptible to breakage and does not require a separate tube to be inspected and can be packaged individually. The reagent storage is not easy because the volume of the reagent is large.

In addition, when the specimen containing the solidified material is dropped, the specimen fails to expand due to the clogging phenomenon. When the assembly of the housing structure is poor, the specimen can not be sufficiently absorbed by the specimen absorbent pad and is developed along the upper surface of the strip Often, deployments fail. In addition, the strip-type and cassette-type diagnostic kits can be configured individually, making it difficult to carry out two or more kinds of diagnoses at the same time or collecting a group of subjects and performing them at once. Therefore, it is troublesome and costly to prepare a separate kit Follow.

Korean Registered Utility Model No. 20-0259551

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned problems,

Since the kit part is transported upright, there is no overflow phenomenon, and the kit can be stably supported by the structure that can raise the strip using the injection molding (housing). All processes except the sampling are performed in a closed structure, It is possible to complete the transportation and rapid diagnosis in 3 to 5 minutes by the sealing structure which is easy to use and is not affected by the external environment because it can prevent the secondary infection of the cover, And a connecting part connected to a multi-stage so as to be able to cope with a two-pack type and a three-pack solution, thereby increasing the efficiency.

In order to accomplish the above object, the present invention provides a method of preparing a reagent, the method comprising the steps of: forming an outer portion of a soft, flexible and elastic material; injecting a specimen from the outside; opening the upper portion to mix with a reagent stored therein; A cover portion having a first stopper protruded from the one end of the outer periphery of the coupling portion so as not to be rotated at a predetermined interval or more during rotation;

The outer periphery is formed in a conical shape of a downwardly directed light so as to be easily coupled to the inside of the cover portion and the one end portion of the outer periphery is engaged with the engaging portion when engaged with the inside of the cover portion, And a through hole formed at a central portion of the through hole is protruded from the center of the through hole. The through hole formed in the central portion of the through hole has an inner circumferential side extending downward An adapter formed in an expanded shape;

And an opening and closing part for opening and closing the through hole of the adapter in accordance with the rotation of the cover part is formed horizontally at a center part of the cover part and the tube part are connected to each other so that the opening part is closely inserted And a rib portion protruding from one end surface of the opening and closing portion protruding from the blocking portion to prevent the reagent conveyed through the through hole from being discharged to the outside while covering the outer circumference of the sealing portion, A connecting part formed at the opening / closing part between the rib and the rib to form a connecting port so that the reagent transferred through the through hole of the adapter penetrates and is transmitted to the tube part;

A kit portion coupled to a lower central portion of the connection portion and provided in the tube portion and having a strip type kit coupled thereto;

And a tube unit coupled to one side of the connection unit to open one side to communicate with the connection unit and to store the specimen and the reagent transferred through the connection unit. .

A second stopper is protruded from the inner periphery of the connecting portion to which the cover portion of the present invention is coupled so as not to be rotated beyond a predetermined distance when the cover portion is rotated. The second stopper contacts the first stopper of the cover portion, The present invention relates to a sealed type rapid diagnostic kit capable of preventing secondary infection.

A kit portion provided in the tube portion is coupled to the coupling groove of the coupling protrusion so as to collect a specimen of the tube portion. According to another aspect of the present invention, Which is capable of preventing secondary infection.

Also, the kit part of the present invention includes: a kit body having a coupling protrusion formed at an end thereof to be coupled to an engaging groove of the engaging projection, and having a connecting groove formed therein for inserting the strip type kit;

A kit cover for covering the connection groove of the kit body to support the strip type kit;

And a strip type kit inserted into the connection groove of the kit body and having an end protruding outside the kit body to be in direct contact with the specimen stored in the tube portion. To a rapid diagnostic kit.

The present invention also relates to a sealed type rapid diagnostic kit capable of preventing secondary infection, characterized in that the cover is screwed to open and close the inside of the cover portion on the opened upper side of the cover portion of the present invention.

The present invention also relates to a sealed type rapid diagnostic kit capable of preventing secondary infection, characterized in that a swap coupling is protruded from the inner surface of the lid of the present invention so that a swab to be sampled is coupled.

The cover portion, the adapter, and the connection portion of the present invention may be formed in a plurality of ways, and the cover portion may be continuously connected to the lower portion of the connection portion. The tube portion may be connected to the end portion of the final connection portion, The present invention relates to a sealed type rapid diagnostic kit capable of preventing secondary infection.

As described above, the sealed type rapid diagnostic kit of the present invention is capable of preventing the secondary infection and has a structure in which the kit can be raised and transported, thereby preventing overflow phenomenon and allowing the strip to be raised using an injection molding (housing) And all the procedures except the sampling are done in a closed structure. Therefore, it is possible to prevent the secondary infection of the diagnostic tester, to reduce troublesome steps and to use it conveniently, It is possible to complete the transportation and rapid diagnosis within 3 to 5 minutes by connecting the cover part and the adapter part to each other.

1 is a perspective view of a sealed rapid diagnostic kit according to an embodiment of the present invention,
FIG. 2 is a sectional view showing a closed type rapid diagnostic kit according to an embodiment of the present invention,
3 is an exploded view of a cover according to an embodiment of the present invention,
FIG. 4 is a perspective view showing a partial cross-section of an adapter according to an embodiment of the present invention,
5 is an exploded view of an adapter according to an embodiment of the present invention,
FIG. 6 is a perspective view illustrating a cross-section of a connection portion according to an embodiment of the present invention,
FIG. 7 is an exploded view illustrating a connection portion according to an embodiment of the present invention,
8 is a perspective view illustrating a kit unit according to an embodiment of the present invention,
9 is a perspective view showing a part of a cross section of a kit part according to an embodiment of the present invention,
10 is a cross-sectional view illustrating a closed type rapid diagnostic kit according to another embodiment of the present invention.

The present invention having such characteristics can be more clearly described by the preferred embodiments thereof.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Before describing in detail several embodiments of the present invention with reference to the accompanying drawings, it is to be understood that the present invention is not limited to the details of construction and the arrangement of components shown in the following detailed description or illustrated in the drawings will be. The invention may be embodied and carried out in other embodiments and carried out in various ways. It should also be noted that the device or element orientation (e.g., "front," "back," "up," "down," "top," "bottom, Expressions and predicates used herein for terms such as "left," " right, "" lateral, " and the like are used merely to simplify the description of the present invention, Or that the element has to have a particular orientation. Also, terms such as " first "and" second "are used herein for the purpose of the description and the appended claims, and are not intended to indicate or imply their relative importance or purpose.

Therefore, the embodiments described in this specification and the configurations shown in the drawings are merely the most preferred embodiments of the present invention and do not represent all the technical ideas of the present invention. Therefore, It is to be understood that equivalents and modifications are possible.

FIG. 1 is a perspective view showing a closed type rapid diagnostic kit according to an embodiment of the present invention, FIG. 2 is a sectional view showing a closed type rapid diagnostic kit according to an embodiment of the present invention, and FIG. Figure 4 is a perspective view of a portion of an adapter according to one embodiment of the present invention, Figure 5 is an exploded view of an adapter in accordance with an embodiment of the present invention, Figure 6 is a cross- 8 is a perspective view showing a kit unit according to an embodiment of the present invention, and FIG. 9 is a perspective view showing a connection unit according to an embodiment of the present invention. FIG. 10 is a cross-sectional view illustrating a closed type rapid diagnostic kit according to another embodiment of the present invention. FIG. 10 is a perspective view showing a part of a kit part according to an embodiment of the present invention.

1 to 10, a sealed type rapid diagnostic kit according to the present invention, which is capable of preventing secondary infection, comprises a cover 10, an adapter 20, a connecting portion 30, a tube portion 40, , And a kit part.

As shown in FIGS. 1 to 3, the cover part 10 is formed of a flexible and flexible material (LDPE, LLDPE, other rubber material and elastic material) Is transported to the opened side. At this time, the upper side of the cover portion 10 is opened to mix with the reagent stored therein and the thread is formed on the opened outer circumference.

A lid 13 is screwed on the upper side of the opened cover part 10 to open and close the inside of the cover part 10. A swap (not shown) for collecting a specimen is formed on the inner surface of the lid 13, The swap coupling member 14 is protruded. At this time, the present invention can be coupled to the swap coupling 14 when the specimen is collected by the swap, or can be inserted into the cover 10 immediately after opening the lid 13. In addition to the swap, a toothpick or the like may be used.

Here, the cover 10 is made of rubber, silicone, or plastic, which is a soft elastic body, and transmits pressure to the inside by the external pressure of the user. The cover 10, which is a soft body, One side is opened, and the coupling part 11 is protruded to be connected to the connection part 30 on the open side. At this time, the reagent and the sample are discharged through the coupling part 11.

A screw thread is formed on the outer circumference of the coupling portion 11 so as to be screwed with the coupling portion 30, and the coupling portion 11 is integrally formed with the adapter 20, The first stopper 12 is protruded from the one end of the outer periphery of the cover portion 10 so as not to be rotated over a predetermined distance when the cover portion 10 is rotated. At this time, the engaging portion 11 may be made of a harder material than the body of the cover portion 10 and may be screwed to the connecting portion 30 so that even when the cover portion 10 is pressed from the outside, ) Is not deformed.

The first stopper 12 is engaged with the second stopper 31 formed on the inner periphery of the connecting portion 30 when the cover portion 10 rotates along the thread in the connecting portion 30, Will no longer be seen. At this time, if the cover portion 10 is forcibly rotated in the rotating direction, the first stopper 12 and the second stopper 31 may be detached, and the cover portion 10 may be discharged to the connection portion 30. [

Meanwhile, the reagent is provided inside the cover part 10, and the reagent is used for culturing or preserving a culture medium, a tissue, or a body fluid. The reagent is as follows. In the present invention, these compositions can be used.

1) Guanidine thiocyanate

2) Tris

3) EGTA

4) Mercaptoethanol

5) Sarcosyl

6) Trehalose

In the present invention, a reagent comprising the above composition is used, but the reagent can be changed depending on the purpose and use of the pipette swap device.

2 and 4 to 5, the adapter 20 is integrally inserted into one opened side of the cover portion 10, and has a through hole through which the reagent of the cover portion 10 is transferred to the center portion A hole 23 is formed. At this time, a storage groove 25 is formed at one side of the through hole 23 to temporarily store the reagent transferred from the cover portion 10, and a through hole 23 is formed in the bottom surface of the storage groove 25 .

A filter 26 for filtering foreign substances contained in the specimen transferred from the cover unit 10 is further provided in the storage groove 25 and the specimen and the reagent filtered through the filter 26 are passed through the through- And is transmitted to the connection portion 30 through the connection portion 23. At this time, the filter 26 is made of UHMWPE, glass fiber or the like, and the pore size of the filter 26 is 10-200 um (30/70/110 um).

The adapter 20 is formed in a conical shape so as to be easily coupled to the inside of the coupling portion 11, and the adapter 20 is formed at the one end of the outer periphery of the adapter 20, The step portion 21 is protruded so as to be caught by the engaging portion 11. As shown in Fig. That is, the adapter 20 has the stepped portion 21 protruding along the outer periphery of the adapter 20 in the "ㅗ" shape so that the depth of the adapter 20 can be controlled by the coupling portion 11.

A sealing portion 22 is formed at a center of one side of the adapter 20, that is, on one side of the side where the step portion 21 is formed, in close contact with the opening / closing portion 32 of the connecting portion 30, The through hole 23 formed in the central portion of the sealing portion 22 is formed in a shape in which the inner circumference is expanded downward or in the form of a funnel And can be brought into close contact with the blocking portion 33 of the connecting portion 30. [

An insertion groove 24 is formed on one surface of the adapter 20 protruding from the sealing part 22 so that the rib 34 of the connection part 30 is inserted. And is formed into a circular shape in plan view.

That is, the rib 34 and the blocking portion 33 of the connection portion 30 are closely inserted into the insertion hole 24 of the adapter 20 and the through hole 23 of the sealing portion 22, respectively, 30 of the adapter 20 can be opened and closed.

As shown in Figs. 1 to 2 and Figs. 6 to 7, the connection portion 30 is opened at both sides to connect the cover portion 10 and the tube portion 40 to each other, A female screw thread is formed so that the cover portion 10 and the tube portion 40 are screwed together.

A second stopper 31 protrudes from the inner circumference of the connection portion 30 to which the cover portion 10 is coupled so as not to be rotated over a predetermined interval when the cover portion 10 rotates, (31) contacts the first stopper (12) of the cover portion (10) to control the turning radius of the cover portion (10).

An opening and closing part 32 for opening and closing the through hole 23 of the adapter 20 according to the rotation of the cover part 10 is horizontally formed in the inner central part of the connecting part 30, And the through hole 23 of the sealing portion 22 is opened and closed. (The manner in which the opening and closing portion 32 opens and closes the through hole 23 of the sealing portion 22 will be described below.)

The opening and closing part 32 is formed in a circular plate shape so as to be horizontally formed at an inner central part of the connecting part 30. The opening and closing part 32 is formed on one side of the opening and closing part 32, A blocking portion 33 is formed at the center of the sealing portion 22 so as to protrude from the through hole 23 of the sealing portion 22 to block the through hole 23. [ At this time, the cut-off portion 33 is formed in the form of a funnel-like funnel so as to be in close contact with the through-hole 23 of the sealing portion 22. [

The reagent conveyed through the through hole 23 is wound around the outer circumferential edge of the sealing part 22 on one end face of the opening / closing part 32 (on one side where the blocking part 33 is formed) 34 are protruded. That is, the ribs 34 are cylindrically formed at the central portion and are spaced apart from each other, and a sealing portion (not shown) of the adapter 20 is provided between the inner periphery of the ribs 34 and the blocking portion 33 22).

The reagent conveyed through the through hole 23 of the adapter 20 penetrates through the opening and closing part 32 between the blocking part 33 and the rib 34 to be connected to the tube part 40 And the connecting port 35 is formed as a long hole, and is formed in a planar arc shape.

The other side of the opening / closing part 32, that is, the opposite side of the blocking part 33, has a coupling protrusion 36 formed at the center thereof with a coupling groove 37 protruding downward, A swab 50 is detachably attached to the groove 37 so as to collect a specimen of the tube portion 40. At this time, the swab 50 is provided inside the tube 40 to collect the specimen through the end of the swab 50. Here, the swab 50 is detached from the connection part 30 at the same time when the connection part 30 is detached from the tube part 40.

The fixing protrusion 38 protrudes in the longitudinal direction of the coupling groove 37 so that the swab 50 can not be easily detached when the swab 50 is coupled to the circumference of the coupling groove 37 of the coupling protrusion 36 And a plurality of the fixing protrusions 38 are spaced apart from each other along the inner circumference of the coupling groove 37. As such, the kit portion 50 is coupled to the center of the plurality of fixing projections 38.

As shown in FIGS. 1 and 2, the tube 40 is connected to one side of the connection part 30 so that one side thereof is opened and the reagent of the sample and the cover part 10 to be inspected are stored therein . At this time, the tube part 40 is in the form of a transparent tube, and the sample or reagent provided therein can be visually confirmed.

The inner bottom surface of the tube part 40 is connected to the outer surface of the tube part 40 through the end part of the kit part 50, And is sloped toward the center side in the shape of a vertical stripe so as to be easy to carry or to be conveyed downward.

2 and 8 to 9, the kit unit 50 includes a kit body 51 to be coupled to a lower central portion of the connection unit 30 and to be disposed in the tube unit 40, a kit cover 52 And a strip type kit 53. The strip-

The kit body 51 is formed in a rectangular shape and has an engaging hole 54 protruding from the upper end surface of the kit body 51 so as to be engaged with the engaging groove 37 of the engaging projection 36. On one surface of the kit body 51, The connection groove 55 is formed so that the strip type kit 53 is inserted.

The kit cover 52 is attached to the kit body 51 so as to cover the connection groove 55 of the kit body 51 so as to support the strip type kit 53 while the strip type kit 53 is detached ≪ / RTI >

The strip type kit 53 is inserted into the connection groove 55 of the kit body 51 and has an end protruding outward from the kit body 51 to directly contact the specimen stored in the tube portion 40. [ The strip type kit 53 absorbs the specimen in a vertically erected state and does not overflow to store the absorbed specimen in the connection groove 55 of the kit body 51.

10, the cover unit 10, the adapter 20, and the connection unit 30 are sequentially connected to each other. In this case, the cover unit 10 The adapter 20 and the connection part 30 are connected to the lower part of the connection part 30 in such a manner that the cover part 10 is connected.

Therefore, a plurality of reagents can be used to mix with the specimen. The tube portion 40 is connected to the end of the final connection portion 30, and the final mixed specimen is stored in the tube portion 40.

Hereinafter, a method of using the sealed rapid diagnostic kit described above will be described in detail.

As shown in FIGS. 1 to 10, in the method of using the closed type rapid diagnostic kit of the present invention, a specimen is first inserted into the tube portion 40 and then screwed to the connection portion 30 to be coupled. At this time, the cover portion 10 is screwed to the other side of the connection portion 30, and the adapter 20 is coupled to the connection portion 11 of the cover portion 10. The reagent is stored in the cover 10.

When the tube portion 40 is coupled to the connection portion 30, the cover portion 10 is rotated in the open direction. The first stopper 12 of the cover portion 10 and the second stopper The sealing portion 22 which was in close contact with the blocking portion 33 of the opening and closing portion 32 is spaced apart from the blocking portion 33 by rotation (not further rotated by the stopper) .

When the user pushes the outside of the cover portion 10, the reagent in the cover portion 10 is transferred through the through hole 23 of the adapter 20, And is discharged to the outside through the through hole (23). At this time, the discharged reagent is blocked by the rib 34 of the opening / closing part 32 and can be transported only to the connection port 35 of the opening / closing part 32. The reagent penetrated through the connection port 35 passes through the tube part 40).

The reagent of the cover part 10 is simply and easily inserted into the tube part 40 and the cover part 10 is rotated in the closing direction when the insertion is completed so that the expanded through hole 23 of the sealing part 22 Is in close contact with the blocking portion 33 of the opening and closing portion 32 so that the specimen and the reagent in the tube portion 40 are not discharged through the connecting portion 30 to prevent secondary infection.

The specimen put into the tube part 40 is absorbed and transported through the strip type kit 53 of the kit part 50.

10: cover part 11: engaging part
12: first stopper 13: cover
14: Swap coupling port
20: Adapter 21: Short jaw
22: sealing part 23: through hole
24: insertion groove 25: storage groove
26: Filter
30: connection part 31: second stopper
32: opening and closing part 33:
34: ribs 35: ligature
36: engaging projection 37: engaging groove
38: Fixing projection
40: tube portion
50: kit part 51: kit body
52: Kit cover 53: Strip type kit
54: engaging hole 55: connecting groove

Claims (8)

The upper part is opened to be mixed with the reagent stored in the inside, the engaging part 11 is protruded from the lower part, and the engaging part 11 , A cover (10) having a first stopper (12) protruded so as not to be rotated at a predetermined interval or more upon rotation;
The outer circumferential portion is formed in a conical shape of a downwardly converging light so as to be integrally inserted into one side of the opened portion of the cover portion 10 and easily coupled to the inside of the cover portion 10, And the reagent conveyed from the cover portion 10 is temporarily stored in the storage groove 25 and the through hole 23 so that the reagent transferred from the cover portion 10 is temporarily stored and transferred. And a through hole (23) formed at a central portion of the sealing portion (22), the adapter (20) being formed in such a manner that an inner circumference of the through hole (23) is expanded downward;
An opening and closing part 32 for opening and closing the through hole 23 of the adapter 20 according to the rotation of the cover part 10 is provided at the center so that the cover part 10 and the tube part 40 are connected to each other, And a blocking portion 33 protruding from the central portion of the opening and closing portion 32 for blocking the through hole 23 by being closely inserted into the expanded through hole 23 of the sealing portion 22, A rib seal 34 is formed on one end surface of the opening and closing part 32 protruding from the blocking part 33 so as to surround the outer circumference of the sealing part 22 and prevent the reagent transferred through the through hole 23 from being discharged to the outside. A reagent conveyed through the through hole 23 of the adapter 20 penetrates through the opening and closing part 32 between the blocking part 33 and the rib 34 to be connected to the tube part 40 A connecting portion 30 on which the first and second electrodes 30 and 32 are formed;
A kit unit 50 coupled to a lower central portion of the connection unit 30 and provided in the tube unit 40 and having a strip type kit 53 coupled thereto;
A tube part 40 coupled to one side of the connection part 30 and having one side opened to communicate with the connection part 30 and storing the specimen and the reagent transferred through the connection part 30;
Wherein the second type of infection is capable of preventing secondary infection.
The method according to claim 1,
A second stopper 31 is protruded from the inner periphery of the connection portion 30 to which the cover portion 10 is coupled so as not to be rotated beyond a predetermined interval when the cover portion 10 is rotated, ) Is brought into contact with the first stopper (12) of the cover part (10) to control the turning radius of the cover part (10).
The method according to claim 1,
The other central portion of the opening / closing portion 32 has a coupling protrusion 36 formed at a center thereof with a coupling groove 37 protruding downward and a coupling hole 37 of the coupling protrusion 36, And a kit part provided in the tube part (40) is coupled to the second part to collect the second part.
The method of claim 3,
The kit part (50)
A coupling body 54 is formed at an end of the coupling protrusion 36 so as to be engaged with the coupling groove 37 of the coupling protrusion 36 and a coupling body 55 is formed to insert the strip- )Wow;
A kit cover 52 for covering the connection groove 55 of the kit body 51 to support the strip type kit 53;
A strip type kit 53 inserted into the connection groove 55 of the kit body 51 and having an end protruding outside the kit body 51 to directly contact the specimen stored in the tube part 40;
Wherein the second type of infection is capable of preventing secondary infection.
The method according to claim 1,
Wherein the lid (13) is screwed to open and close the inside of the cover part (10) on the opened upper side of the cover part (10).
6. The method of claim 5,
And a swap coupling (14) is protruded from the inner surface of the lid (13) so that a swab to be sampled is coupled to the inner surface of the lid (13).
The method according to claim 1,
A plurality of the cover portions 10 and the adapters 20 and the connection portions 30 are continuously formed in such a manner that the cover portions 10 are connected to the lower side portions of the connection portions 30, And a tubular portion (40) is connected to an end of the tubular portion (40), so that a plurality of reagents can be provided.
The method according to claim 1,
Wherein a filter (26) is formed in the storage groove (25) of the adapter (20) so as to filter foreign substances contained in the sample transferred from the cover part (10).

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