CN112263862A - Sample preservation liquid bottle, sample slide device and cell pretreatment method - Google Patents
Sample preservation liquid bottle, sample slide device and cell pretreatment method Download PDFInfo
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- CN112263862A CN112263862A CN202011074179.7A CN202011074179A CN112263862A CN 112263862 A CN112263862 A CN 112263862A CN 202011074179 A CN202011074179 A CN 202011074179A CN 112263862 A CN112263862 A CN 112263862A
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- liquid bottle
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- bottle
- chamber
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- 239000007788 liquid Substances 0.000 title claims abstract description 53
- 238000004321 preservation Methods 0.000 title claims abstract description 19
- 238000002203 pretreatment Methods 0.000 title abstract description 5
- 238000005070 sampling Methods 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 9
- 239000000523 sample Substances 0.000 claims description 21
- 239000007853 buffer solution Substances 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 2
- 239000012488 sample solution Substances 0.000 claims description 2
- 239000003761 preservation solution Substances 0.000 abstract description 5
- 239000012535 impurity Substances 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000003097 mucus Anatomy 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000010902 straw Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000003693 cell processing method Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000002558 medical inspection Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
- B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
- B01D29/03—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements self-supporting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
- G01N2001/4088—Concentrating samples by other techniques involving separation of suspended solids filtration
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention provides a sample preservation liquid bottle, comprising: the device comprises a tube body, a filter screen and a liquid bottle body; the liquid bottle body is internally provided with a tube body and a filter screen, and the filter screen divides the liquid bottle body into a first cavity and a second cavity; the filter screen is positioned at the bottom of the first cavity, and the pipe body is connected with the filter screen; the upper bottom of the tube body is provided with an easy-to-puncture part, so that the tube body is in a closed state in the process of not sampling; after the top cover of the liquid bottle body is screwed tightly, a gap is reserved between the top cover and the top of the tube body. The invention provides a sample slide device, which comprises a sample preservation liquid bottle. The invention provides a cell pretreatment method, which uses the sample preservation solution bottle to carry out cell pretreatment. The invention adopts the technical characteristic that a gap is left between the bottle cap of the sample preservation liquid bottle and the tube body after the bottle cap of the sample preservation liquid bottle is screwed tightly, so that the part easy to puncture is not polluted by the outside, and the near authenticity of the sample is kept.
Description
Technical Field
The invention relates to the technical field of biological inspection, in particular to a sample preservation liquid bottle, a sample sheet making device and a cell processing method, and particularly relates to a sample preservation liquid bottle.
Background
At present, the application range of medical inspection technology in disease screening and detection is wider and wider, and the processing before inspection is important except for the requirement on the accuracy of instruments. The screening of liquid-based cells includes: sampling by a cell brush, storing a sample, pretreating the sample, preparing and dyeing a slide, and scanning microscopic examination. Since cells collected by a cytobrush often contain impurities such as mucus, large cell aggregates, etc., the prior art methods of slide preparation often require pretreatment of the sample. The most common method is to transfer the sample from a preservation liquid cup to a centrifugal device, add the gradient centrifugate and achieve the purpose of separating impurities through multiple centrifugations. This operation is time consuming and laborious and increases the risk of contamination. If the sample is not pretreated, the prepared smear has dense impurities and uneven cell distribution, which is not beneficial to observing the cell morphology.
Through the retrieval, patent document CN209609670U discloses a body and filter equipment, filter equipment is used for filtering the foreign matter, filter equipment sets up in the inside of body to divide into first holding chamber and second holding chamber with the inside of body, during the sample, first holding intracavity is arranged in to the cervical brush, the second holding intracavity is arranged in to the straw, the filter screen blocks foreign matters such as mucus or leucorrhea in first holding chamber, the cell passes in the filter screen gets into in the second holding chamber, the straw is taken a sample in the second holding intracavity. However, the prior art has the disadvantages that the filter screen is arranged at one side of the bottle body, and the cells have higher specific gravity and can settle at one side of the bottom of the bottle body, so that a considerable number of cells cannot be taken during sampling, and the sampling representativeness is reduced, and even the missed detection is caused. Patent document CN205562242U discloses a cup body and a cup cover or a cup plug matched with the cup body, wherein a filter device is arranged in the cup body, which is disadvantageous in that the design of sleeve type is disadvantageous, the sleeve needs to be lifted up to take out a cytobrush during sampling, and operation steps are increased, and the cup is especially not favorable for full-automatic sample pretreatment. And cross contamination is easily caused in the process of lifting the sleeve, and the accuracy of a detection result is influenced.
Disclosure of Invention
In view of the above-mentioned problems, it is an object of the present invention to provide a specimen preservation solution bottle, a specimen slide device, and a method for pretreating cells, in which the bottle body is combined with a tube body by a filter, so that a specimen can be filtered and sampled without pouring out a liquid and removing a cell brush.
According to the present invention there is provided a specimen preservation liquid bottle comprising: the device comprises a tube body, a filter screen and a liquid bottle body;
the liquid bottle body is internally provided with a tube body and a filter screen, and the filter screen divides the liquid bottle body into a first cavity and a second cavity; the filter screen is positioned at the bottom of the first cavity, and the pipe body is connected with the filter screen; the upper bottom of the tube body is provided with an easy-to-puncture part, so that the tube body is in a closed state in the process of not sampling;
when the top cover of the liquid bottle body is screwed tightly, a gap or no gap is left between the top cover and the top of the tube body.
Preferably, a cyclic structure is also included; the filter screen passes through annular structure and liquid bottle body fastening connection, and annular structure adopts following arbitrary one form to form:
-a caulking groove snap form;
-widening the screen casing;
the height of the ring structure is greater than a set threshold.
Preferably, the top of the first cavity and the second cavity is opened upwards, the first cavity is used for placing a cell brush, and the second cavity is used for containing cell sap to be sampled.
Preferably, the top of the second cavity is connected with the filter screen, and the top of the second cavity is provided with an opening communicated with the pipe body.
Preferably, the bottom of the first chamber is connected with a filter screen, and the cells in the first chamber can only be collected into the second chamber through the filter screen.
Preferably, the top openings of the first and second cavities are located below the liquid level, and the filter screen is located below the liquid level.
Preferably, the inner wall of the second cavity is coated with a buffer solution, so that the cell sampling solution does not remain on the inner wall of the cavity.
Preferably, when the pipe body is positioned at the geometric center of the filter screen, the bottom of the second cavity is in a conical structure, and the conical structure can be used for enriching settled cells; when the body was located one side of filter screen, the bottom of second cavity was the wedge structure, and the filter area of cell sampling liquid can be increaseed to the wedge structure.
According to the invention, the sample slide device comprises the sample preservation liquid bottle.
According to the cell pretreatment method provided by the invention, the sample preservation solution bottle is used for cell pretreatment.
Compared with the prior art, the invention has the following beneficial effects:
1. after the bottle cap of the sample preservation liquid bottle is screwed, the technical characteristic that a gap is reserved between the bottle cap and the tube body is adopted, so that the part easy to puncture is not polluted by the outside, and the near authenticity of the sample is kept.
2. Through set up easy puncture portion on the body, can not pour out the cell sap and can carry out the puncture sample to prevent the secondary pollution in the cell sap transportation process.
3. Through setting up and placing the cytobrush in first cavity, can be under the condition of not taking out the cytobrush, can carry out sample preliminary treatment, be convenient for realize the full automatization sample of machine.
4. Through making the bottle utilize the combination of filter screen and body to can filter and sample the sample under the condition of not pouring out liquid and taking out the cell brush.
5. Through adopting the filter screen for the preservation liquid bottle has the function of filtering the impurity of desquamation cell sample. Avoid pouring out liquid and filter, reduced the risk that the cell sample is polluted by external environment in the bottle.
Drawings
Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:
fig. 1 is a schematic view of the overall structure of a specimen preservation solution bottle.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that it would be obvious to those skilled in the art that various changes and modifications can be made without departing from the spirit of the invention. All falling within the scope of the present invention.
As shown in fig. 1, the specimen preservation liquid bottle according to the present invention includes an easy puncture portion 1101, a tube 1102, a filter 1103, a liquid bottle main body 1104, a first cavity 1105, a second cavity 1106, and an insertion groove 1107, wherein the filter 1103 and the tube 1102 are disposed in the liquid bottle main body 2, and the filter 1103 and the tube 1102 divide the liquid bottle main body 1104 into the first cavity 1105 and the second cavity 1106.
As can be seen, the top of the first chamber 1105 and the second chamber 1106 are open upward, the first chamber 1105 is used for placing a cell brush, and the second chamber 1106 is used for containing the cell fluid to be sampled. The top end opening of the pipe 1102 is closed by the easy-piercing portion 1101, and cells in the first chamber 1105 can be collected into the second chamber 1106 only through the mesh 1103.
The openings of the first chamber 1105 and the second chamber 1106 are located below the liquid level, and the sieve 1103 is located below the liquid level; when the sampling needle pierces the pierceable portion 1101, it enters the second cavity 1106 through the tube 1102, and the settled cells are aspirated.
The caulking groove 1107 that the liquid bottle body 1104 set up and the frame looks joint of filter screen 1103 for it is fixed, guarantee that body 1102 does not take place the skew when the atress.
As shown in fig. 1, the pipe 1102 is located at the geometric center of the screen 1103 and is detachably connected; the top of the second chamber 1106 is connected to the screen 1103, and the top of the second chamber has an opening communicating with the pipe 1102. When the pipe 1102 is located in the center of the filter screen 1103, the bottom of the second chamber 1106 is a tapered structure, and the tapered structure is used for enriching settled cells, thereby facilitating the suction of the reagent needle.
The easy-to-pierce portion 1101 is an aluminum foil easy to pierce by a sampling needle,
the invention also provides a sample slide device which comprises the sample preservation liquid bottle.
Furthermore, the invention also provides a cell pretreatment method, which uses the sample preservation solution bottle to carry out cell solution pretreatment.
The following are the present inventionPreferred embodiment(s) of the inventionAs will be further explained.
The inner wall of the second chamber 1106 may be coated with a buffer solution, so that the cell sample solution does not remain on the inner wall of the chamber.
The optimal scheme is that the included angle between the section of the conical structure at the bottom of the second cavity 1106 and the bottom of the liquid bottle body 1104 is 60 degrees.
The aperture of the filter screen is between 20 meshes and 100 meshes, and 60 meshes is preferably adopted.
The following are the present inventionVariation exampleAs will be further explained.
In the invention, the filter screen 1103 is fixedly connected with the liquid bottle body 1104 and can adopt a caulking groove clamping form; the outer frame of the filter screen can be widened to form a ring structure with a certain height, and the ring structure is pressed and contacted with the liquid bottle body 1104 to achieve the purpose of fixing. Wherein, the height of the annular structure is larger than a set threshold value.
The pipe 1102 and the filter screen 1103 can be integrally formed into a whole, welded and adhered, or embedded in a groove to form a detachable connection structure.
The working principle is as follows:
medical staff samples the back with the cell brush, places the cell brush on filter screen 1103, and through shaking the dissolution, the cell that subsides of dispersion passes through filter screen 1103 and gets into second cavity 1106, and the cell enrichment is gone up to the substructure of second cavity 1106. During sampling, the reagent needle pierces the easy-to-pierce portion 1101, and enters the second cavity 1106 through the tube 1102, so as to aspirate a sufficient amount of cells from the bottom and transfer the slide.
The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes or modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention. The embodiments and features of the embodiments of the present application may be combined with each other arbitrarily without conflict.
Claims (10)
1. A specimen holding fluid bottle, comprising: the device comprises a pipe body (1102), a filter screen (1103) and a liquid bottle body (1104);
a tube body (1102) and a filter screen (1103) are arranged in the liquid bottle body (1104), and the filter screen (1103) divides the liquid bottle body (1104) into a first cavity (1105) and a second cavity (1106);
the filter screen (1103) is positioned at the bottom of the first cavity (1105), and the pipe body (1102) is connected with the filter screen (1103);
the upper bottom of the tube body (1102) is provided with an easy-to-puncture part (1101) so that the tube body (1102) is in a closed state in the non-sampling process;
when the top cover of the liquid bottle body (1104) is screwed tightly, a gap or no gap is left between the top cover and the top of the tube body (1102).
2. The specimen holding liquid bottle according to claim 1, further comprising a ring structure;
the filter screen (1103) is fixedly connected with the liquid bottle body (1104) through an annular structure;
the ring structure is formed by adopting any one of the following forms:
-a caulking groove snap form;
-widening the screen casing;
the height of the ring-shaped structure is greater than a set threshold.
3. The specimen preservation liquid bottle according to claim 1, characterized in that the top of the first cavity (1105) and the second cavity (1106) are opened upward, the first cavity (1105) is used for placing a cell brush, and the second cavity (1106) is used for containing the cell liquid to be sampled.
4. The bottle of claim 3, wherein the top of the second chamber (1106) is connected to a screen (1103), and the top of the second chamber (1106) is provided with an opening communicating with the tube (1102).
5. A bottle as claimed in claim 3, wherein the bottom of the first chamber (1105) is connected to a screen (1103), and the cells in the first chamber (1105) can only be collected into the second chamber (1106) through the screen (1103).
6. The bottle of claim 1, wherein the top openings of the first chamber (1105) and the second chamber (1106) are located below the liquid level, and the screen (1103) is located below the liquid level.
7. The bottle of claim 1, wherein the second chamber (1106) has a buffer solution applied to the inner wall thereof to prevent the sample solution from remaining on the inner wall.
8. The bottle of claim 4, wherein when the tube (1102) is located at the geometric center of the screen (1103), the bottom of the second chamber (1106) is in a tapered structure, and the tapered structure can be used for enriching settled cells; when body (1102) was located one side of filter screen (1103), the bottom of second cavity (1106) was the wedge structure, and the filter area of cell sample liquid can be increaseed to the wedge structure.
9. A specimen-producing device comprising the specimen-holding liquid bottle according to any one of claims 1 to 8.
10. A method for pretreating cells, comprising the step of pretreating cells with the use of the specimen-retaining liquid bottle according to any one of claims 1 to 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011074179.7A CN112263862A (en) | 2020-10-09 | 2020-10-09 | Sample preservation liquid bottle, sample slide device and cell pretreatment method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011074179.7A CN112263862A (en) | 2020-10-09 | 2020-10-09 | Sample preservation liquid bottle, sample slide device and cell pretreatment method |
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| Publication Number | Publication Date |
|---|---|
| CN112263862A true CN112263862A (en) | 2021-01-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011074179.7A Pending CN112263862A (en) | 2020-10-09 | 2020-10-09 | Sample preservation liquid bottle, sample slide device and cell pretreatment method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113358445A (en) * | 2021-06-01 | 2021-09-07 | 南京九川科学技术有限公司 | Suspension dyeing method of liquid-based cells |
| CN113740136A (en) * | 2021-11-05 | 2021-12-03 | 北京艾科瑞医学生物技术有限公司 | Device and method for pretreating tubercle bacillus to-be-detected sample |
| CN114891612A (en) * | 2022-05-25 | 2022-08-12 | 深圳市疾病预防控制中心（深圳市卫生检验中心、深圳市预防医学研究所） | Isolated virus sampling tube and use method thereof |
| CN116920972A (en) * | 2023-07-19 | 2023-10-24 | 深路医学科技(武汉)有限公司 | Sample bottle |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113358445A (en) * | 2021-06-01 | 2021-09-07 | 南京九川科学技术有限公司 | Suspension dyeing method of liquid-based cells |
| CN113740136A (en) * | 2021-11-05 | 2021-12-03 | 北京艾科瑞医学生物技术有限公司 | Device and method for pretreating tubercle bacillus to-be-detected sample |
| CN114891612A (en) * | 2022-05-25 | 2022-08-12 | 深圳市疾病预防控制中心（深圳市卫生检验中心、深圳市预防医学研究所） | Isolated virus sampling tube and use method thereof |
| CN116920972A (en) * | 2023-07-19 | 2023-10-24 | 深路医学科技(武汉)有限公司 | Sample bottle |
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Application publication date: 20210126 |
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| RJ01 | Rejection of invention patent application after publication |