CN216366349U

CN216366349U - Filter sleeve for photodynamic therapy under endoscope

Info

Publication number: CN216366349U
Application number: CN202122265280.7U
Authority: CN
Inventors: 张兵; 王宏志; 程庭清; 梁敏; 储焰南
Original assignee: Hefei Institutes of Physical Science of CAS
Current assignee: Hefei Institutes of Physical Science of CAS
Priority date: 2021-09-17
Filing date: 2021-09-17
Publication date: 2022-04-26
Anticipated expiration: 2031-09-17

Abstract

The utility model discloses a light filtering sleeve for photodynamic therapy under an endoscope; the method comprises the following steps: optical filter, sleeve pipe. One end of the sleeve is connected with the optical filter; the other end of the sleeve is used for being connected with the front end of an endoscope; the optical filter is used for filtering light with specific wavelength; the optical filter is provided with a first through hole through which an optical fiber in the endoscope can penetrate. The light filtering sleeve can filter background light caused by laser emitted from the optical fiber, filter interference of treatment laser on optical imaging, and obtain clear optical images through an endoscope in the treatment process, so that doctors can conveniently operate and treat the optical images, the operation difficulty is reduced, the operation precision is improved, and the treatment effect is greatly improved.

Description

Filter sleeve for photodynamic therapy under endoscope

Technical Field

The utility model relates to the technical field of photodynamic therapy, in particular to a light filtering sleeve for photodynamic therapy under an endoscope.

Background

Photodynamic Therapy (PDT) is applied to tumor treatment, and is a non-invasive treatment method for selectively killing tumor cells. Compared with the traditional operation, radiotherapy and chemotherapy, the traditional Chinese medicine composition has the characteristics of minimal or no wound, targeted therapy, high applicability, repeatability, no drug resistance and the like. During treatment, a photosensitive medicament is externally applied or injected intravenously, the photosensitive medicament can be selectively, high-concentration and long-time gathered in tumor tissues, most of photosensitizers in normal tissues can be discharged out of the body within 24-48 hours, then specific wavelength laser, namely treatment laser, corresponding to the photosensitizers is adopted to irradiate the tumor tissues within a certain time interval, the photosensitizers which are retained in the tumor tissues absorb the laser energy of the treatment laser, a series of chemical withdrawal reactions are carried out to generate singlet oxygen or free radicals with strong activity, the products can kill tumor cells, the tumor tissues are changed into necrotic tissues, and then the necrotic tissues are stripped, shed or absorbed by the body. Photodynamic therapy requires three basic components: oxygen, photosensitizer, visible light, i.e. therapeutic laser.

When the photodynamic therapy is carried out on the tumor tissue in the body, an endoscope technology is needed to be adopted, the medical laser optical fiber is sent to a focus part, the optical fiber is sent to the focus tissue in the body through the endoscope, the optical fiber emits the treatment laser and irradiates the focus tissue, in the laser irradiation process, an operating doctor is needed to continuously observe the focus tissue, and an optical image is obtained through the endoscope, so that the focus tissue is observed, the transmitting end of the optical fiber is observed, and the irradiation position of the laser is adjusted. Currently, commonly used endoscopes include electronic endoscopes and fiberscope endoscopes. The endoscope mostly adopts the modes of white light irradiation and optical imaging to obtain an in-vivo optical image in real time. However, when the optical fiber emits laser outwards to irradiate tumor tissue, under the irradiation of high-brightness and high-intensity laser, a strong background light is generated, so that a clear optical image cannot be obtained through an endoscope, an optical image in the treatment process cannot be displayed on a monitor, and focal tissues in the treatment process and the emission end of the optical fiber cannot be observed. In the prior art, in order to solve the problem, the treatment needs to be stopped every 1-3 min in the treatment process, namely, the outward laser of the optical fiber is cut off every 1-3 min, so that the change of focal tissues is observed and correspondingly adjusted, the operation difficulty is increased, the operation precision is reduced, and the treatment effect is greatly reduced.

SUMMERY OF THE UTILITY MODEL

In order to overcome the defects in the prior art, the utility model provides the light filtering sleeve for photodynamic therapy under the endoscope, which can filter background light caused by laser emitted outwards by the optical fiber, filter the interference of the therapeutic laser on optical imaging, and still can obtain clear optical images through the endoscope in the treatment process, thereby helping doctors to operate and treat more conveniently, reducing the difficulty of the operation, improving the accuracy of the operation and greatly improving the treatment effect.

In order to achieve the purpose, the utility model adopts the following technical scheme that:

an optical filtering cannula for use in endoscopic photodynamic therapy, comprising: optical filter, sleeve;

one end of the sleeve is connected with the optical filter; the other end of the sleeve is used for being connected with the front end of an endoscope;

the optical filter is used for filtering light with specific wavelength;

the optical filter is provided with a first through hole through which an optical fiber in the endoscope can penetrate.

The optical filter consists of a transparent substrate and a filter film plated on the end face of the transparent substrate, and the filter film is used for filtering light with a specific wavelength;

light of a particular wavelength is referred to as: light of the same wavelength as the laser light emitted by the optical fiber in the endoscope.

The two end faces of the transparent substrate of the optical filter are respectively plated with optical filter films, and the optical filter films plated on the two end faces have different filtering wavelengths and are used for filtering light with two different wavelengths.

One end of the sleeve is connected with a plurality of optical filters; the optical filters are arranged along the axial direction to form an optical filter group for filtering a plurality of light with different wavelengths.

The first through hole is aligned with an optical fiber penetrating and exiting port on the front end of the endoscope.

The value range of the hole diameter d1 of the first through hole is 1 mm-4 mm.

The side wall of the sleeve is provided with at least 1 second through hole.

The optical filter is clamped and fixed at one end of the sleeve, and a groove for clamping the optical filter is formed in the inner wall of the end, connected with the optical filter, of the sleeve in the circumferential direction.

The optical filter is clamped and fixed at one end of the sleeve, and steps for clamping the optical filter are arranged on the edge of the optical filter.

The utility model has the advantages that:

(1) the light filtering sleeve is arranged at the front end of the endoscope, can filter background light caused by laser emitted outwards by the optical fiber, can obtain clear optical images through the endoscope in the treatment process, does not need to stop treatment every 1-3 min in the treatment process, reduces the difficulty of the operation, improves the operation precision, and greatly improves the treatment effect.

(2) The filtering sleeve provided by the utility model selectively filters the interference of the treatment laser on optical imaging by adopting a narrow-band filtering mode on the treatment laser, and can obtain clear real-time images under the irradiation of white light, thereby helping doctors to operate and treat more conveniently.

(3) The filter sleeve can be used for filtering two lights with different wavelengths and meeting the use requirements of different photodynamic laser light sources by selectively plating two different narrow-band total reflection films, namely filter films, on two end faces of a transparent substrate of the optical filter aiming at different light sources.

(4) The filter sleeve can select a plurality of filters to be arranged axially to form a filter set aiming at more light sources with different wavelengths, and is used for filtering a plurality of light with different wavelengths, so that the use of more photodynamic laser light sources is met.

(5) The light filtering sleeve pipe is simple and convenient to mount and dismount, can be used for one time, and can be reused after being sterilized.

(6) According to the light filtering sleeve, the through holes with the thickness of 1 mm-4mm are formed in the light filter, so that the optical fibers with different specifications can pass through and be used.

(7) According to the light filtering sleeve, the second through hole for discharging liquid is formed in the side wall of the sleeve, so that doctors can operate and treat the light filtering sleeve more conveniently.

Drawings

Fig. 1 is an overall schematic view of a filter sleeve for endoscopic photodynamic therapy.

Fig. 2 is a schematic diagram of a filter sleeve including a plurality of filters.

FIG. 3 is a first schematic diagram of the connection between the filter and the sleeve.

FIG. 4 is a second schematic diagram of the connection between the filter and the sleeve.

Reference numerals

11-optical filter, 12-sleeve, 2-endoscope, 21-endoscope front end, 3-optical fiber, 111-first through hole,

121-second through hole, 211-fiber through hole 211, 13-groove, 14-step

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

As shown in fig. 1, a filter sleeve for endoscopic photodynamic therapy comprises: filter 11, sleeve 12.

The optical filter 11 is arranged at one end of the sleeve 12; the other end of the sleeve 12 is used for being connected with the endoscope front end 21, namely, the other end of the sleeve 12 is sleeved on the endoscope front end 21.

The optical filter 11 is used for filtering light with a specific wavelength, that is, filtering background light, and the background light is transmitted to the endoscope front end 21 after being filtered by the optical filter 11.

The optical filter 11 is provided with a first through hole 111 through which the optical fiber 3 in the endoscope 2 can penetrate; the first through hole 111 is aligned with the optical fiber through-out port 211 on the endoscope front end 21;

the hole diameter d1 of the first through hole 111 is more than or equal to d2+ a; where d2 is the diameter of fiber 3; a is a set threshold value, and the value range of a is 0.5mm-4 mm. Or, the value range of the hole diameter d1 of the first through hole 111 is directly set to be 1mm to 4 mm.

The optical filter 11 is composed of a transparent substrate and a filter film plated on the end face of the transparent substrate, the filter film is a narrow-band total reflection film, the transparent substrate can be a glass sheet, the thickness of the transparent substrate is 0.5 mm-3 mm, and the transparent substrate is used for filtering light with a specific wavelength, namely background light.

Light of a particular wavelength is referred to as: the same wavelength as the treatment laser, i.e. the same wavelength as the laser emitted by the optical fiber 3 in the endoscope 2.

Both end faces of the transparent substrate of the optical filter 11 may be plated with optical filter films, and if the optical filter films plated on both end faces have different filtering wavelengths, light with two different wavelengths can be filtered.

As shown in fig. 2, the filter sleeve may further include a plurality of filters 11, and the filters 11 are axially arranged to form a filter set, and the filter set is disposed at one end of the sleeve 12. The filter films coated on the end faces of the transparent substrates of the optical filters 11 have different filtering wavelengths, and the optical filters 11 are arranged along the axial direction to form a filter set, so that light with various wavelengths can be filtered. Wherein, two end faces of the transparent substrate of the plurality of optical filters 11 can be selected to be coated with a filter film on one end face or coated with a filter film on both end faces; the plurality of filters 11 may be attached to each other or not attached to each other in the axial direction. Fig. 2 shows a filter set in which three filters 11 are arranged in the axial direction.

One or more second through holes 121 for discharging liquid are opened on the side wall of the sleeve 12.

As shown in fig. 3, the optical filter 11 or the optical filter set may be selectively fixed in one end of the sleeve 12 in a clamping manner, and a groove 13 for fixing the optical filter 11 or the optical filter set in a clamping manner is circumferentially arranged on an inner wall of one end of the sleeve 12 connected to the optical filter 11.

Alternatively, as shown in fig. 4, the optical filter 11 or the optical filter set is fixed to one end of the sleeve 12 in a snap-fit manner, and steps 14 for fixing the optical filters 11 and the sleeve 12 in a snap-fit manner are provided on the edge of the optical filter 11 along the circumferential direction.

A filter tube sleeve for photodynamic therapy under an endoscope is arranged on the front end 21 of the endoscope, and the output end of the filter tube sleeve, namely an optical filter 11 or the output end of a filter set, namely the output end of a filter film, faces towards the front end 21 of the endoscope. The filter tube sleeve can filter out light with specific wavelength.

When treating internal tumour tissue, adopt the scope technique, optic fibre 3 sends into internal focus tissue department through scope 2, treatment laser is launched to optic fibre, and shine and put focus tissue, among the laser irradiation process, need the operation doctor constantly to observe focus tissue, acquire optical image through scope 2, thereby observe focus tissue and observe the transmitting terminal of optic fibre 3, thereby adjust the irradiation position of laser, but because optic fibre 3 outwards launches laser, at hi-lite, under the laser irradiation of high strength, cause a very strong background light, can't obtain clear optical image through scope 2, thereby can't observe focus tissue and observe the transmitting terminal of optic fibre 3. In the prior art, in order to solve the problem, the treatment needs to be stopped every 1-3 min in the treatment process, namely, the outward-emitting laser of the optical fiber 3 is cut off every 1-3 min, so that the change of the lesion tissues is observed and correspondingly adjusted. However, in the present invention, the front end 21 of the endoscope 2 is provided with a filter sleeve, and the filter on the filter sleeve can filter out the background light caused by the laser emitted from the optical fiber 3, so that a clear optical image can be obtained through the endoscope 2.

The utility model is not to be considered as limited to the specific embodiments shown and described, but is to be understood to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the utility model as defined by the appended claims.

Claims

1. An optical filtering sleeve for use in endoscopic photodynamic therapy, comprising: a filter (11) and a sleeve (12);

one end of the sleeve (12) is connected with the optical filter (11); the other end of the sleeve (12) is used for being connected with the front end (21) of the endoscope;

the optical filter (11) is used for filtering light with specific wavelength;

the optical filter (11) is provided with a first through hole (111) through which the optical fiber (3) in the endoscope (2) can penetrate.

2. The filter sleeve for the photodynamic therapy under endoscope according to the claim 1, wherein the filter (11) is composed of a transparent substrate and a filter film coated on the end surface of the transparent substrate, the filter film is used for filtering the light with specific wavelength;

light of a particular wavelength is referred to as: the light has the same wavelength as the laser light emitted by the optical fiber (3) in the endoscope (2).

3. A filter sleeve for use in photodynamic therapy under endoscope according to claim 2, wherein the two end faces of the transparent substrate of the filter (11) are coated with respective filter films, and the filter films coated on the two end faces have different filter wavelengths for filtering out light with two different wavelengths.

4. A filter sleeve for use in photodynamic therapy under an endoscope according to claim 2 or 3, wherein one end of said sleeve (12) is connected to a plurality of filters (11); the optical filters (11) are axially arranged to form an optical filter group for filtering a plurality of light with different wavelengths.

5. A filter sleeve for use in photodynamic therapy under an endoscope according to claim 1, wherein said first through hole (111) is aligned with a fiber passage opening (211) in a front end (21) of the endoscope.

6. The filter sleeve for the photodynamic therapy under endoscope according to claim 1 or 5, characterized in that the hole diameter d1 of the first through hole (111) has a value in the range of 1mm to 4 mm.

7. An endoscopic photodynamic therapy filter sleeve according to claim 1, wherein said sleeve (12) has at least 1 second through hole (121) formed in a side wall thereof.

8. The filter sleeve for the photodynamic therapy under the endoscope according to claim 1, wherein the filter (11) is fixed on one end of the sleeve (12) in a clamping manner, and a groove (13) for clamping the filter (11) is arranged on the inner wall of one end of the sleeve (12) connected with the filter (11) along the circumferential direction.

9. A filter sleeve for photodynamic therapy under an endoscope according to claim 1, wherein the filter (11) is fixed on one end of the sleeve (12) in a clamping manner, and a step (14) for clamping the filter (11) is arranged on the edge of the filter (11).