WO2019128417A1

WO2019128417A1 - Pdt mask plate and pdt endoscope body

Info

Publication number: WO2019128417A1
Application number: PCT/CN2018/111381
Authority: WO
Inventors: 董二伟; 冯能云; 陈云亮
Original assignee: 深圳开立生物医疗科技股份有限公司
Priority date: 2017-12-27
Filing date: 2018-10-23
Publication date: 2019-07-04
Also published as: CN108066894A; CN108066894B

Abstract

The present invention relates to a PDT mask plate and a PDT endoscope body. A PDT mask plate, the PDT mask plate being provided with a first color block; the first color block is plated with a narrowband optical film , and has an optical index as follows: the first color block transmits through a cut-off in a 400 nm to 600 nm band and the cut-off depth is greater than OD4; the transmittance of the first color block in a 617 nm to 647 nm band is 0.1<t<1%; the first color block transmits through a cut-off in a 660 nm to 1100 nm band and the cut-off depth is greater than OD4. The PDT mask plate of the present invention is provided with the first color block which is plated with the narrowband optical film, and the first color block has a special optical index with respect to a PDT treatment band, that is, the transmittance of the first color block with respect to treatment light and illumination light is low, such that overexposure of an image of a photographed object is avoided without reducing the irradiation intensity of PDT treatment light, and real-time visualization of a PDT treatment process is ensured while avoiding the extension of irradiation time of PDT treatment light.

Description

PDT mask and PDT mirror body

The present application claims priority to Chinese Patent Application No. 200911443852.8, entitled "PDT Masking Plate and PDT Mirror Body", filed on December 27, 2017, the entire contents of In this application.

Technical field

The invention relates to a PDT mask and a PDT mirror.

Background technique

Photodynamic Therapy (PDT) has proven to be an effective treatment for malignant tumors and precancerous lesions. The clinical operation of PDT consists of the following two main steps: (1) intravenous injection of photosensitizer into the patient, after being metabolized in the human body for several hours or tens of hours, enriched in the lesion tissue; (2) based on photosensitizer The spectral absorption characteristic is to illuminate the lesion tissue with a specific band and a corresponding dose of therapeutic light. The principle of PDT treatment of tumors is as follows: after the photosensitizer molecules enriched in the lesion tissue absorb photons, the energy state changes from steady state to high energy state, and the energy is transferred to the oxygen molecules (three-state oxygen 3O2) in the biological tissue, so that Activated to form singlet oxygen (1O2) and superoxide anion radical (O2-), the latter two have a strong destructive effect on a variety of biological macromolecules in tumor cells, resulting in tumor necrosis, apoptosis, tumor tissue The microvascular endothelium is damaged and forms a microthrombus, which ultimately achieves the purpose of destroying the tumor tissue.

The therapeutic light used in the treatment of tumors by PDT can be irradiated into the intraluminal tumor tissue through the light guiding fibers, for example, in the patent document WO2002007629A1. Moreover, PDT can also be combined with an endoscope to monitor the treatment process of the tumor in the cavity in real time. When combined with the endoscope, the therapeutic light of the PDT can be through the special light guiding fiber for PDT treatment, and the surgical instrument channel extends through the endoscope. The body cavity is irradiated to the tumor tissue, such as patent documents JP2006130183A, JP2005080836A, JP2008125821A, CN101677755A, or integrated with the endoscope cold light source, so that the ordinary observation light and the PDT treatment light are transmitted to the endoscope through the light guiding optical fiber of the same endoscope. The lens end is subjected to intracavity irradiation as disclosed in JP2011067269A and JP2011167229A.

In actual treatment, the treatment time of PDT treatment is usually several tens of minutes. Therefore, real-time visual monitoring of PDT treatment process by endoscope can help medical staff to evaluate the treatment effect by observing changes in the tissue morphology of the lesion, and then quantitatively control it. It treats light dose and effectively reduces the risk of clinical treatment such as perforation and hemorrhage of mucosal tissue. However, the therapeutic optical power of PDT can usually reach 1-2W, and the optical power density can usually reach the order of 0.1W/cm2-1W/cm2 when the lesion area is irradiated at a close distance. Therefore, when PDT is combined with endoscope for intracavitary tumor treatment, It is often the case that the intensity of the therapeutic light reflected by the image received by the image sensor far exceeds the linear response range of the image sensor, resulting in overexposure of the image, which in turn makes it impossible to use the endoscope to monitor the adverse effects of the PDT treatment process in real time.

On the other hand, in the implementation of PDT treatment, a spot area capable of recognizing the treatment light is also needed to help the medical staff judge that the treatment light irradiation area accurately covers the diseased tissue. Therefore, the intensity of the treatment light reflected by the image received by the image sensor should not be too low, so that the human eye cannot accurately recognize the treatment spot irradiation area, which may cause the PDT treatment effect due to the spot irradiation area not accurately covering the lesion area. reduce.

The prior art separately proposes the following technical solutions to achieve the purpose of real-time monitoring of the PDT treatment process by using an endoscope. Further, some technical solutions can not only monitor the PDT treatment process in real time, but also identify the PDT treatment light irradiation area during PDT treatment.

In the patent document CN101677755A, there is proposed an image generating apparatus that provides an optical cut filter between a subject and an imaging section, and reflects a portion of the first wavelength band (for illumination) reflected on the object. The light of the second wavelength band is cut off; and at the same time, the compensation processing unit performs corresponding compensation processing on the image brightness and color loss caused by the optical cut filter at the second wavelength band.

In the patent document JP2011067269A, an endoscope apparatus is proposed in which an optical filter is disposed between a subject and an imaging unit to attenuate light in a therapeutic light band entering the imaging unit, thereby ensuring observation in ordinary light. The color of the image during PDT treatment and photodynamic fluorescence diagnosis is almost unaffected by PDT treatment light.

In the patent document JP2008125821A, an endoscope apparatus is proposed which quantitatively controls an image sensor during an electronic shutter opening time by controlling an electronic shutter time and a PDT treatment light on and off time in each frame period of an image. The received PDT treatment light reflected by the subject ensures that there is no overexposure of the reflected light image reflected by the subject due to excessive light intensity of the PDT treatment.

In the patent document JP2012065945A, an endoscope device is proposed which closes the PDT treatment light during the time when the electronic shutter is turned on by controlling the electronic shutter time and the PDT treatment light on and off time in each frame period of the image. And during this period, the guiding light (the wavelength and spot illumination area is the same as the treatment light, but the power is only on the order of milliwatts to indicate the position of the treatment spot) is turned on, thereby ensuring that PDT is not present during PDT treatment. If the treatment light intensity is too high, the reflected light image reflected by the object is overexposed, and at the same time, the guided light irradiation spot can be observed in the reflected light image reflected by the object, thereby helping the medical staff to timely judge the therapeutic light irradiation. Whether the position of the spot covers the lesion area, and based on this, it is judged whether or not the irradiation area of the PDT treatment light should be adjusted.

Patent Document CN101677755A proposes a method of providing an optical cutoff filter between a subject and an endoscope imaging unit, and turning off the light of the second wavelength band which is a part of the first wavelength band, but has the following problems:

(1) The claim of the patent mentions that the optical cut-off filter cuts off the light of the second wavelength band, that is, the reflected light of the object reflected into the second wavelength band of the image sensor of the image pickup unit. The intensity is almost zero. When the light of the second wavelength band is used as the PDT treatment light source, there is a problem that the treatment spot irradiation area cannot be observed by the reflected light image reflected by the subject, and thus the PDT may be caused by the PDT treatment spot not completely covering the lesion area. Treatment is difficult to achieve the desired results.

Patent Document JP2011067269A proposes a method of providing an optical filter between a subject and an endoscope imaging unit, and attenuating light in a therapeutic light band entering the imaging unit, but it is not clear that the optical filter is filtered. Light characteristics. This causes a problem that if the amount of light of the PDT treatment light in the reflected light reflected by the subject is too high, the structure details of the subject cannot be clearly observed in the reflected light image; or the reflected light reflected by the object The low amount of light in the PDT treatment light will result in the inability to clearly observe the illumination spot of the PDT treatment light in the reflected light image, which may result in a decrease in the therapeutic effect due to the fact that the spot of the PDT treatment light does not accurately cover the lesion area.

Patent document JP2008125821A and JP2012065945A both reduce the influence of PDT treatment light on the image by means of signal timing control, that is, controlling the PDT treatment reflected by the object received by the image sensor within the electronic shutter on time of one frame period. The amount of light. This signal control method has the following disadvantages:

(1) If the electronic shutter is turned on for a long time, the exposure time of the PDT treatment light is limited in one frame period, which will lead to prolonged PDT treatment time and increased surgical risk;

(2) If the electronic shutter opening time is short, the image brightness will be insufficient and the signal-to-noise ratio will be deteriorated.

In summary, current PDT treatments have problems with overexposure or inability to visualize.

Summary of the invention

In order to overcome the deficiencies of the prior art described above, it is an object of the present invention to provide a PDT mask and a PDT mirror.

The technical solution of the present invention is:

A PDT mask plate, the PDT mask plate is provided with a first color block; the first color block is plated with a narrow band light film system, and the optical index is: 400 nm-600 nm band transmission cutoff and cutoff depth > OD4, The transmittance in the 617 nm-647 nm band is 0.1 < t < 1%, and the 660 nm - 1100 nm band is cut off and the cut-off depth is > OD4.

A further technical solution is that the PDT mask is further provided with a second color block, a third color block and a fourth color block which are coated with a narrow strip light film system; and the optical index of the second color block is 400 nm-560 nm. Band pass cutoff and cutoff depth > OD2, 590nm transmittance > 45% and full width at half maximum > 20nm, 617nm-647nm band pass cutoff and cutoff depth > OD4, 670nm transmittance > 45% and full width at half maximum > 20nm, 700nm -1100nm band transmission cutoff and cutoff depth > OD2; optical index of the third color block is: 400nm-480nm band transmission cutoff and cutoff depth > OD2, 535nm transmittance > 65% and full width at half maximum <60nm, 617nm -647nm band through cutoff and cutoff depth > OD4, 650nm-1100nm band pass cutoff and cutoff depth > OD2; the fourth color block optical index is 450nm transmittance > 50% and full width at half maximum <60nm, 500nm- The 610 nm band has a cut-off and cut-off depth > OD2, the 617 nm-647 nm band passes through and the cut-off depth is > OD4, the 650 nm - 1100 nm band passes through and the cut-off depth > OD2.

A further technical solution is that the first color block, the second color block, the third color block, and the fourth color block are arranged in a 2×2 matrix.

A PDT mirror body includes: a body, an image sensor module disposed on the body; and the image sensor module is provided with the PDT mask board described above

A further technical solution is that the PDT mirror body further includes a first optical fiber for introducing therapeutic light, a second optical fiber for introducing illumination light, and the body is provided with a clamp hole for mounting the optical fiber for mounting Two optical fiber illumination light guide holes.

A further technical solution is that the number of the second optical fibers and the illumination light guiding holes is two.

A further technical solution is that the body is further provided with a water vapor nozzle at the end.

A further technical solution is that the therapeutic light is 632 nm ± 15 nm laser or narrow band LED light.

The technical effect of the present invention compared with the prior art is: a PDT mask, the PDT mask is provided with a first color block of a narrow strip light film system, and the first color block has a special optical index for the PDT treatment band. The transmittance of the therapeutic light and the illumination light is relatively low, and the image of the subject is prevented from being overexposed without reducing the intensity of the light irradiation of the PDT treatment, and the PDT treatment is ensured while avoiding prolonging the light irradiation time of the PDT treatment. Process real-time visualization.

Further, the PDT mask is provided with a second color block, a third color block, and a fourth color block which are plated with a narrow light film system, and the light intensity of the PDT therapeutic light band reflected by the object entering the imaging portion is appropriately reduced. On the one hand, it ensures that the image of the subject will not be overexposed due to the excessive light intensity of the PDT treatment, and on the other hand, it can display the spot irradiation area of the PDT treatment light in real time in the image of the subject, thereby contributing to the medical staff. Timely adjust the spot size and position of the PDT treatment light to accurately cover the lesion area of the subject to ensure the clinical effect of PDT treatment.

The invention is further described below in conjunction with the drawings and specific embodiments.

DRAWINGS

Figure 1 is a schematic view of a PDT mask;

2 is a schematic view of a PDT mirror body;

Figure 3 is a circuit block diagram of a PDT mirror body;

4 is a spectral characteristic diagram of a second, third, and fourth color block of a PDT mirror mask;

Figure 5 is a graph showing the spectral characteristics of a first color block of a PDT mirror mask.

Reference numeral

10 PDT mask 20 PDT mirror

1 first color block 2 second color block

3 third color block 4 fourth color block

5 body 51 clamp hole

52 Lighting light guide hole 53 Water vapor nozzle

6 image sensor module

Detailed ways

In order to more fully understand the technical content of the present invention, the technical solutions of the present invention are further described and illustrated in conjunction with the schematic drawings, but are not limited thereto.

A PDT mask is provided with a first color block. The first color block is coated with a narrow strip light film system, and its optical index is: 400nm-600nm band transmission cutoff and cutoff depth>OD4, 617nm-647nm band transmittance is 0.1<t<1%, 660nm-1100nm band transmission cutoff And the cutoff depth is > OD4.

As shown in FIG. 1, a PDT mask 10 is provided with a first color block 1, a second color block 2, a third color block 3, and a fourth color block 4.

The first color block 1 is coated with a narrow strip optical film system, and its optical index is: 400 nm-600 nm band transmission cutoff and cut-off depth > OD4, 617 nm-647 nm band transmittance is 0.1 < t < 1%, 660 nm - 1100 nm band transmission Cutoff and cutoff depth > OD4.

The optical index of the second color patch 2 is: 400 nm to 560 nm band transmission cutoff and cutoff depth > OD2, 590 nm transmittance > 45% and full width at half maximum > 20 nm, 617 nm - 647 nm band transmission cutoff and cutoff depth > OD4, 670 nm The transmittance is >45% and the full width at half maximum is >20 nm, and the pass wavelength of the 700 nm-1100 nm band is cut off and the cutoff depth is >OD2.

The optical index of the third color block 3 is: 400 nm to 480 nm band transmission cutoff and cutoff depth > OD2, 535 nm transmittance > 65% and full width at half maximum < 60 nm, 617 nm - 647 nm band transmission cutoff and cutoff depth > OD4, 650 nm -1100 nm band pass cutoff and cutoff depth > OD2.

The optical index of the fourth color block 4 is 450 nm transmittance >50% and half-height full width <60 nm, 500 nm-610 nm band transmission cutoff and cut-off depth > OD2, 617 nm-647 nm band transmission cutoff and cut-off depth > OD4, 650 nm- The 1100 nm band passes through and the cutoff depth is > OD2.

Preferably, the first color block 1, the second color block 2, the third color block 3, and the fourth color block 4 are arranged in a 2X2 matrix. Specifically, the first color block 1, the second color block 2, and the third color The block 3 and the fourth color block 4 may be arbitrarily arranged in a 2×2 matrix. Specifically, according to actual needs, the PDT mask 10 is provided with a plurality of 2×2 first color blocks 1, second color blocks 2, and third color. Block 3, the fourth color block 4 matrix.

As shown in FIG. 2, a PDT mirror body 20 includes a body 5, an image sensor module 6 disposed on the body 5, and an image sensor module 6 provided with the PDT mask 10 described above.

Specifically, the PDT scope 20 further includes a first optical fiber for introducing therapeutic light, a second optical fiber for introducing illumination light, and the body 5 is provided with a clamp hole 51 for mounting the optical fiber for mounting the illumination of the second optical fiber. Light guide hole 52.

Specifically, the number of the second optical fibers and the illumination light guiding holes 52 is two.

Specifically, the body 5 is further provided with a water vapor vent 53 at the end.

Specifically, the treatment light is 632 nm ± 15 nm laser or narrow band LED light.

As shown in FIG. 3, the circuit of the PDT mirror body adopts the circuit structure as shown in the figure.

As shown in FIG. 4 and FIG. 5, the spectral transmittance characteristics of the PDT mirror mask, wherein the second color block 2 of the mask is an R color block, and the third color block 3 is a G color block and a fourth color block. 4 is a B color block, and the second color block 2, the third color block 3, and the fourth color block 4 are cut off at a therapeutic light band of 632 nm ± 15 nm, and the cutoff depth is greater than OD4. The first color block is a PDT color block which is transparent at a therapeutic light band of 632 nm±15 nm, and the transmittance t is between 0.1% and 1%, and is cut off at a wavelength of 400 nm to 600 nm and 660 nm to 1100 nm. The depth is greater than OD4.

The principle of the work process is as follows:

1. Endoscopic clinical examination mode: in the case of white light illumination or special light illumination, the transmittance of the first color block of the mask 4 is between 0.1% and 1%, which is far lower than the second color block 2 and the third color of the mask. The transmittance of the block 3, the fourth color block 4, the image color obtaining in the white light illumination mode or the special light illumination mode, and the image brightness are obtained through the mask first color block, the second color block 2, the third color block 3, The pixel response output signal of the fourth color block 4 filter color block synthesizes a white light image to observe the lesion position. The first color block, the second color block 2, the third color block 3, and the fourth color block 4 of the mask respectively correspond to the R4, R1, G, and B components of the color information, and the R4, R1, G, and B colors are properly configured. The component ratio can obtain normal white light image information.

2. In the PDT treatment stage, after the treatment light is turned on, the treatment light intensity is hundreds of times and thousands of times of the illumination intensity of the mirror body, but the second color block 2, the third color block 3, and the fourth color block 4 of the mask are The treatment light band is the cut-off depth of the cut-off depth is greater than OD4, and the treatment light does not affect the response of the pixels under the second color block 2, the third color block 3, and the fourth color block 4 of the mask to the illumination light, and the mask second The signals of the pixel response under the color block 2, the third color block 3, and the fourth color block 4 are from the mirror illumination light. The first color block of the mask has a certain transmittance to the treatment light, and the transmittance t is between 0.1% and 1%. After the treatment light is turned on, the pixels under the first color block of the mask can output voltage signal information, and the voltage The signal information shows the illumination area information of the treatment light, which realizes the visualization of the therapeutic effect of the PDT treatment process and the visualization of the treatment light irradiation position.

The above technical description of the present invention is further described by way of example only, and is not to be understood by the reader, but the embodiments of the present invention are not limited thereto, and any technology extending or re-creating according to the present invention is subject to the present invention. The protection of the invention is defined by the claims.

Claims

The PDT mask is characterized in that the PDT mask is provided with a first color block; the first color block is coated with a narrow strip light film, and the optical index is: 400 nm-600 nm band cutoff and cut off The depth>OD4, 617nm-647nm band transmittance is 0.1<t<1%, the 660nm-1100nm band transmission cutoff and the cutoff depth>OD4.
The PDT mask according to claim 1, wherein the PDT mask is further provided with a second color block, a third color block, and a fourth color block of a narrow strip light film system; The optical index of the block is: 400nm-560nm band transmission cutoff and cutoff depth > OD2, 590nm transmittance > 45% and full width at half maximum > 20nm, 617nm-647nm band pass cutoff and cutoff depth > OD4, 670nm transmittance > 45% and full width at half maximum >20 nm, transmission through 700nm-1100nm band and cutoff depth >OD2; optical index of the third color block is: 400nm-480nm band transmission cutoff and cutoff depth>OD2, 535nm transmittance> 65% and full width at half maximum <60nm, 617nm-647nm band transmission cutoff and cutoff depth>OD4, 650nm-1100nm band transmission cutoff and cutoff depth>OD2; optical index of the fourth color block is 450nm transmittance>50 % and half-height full width <60nm, 500nm-610nm band transmission cutoff and cutoff depth>OD2, 617nm-647nm band transmission cutoff and cutoff depth>OD4, 650nm-1100nm band pass cutoff and cutoff depth>OD2.
The PDT mask according to claim 2, wherein the first color block, the second color block, the third color block, and the fourth color block are arranged in a 2×2 matrix.
A PDT mirror body, comprising: a body, an image sensor module disposed on the body; and the image sensor module is provided with the PDT mask according to any one of claims 1-3.
The PDT scope according to claim 4, wherein said PDT mirror body further comprises a first optical fiber for introducing therapeutic light, a second optical fiber for introducing illumination light; and said body is provided with an optical fiber for mounting A clamp hole for mounting an illumination light guide hole of the second optical fiber.
The PDT scope according to claim 5, wherein the number of the second optical fibers and the illumination light guiding holes is two.
A PDT mirror according to claim 5, wherein said body is further provided with a water vapor vent at the end.
The PDT scope according to claim 5, wherein the treatment light is 632 nm ± 15 nm laser or narrow band LED light.